dihydropyrimidinase-like 3 (DPYSL3) - coding DNA reference sequence

(used for variant description)

(last modified March 15, 2013)


This file was created to facilitate the description of sequence variants on transcript NM_001197294.1 in the DPYSL3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000005.9, covering DPYSL3 transcript NM_001197294.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5018
                                           tgctccgcgcgctagctg       c.-181

 .         .         .         .         .         .                g.5078
 gctgtgtggctcgctggctcgctagggacaagcaggaatcggagcagcactgccgcctct       c.-121

 .         .         .         .         .         .                g.5138
 ggcgcgaaggctcaggcgcctcctcccgccacagtcactgtggctcggcgcacgctgccg       c.-61

 .         .         .         .         .         .                g.5198
 gcggctgccctttccgcctctggggaagaaaaacccgcgggccgctttcgtgcttgaacc       c.-1

          .         .         .         .         .         .       g.5258
 ATGGCCTCGGGCCGGAGGGGCTGGGACAGCTCCCACGAAGACGATCTGCCCGTGTACCTG       c.60
 M  A  S  G  R  R  G  W  D  S  S  H  E  D  D  L  P  V  Y  L         p.20

          .         .         .         .         .         .       g.5318
 GCCAGGCCGGGCACCACGGACCAGGTCCCGCGGCAGAAATACGGCGGCATGTTCTGCAAC       c.120
 A  R  P  G  T  T  D  Q  V  P  R  Q  K  Y  G  G  M  F  C  N         p.40

          .         .         .         .         .         .       g.5378
 GTGGAGGGCGCCTTCGAGAGCAAGACGCTGGATTTCGATGCCCTCAGCGTGGGGCAGCGG       c.180
 V  E  G  A  F  E  S  K  T  L  D  F  D  A  L  S  V  G  Q  R         p.60

          .         .         .         .         .         .       g.5438
 GGCGCGAAGACTCCTCGGAGCGGCCAGGGCAGCGACCGAGGATCGGGGAGTCGGCCCGGG       c.240
 G  A  K  T  P  R  S  G  Q  G  S  D  R  G  S  G  S  R  P  G         p.80

          .         .         .         .         .         .       g.5498
 ATCGAGGGGGACACCCCGCGCAGGGGCCAAGGCCGGGAAGAGAGCAGGGAGCCCGCGCCC       c.300
 I  E  G  D  T  P  R  R  G  Q  G  R  E  E  S  R  E  P  A  P         p.100

          .         .         .         .         .         .       g.5558
 GCCTCCCCCGCCCCCGCCGGGGTAGAGATCCGGAGCGCCACCGGCAAAGAGGTGTTGCAG       c.360
 A  S  P  A  P  A  G  V  E  I  R  S  A  T  G  K  E  V  L  Q         p.120

          .         .  | 02      .         .         .         .    g.90132
 AACCTCGGCCCCAAGGACAAG | AGTGACCGTCTCCTTATCAAGGGAGGCAGAATCGTCAAT    c.420
 N  L  G  P  K  D  K   | S  D  R  L  L  I  K  G  G  R  I  V  N      p.140

          .         .         .         .         . | 03       .    g.96435
 GATGATCAGTCCTTTTATGCTGATATTTACATGGAAGATGGCTTAATAAA | ACAAATTGGA    c.480
 D  D  Q  S  F  Y  A  D  I  Y  M  E  D  G  L  I  K  |  Q  I  G      p.160

          .         .         .         .         .         .       g.96495
 GACAATCTGATTGTTCCTGGAGGAGTGAAGACCATTGAAGCCAATGGGAAGATGGTGATC       c.540
 D  N  L  I  V  P  G  G  V  K  T  I  E  A  N  G  K  M  V  I         p.180

          .         .         .         .         .         .       g.96555
 CCTGGAGGCATCGATGTCCATACTCACTTCCAGATGCCATATAAGGGAATGACCACAGTA       c.600
 P  G  G  I  D  V  H  T  H  F  Q  M  P  Y  K  G  M  T  T  V         p.200

