desmocollin 2 (DSC2) - coding DNA reference sequence

(used for variant description)

(last modified December 24, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_004949.3 in the DSC2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000018.9, covering DSC2 transcript NM_004949.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5034
                           gtgcagtcagggcttctgctgggcagggccggct       c.-421

 .         .         .         .         .         .                g.5094
 gttaatctcgcctggcggagcggacaccggggcgtggtgggggagatgggccttataggt       c.-361

 .         .         .         .         .         .                g.5154
 ggcgtccgctggtgagaaacaccttgcgcaggtaaaagggtggcggcgagagggagttcc       c.-301

 .         .         .         .         .         .                g.5214
 cacccgtggctttcttagagaaatgaagtcttaagtcttaaatagacaacaaggaggggc       c.-241

 .         .         .         .         .         .                g.5274
 cgatcggtgtcttttggacgcgtctggagcccctccctccgccaaaggaaaagccccttg       c.-181

 .         .         .         .         .         .                g.5334
 gatgagaggcaggcgcttcagagaagctaagaaaagcacctctccgcgcgccccacctcc       c.-121

 .         .         .         .         .         .                g.5394
 tccgcctcgcgctcctcctgagcagcgggcccagactgcgctccggccgcggccctcgcc       c.-61

 .         .         .         .         .         .                g.5454
 ccgcggagccctcctaccccggcccgacgctcggcccgcgacctgccccgagccctctcc       c.-1

          .         .         .         .         .         .       g.5514
 ATGGAGGCAGCCCGCCCCTCCGGCTCCTGGAACGGAGCCCTCTGCCGGCTGCTCCTGCTG       c.60
 M  E  A  A  R  P  S  G  S  W  N  G  A  L  C  R  L  L  L  L         p.20

           | 02        .         .         .         .         .    g.13833
 ACCCTCGCG | ATCTTAATATTTGCCAGTGATGCCTGCAAAAATGTGACATTACATGTTCCC    c.120
 T  L  A   | I  L  I  F  A  S  D  A  C  K  N  V  T  L  H  V  P      p.40

          .         .         .     | 03   .         .         .    g.15151
 TCCAAACTAGATGCCGAGAAACTTGTTGGTAGAG | TTAACCTGAAAGAGTGCTTTACAGCT    c.180
 S  K  L  D  A  E  K  L  V  G  R  V |   N  L  K  E  C  F  T  A      p.60

          .         .         .         .         .         .       g.15211
 GCAAATCTAATTCATTCAAGTGATCCTGACTTCCAAATTTTGGAGGATGGTTCAGTCTAT       c.240
 A  N  L  I  H  S  S  D  P  D  F  Q  I  L  E  D  G  S  V  Y         p.80

          .         .         .         .         .         .       g.15271
 ACAACAAATACTATTCTATTGTCCTCGGAGAAGAGAAGTTTTACCATATTACTTTCCAAC       c.300
 T  T  N  T  I  L  L  S  S  E  K  R  S  F  T  I  L  L  S  N         p.100

          .         .         .         .         .     | 04   .    g.16284
 ACTGAGAACCAAGAAAAGAAGAAAATATTTGTCTTTTTGGAGCATCAAACAAAG | GTCCTA    c.360
 T  E  N  Q  E  K  K  K  I  F  V  F  L  E  H  Q  T  K   | V  L      p.120

          .         .         .         .         .         .       g.16344
 AAGAAAAGACATACTAAAGAAAAAGTTCTAAGGCGCGCCAAGAGAAGATGGGCTCCAATT       c.420
 K  K  R  H  T  K  E  K  V  L  R  R  A  K  R  R  W  A  P  I         p.140

          .         .         .         .         .     | 05   .    g.17837
 CCTTGTTCGATGCTAGAAAACTCCTTGGGTCCTTTTCCACTTTTCCTTCAACAG | GTTCAA    c.480
 P  C  S  M  L  E  N  S  L  G  P  F  P  L  F  L  Q  Q   | V  Q      p.160

          .         .         .         .         .         .       g.17897
 TCTGACACGGCCCAAAACTATACCATATACTATTCCATAAGAGGTCCTGGAGTTGACCAA       c.540
 S  D  T  A  Q  N  Y  T  I  Y  Y  S  I  R  G  P  G  V  D  Q         p.180

