dopamine receptor D2 (DRD2) - coding DNA reference sequence

(used for variant description)

(last modified July 19, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_000795.3 in the DRD2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000011.9, covering DRD2 transcript NM_000795.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5055
      actgctccccgcgggccagagccggccgagctgctgcccgccggggctctgaacg       c.-181

 .         .         .         .         .         .                g.5115
 gcgcggcggggccgggagccagggaccggccgaggagagtggcggccccggacggctgcc       c.-121

 .         .         .         .         .         .                g.5175
 ggaggggcggccgcgcgtggatgcggcgggagctggaagcctcaagcagccggcgccgtc       c.-61

 .         .         .         | 02         .         .             g.55628
 tctgcccccgggcgccctatggcttgaag | agcctggccacccagtggctccaccgccctg    c.-1

          .         .         .         .         .         .       g.55688
 ATGGATCCACTGAATCTGTCCTGGTATGATGATGATCTGGAGAGGCAGAACTGGAGCCGG       c.60
 M  D  P  L  N  L  S  W  Y  D  D  D  L  E  R  Q  N  W  S  R         p.20

          .         .         .         .         .         .       g.55748
 CCCTTCAACGGGTCAGACGGGAAGGCGGACAGACCCCACTACAACTACTATGCCACACTG       c.120
 P  F  N  G  S  D  G  K  A  D  R  P  H  Y  N  Y  Y  A  T  L         p.40

          .         .         .         .         .         .       g.55808
 CTCACCCTGCTCATCGCTGTCATCGTCTTCGGCAACGTGCTGGTGTGCATGGCTGTGTCC       c.180
 L  T  L  L  I  A  V  I  V  F  G  N  V  L  V  C  M  A  V  S         p.60

          .         .         .         .         .         .       g.55868
 CGCGAGAAGGCGCTGCAGACCACCACCAACTACCTGATCGTCAGCCTCGCAGTGGCCGAC       c.240
 R  E  K  A  L  Q  T  T  T  N  Y  L  I  V  S  L  A  V  A  D         p.80

          .         .         .         .      | 03  .         .    g.62158
 CTCCTCGTCGCCACACTGGTCATGCCCTGGGTTGTCTACCTGGAG | GTGGTAGGTGAGTGG    c.300
 L  L  V  A  T  L  V  M  P  W  V  V  Y  L  E   | V  V  G  E  W      p.100

          .         .         .         .         .         .       g.62218
 AAATTCAGCAGGATTCACTGTGACATCTTCGTCACTCTGGACGTCATGATGTGCACGGCG       c.360
 K  F  S  R  I  H  C  D  I  F  V  T  L  D  V  M  M  C  T  A         p.120

          .         .         .      | 04  .         .         .    g.63305
 AGCATCCTGAACTTGTGTGCCATCAGCATCGACAG | GTACACAGCTGTGGCCATGCCCATG    c.420
 S  I  L  N  L  C  A  I  S  I  D  R  |  Y  T  A  V  A  M  P  M      p.140

          .         .         .         .         .         .       g.63365
 CTGTACAATACGCGCTACAGCTCCAAGCGCCGGGTCACCGTCATGATCTCCATCGTCTGG       c.480
 L  Y  N  T  R  Y  S  S  K  R  R  V  T  V  M  I  S  I  V  W         p.160

          .         .         .         .         .   | 05     .    g.64676
 GTCCTGTCCTTCACCATCTCCTGCCCACTCCTCTTCGGACTCAATAACGCAG | ACCAGAAC    c.540
 V  L  S  F  T  I  S  C  P  L  L  F  G  L  N  N  A  D |   Q  N      p.180

          .         .         .         .         .         .       g.64736
 GAGTGCATCATTGCCAACCCGGCCTTCGTGGTCTACTCCTCCATCGTCTCCTTCTACGTG       c.600
 E  C  I  I  A  N  P  A  F  V  V  Y  S  S  I  V  S  F  Y  V         p.200

          .         .         .         .         .         .       g.64796
 CCCTTCATTGTCACCCTGCTGGTCTACATCAAGATCTACATTGTCCTCCGCAGACGCCGC       c.660
 P  F  I  V  T  L  L  V  Y  I  K  I  Y  I  V  L  R  R  R  R         p.220

          .         .         .         .         .         .       g.64856
 AAGCGAGTCAACACCAAACGCAGCAGCCGAGCTTTCAGGGCCCACCTGAGGGCTCCACTA       c.720
 K  R  V  N  T  K  R  S  S  R  A  F  R  A  H  L  R  A  P  L         p.240

     | 06    .         .         .         .         .         .    g.65875
 AAG | GGCAACTGTACTCACCCCGAGGACATGAAACTCTGCACCGTTATCATGAAGTCTAAT    c.780
 K   | G  N  C  T  H  P  E  D  M  K  L  C  T  V  I  M  K  S  N      p.260

          .         .         . | 07       .         .         .    g.67426
 GGGAGTTTCCCAGTGAACAGGCGGAGAGTG | GAGGCTGCCCGGCGAGCCCAGGAGCTGGAG    c.840
 G  S  F  P  V  N  R  R  R  V   | E  A  A  R  R  A  Q  E  L  E      p.280

          .         .         .         .         .         .       g.67486
 ATGGAGATGCTCTCCAGCACCAGCCCACCCGAGAGGACCCGGTACAGCCCCATCCCACCC       c.900
 M  E  M  L  S  S  T  S  P  P  E  R  T  R  Y  S  P  I  P  P         p.300

