dentin sialophosphoprotein (DSPP) - coding DNA reference sequence

(used for variant description)

(last modified July 9, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_014208.3 in the DSPP gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011595.1, covering DSPP transcript NM_014208.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
 .         .         .         .         .         .                g.5060
 atgcaaaagtccaggacagtgggccactttcagtcttcaaagagaaagataagaaattct       c.-61

 .         .         .         .  | 02      .         .             g.7380
 ggattttcaaaatccttttgaagccttttaag | ccattgattattattattcctaaagaaa    c.-1

          .         .         .         .         .  | 03      .    g.8585
 ATGAAGATAATTACATATTTTTGCATTTGGGCAGTAGCATGGGCCATTCCA | GTTCCTCAA    c.60
 M  K  I  I  T  Y  F  C  I  W  A  V  A  W  A  I  P   | V  P  Q      p.20

          .         .         .         .         .         .       g.8645
 AGCAAACCACTGGAGAGACATGTCGAAAAATCCATGAATTTGCATCTCCTAGCAAGATCA       c.120
 S  K  P  L  E  R  H  V  E  K  S  M  N  L  H  L  L  A  R  S         p.40

          .      | 04  .         .         .         .         .    g.8838
 AATGTGTCAGTACAG | GATGAGTTAAATGCCAGTGGAACCATCAAAGAAAGTGGTGTCCTG    c.180
 N  V  S  V  Q   | D  E  L  N  A  S  G  T  I  K  E  S  G  V  L      p.60

          .         .         .         .         .         .       g.8898
 GTGCATGAAGGTGATAGAGGAAGGCAAGAGAATACCCAAGATGGTCACAAGGGAGAAGGG       c.240
 V  H  E  G  D  R  G  R  Q  E  N  T  Q  D  G  H  K  G  E  G         p.80

          .         .         .         .         .         .       g.8958
 AATGGCTCTAAGTGGGCAGAAGTAGGAGGGAAGAGTTTTTCTACATATTCCACATTAGCA       c.300
 N  G  S  K  W  A  E  V  G  G  K  S  F  S  T  Y  S  T  L  A         p.100

          .         .         .         .         .         .       g.9018
 AACGAAGAGGGGAATATTGAGGGCTGGAATGGGGACACAGGAAAAGCAGAAACATATGGT       c.360
 N  E  E  G  N  I  E  G  W  N  G  D  T  G  K  A  E  T  Y  G         p.120

          .         .         .         .         .         .       g.9078
 CATGATGGAATACATGGGAAAGAAGAAAACATCACAGCAAATGGCATCCAGGGACAAGTA       c.420
 H  D  G  I  H  G  K  E  E  N  I  T  A  N  G  I  Q  G  Q  V         p.140

          .         .         .         .         .         .       g.9138
 AGCATCATTGACAATGCTGGAGCCACAAACAGAAGCAACACTAATGGAAATACTGATAAG       c.480
 S  I  I  D  N  A  G  A  T  N  R  S  N  T  N  G  N  T  D  K         p.160

          .         .         .         .         .         .       g.9198
 AATACCCAAAATGGGGATGTTGGCGATGCAGGTCACAATGAGGATGTCGCTGTTGTCCAA       c.540
 N  T  Q  N  G  D  V  G  D  A  G  H  N  E  D  V  A  V  V  Q         p.180

          .         .         .         .         .         .       g.9258
 GAAGATGGACCTCAAGTAGCTGGAAGCAATAACAGTACAGACAATGAGGATGAAATAATT       c.600
 E  D  G  P  Q  V  A  G  S  N  N  S  T  D  N  E  D  E  I  I         p.200

          .         .         .         .         .         .       g.9318
 GAGAATTCCTGTAGAAACGAGGGTAATACAAGTGAAATAACACCTCAGATCAACAGCAAG       c.660
 E  N  S  C  R  N  E  G  N  T  S  E  I  T  P  Q  I  N  S  K         p.220

