dihydropyrimidinase-like 5 (DPYSL5) - coding DNA reference sequence

(used for variant description)

(last modified May 9, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_020134.3 in the DPYSL5 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.11, covering DPYSL5 transcript NM_020134.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5038
                       ccccactctggactcccgcgctgggcgcgctgaggcgg       c.-121

 .         .         .         .         .         .                g.5098
 cccccgagcgagcgcgcgtgcagccgccgccgccccgagcacccgcagctccggcgccgc       c.-61

 .         .         .         .         .         .      | 02      g.55399
 ggcgagacggagacggaccgagccacgggcccccgcggccgcagcatctcggagga | gaac    c.-1

          .         .         .         .         .         .       g.55459
 ATGCTTGCCAACTCAGCCAGCGTGAGGATCCTCATCAAGGGAGGCAAGGTGGTGAACGAT       c.60
 M  L  A  N  S  A  S  V  R  I  L  I  K  G  G  K  V  V  N  D         p.20

          .         .         .         .         .         .       g.55519
 GACTGCACCCACGAGGCTGACGTCTACATCGAGAATGGCATCATCCAGCAGGTGGGCCGC       c.120
 D  C  T  H  E  A  D  V  Y  I  E  N  G  I  I  Q  Q  V  G  R         p.40

          .         .         .         .         .         .       g.55579
 GAGCTCATGATCCCTGGCGGGGCCAAGGTGATTGATGCCACAGGAAAACTGGTGATCCCT       c.180
 E  L  M  I  P  G  G  A  K  V  I  D  A  T  G  K  L  V  I  P         p.60

          .         .         .         .         .         .       g.55639
 GGTGGCATCGACACCAGCACCCACTTCCACCAGACCTTCATGAATGCCACGTGCGTGGAC       c.240
 G  G  I  D  T  S  T  H  F  H  Q  T  F  M  N  A  T  C  V  D         p.80

          .         .  | 03      .         .         .         .    g.81825
 GACTTCTACCATGGGACCAAG | GCAGCACTCGTCGGAGGCACCACCATGATCATCGGCCAC    c.300
 D  F  Y  H  G  T  K   | A  A  L  V  G  G  T  T  M  I  I  G  H      p.100

          .         .         .         .         .         .       g.81885
 GTCCTGCCCGACAAGGAGACCTCCCTTGTGGACGCTTATGAGAAGTGCCGAGGTCTGGCC       c.360
 V  L  P  D  K  E  T  S  L  V  D  A  Y  E  K  C  R  G  L  A         p.120

          .         .         .         .         .         .       g.81945
 GACCCCAAGGTCTGCTGTGATTACGCCCTCCACGTGGGGATCACCTGGTGGGCACCCAAG       c.420
 D  P  K  V  C  C  D  Y  A  L  H  V  G  I  T  W  W  A  P  K         p.140

  | 04       .         .         .         .         .         .    g.84212
  | GTGAAAGCAGAAATGGAGACACTGGTGAGGGAGAAGGGTGTCAACTCGTTCCAGATGTTC    c.480
  | V  K  A  E  M  E  T  L  V  R  E  K  G  V  N  S  F  Q  M  F      p.160

          .         .         .         .         .         .       g.84272
 ATGACCTACAAGGACCTGTACATGCTTCGAGACAGTGAGCTGTACCAAGTGTTGCACGCT       c.540
 M  T  Y  K  D  L  Y  M  L  R  D  S  E  L  Y  Q  V  L  H  A         p.180

          .         .         .         .         .         .       g.84332
 TGCAAGGACATTGGGGCAATCGCCCGCGTCCATGCTGAAAATGGGGAGCTTGTGGCCGAG       c.600
 C  K  D  I  G  A  I  A  R  V  H  A  E  N  G  E  L  V  A  E         p.200

  | 05       .         .         .         .         .         .    g.85214
  | GGTGCTAAGGAGGCACTGGATTTGGGGATCACAGGCCCAGAAGGAATCGAGATCAGCCGT    c.660
  | G  A  K  E  A  L  D  L  G  I  T  G  P  E  G  I  E  I  S  R      p.220

           | 06        .         .         .         .     | 07   . g.90163
 CCAGAGGAG | CTGGAAGCTGAAGCCACTCATCGTGTTATCACCATTGCAAACAGG | ACTCAC c.720
 P  E  E   | L  E  A  E  A  T  H  R  V  I  T  I  A  N  R   | T  H   p.240

          .         .         .         .         .         .       g.90223
 TGTCCAATCTACCTGGTCAACGTGTCCAGTATCTCGGCTGGTGACGTTATCGCAGCTGCT       c.780
 C  P  I  Y  L  V  N  V  S  S  I  S  A  G  D  V  I  A  A  A         p.260