          .         .         .         .         .      | 04  .    g.99188
 GATGACTTCTTCCAAGGGACAAAGGCGGCCTTAGCAGGTGGCACCACCATGATCA | TTGAC    c.660
 D  D  F  F  Q  G  T  K  A  A  L  A  G  G  T  T  M  I  I |   D      p.220

          .         .         .         .         .         .       g.99248
 CATGTGGTGCCTGAGCCTGAGTCCAGCCTGACTGAGGCCTATGAGAAATGGAGAGAGTGG       c.720
 H  V  V  P  E  P  E  S  S  L  T  E  A  Y  E  K  W  R  E  W         p.240

          .         .         .         .         .         .       g.99308
 GCTGATGGGAAGAGTTGCTGTGACTATGCCCTGCATGTGGACATCACCCACTGGAATGAC       c.780
 A  D  G  K  S  C  C  D  Y  A  L  H  V  D  I  T  H  W  N  D         p.260

          .         .         .         . | 05       .         .    g.101419
 AGCGTCAAGCAGGAAGTGCAGAACCTCATCAAGGACAAAG | GGGTTAACTCCTTCATGGTT    c.840
 S  V  K  Q  E  V  Q  N  L  I  K  D  K  G |   V  N  S  F  M  V      p.280

          .         .         .         .   | 06     .         .    g.102386
 TATATGGCTTATAAGGATTTGTATCAAGTATCTAACACAGAG | CTCTATGAGATCTTCACC    c.900
 Y  M  A  Y  K  D  L  Y  Q  V  S  N  T  E   | L  Y  E  I  F  T      p.300

          .         .         .         .         .         .       g.102446
 TGCCTGGGAGAGCTGGGGGCCATTGCTCAAGTTCATGCTGAGAATGGGGATATCATTGCC       c.960
 C  L  G  E  L  G  A  I  A  Q  V  H  A  E  N  G  D  I  I  A         p.320

     | 07    .         .         .         .         .         .    g.106317
 CAG | GAGCAAACCCGCATGTTGGAAATGGGGATAACTGGCCCAGAAGGCCATGTACTGAGC    c.1020
 Q   | E  Q  T  R  M  L  E  M  G  I  T  G  P  E  G  H  V  L  S      p.340

          .   | 08     .         .         .         .         .    g.109374
 AGGCCAGAAGAG | CTGGAAGCTGAGGCTGTGTTCCGTGCCATCACCATTGCCAGCCAAACC    c.1080
 R  P  E  E   | L  E  A  E  A  V  F  R  A  I  T  I  A  S  Q  T      p.360

          .         .         .         .         .         .       g.109434
 AATTGCCCTCTCTACGTCACAAAGGTCATGAGCAAGAGTGCAGCTGACCTCATCTCACAA       c.1140
 N  C  P  L  Y  V  T  K  V  M  S  K  S  A  A  D  L  I  S  Q         p.380

          .    | 09    .         .         .         .         .    g.113407
 GCCAGGAAAAAAG | GAAATGTAGTCTTTGGTGAGCCCATCACTGCCAGCCTCGGCATAGAT    c.1200
 A  R  K  K  G |   N  V  V  F  G  E  P  I  T  A  S  L  G  I  D      p.400

          .         .         .         .         .         .       g.113467
 GGAACCCATTATTGGAGCAAGAACTGGGCCAAGGCGGCTGCATTTGTGACATCCCCACCC       c.1260
 G  T  H  Y  W  S  K  N  W  A  K  A  A  A  F  V  T  S  P  P         p.420

          .         .         .         .         . | 10       .    g.114233
 CTGAGCCCTGACCCAACTACTCCGGACTACATCAACTCCTTGCTGGCCAG | CGGGGATCTG    c.1320
 L  S  P  D  P  T  T  P  D  Y  I  N  S  L  L  A  S  |  G  D  L      p.440

          .         .         .         .         .         .       g.114293
 CAGCTATCTGGGAGTGCCCACTGCACCTTCAGCACTGCCCAGAAAGCAATTGGGAAGGAC       c.1380
 Q  L  S  G  S  A  H  C  T  F  S  T  A  Q  K  A  I  G  K  D         p.460

