desmoglein 2 (DSG2) - coding DNA reference sequence

(used for variant description)

(last modified September 19, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_001943.3 in the DSG2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007072.2, covering DSG2 transcript NM_001943.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.4830
                                                     ctggagcc       c.-181

 .         .         .         .         .         .                g.4890
 gcgcctttgggttgggctgggctgggccgcgcaaccgccacgggaagacagccctcgggg       c.-121

 .         .         .         .         .         .                g.4950
 cggggagggagagggtggccgggccggggggaggccggggccagggaggagccgagtgcg       c.-61

 .         .         .         .         .         .                g.5010
 cgctcggggcaggcggcggcgcggagcggtgcggcggcgggaggcggaggcgagggtgcg       c.-1

          .         .         .         .      | 02  .         .    g.25012
 ATGGCGCGGAGCCCGGGACGCGCGTACGCCCTGCTGCTTCTCCTG | ATCTGCTTTAACGTT    c.60
 M  A  R  S  P  G  R  A  Y  A  L  L  L  L  L   | I  C  F  N  V      p.20

          .         .  | 03      .         .         .         .    g.26600
 GGAAGTGGACTTCACTTACAG | GTCTTAAGCACAAGAAATGAAAATAAGCTGCTTCCTAAA    c.120
 G  S  G  L  H  L  Q   | V  L  S  T  R  N  E  N  K  L  L  P  K      p.40

          .         .         .         .         .         .       g.26660
 CATCCTCATTTAGTGCGGCAAAAGCGCGCCTGGATCACCGCCCCCGTGGCTCTTCGGGAG       c.180
 H  P  H  L  V  R  Q  K  R  A  W  I  T  A  P  V  A  L  R  E         p.60

          .         .         .       | 04 .         .         .    g.27585
 GGAGAGGATCTGTCCAAGAAGAATCCAATTGCCAAG | ATACATTCTGATCTTGCAGAAGAA    c.240
 G  E  D  L  S  K  K  N  P  I  A  K   | I  H  S  D  L  A  E  E      p.80

          .         .         .         .         .         .       g.27645
 AGAGGACTCAAAATTACTTACAAATACACTGGAAAAGGGATTACAGAGCCACCTTTTGGT       c.300
 R  G  L  K  I  T  Y  K  Y  T  G  K  G  I  T  E  P  P  F  G         p.100

          .         .         .         .         .         .       g.27705
 ATATTTGTCTTTAACAAAGATACTGGAGAACTGAATGTTACCAGCATTCTTGATCGAGAA       c.360
 I  F  V  F  N  K  D  T  G  E  L  N  V  T  S  I  L  D  R  E         p.120

          .         | 05         .         .         .         .    g.27899
 GAAACACCATTTTTTCTG | CTAACAGGTTACGCTTTGGATGCAAGAGGAAACAATGTAGAG    c.420
 E  T  P  F  F  L   | L  T  G  Y  A  L  D  A  R  G  N  N  V  E      p.140

          .         .         .         .         .         .       g.27959
 AAACCCTTAGAGCTACGCATTAAGGTTCTTGATATCAATGACAACGAACCAGTGTTCACA       c.480
 K  P  L  E  L  R  I  K  V  L  D  I  N  D  N  E  P  V  F  T         p.160

          .         .         .         .    | 06    .         .    g.28858
 CAGGATGTCTTTGTTGGGTCTGTTGAAGAGTTGAGTGCAGCAC | ATACTCTTGTGATGAAA    c.540
 Q  D  V  F  V  G  S  V  E  E  L  S  A  A  H |   T  L  V  M  K      p.180

          .         .         .         .         .         .       g.28918
 ATCAATGCAACAGATGCAGATGAGCCCAATACCCTGAATTCGAAAATTTCCTATAGAATC       c.600
 I  N  A  T  D  A  D  E  P  N  T  L  N  S  K  I  S  Y  R  I         p.200