          . | 08       .         .         .         .         .    g.91527
 AAGATGCAAG | GGAAGGTTGTGCTGGCGGAGACCACCACTGCACATGCCACGCTGACAGGC    c.840
 K  M  Q  G |   K  V  V  L  A  E  T  T  T  A  H  A  T  L  T  G      p.280

          .         .         .         .         .         .       g.91587
 TTACACTACTACCACCAGGACTGGTCCCACGCGGCTGCCTATGTCACGGTGCCTCCCCTG       c.900
 L  H  Y  Y  H  Q  D  W  S  H  A  A  A  Y  V  T  V  P  P  L         p.300

          .         .         .         .        | 09.         .    g.96943
 AGACTGGACACCAACACCTCAACCTACCTCATGAGCCTGCTGGCCAA | TGACACTCTGAAC    c.960
 R  L  D  T  N  T  S  T  Y  L  M  S  L  L  A  N  |  D  T  L  N      p.320

          .         .         .         .         .         .       g.97003
 ATCGTGGCATCAGATCACCGGCCTTTCACCACAAAGCAGAAAGCTATGGGCAAGGAAGAC       c.1020
 I  V  A  S  D  H  R  P  F  T  T  K  Q  K  A  M  G  K  E  D         p.340

          .         .         .         .         .         .       g.97063
 TTCACCAAGATCCCACATGGAGTGAGTGGCGTGCAGGACCGCATGAGCGTCATCTGGGAG       c.1080
 F  T  K  I  P  H  G  V  S  G  V  Q  D  R  M  S  V  I  W  E         p.360

           | 10        .         .         .         .         .    g.98900
 AGAGGAGTG | GTTGGAGGAAAGATGGATGAGAACCGTTTTGTGGCCGTTACCAGTTCCAAC    c.1140
 R  G  V   | V  G  G  K  M  D  E  N  R  F  V  A  V  T  S  S  N      p.380

          .         .         .         .         .         .       g.98960
 GCAGCTAAGCTTCTGAACCTGTATCCCCGCAAGGGCCGCATTATTCCCGGAGCCGATGCT       c.1200
 A  A  K  L  L  N  L  Y  P  R  K  G  R  I  I  P  G  A  D  A         p.400

          .         .         .   | 11     .         .         .    g.99470
 GATGTGGTGGTGTGGGACCCAGAAGCCACAAA | GACCATCTCAGCCAGCACGCAGGTCCAG    c.1260
 D  V  V  V  W  D  P  E  A  T  K  |  T  I  S  A  S  T  Q  V  Q      p.420

          .         .         .         .         .         .       g.99530
 GGAGGAGACTTCAACCTGTATGAGAACATGCGCTGCCACGGCGTGCCACTGGTCACCATC       c.1320
 G  G  D  F  N  L  Y  E  N  M  R  C  H  G  V  P  L  V  T  I         p.440

          .         .         .         .         .         .       g.99590
 AGCCGGGGGCGCGTCGTGTATGAGAACGGCGTCTTCATGTGCGCCGAGGGCACCGGCAAG       c.1380
 S  R  G  R  V  V  Y  E  N  G  V  F  M  C  A  E  G  T  G  K         p.460

          .         .         .         .         .         .       g.99650
 TTCTGTCCCCTGAGGTCCTTCCCAGACACTGTCTACAAGAAGCTGGTCCAGAGAGAGAAG       c.1440
 F  C  P  L  R  S  F  P  D  T  V  Y  K  K  L  V  Q  R  E  K         p.480

  | 12       .         .         .         .         .         .    g.101615
  | ACTTTAAAGGTTAGAGGAGTGGACCGCACTCCCTACCTGGGGGATGTCGCTGTTGTCGTG    c.1500
  | T  L  K  V  R  G  V  D  R  T  P  Y  L  G  D  V  A  V  V  V      p.500

          .         .         .         .         .         .       g.101675
 CACCCTGGGAAAAAAGAGATGGGAACCCCACTCGCAGACACTCCTACCCGGCCCGTCACC       c.1560
 H  P  G  K  K  E  M  G  T  P  L  A  D  T  P  T  R  P  V  T         p.520

          .         .         .         .          | 13        .    g.103820
 CGGCATGGGGGCATGAGGGACCTTCACGAATCCAGCTTCAGCCTCTCTG | GCTCTCAGATC    c.1620
 R  H  G  G  M  R  D  L  H  E  S  S  F  S  L  S  G |   S  Q  I      p.540