          .         .         .         .         .         .       g.114353
 AACTTCACAGCCATTCCTGAGGGCACCAATGGTGTGGAGGAGCGGATGTCTGTCATCTGG       c.1440
 N  F  T  A  I  P  E  G  T  N  G  V  E  E  R  M  S  V  I  W         p.480

          .   | 11     .         .         .         .         .    g.115852
 GACAAGGCTGTG | GCCACAGGGAAAATGGACGAAAACCAGTTCGTGGCTGTGACAAGCACA    c.1500
 D  K  A  V   | A  T  G  K  M  D  E  N  Q  F  V  A  V  T  S  T      p.500

          .         .         .         .         .         .       g.115912
 AACGCTGCCAAGATCTTCAACCTGTATCCCCGCAAGGGAAGAATATCTGTGGGTTCTGAC       c.1560
 N  A  A  K  I  F  N  L  Y  P  R  K  G  R  I  S  V  G  S  D         p.520

          .         .         .         .         .         .       g.115972
 AGCGACCTCGTCATCTGGGATCCAGATGCTGTGAAGATCGTCTCTGCCAAGAACCACCAG       c.1620
 S  D  L  V  I  W  D  P  D  A  V  K  I  V  S  A  K  N  H  Q         p.540

     | 12    .         .         .         .         .         .    g.117268
 TCT | GCGGCAGAGTACAACATCTTTGAAGGGATGGAGCTGCGCGGGGCTCCTCTGGTTGTC    c.1680
 S   | A  A  E  Y  N  I  F  E  G  M  E  L  R  G  A  P  L  V  V      p.560

          .         .         .         .         .         .       g.117328
 ATCTGCCAGGGCAAGATCATGCTGGAAGATGGCAACCTGCACGTGACCCAGGGGGCTGGC       c.1740
 I  C  Q  G  K  I  M  L  E  D  G  N  L  H  V  T  Q  G  A  G         p.580

          .         .         .         .         .         .       g.117388
 CGCTTCATACCCTGCAGCCCGTTCTCCGACTATGTCTACAAGCGCATTAAAGCACGGAGG       c.1800
 R  F  I  P  C  S  P  F  S  D  Y  V  Y  K  R  I  K  A  R  R         p.600

     | 13    .         .         .         .         .         .    g.119392
 AAG | ATGGCAGACCTGCATGCCGTCCCAAGGGGCATGTACGATGGGCCTGTGTTTGACCTG    c.1860
 K   | M  A  D  L  H  A  V  P  R  G  M  Y  D  G  P  V  F  D  L      p.620

          .         .         .         .         .         .       g.119452
 ACCACCACCCCCAAAGGTGGCACCCCCGCAGGCTCTGCTCGGGGCTCTCCTACTCGGCCG       c.1920
 T  T  T  P  K  G  G  T  P  A  G  S  A  R  G  S  P  T  R  P         p.640

          .         .         .         .       | 14 .         .    g.120947
 AACCCACCTGTGAGGAATCTTCATCAGTCGGGATTTAGCCTGTCAG | GCACCCAAGTGGAT    c.1980
 N  P  P  V  R  N  L  H  Q  S  G  F  S  L  S  G |   T  Q  V  D      p.660

          .         .         .         .         .         .       g.121007
 GAGGGGGTTCGCTCAGCCAGCAAGCGCATCGTGGCGCCCCCAGGCGGCCGTTCTAATATC       c.2040
 E  G  V  R  S  A  S  K  R  I  V  A  P  P  G  G  R  S  N  I         p.680

          .                                                         g.121022
 ACATCTCTGAGTTAA                                                    c.2055
 T  S  L  S  X                                                      p.684

          .         .         .         .         .         .       g.121082
 gcaagccttcctcaaagagaggggcagaagcaagaagagattgttttgaagccaaaatgg       c.*60

          .         .         .         .         .         .       g.121142
 tacaccgatatttaagaaggaaagcgaatccaaacggttgtgatctaaagaatcaataag       c.*120

          .         .         .         .         .         .       g.121202
 cctcaagccttatgtttctccaatgttacgctcgcttgcctagctttacgaatattgctt       c.*180