          .         .         .         .         .         .       g.28978
 GTATCTCTGGAGCCTGCTTATCCTCCAGTGTTCTACCTAAATAAAGATACAGGAGAGATT       c.660
 V  S  L  E  P  A  Y  P  P  V  F  Y  L  N  K  D  T  G  E  I         p.220

          .         .         . | 07       .         .         .    g.31236
 TATACAACCAGTGTTACCTTGGACAGAGAG | GAACACAGCAGCTACACTTTGACAGTAGAA    c.720
 Y  T  T  S  V  T  L  D  R  E   | E  H  S  S  Y  T  L  T  V  E      p.240

          .         .         .         .         .         .       g.31296
 GCAAGAGATGGCAATGGAGAAGTTACAGACAAACCTGTAAAACAAGCTCAAGTTCAGATT       c.780
 A  R  D  G  N  G  E  V  T  D  K  P  V  K  Q  A  Q  V  Q  I         p.260

          .         .         .         .         | 08         .    g.31473
 CGTATTTTGGATGTCAATGACAATATACCTGTAGTAGAAAATAAAGTG | CTTGAAGGGATG    c.840
 R  I  L  D  V  N  D  N  I  P  V  V  E  N  K  V   | L  E  G  M      p.280

          .         .         .         .         .         .       g.31533
 GTTGAAGAAAATCAAGTCAACGTAGAAGTTACGCGCATAAAAGTGTTCGATGCAGATGAA       c.900
 V  E  E  N  Q  V  N  V  E  V  T  R  I  K  V  F  D  A  D  E         p.300

          .         .         .         .         .         .       g.31593
 ATAGGTTCTGATAATTGGCTGGCAAATTTTACATTTGCATCAGGAAATGAAGGAGGTTAT       c.960
 I  G  S  D  N  W  L  A  N  F  T  F  A  S  G  N  E  G  G  Y         p.320

          .         .         .         .         .     | 09   .    g.37751
 TTCCACATAGAAACAGATGCTCAAACTAACGAAGGAATTGTGACCCTTATTAAG | GAAGTA    c.1020
 F  H  I  E  T  D  A  Q  T  N  E  G  I  V  T  L  I  K   | E  V      p.340

          .         .         .         .         .         .       g.37811
 GATTATGAAGAAATGAAGAATCTTGACTTCAGTGTTATTGTCGCTAATAAAGCAGCTTTT       c.1080
 D  Y  E  E  M  K  N  L  D  F  S  V  I  V  A  N  K  A  A  F         p.360

          .         .         .         .         .         .       g.37871
 CACAAGTCGATTAGGAGTAAATACAAGCCTACACCCATTCCCATCAAGGTCAAAGTGAAA       c.1140
 H  K  S  I  R  S  K  Y  K  P  T  P  I  P  I  K  V  K  V  K         p.380

          .         .         .         .         .         .       g.37931
 AATGTGAAAGAAGGCATTCATTTTAAAAGCAGCGTCATCTCAATTTATGTTAGCGAGAGC       c.1200
 N  V  K  E  G  I  H  F  K  S  S  V  I  S  I  Y  V  S  E  S         p.400

          .         .         .         .         .         .       g.37991
 ATGGATAGATCAAGCAAAGGCCAAATAATTGGAAATTTTCAAGCTTTTGATGAGGACACT       c.1260
 M  D  R  S  S  K  G  Q  I  I  G  N  F  Q  A  F  D  E  D  T         p.420

          .         . | 10       .         .         .         .    g.42068
 GGACTACCAGCCCATGCAAG | ATATGTAAAATTAGAAGATAGAGATAATTGGATCTCTGTG    c.1320
 G  L  P  A  H  A  R  |  Y  V  K  L  E  D  R  D  N  W  I  S  V      p.440

          .         .         .         .         .         .       g.42128
 GATTCTGTCACATCTGAAATTAAACTTGCAAAACTTCCTGATTTTGAATCTAGATATGTT       c.1380
 D  S  V  T  S  E  I  K  L  A  K  L  P  D  F  E  S  R  Y  V         p.460