          .         .         .         .         .         .       g.9378
 AGAAATGGGACTAAGGAAGCTGAGGTAACACCAGGCACTGGAGAAGATGCTGGCCTGGAT       c.720
 R  N  G  T  K  E  A  E  V  T  P  G  T  G  E  D  A  G  L  D         p.240

          .         .         .         .         .         .       g.9438
 AATTCCGATGGGAGTCCTAGTGGGAATGGAGCAGATGAGGATGAAGACGAGGGTTCTGGT       c.780
 N  S  D  G  S  P  S  G  N  G  A  D  E  D  E  D  E  G  S  G         p.260

          .         .         .         .         .         .       g.9498
 GATGATGAAGATGAAGAAGCAGGGAATGGAAAAGACAGTAGTAATAACAGCAAGGGCCAG       c.840
 D  D  E  D  E  E  A  G  N  G  K  D  S  S  N  N  S  K  G  Q         p.280

          .         .         .         .         .         .       g.9558
 GAGGGCCAGGACCATGGGAAAGAAGATGATCATGATAGTAGCATAGGTCAAAATTCAGAT       c.900
 E  G  Q  D  H  G  K  E  D  D  H  D  S  S  I  G  Q  N  S  D         p.300

          .         .         .         .         .         .       g.9618
 AGTAAAGAATATTATGACCCTGAAGGCAAAGAAGATCCCCATAATGAAGTTGATGGAGAC       c.960
 S  K  E  Y  Y  D  P  E  G  K  E  D  P  H  N  E  V  D  G  D         p.320

          .         .         .         .         .         .       g.9678
 AAGACCTCCAAGAGTGAGGAGAATTCTGCTGGTATTCCAGAAGACAATGGCAGCCAAAGA       c.1020
 K  T  S  K  S  E  E  N  S  A  G  I  P  E  D  N  G  S  Q  R         p.340

          .         .         .         .         .         .       g.9738
 ATAGAGGACACCCAGAAGCTCAACCATAGAGAAAGCAAACGCGTAGAAAATAGAATCACC       c.1080
 I  E  D  T  Q  K  L  N  H  R  E  S  K  R  V  E  N  R  I  T         p.360

          .         .         .         .   | 05     .         .    g.10274
 AAAGAATCAGAGACACATGCTGTTGGGAAGAGCCAAGATAAG | GGAATAGAAATCAAGGGT    c.1140
 K  E  S  E  T  H  A  V  G  K  S  Q  D  K   | G  I  E  I  K  G      p.380

          .         .         .         .         .         .       g.10334
 CCCAGCAGTGGCAACAGAAATATTACCAAAGAAGTTGGGAAAGGCAACGAAGGTAAAGAG       c.1200
 P  S  S  G  N  R  N  I  T  K  E  V  G  K  G  N  E  G  K  E         p.400

          .         .         .         .         .         .       g.10394
 GATAAAGGACAACATGGAATGATCTTGGGCAAAGGCAATGTCAAGACACAAGGAGAGGTT       c.1260
 D  K  G  Q  H  G  M  I  L  G  K  G  N  V  K  T  Q  G  E  V         p.420

          .         .         .         .         .         .       g.10454
 GTCAACATAGAAGGACCTGGCCAAAAATCAGAACCAGGAAATAAAGTTGGACACAGCAAT       c.1320
 V  N  I  E  G  P  G  Q  K  S  E  P  G  N  K  V  G  H  S  N         p.440

          .         .         .         .         .         .       g.10514
 ACAGGTAGTGACAGCAATAGTGATGGATATGACAGTTATGATTTTGATGATAAGTCCATG       c.1380
 T  G  S  D  S  N  S  D  G  Y  D  S  Y  D  F  D  D  K  S  M         p.460

          .         .         .         .         .         .       g.10574
 CAAGGAGATGATCCCAATAGCAGTGATGAATCTAATGGCAATGATGATGCTAATTCAGAA       c.1440
 Q  G  D  D  P  N  S  S  D  E  S  N  G  N  D  D  A  N  S  E         p.480