          .         .         .         .         .         .       g.17957
 GAACCTCGGAATTTATTTTATGTGGAGAGAGACACTGGAAACTTGTATTGTACTCGTCCT       c.600
 E  P  R  N  L  F  Y  V  E  R  D  T  G  N  L  Y  C  T  R  P         p.200

          .         .         . | 06       .         .         .    g.19642
 GTAGATCGTGAGCAGTATGAATCTTTTGAG | ATAATTGCCTTTGCAACAACTCCAGATGGG    c.660
 V  D  R  E  Q  Y  E  S  F  E   | I  I  A  F  A  T  T  P  D  G      p.220

          .         .         .         .         .         .       g.19702
 TATACTCCAGAACTTCCACTGCCCCTAATAATCAAAATAGAGGATGAAAATGATAACTAC       c.720
 Y  T  P  E  L  P  L  P  L  I  I  K  I  E  D  E  N  D  N  Y         p.240

          .         .         .         .         .      | 07  .    g.20688
 CCAATTTTTACAGAAGAAACTTATACTTTTACAATTTTTGAAAATTGCAGAGTGG | GCACT    c.780
 P  I  F  T  E  E  T  Y  T  F  T  I  F  E  N  C  R  V  G |   T      p.260

          .         .         .         .         .         .       g.20748
 ACTGTGGGACAAGTGTGTGCTACTGACAAAGATGAGCCTGACACGATGCACACACGCCTG       c.840
 T  V  G  Q  V  C  A  T  D  K  D  E  P  D  T  M  H  T  R  L         p.280

          .         .         .         .         .         .       g.20808
 AAGTACTCCATCATTGGGCAGGTGCCACCATCACCCACCCTATTTTCTATGCATCCAACT       c.900
 K  Y  S  I  I  G  Q  V  P  P  S  P  T  L  F  S  M  H  P  T         p.300

          .         .         .         .   | 08     .         .    g.24380
 ACAGGCGTGATCACCACAACATCATCTCAGCTAGACAGAGAG | TTAATTGACAAGTACCAG    c.960
 T  G  V  I  T  T  T  S  S  Q  L  D  R  E   | L  I  D  K  Y  Q      p.320

          .         .         .         .         .         .       g.24440
 TTGAAAATAAAAGTACAAGACATGGATGGTCAGTATTTTGGTCTACAGACAACTTCAACT       c.1020
 L  K  I  K  V  Q  D  M  D  G  Q  Y  F  G  L  Q  T  T  S  T         p.340

          .         .         .         .         .        | 09.    g.25002
 TGTATCATTAACATTGATGATGTAAATGACCACTTGCCAACATTTACTCGTACTTCT | TAT    c.1080
 C  I  I  N  I  D  D  V  N  D  H  L  P  T  F  T  R  T  S   | Y      p.360

          .         .         .         .         .         .       g.25062
 GTGACATCAGTGGAAGAAAATACAGTTGATGTGGAAATCTTACGAGTTACTGTTGAGGAT       c.1140
 V  T  S  V  E  E  N  T  V  D  V  E  I  L  R  V  T  V  E  D         p.380

          .         .         .         .         .         .       g.25122
 AAGGACTTAGTGAATACTGCTAACTGGAGAGCTAATTATACCATTTTAAAGGGCAATGAA       c.1200
 K  D  L  V  N  T  A  N  W  R  A  N  Y  T  I  L  K  G  N  E         p.400

          .         .         .         .         .         .       g.25182
 AATGGCAATTTTAAAATTGTAACAGATGCCAAAACCAATGAAGGAGTTCTTTGTGTAGTT       c.1260
 N  G  N  F  K  I  V  T  D  A  K  T  N  E  G  V  L  C  V  V         p.420

     | 10    .         .         .         .         .         .    g.27127
 AAG | CCTTTGAATTATGAAGAAAAGCAACAGATGATCTTGCAAATTGGTGTAGTTAATGAA    c.1320
 K   | P  L  N  Y  E  E  K  Q  Q  M  I  L  Q  I  G  V  V  N  E      p.440