          .         .         .         .    | 11    .         .    g.42977
 CAAAATGGCACATACACTGTAAAGATTGTGGCCATATCAGAAG | ATTATCCTAGAAAAACC    c.1440
 Q  N  G  T  Y  T  V  K  I  V  A  I  S  E  D |   Y  P  R  K  T      p.480

          .         .         .         .         .         .       g.43037
 ATCACTGGCACAGTCCTTATCAATGTTGAAGACATCAACGACAACTGTCCCACACTGATA       c.1500
 I  T  G  T  V  L  I  N  V  E  D  I  N  D  N  C  P  T  L  I         p.500

          .         .         .         .         .         .       g.43097
 GAGCCTGTGCAGACAATCTGTCACGATGCAGAGTATGTGAATGTTACTGCAGAGGACCTG       c.1560
 E  P  V  Q  T  I  C  H  D  A  E  Y  V  N  V  T  A  E  D  L         p.520

          .         .         .         .         .         .       g.43157
 GATGGACACCCAAACAGTGGCCCTTTCAGTTTCTCCGTCATTGACAAACCACCTGGCATG       c.1620
 D  G  H  P  N  S  G  P  F  S  F  S  V  I  D  K  P  P  G  M         p.540

          .         .         .  | 12      .         .         .    g.45538
 GCAGAAAAATGGAAAATAGCACGCCAAGAAA | GTACCAGTGTGCTGCTGCAACAAAGTGAG    c.1680
 A  E  K  W  K  I  A  R  Q  E  S |   T  S  V  L  L  Q  Q  S  E      p.560

          .         .         .         .         .         .       g.45598
 AAAAAGCTTGGGAGAAGTGAAATTCAGTTCCTGATTTCAGACAATCAGGGTTTTAGTTGT       c.1740
 K  K  L  G  R  S  E  I  Q  F  L  I  S  D  N  Q  G  F  S  C         p.580

          .         .         .         .         .         .       g.45658
 CCTGAAAAGCAGGTCCTTACACTCACAGTTTGTGAGTGTCTGCATGGCAGCGGCTGCAGG       c.1800
 P  E  K  Q  V  L  T  L  T  V  C  E  C  L  H  G  S  G  C  R         p.600

          .         .         .         .         .         .       g.45718
 GAAGCACAGCATGACTCCTATGTGGGCCTGGGACCCGCAGCAATTGCGCTCATGATTTTG       c.1860
 E  A  Q  H  D  S  Y  V  G  L  G  P  A  A  I  A  L  M  I  L         p.620

          .          | 13        .         .         .         .    g.47992
 GCCTTTCTGCTCCTGCTAT | TGGTACCACTTTTACTGCTGATGTGCCATTGCGGAAAGGGC    c.1920
 A  F  L  L  L  L  L |   V  P  L  L  L  L  M  C  H  C  G  K  G      p.640

          .         .         .         .         .         .       g.48052
 GCCAAAGGCTTTACCCCCATACCTGGCACCATAGAGATGCTGCATCCTTGGAATAATGAA       c.1980
 A  K  G  F  T  P  I  P  G  T  I  E  M  L  H  P  W  N  N  E         p.660

          .         .  | 14      .         .         .         .    g.49317
 GGAGCACCACCTGAAGACAAG | GTGGTGCCATCATTTCTGCCAGTGGATCAAGGGGGCAGT    c.2040
 G  A  P  P  E  D  K   | V  V  P  S  F  L  P  V  D  Q  G  G  S      p.680

          .         .         .         .         .         .       g.49377
 CTAGTAGGAAGAAATGGAGTAGGAGGTATGGCCAAGGAAGCCACGATGAAAGGAAGTAGC       c.2100
 L  V  G  R  N  G  V  G  G  M  A  K  E  A  T  M  K  G  S  S         p.700

          .         .         .         .         .         .       g.49437
 TCTGCTTCCATTGTCAAAGGGCAACATGAGATGTCCGAGATGGATGGAAGGTGGGAAGAA       c.2160
 S  A  S  I  V  K  G  Q  H  E  M  S  E  M  D  G  R  W  E  E         p.720