          .         .         .         .         .         .       g.121262
 tgttttctgtttatgcatagccttgatttgtttgactcccctccccccatttacatgcat       c.*240

          .         .         .         .         .         .       g.121322
 gcaatcagacaggccactaaggtaaaagagtctgctctatcatagtgttgagagcgtgtg       c.*300

          .         .         .         .         .         .       g.121382
 tagtgctgcatcttatgacaaggggacagacaagctgggacgtcagggaaatgaacaaaa       c.*360

          .         .         .         .         .         .       g.121442
 gggacgcaggttatttggggtgagtgggtggtgggagcctggagcaaggtggagggtgca       c.*420

          .         .         .         .         .         .       g.121502
 gaggggctggggtagggcatgtaggagggaggtgggtgggtcaggtgagtggaaggggtg       c.*480

          .         .         .         .         .         .       g.121562
 ttgtatattgtgttgatgacgtacgttatttccatggaagatagccgctgtggcagctgt       c.*540

          .         .         .         .         .         .       g.121622
 cacatcaccacagctccctagggtctgccgagaaggcaggcagtctttgggttctgttct       c.*600

          .         .         .         .         .         .       g.121682
 ttgtcacgtcccctacaagtaaattttgtttctttgaacgtttattaaaatgccaagacc       c.*660

          .         .         .         .         .         .       g.121742
 caaccatttcttccacctgcttgattgtgccagtgtttgctcaggcctctttcttagtgt       c.*720

          .         .         .         .         .         .       g.121802
 tgctttcaaatccttctctttcctgggttgggaaggccaggcagggacagagcaaatgac       c.*780

          .         .         .         .         .         .       g.121862
 acttctcttcctcttgccctccctgcctctttggtgctcttaaaagccagcagctgagaa       c.*840

          .         .         .         .         .         .       g.121922
 catagcacaggcccacgtggtgagggcacccacagcttaaagacgcttccttctaaacac       c.*900

          .         .         .         .         .         .       g.121982
 ggcgaggtcacctctcactcttctgtctttgcaaaccgagaagagtggcatgcttctggc       c.*960

          .         .         .         .         .         .       g.122042
 atcccaagtcaggattttagctcagatgaggcagaatgaagggcctctcttacaggcagt       c.*1020

          .         .         .         .         .         .       g.122102
 ttgtgtttgattctctcgatcctggcacatccatgataaataggagtttttgaaagttgg       c.*1080

          .         .         .         .         .         .       g.122162
 ttttattaggtgttccctaatttttaccgtaataggtcatctcagcttatatgaaagtca       c.*1140

          .         .         .         .         .         .       g.122222
 agtggggaactgggaaagccaaagtcagtcttgagcagagggagcacattttgtggacct       c.*1200

          .         .         .         .         .         .       g.122282
 ggttccacctttccattccaaaccacctgtttccccttccattagcagaaactctggggg       c.*1260

          .         .         .         .         .         .       g.122342
 aactttgtgtctcagtcctagaatctccccaagtgagtggaagtgacatgatgcagtctt       c.*1320

          .         .         .         .         .         .       g.122402
 cctcatggggcacctgaaagaaattagtgtgggtgcttcgatctaccttgtctgtcagag       c.*1380

          .         .         .         .         .         .       g.122462
 ttgaatatctctttccctatcatgctgcttctgaaaattcagttttggagcaagtcctgt       c.*1440

          .         .         .         .         .         .       g.122522
 gagcaagataagaatctatagaaccaagatgctcattttcagaagaaatatgttcaacct       c.*1500

          .         .         .         .         .         .       g.122582
 gggatcagacttccatgctctggggaatccaagtggtagcacctgtaaccctgtgtacta       c.*1560

          .         .         .         .         .         .       g.122642
 agtgctttgaagagaagagcaggcctcagacaccttttaattgcttaggagaaaccattg       c.*1620

          .         .         .         .         .         .       g.122702
 tctctgactgcaggtttgaataagttgaagaccagagaaaagtacacactgggctacaaa       c.*1680

          .         .         .         .         .         .       g.122762
 ggaatttggagatagccaaggaacaggatttcccctagcaagctaccttctgttcaaatc       c.*1740