          .         .         .         .         .         .       g.27187
 GCTCCATTTTCCAGAGAGGCTAGTCCAAGATCAGCCATGAGCACAGCAACAGTTACTGTT       c.1380
 A  P  F  S  R  E  A  S  P  R  S  A  M  S  T  A  T  V  T  V         p.460

          .         .         .         .         .         .       g.27247
 AATGTAGAAGATCAGGATGAGGGCCCTGAGTGTAACCCTCCAATACAGACTGTTCGCATG       c.1440
 N  V  E  D  Q  D  E  G  P  E  C  N  P  P  I  Q  T  V  R  M         p.480

          .         .         .         .         .         .       g.27307
 AAAGAAAATGCAGAAGTGGGAACAACAAGCAATGGATATAAAGCATATGACCCAGAAACA       c.1500
 K  E  N  A  E  V  G  T  T  S  N  G  Y  K  A  Y  D  P  E  T         p.500

          .         . | 11       .         .         .         .    g.27473
 AGAAGTAGCAGTGGCATAAG | GTATAAGAAATTAACTGATCCAACAGGGTGGGTCACCATT    c.1560
 R  S  S  S  G  I  R  |  Y  K  K  L  T  D  P  T  G  W  V  T  I      p.520

          .         .         .         .         .         .       g.27533
 GATGAAAATACAGGATCAATCAAAGTTTTCAGAAGCCTGGATAGAGAGGCAGAGACCATC       c.1620
 D  E  N  T  G  S  I  K  V  F  R  S  L  D  R  E  A  E  T  I         p.540

          .         .         .         .    | 12    .         .    g.32532
 AAAAATGGCATATATAATATTACAGTCCTTGCATCAGACCAAG | GAGGGAGAACATGTACG    c.1680
 K  N  G  I  Y  N  I  T  V  L  A  S  D  Q  G |   G  R  T  C  T      p.560

          .         .         .         .         .         .       g.32592
 GGGACACTGGGCATTATACTTCAAGACGTGAATGATAACAGCCCATTCATACCTAAAAAG       c.1740
 G  T  L  G  I  I  L  Q  D  V  N  D  N  S  P  F  I  P  K  K         p.580

          .         .         .         .         .         .       g.32652
 ACAGTGATCATCTGCAAACCCACCATGTCATCTGCGGAGATTGTTGCGGTTGATCCTGAT       c.1800
 T  V  I  I  C  K  P  T  M  S  S  A  E  I  V  A  V  D  P  D         p.600

          .         .         .         .         .         .       g.32712
 GAGCCTATCCATGGCCCACCCTTTGACTTTAGTCTGGAGAGTTCTACTTCAGAAGTACAG       c.1860
 E  P  I  H  G  P  P  F  D  F  S  L  E  S  S  T  S  E  V  Q         p.620

          .         .         | 13         .         .         .    g.35613
 AGAATGTGGAGACTGAAAGCAATTAATG | ATACAGCAGCACGTCTTTCCTATCAGAATGAT    c.1920
 R  M  W  R  L  K  A  I  N  D |   T  A  A  R  L  S  Y  Q  N  D      p.640

          .         .         .         .         .         .       g.35673
 CCTCCATTTGGCTCATATGTAGTACCTATAACAGTGAGAGATAGACTTGGCATGTCTAGT       c.1980
 P  P  F  G  S  Y  V  V  P  I  T  V  R  D  R  L  G  M  S  S         p.660

          .         .         .         .         .         .       g.35733
 GTCACTTCATTGGATGTTACACTGTGTGACTGCATTACCGAAAATGACTGCACACATCGT       c.2040
 V  T  S  L  D  V  T  L  C  D  C  I  T  E  N  D  C  T  H  R         p.680

          .         .         .         .         .         .       g.35793
 GTAGATCCAAGGATTGGCGGTGGAGGAGTACAACTTGGAAAGTGGGCCATCCTTGCAATA       c.2100
 V  D  P  R  I  G  G  G  G  V  Q  L  G  K  W  A  I  L  A  I         p.700