          .         .         .         .         .         .       g.49497
 CACAGAAGCCTGCTTTCTGGTAGAGCTACCCAGTTTACAGGGGCCACAGGCGCTATCATG       c.2220
 H  R  S  L  L  S  G  R  A  T  Q  F  T  G  A  T  G  A  I  M         p.740

          .         .         .         .         .         .       g.49557
 ACCACTGAAACCACGAAGACCGCAAGGGCCACAGGGGCTTCCAGAGACATGGCCGGAGCT       c.2280
 T  T  E  T  T  K  T  A  R  A  T  G  A  S  R  D  M  A  G  A         p.760

          .         .         .         .         .     | 15   .    g.52485
 CAGGCAGCTGCTGTTGCACTGAACGAAGAATTCTTAAGAAATTATTTCACTGAT | AAAGCG    c.2340
 Q  A  A  A  V  A  L  N  E  E  F  L  R  N  Y  F  T  D   | K  A      p.780

          .         .         .         .         .         .       g.52545
 GCCTCTTACACTGAGGAAGATGAAAATCACACAGCCAAAGATTGCCTTCTGGTTTATTCT       c.2400
 A  S  Y  T  E  E  D  E  N  H  T  A  K  D  C  L  L  V  Y  S         p.800

          .         .         .         .         .         .       g.52605
 CAGGAAGAAACTGAATCGCTGAATGCTTCTATTGGTTGTTGCAGTTTTATTGAAGGAGAG       c.2460
 Q  E  E  T  E  S  L  N  A  S  I  G  C  C  S  F  I  E  G  E         p.820

          .         .         .         .         .         .       g.52665
 CTAGATGACCGCTTCTTAGATGATTTGGGACTTAAATTCAAGACACTAGCTGAAGTTTGC       c.2520
 L  D  D  R  F  L  D  D  L  G  L  K  F  K  T  L  A  E  V  C         p.840

          .         .         .         .         .         .       g.52725
 CTGGGTCAAAAAATAGATATAAATAAGGAAATTGAGCAGAGACAAAAACCTGCCACAGAA       c.2580
 L  G  Q  K  I  D  I  N  K  E  I  E  Q  R  Q  K  P  A  T  E         p.860

          .         .         .         .         .         .       g.52785
 ACAAGTATGAACACAGCTTCACATTCACTCTGTGAGCAAACTATGGTTAATTCAGAGAAT       c.2640
 T  S  M  N  T  A  S  H  S  L  C  E  Q  T  M  V  N  S  E  N         p.880

          .         .         .         .         .         .       g.52845
 ACCTACTCCTCTGGCAGTAGCTTCCCAGTTCCAAAATCTTTGCAAGAAGCCAATGCAGAG       c.2700
 T  Y  S  S  G  S  S  F  P  V  P  K  S  L  Q  E  A  N  A  E         p.900

          .         .         .         .         .         .       g.52905
 AAAGTAACTCAGGAAATAGTCACTGAAAGATCTGTGTCTTCTAGGCAGGCGCAAAAGGTA       c.2760
 K  V  T  Q  E  I  V  T  E  R  S  V  S  S  R  Q  A  Q  K  V         p.920

          .         .         .         .         .         .       g.52965
 GCTACACCTCTTCCTGACCCAATGGCTTCTAGAAATGTGATAGCAACAGAAACTTCCTAT       c.2820
 A  T  P  L  P  D  P  M  A  S  R  N  V  I  A  T  E  T  S  Y         p.940

          .         .         .         .         .         .       g.53025
 GTCACAGGGTCCACTATGCCACCAACCACTGTGATCCTGGGTCCTAGCCAGCCACAGAGC       c.2880
 V  T  G  S  T  M  P  P  T  T  V  I  L  G  P  S  Q  P  Q  S         p.960