          .         .         .         .         .         .       g.103880
 GATGACCATGTTCCAAAGCGAGCTTCAGCTCGGATCCTCGCTCCTCCCGGAGGCAGGTCG       c.1680
 D  D  H  V  P  K  R  A  S  A  R  I  L  A  P  P  G  G  R  S         p.560

          .                                                         g.103895
 AGTGGCATTTGGTAA                                                    c.1695
 S  G  I  W  X                                                      p.564

          .         .         .         .         .         .       g.103955
 aggcattgccaagccccccgagtgaggacgcaccgccgccaccagcccgcaactctccag       c.*60

          .         .         .         .         .         .       g.104015
 ccgaagctgcaggggcaggagaggctgggctgggtggcacaccacccgaggggggccccg       c.*120

          .         .         .         .         .         .       g.104075
 ggacccacggagccctccctatgtctgcaaagtgattcactgtgcttcgagccaactcta       c.*180

          .         .         .         .         .         .       g.104135
 acaggcactttgagatgtgttcctcctgctgtagtcctttctgccttggcctcggcgggc       c.*240

          .         .         .         .         .         .       g.104195
 ttttctggggcccaggaagcccacactatgcacagagcccaatgcatagagccctggcca       c.*300

          .         .         .         .         .         .       g.104255
 gcccttcctctcactcctgcctccgctggctttgggaaagcccagactttagtgccctgc       c.*360

          .         .         .         .         .         .       g.104315
 cccctggctgactggccagttgcccagagcactttagcagatgtggtttcaaagtaaagg       c.*420

          .         .         .         .         .         .       g.104375
 cctcctcccccaccccttaggccccgtggtgacatttcccaagtcagacagatgtcagct       c.*480

          .         .         .         .         .         .       g.104435
 tcccagccatgcccaggacgtcctatctcccccaacccacctctggccctgtgtaggggc       c.*540

          .         .         .         .         .         .       g.104495
 agggatgggggtggctgggactcctggtgcccctcgccagcttctcctgcgccccgccca       c.*600

          .         .         .         .         .         .       g.104555
 caccctcggggggtcacaggcccagaagggtagctgggcggggctcgaggctggtgccag       c.*660

          .         .         .         .         .         .       g.104615
 gcgcgtgtaaatggttttgttttgcacgtttggtttgcgcagtagtttggtttgacttgt       c.*720

          .         .         .         .         .         .       g.104675
 ttgtgcatcctgtgaaaaataacggtgcttgtgtcactagcatagaatagcgacaggaat       c.*780

          .         .         .         .         .         .       g.104735
 agatgtggtccttaggagacgctgcacttgacaccaaccagacagcacagggcaggggtg       c.*840

          .         .         .         .         .         .       g.104795
 gtggagggggctgggctcacaggcctctcttttccccgcctgcagtcttctgggctgcgg       c.*900

          .         .         .         .         .         .       g.104855
 gaggccctggccctttccccttcccctcccctccttgtctagtttcccacattccaaaag       c.*960

          .         .         .         .         .         .       g.104915
 ggggcctgggatgctagccccagagatgccagcccttcaggaagcaggtgtcctttcccc       c.*1020

          .         .         .         .         .         .       g.104975
 tctctgcccctgatcactcccagcactccccttgccttcccctgtcttcacctgccacca       c.*1080

          .         .         .         .         .         .       g.105035
 cacacacacacacacacacacacacacacacacacgcacggcttcctataacttcttcct       c.*1140

          .         .         .         .         .         .       g.105095
 gctggacagagactcagcgctcctcctgtgtgactggcaagaggcctcatgcctgctgag       c.*1200

          .         .         .         .         .         .       g.105155
 agaggaggagtgggagaggggcttgccagacaccagagagggagaccccaggcccacagg       c.*1260

          .         .         .         .         .         .       g.105215
 acctggctgtcgaacccgcattgctgctcaggtgccgtgatctcccgtggtcggcaccag       c.*1320

          .         .         .         .         .         .       g.105275
 gcccttgccagctcatggcctcatcttctcccctgtccatccaggtgggccctccctgct       c.*1380

          .         .         .         .         .         .       g.105335
 tctaaagccccacagaagttcccatggaaacactagaggccgggtgtctccttccacctc       c.*1440

          .         .         .         .         .         .       g.105395
 cagtgatctgggaagtgacccagccgcctgcccttgttaagcctggtctgccccgtggga       c.*1500

          .         .         .         .         .         .       g.105455
 agtgacttcatgttgcacatgtgatttcagcccccgaggcttgcgcgaggcttctggacc       c.*1560

          .         .         .         .         .         .       g.105515
 ctcggttaaaggtcagcccctggccgggtgcggtggctcacgcctgtaatcccagcactt       c.*1620

          .         .         .         .         .         .       g.105575
 tgggaggccaaggcgggtggatcatggagtcaggagatcgagaccatcctggctaacacg       c.*1680