          .         .      | 14  .         .         .         .    g.36607
 TTGTTGGGCATAGCATTGCTCTTTT | GCATCCTGTTTACGCTGGTCTGTGGGGCTTCTGGG    c.2160
 L  L  G  I  A  L  L  F  C |   I  L  F  T  L  V  C  G  A  S  G      p.720

          .         .         .         .         .         .       g.36667
 ACGTCTAAACAACCAAAAGTAATTCCTGATGATTTAGCCCAGCAGAACCTAATTGTATCA       c.2220
 T  S  K  Q  P  K  V  I  P  D  D  L  A  Q  Q  N  L  I  V  S         p.740

          .         .         . | 15       .         .         .    g.38301
 AACACAGAAGCTCCTGGAGATGACAAAGTG | TATTCTGCGAATGGCTTCACAACCCAAACT    c.2280
 N  T  E  A  P  G  D  D  K  V   | Y  S  A  N  G  F  T  T  Q  T      p.760

          .         .         .         .         .         .       g.38361
 GTGGGCGCTTCTGCTCAGGGAGTTTGTGGCACCGTGGGATCAGGAATCAAAAACGGAGGT       c.2340
 V  G  A  S  A  Q  G  V  C  G  T  V  G  S  G  I  K  N  G  G         p.780

          .         .         .         .         .         .       g.38421
 CAGGAGACCATCGAAATGGTGAAAGGAGGACACCAGACCTCGGAATCCTGCCGGGGGGCT       c.2400
 Q  E  T  I  E  M  V  K  G  G  H  Q  T  S  E  S  C  R  G  A         p.800

          .         .         .         .         .         .       g.38481
 GGCCACCATCACACCCTGGACTCCTGCAGGGGAGGACACACGGAGGTGGACAACTGCAGA       c.2460
 G  H  H  H  T  L  D  S  C  R  G  G  H  T  E  V  D  N  C  R         p.820

          .         .         .         .         | 16         .    g.39090
 TACACTTACTCGGAGTGGCACAGTTTTACTCAGCCCCGTCTTGGTGAA | GAATCCATTAGA    c.2520
 Y  T  Y  S  E  W  H  S  F  T  Q  P  R  L  G  E   | E  S  I  R      p.840

          .         .                                           g.39114
 GGACACACTCTGATTAAAAATTAA |                                        c.2545
 G  H  T  L  I  K  N  X                                          p.847

          . | 17       .         .         .         .         .    g.39260
 acaatgaaag | aaagtgtatctgtgtaatcaagatgaaaatcacaagcatgcccaagacta    c.*60

          .         .         .         .         .         .       g.39320
 tgtcctgacatataactatgaaggaagaggatcggtggctgggtctgtaggttgttgcag       c.*120

          .         .         .         .         .         .       g.39380
 tgaacgacaagaagaagatgggcttgaatttttggataatttggagcccaaatttaggac       c.*180

          .         .         .         .         .         .       g.39440
 actagcagaagcatgcatgaagagatgagtgtgttctaataagtctctgaaagccagtgg       c.*240

          .         .         .         .         .         .       g.39500
 ctttatgacttttaaaaaaaattacaaaccaagaattttttaaagcagaagatgctattt       c.*300

          .         .         .         .         .         .       g.39560
 gtgggggtttttctctcattatttggatggaatctctttggtcaaatgcacatttacaga       c.*360

          .         .         .         .         .         .       g.39620
 gagacactataaacaagtacacaaatttttcaatttttacatatttttaaattacttatc       c.*420

          .         .         .         .         .         .       g.39680
 ttctatccaaggaggtctacagagaaattaaagtctgccttatttgttacatttgggtat       c.*480

          .         .         .         .         .         .       g.39740
 aatgacaacagccaatttatagtgcaataaaatgtaattaattcaagtccttattataga       c.*540

          .         .         .         .         .         .       g.39800
 ctatttgaagcacaacctaatggaaaattgtagagaccttgctttaacattatctccagt       c.*600

          .         .         .         .         .         .       g.39860
 taattaagtgttcatgtggtgcttggaaactgttgttttcctgaacatctaaagtgtgta       c.*660