          .         .         .         .         .         .       g.53085
 CTTATTGTGACAGAGAGGGTGTATGCTCCAGCTTCTACCTTGGTAGATCAGCCTTATGCT       c.2940
 L  I  V  T  E  R  V  Y  A  P  A  S  T  L  V  D  Q  P  Y  A         p.980

          .         .         .         .         .         .       g.53145
 AATGAAGGTACAGTTGTGGTCACTGAAAGAGTAATACAGCCTCATGGGGGTGGATCGAAT       c.3000
 N  E  G  T  V  V  V  T  E  R  V  I  Q  P  H  G  G  G  S  N         p.1000

          .         .         .         .         .         .       g.53205
 CCTCTGGAAGGCACTCAGCATCTTCAAGATGTACCTTACGTCATGGTGAGGGAAAGAGAG       c.3060
 P  L  E  G  T  Q  H  L  Q  D  V  P  Y  V  M  V  R  E  R  E         p.1020

          .         .         .         .         .         .       g.53265
 AGCTTCCTTGCCCCCAGCTCAGGTGTGCAGCCTACTCTGGCCATGCCTAATATAGCAGTA       c.3120
 S  F  L  A  P  S  S  G  V  Q  P  T  L  A  M  P  N  I  A  V         p.1040

          .         .         .         .         .         .       g.53325
 GGACAGAATGTGACAGTGACAGAAAGAGTTCTAGCACCTGCTTCCACTCTGCAATCCAGT       c.3180
 G  Q  N  V  T  V  T  E  R  V  L  A  P  A  S  T  L  Q  S  S         p.1060

          .         .         .         .         .         .       g.53385
 TACCAGATTCCCACTGAAAATTCTATGACGGCTAGGAACACCACGGTGTCTGGAGCTGGA       c.3240
 Y  Q  I  P  T  E  N  S  M  T  A  R  N  T  T  V  S  G  A  G         p.1080

          .         .         .         .         .         .       g.53445
 GTCCCTGGCCCTCTGCCAGATTTTGGTTTAGAGGAATCTGGTCATTCTAATTCTACCATA       c.3300
 V  P  G  P  L  P  D  F  G  L  E  E  S  G  H  S  N  S  T  I         p.1100

          .         .         .         .         .                 g.53502
 ACCACATCTTCCACCAGAGTTACCAAGCATAGCACTGTACAGCATTCTTACTCCTAA          c.3357
 T  T  S  S  T  R  V  T  K  H  S  T  V  Q  H  S  Y  S  X            p.1118

          .         .         .         .         .         .       g.53562
 acagcagtcagccacaaactgacccagagtttaattagcagtgactaatttcatgtttcc       c.*60

          .         .         .         .         .         .       g.53622
 aatgtacctgatttttcatgagccttacagacacacagagacacatacacattgatctta       c.*120

          .         .         .         .         .         .       g.53682
 aaatttttctcagtcactgatatgcaaaggaccacactgtctctgcttccaggagtattt       c.*180

          .         .         .         .         .         .       g.53742
 tagaaatgttccacaatttactgaagacatagagatgatgctgctgcttaggtgcctttt       c.*240

          .         .         .         .         .         .       g.53802
 agcaagctatgcaaacaatcctgataaaacaagatacatagagagtcaatctggcttctg       c.*300

          .         .         .         .         .         .       g.53862
 agaatttaccaagtgaacagagtacctagttcatcagccgtccagtaaagcaacccagga       c.*360

          .         .         .         .         .         .       g.53922
 aactgactgggtctctttgcctaccgtattaacattaaacattgatgttctgtattctgt       c.*420

          .         .         .         .         .         .       g.53982
 actttactgcacccagcagactttcaacaactcattgatccaaagatacatgcacagtct       c.*480

          .         .         .         .         .         .       g.54042
 gagcaccagctatggtgctcataacttctttaagacttgaaccctttcaatctgtgtgat       c.*540

          .         .         .         .         .         .       g.54102
 tcattaaattggaccattgatgataagaatacacattgtatgtttctgtgcacatgacag       c.*600