          .         .         .         .         .         .       g.122822
 atgaaaaaagactatttccccttagaatagggaagcttgctattttaaagctcttgtagt       c.*1800

          .         .         .         .         .         .       g.122882
 gcttttcttttaagggagatgtagtaaaagggaaaatgtagctcttagtttacacttcaa       c.*1860

          .         .         .         .         .         .       g.122942
 agatgtgggggtctttcagagaactaagaataacagttttatgtgcagagagagtttgcc       c.*1920

          .         .         .         .         .         .       g.123002
 agatctgaagcatatacctcattgactaggctgttactttgggataggttgcagtaccag       c.*1980

          .         .         .         .         .         .       g.123062
 ccacagccagcagatagaggaaaagacacacataaactcgcttctgagcgtccacttctg       c.*2040

          .         .         .         .         .         .       g.123122
 cactctctgctctgctgttactcagcccctgagtctgactcatctctgcacaacctctct       c.*2100

          .         .         .         .         .         .       g.123182
 gtgccatgaagataagtcttccatggccaaatcggtcatccgcactgcccttgggacttc       c.*2160

          .         .         .         .         .         .       g.123242
 cgaagtgaaccattccaccagaacctttgattctgcacaagatttccttgctctgggaac       c.*2220

          .         .         .         .         .         .       g.123302
 aacccccaaatgcccttgggaggaacaacatgagctcaggaagcctctctttcttcactt       c.*2280

          .         .         .         .         .         .       g.123362
 accattactaactctccaagcatagaaatccctgggaattgcgagaataactcccactat       c.*2340

          .         .         .         .         .         .       g.123422
 tttaaaatttatattcagatttgtttcgtttcataagacacatcaaacaggcctatacaa       c.*2400

          .         .         .         .         .         .       g.123482
 aaggtttaggaaaagaaaacaatggtgagtcccggccctcttcgaattcactggcacctc       c.*2460

          .         .         .         .         .         .       g.123542
 atgcaagtgtaggaaggcacgctggatcgtctatctgattccaaagctgtcctttgccat       c.*2520

          .         .         .         .         .         .       g.123602
 ctcatcccttggcctgccccccaaccctgaggatgcccctgccatccccccaacctcctc       c.*2580

          .         .         .         .         .         .       g.123662
 atattgcctctgaacccagatggcaatccatcccggttctctctgagggccacgggcttg       c.*2640

          .         .         .         .         .         .       g.123722
 ggtagtggaaagggtgtttgggaaattgttaaatcagttacccgtagtagagctatttct       c.*2700

          .         .         .         .         .         .       g.123782
 tgtacttctaagttttctagaagtggaaggattgtagtcatcctgaaaatgggtttactt       c.*2760

          .         .         .         .         .         .       g.123842
 caaaatccctcagccttgttcttcacgactgtctatactgagagtgtcatgtttccacaa       c.*2820

          .         .         .         .         .         .       g.123902
 agggctgacacctgagcctggattttcactcatccctgagaagccctttccagtagggtg       c.*2880

          .         .         .         .         .         .       g.123962
 ggcaattcccaacttccttgccacaagcttcccaggctttctcccctggaaaactccagc       c.*2940

          .         .         .         .         .         .       g.124022
 ttgagtcccagatacactcatgggctgccctgggcagccagcattcattgtaagttccct       c.*3000

          .         .         .         .         .         .       g.124082
 ctttgaaaactggtgtgtgggtgttcagttctgtgtctggtgggtatggacagacagtaa       c.*3060

          .         .         .         .         .         .       g.124142
 tctcctgtgatctgtgctagctgtgaggcagctctggaacgtgaagagctgtttggtttg       c.*3120

          .         .         .         .         .         .       g.124202
 aaccgtgaacaaaactgtgttttgagtttagctgacattaaagaaaaaagttcatcacgt       c.*3180

          .         .         .         .                           g.124249
 gactgttaatgtaaacctggttattaaaataactatgaaattaccaa                    c.*3227

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Dihydropyrimidinase-like 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 03
©2004-2013 Leiden University Medical Center