          .         .         .         .         .         .       g.39920
 gactgcattcttgctattattttattcttgtaatgtgaccttttcactgtgcaaagggag       c.*720

          .         .         .         .         .         .       g.39980
 atttctagccaggcattgactattacaatttcattttggtggagtttagttttaggtttt       c.*780

          .         .         .         .         .         .       g.40040
 attgtatataaaatcctgcactgaatctgtgtctcctctgttacctacttttgccagtga       c.*840

          .         .         .         .         .         .       g.40100
 aatttaagttttaaaatactttcagaatgtatttttactactgcaagtttttggtcttta       c.*900

          .         .         .         .         .         .       g.40160
 aaatgtcaagtagcatctctctctttctctctgtctctttctgtttctctctccagtttt       c.*960

          .         .         .         .         .         .       g.40220
 ttttttttttttaatttccatatgggctaaagaatccaaatattttaaaaatctgtctct       c.*1020

          .         .         .         .         .         .       g.40280
 cttttcttctctcataaagtgaattattccttttttttgttttatgtaagtgtatatatt       c.*1080

          .         .         .         .         .         .       g.40340
 cttagtttttcttgaaatcattgtaatgttaactttgttgtttcaaatatcttggtgatt       c.*1140

          .         .         .         .         .         .       g.40400
 gcttcattatctcttcaacaaaaaaaacctttaattttgccattgaaactgtagaactat       c.*1200

          .         .         .         .         .         .       g.40460
 gccatgcttttattagaagcagtgctctgtgttaacaacaagaatggtgtaattagaatt       c.*1260

          .         .         .         .         .         .       g.40520
 gggatgtggatatttactgtatgacaacacatttacagttctgtaatgcaaggatgcagt       c.*1320

          .         .         .         .         .         .       g.40580
 ttaaaaatgtgaagtagtgatggtttttgaaataagctttaaaatatagggatcttgaag       c.*1380

          .         .         .         .         .         .       g.40640
 gctccctggggtaactattttataacttagataaaatggctagtcatatctgtgtgtttg       c.*1440

          .         .         .         .         .         .       g.40700
 taaagttatttttttaatattttaagattacaattttaacaaatgtagaaatgagccaaa       c.*1500

          .         .         .         .         .         .       g.40760
 ctatttaaattttaaaacagtaaaacaaaatgaaacttaatagctcacaaaattccagtc       c.*1560

          .         .         .         .         .         .       g.40820
 catgtttcatgacttattttagtcaatgaattttctatttatactaaacatatggacatt       c.*1620

          .         .         .         .         .         .       g.40880
 ttaaatgtgtttctaatatttttgattatctataatgtgcctgtcttcaattcacaagat       c.*1680

          .         .         .         .         .         .       g.40940
 tgggttataacaattatttgccagattaacactagggaattatttgataaccagcttatc       c.*1740

          .         .         .         .         .         .       g.41000
 ttatcagtagttttattgctgatcaggcaaaaatagttttccaaagttatttttaataaa       c.*1800

          .         .         .         .         .         .       g.41060
 gtatatacaaaattcttatatattactagtcatgataaagtaaattaagcagtttttaaa       c.*1860

          .         .         .         .         .         .       g.41120
 acttagtgtgagtttgttcatcacaggtctgatatgagtttaagggatttcgcactccct       c.*1920

          .         .         .         .         .         .       g.41180
 gaatcagagaagtaagaccccttccttagattcctgttatacattttttaaaatgtagag       c.*1980

          .         .         .         .         .         .       g.41240
 tttgttttggagacattttcagtgcattgttattgccatatttatataatatgactattc       c.*2040

          .         .         .         .         .         .       g.41300
 taaaggctgtgaggccatggggtattggttaagttgcttgcttttgctttgtccattttc       c.*2100

          .         .         .         .         .         .       g.41360
 atcattttaaaatgggggataataacagaacttgtttcctagggccattgtaagtcactt       c.*2160

          .         .         .         .         .         .       g.41420
 gaataaaaaatagttttgaagcatgagagtcatacagagcggtccacctaaaaggcactc       c.*2220

          .         .                                               g.41447
 ctgataataataaatgattttaaacaa                                        c.*2247

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Desmocollin 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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