          .         .         .         .         .         .       g.54162
 tgtgtgtgtgtgcacgtacatactgtatagtcttaaaaatagcattatactggccagggg       c.*660

          .         .         .         .         .         .       g.54222
 tggtggctaacgcctgtaatcccagcactttgggaggccgaggcgggtggatcaactgtg       c.*720

          .         .         .         .         .         .       g.54282
 gtcaggagtttgagatcagccaggccaacctggtgaaaccccgtctctactaaaaataca       c.*780

          .         .         .         .         .         .       g.54342
 aaaattagctgggcgtgatggtgggcgcctgtaatcccagctacttgggaggctgaggca       c.*840

          .         .         .         .         .         .       g.54402
 ggagaatcacttgaacccgggaggcggaggttgcagtgagccgagatcgcaccattgcac       c.*900

          .         .         .         .         .         .       g.54462
 tccagtctgggcaacagagtgagattccgtctcaaaaaaaaaaagaaaaggaaaaaaaaa       c.*960

          .         .         .         .         .         .       g.54522
 tagcattatacctcttccttgtctcaaccgccatgaaaattctgaacactccaaattcag       c.*1020

          .         .         .         .         .         .       g.54582
 ttgaataatccaaaacaaaatttataagtataaaataattttacttcttatagtaatagt       c.*1080

          .         .         .         .         .         .       g.54642
 atactttaaaaagcctcagggtatattatcttctaaacagctacaattcagtgcagctac       c.*1140

          .         .         .         .         .         .       g.54702
 attaaccaactatgttctctagttgagaacaactaggcctatttcactgctgtgtagcct       c.*1200

          .         .         .         .         .         .       g.54762
 cagtgcctaacatgggtgccaaataaatattcgtagaattacactgaattgtaaaaacca       c.*1260

          .         .         .         .         .         .       g.54822
 ttcgtttttgtttacaattgccaaaaatctcaaaaggccctgtatttatgtaattctttg       c.*1320

          .         .         .         .         .         .       g.54882
 aaattattattttattttgatttctcagttattgactggctgggtgtgacttagtacata       c.*1380

          .         .         .         .         .         .       g.54942
 agtactcaatattataaaaacctcaaataattgacttgattttacacaacatccttccct       c.*1440

          .         .         .         .         .         .       g.55002
 tttctacaagttaatttttttacaaatcatttgggttatctcctaaataggttatatttt       c.*1500

          .         .         .         .         .         .       g.55062
 attgcttctagaaacaatgtttcaaaatatatgtgcattatcagtaataatttgtataaa       c.*1560

          .         .         .         .         .         .       g.55122
 tatttcccacaacaattttcataattttcaaagactaatttcttgactgaagatattttg       c.*1620

          .         .         .         .         .         .       g.55182
 ctagggaagtgaaactttaaaattttgtagattttaaaaaatattgttgaatggtgtcat       c.*1680

          .         .         .         .         .         .       g.55242
 gcaaaggatttatatagtgtgctcccactaactgtacagatcaggacacatatttttaga       c.*1740

          .         .         .         .         .         .       g.55302
 catctaagtctgtagcttaaatggaggttactcttccatcatctagaattgtttacttag       c.*1800

          .         .         .         .         .         .       g.55362
 taattgttgtttcttttattattatagacttactatcagttttattttgccaagtatgca       c.*1860

          .         .         .         .         .         .       g.55422
 acaggtatatcactagtatatgaaaatgtaaatatcacttgtgtactcaaacaaaagttg       c.*1920

          .         .         .         .         .         .       g.55482
 gtcttaagcttccaccttgagcagccttggaaacctaacctgcctcttttagcataatca       c.*1980

          .         .         .         .         .         .       g.55542
 cattttctaaatgattttctttgttcctgaaaaagtgatttgtattagttttacatttgt       c.*2040

          .         .         .         .         .         .       g.55602
 tttttggaagattatatttgtatatgtatcatcataaaatatttaaataaaaagtatctt       c.*2100

                                                                    g.55610
 tagagtga                                                           c.*2108

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Desmoglein 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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