          .         .         .         .         .         .       g.105635
 gtgaaaccccgtctctactaaaaatacaaaaattacccaggcgtggtggcgggcgcctgt       c.*1740

          .         .         .         .         .         .       g.105695
 agtcccagctactgaggaggctgaggcaggagaatagcgtgaacccgggaggcggagctt       c.*1800

          .         .         .         .         .         .       g.105755
 gcagtgagccaagatcacgccactgcacttcagcctggacgacagagtgagactccatct       c.*1860

          .         .         .         .         .         .       g.105815
 caaaaaacagacaaacaaaaaagtcagcccctgcacatctctgtagtgcttttcatgtat       c.*1920

          .         .         .         .         .         .       g.105875
 tcaaaccacttccgtatatgacctctcacttagtcctcatgacaatggagcacttattat       c.*1980

          .         .         .         .         .         .       g.105935
 tcttcccattttacagatgaggaaactaagacccagaaagttcaggtcctctgaccccag       c.*2040

          .         .         .         .         .         .       g.105995
 aagtgtctgtgatgaccctcccaaccttggctatctaccccacctgtggagaggaggtct       c.*2100

          .         .         .         .         .         .       g.106055
 ggggtgacatctattgtagatcccacctgagagtttaaccaatgagaagacttactttcc       c.*2160

          .         .         .         .         .         .       g.106115
 tggtaggcagcctgctttgttttgcacaggaagatagattttttttctcatctttcttat       c.*2220

          .         .         .         .         .         .       g.106175
 aaacaacctcatgcacattctgtgtttgagccaagactagtcacccattgggggctaacc       c.*2280

          .         .         .         .         .         .       g.106235
 gtgcagtgtgagctgcgtccacaccctcacttctcccttcactccccctttcctcactca       c.*2340

          .         .         .         .         .         .       g.106295
 ggggctgagaggacagaggtggtcagccggggagcagaggtggcgaaggggctcatggca       c.*2400

          .         .         .         .         .         .       g.106355
 agtggcagccattggaacaggggtgaggacccaggcctgggaaagccaccagggatgggg       c.*2460

          .         .         .         .         .         .       g.106415
 gaaaccatgacgccgcctcctggtgcagtgcacaccatctctatccctgtcagccctcac       c.*2520

          .         .         .         .         .         .       g.106475
 tgggtcatgggccttgggcagatgtcaaagagcccagcagcagcggtggtggccagctgg       c.*2580

          .         .         .         .         .         .       g.106535
 gcagagcatccttgcttgggctaggaaagctttaccttctctgagtgcctccgcctgaga       c.*2640

          .         .         .         .         .         .       g.106595
 gatgtgtgacccgtggcaccagggaaccacgtcttggagtggtccactgtaggccatgcg       c.*2700

          .         .         .         .         .         .       g.106655
 cttcatccacccccagtccctacataggccctacccttgcccgggagcttctagatagaa       c.*2760

          .         .         .         .         .         .       g.106715
 atcagaaagagattcaaggagccaaatgagcggtcagcccccaccatgcactccttgccc       c.*2820

          .         .         .         .         .         .       g.106775
 cgtgcagagctccagccagcttcgtcaccagccccactggctcctggttggaacgaaagg       c.*2880

          .         .         .         .         .         .       g.106835
 gtctctggttgcactgaatgcagctctcaaactggtcttgtacttgctgaataaatactg       c.*2940

          .         .         .         .         .         .       g.106895
 ttgttcttgccttagctgctctctaggtttgtggggttaagttgccagaaaattgtgcta       c.*3000

          .         .         .         .         .         .       g.106955
 ctgtgtgtgcgtgtgcgtgcgtgtgtgtagtgctaggagtccacagtaggtctctgtcaa       c.*3060

          .         .         .         .         .         .       g.107015
 gccgatgtcgtgatgagggcttttctgatactgacccagaagccacagaaccacaaggaa       c.*3120

          .         .         .         .         .         .       g.107075
 acccaaaccccctccagctgctgaggcgcaggcacagcctggggtcggatggagcctcca       c.*3180

          .         .         .         .         .         .       g.107135
 gcaccccagcacccaggtgacttccccactcccctgtaaatgtcatggtgctaagactgt       c.*3240

          .         .         .         .         .         .       g.107195
 gtcaaccccaagacgacacatggtcctgtgctttggccaccgtttgaggcaaaaactaaa       c.*3300

          .         .         .         .         .                 g.107251
 cagcccgacacgttgtgttctggtgcaggtttgtattaaactgtagctacttctca           c.*3356

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Dihydropyrimidinase-like 5 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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