          .         .         .         .         .         .       g.67546
 AGCCACCACCAGCTGACTCTCCCCGACCCGTCCCACCATGGTCTCCACAGCACTCCCGAC       c.960
 S  H  H  Q  L  T  L  P  D  P  S  H  H  G  L  H  S  T  P  D         p.320

          .         .         .         .         .         .       g.67606
 AGCCCCGCCAAACCAGAGAAGAATGGGCATGCCAAAGACCACCCCAAGATTGCCAAGATC       c.1020
 S  P  A  K  P  E  K  N  G  H  A  K  D  H  P  K  I  A  K  I         p.340

          .         .         .         .         .         .       g.67666
 TTTGAGATCCAGACCATGCCCAATGGCAAAACCCGGACCTCCCTCAAGACCATGAGCCGT       c.1080
 F  E  I  Q  T  M  P  N  G  K  T  R  T  S  L  K  T  M  S  R         p.360

          .         .         .         .         .         | 08    g.69361
 AGGAAGCTCTCCCAGCAGAAGGAGAAGAAAGCCACTCAGATGCTCGCCATTGTTCTCG | GC    c.1140
 R  K  L  S  Q  Q  K  E  K  K  A  T  Q  M  L  A  I  V  L  G |       p.380

          .         .         .         .         .         .       g.69421
 GTGTTCATCATCTGCTGGCTGCCCTTCTTCATCACACACATCCTGAACATACACTGTGAC       c.1200
 V  F  I  I  C  W  L  P  F  F  I  T  H  I  L  N  I  H  C  D         p.400

          .         .         .         .         .         .       g.69481
 TGCAACATCCCGCCTGTCCTGTACAGCGCCTTCACGTGGCTGGGCTATGTCAACAGCGCC       c.1260
 C  N  I  P  P  V  L  Y  S  A  F  T  W  L  G  Y  V  N  S  A         p.420

          .         .         .         .         .         .       g.69541
 GTGAACCCCATCATCTACACCACCTTCAACATTGAGTTCCGCAAGGCCTTCCTGAAGATC       c.1320
 V  N  P  I  I  Y  T  T  F  N  I  E  F  R  K  A  F  L  K  I         p.440

          .                                                         g.69553
 CTCCACTGCTGA                                                       c.1332
 L  H  C  X                                                         p.443

          .         .         .         .         .         .       g.69613
 ctctgctgcctgcccgcacagcagcctgcttcccacctccctgcccaggccggccagcct       c.*60

          .         .         .         .         .         .       g.69673
 cacccttgcgaaccgtgagcaggaaggcctgggtggatcggcctcctcttcaccccggca       c.*120

          .         .         .         .         .         .       g.69733
 ggccctgcagtgttcgcttggctccatgctcctcactgcccgcacaccctcactctgcca       c.*180

          .         .         .         .         .         .       g.69793
 gggcagtgctagtgagctgggcatggtaccagccctggggctgggccccccagctcaggg       c.*240

          .         .         .         .         .         .       g.69853
 gcagctcatagagtcccccctcccacctccagtccccctatccttggcaccaaagatgca       c.*300

          .         .         .         .         .         .       g.69913
 gccgccttccttgaccttcctctggggctctagggttgctggagcctgagtcagggccca       c.*360

          .         .         .         .         .         .       g.69973
 gaggctgagttttctctttgtggggcttggcgtggagcaggcggtggggagagatggaca       c.*420

          .         .         .         .         .         .       g.70033
 gttcacaccctgcaaggcccacaggaggcaagcaagctctcttgccgaggagccaggcaa       c.*480

          .         .         .         .         .         .       g.70093
 cttcagtcctgggagacccatgtaaataccagactgcaggttggaccccagagattccca       c.*540

          .         .         .         .         .         .       g.70153
 agccaaaaaccttagctccctcccgcaccccgatgtggacctctactttccaggctagtc       c.*600

          .         .         .         .         .         .       g.70213
 cggacccacctcaccccgttacagctccccaagtggtttccacatgctctgagaagagga       c.*660

          .         .         .         .         .         .       g.70273
 gccctcatcttgaagggcccaggagggtctatggggagaggaactccttggcctagccca       c.*720

          .         .         .         .         .         .       g.70333
 ccctgctgccttctgacggccctgcaatgtatcccttctcacagcacatgctggccagcc       c.*780

          .         .         .         .         .         .       g.70393
 tggggcctggcagggaggtcaggccctggaactctatctgggcctgggctaggggacatc       c.*840

          .         .         .         .         .         .       g.70453
 agaggttctttgagggactgcctctgccacactctgacgcaaaaccactttccttttcta       c.*900

          .         .         .         .         .         .       g.70513
 ttccttctggcctttcctctctcctgtttcccttcccttccactgcctctgccttagagg       c.*960

          .         .         .         .         .         .       g.70573
 agcccacggctaagaggctgctgaaaaccatctggcctggcctggccctgccctgaggaa       c.*1020

          .         .         .         .         .         .       g.70633
 ggaggggaagctgcagcttgggagagcccctggggcctagactctgtaacatcactatcc       c.*1080

          .         .         .         .         .                 g.70685
 atgcaccaaactaataaaactttgacgagtcaccttccaggacccctgggta               c.*1132

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Dopamine receptor D2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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