          .         .         .         .         .         .       g.10634
 AGTGACAATAACAGCAGTAGCCGAGGAGATGCTTCTTATAACTCTGATGAATCAAAAGAT       c.1500
 S  D  N  N  S  S  S  R  G  D  A  S  Y  N  S  D  E  S  K  D         p.500

          .         .         .         .         .         .       g.10694
 AATGGCAATGGCAGTGACTCAAAAGGAGCAGAAGATGATGACAGTGATAGCACATCAGAC       c.1560
 N  G  N  G  S  D  S  K  G  A  E  D  D  D  S  D  S  T  S  D         p.520

          .         .         .         .         .         .       g.10754
 ACTAATAATAGTGACAGTAATGGCAATGGTAACAATGGGAATGATGACAATGACAAATCA       c.1620
 T  N  N  S  D  S  N  G  N  G  N  N  G  N  D  D  N  D  K  S         p.540

          .         .         .         .         .         .       g.10814
 GACAGTGGCAAAGGTAAATCAGATAGCAGTGACAGTGATAGTAGTGATAGCAGCAATAGC       c.1680
 D  S  G  K  G  K  S  D  S  S  D  S  D  S  S  D  S  S  N  S         p.560

          .         .         .         .         .         .       g.10874
 AGTGATAGTAGTGACAGCAGTGACAGTGACAGCAGTGATAGCAACAGTAGCAGTGATAGT       c.1740
 S  D  S  S  D  S  S  D  S  D  S  S  D  S  N  S  S  S  D  S         p.580

          .         .         .         .         .         .       g.10934
 GACAGCAGTGACAGTGACAGCAGTGATAGCAGTGACAGTGATAGTAGTGATAGCAGCAAT       c.1800
 D  S  S  D  S  D  S  S  D  S  S  D  S  D  S  S  D  S  S  N         p.600

          .         .         .         .         .         .       g.10994
 AGCAGTGACAGTAGTGACAGCAGTGATAGCAGTGACAGTAGTGATAGTAGTGACAGCAGT       c.1860
 S  S  D  S  S  D  S  S  D  S  S  D  S  S  D  S  S  D  S  S         p.620

          .         .         .         .         .         .       g.11054
 GACAGCAAGTCAGACAGCAGCAAATCAGAGAGCGACAGCAGTGATAGTGACAGTAAGTCA       c.1920
 D  S  K  S  D  S  S  K  S  E  S  D  S  S  D  S  D  S  K  S         p.640

          .         .         .         .         .         .       g.11114
 GACAGCAGTGACAGCAACAGCAGTGACAGTAGTGACAACAGTGATAGCAGCGACAGCAGC       c.1980
 D  S  S  D  S  N  S  S  D  S  S  D  N  S  D  S  S  D  S  S         p.660

          .         .         .         .         .         .       g.11174
 AATAGCAGTAACAGCAGTGATAGTAGTGACAGCAGTGATAGCAGTGACAGCAGCAGTAGC       c.2040
 N  S  S  N  S  S  D  S  S  D  S  S  D  S  S  D  S  S  S  S         p.680

          .         .         .         .         .         .       g.11234
 AGTGACAGCAGCAACAGCAGTGATAGTAGTGACAGTAGTGACAGCAGCAATAGCAGTGAG       c.2100
 S  D  S  S  N  S  S  D  S  S  D  S  S  D  S  S  N  S  S  E         p.700

          .         .         .         .         .         .       g.11294
 AGCAGTGATAGTAGTGACAGCAGTGATAGTGACAGCAGTGATAGTAGTGACAGCAGTAAT       c.2160
 S  S  D  S  S  D  S  S  D  S  D  S  S  D  S  S  D  S  S  N         p.720

          .         .         .         .         .         .       g.11354
 AGTAACAGCAGCGATAGTGACAGCAGCAACAGCAGCGATAGCAGTGACAGCAGCAACAGC       c.2220
 S  N  S  S  D  S  D  S  S  N  S  S  D  S  S  D  S  S  N  S         p.740

          .         .         .         .         .         .       g.11414
 AGTGACAGCAGTGATAGCAGTGACAGCAGCAACAGCAGTGACAGTAGCGATAGCAGTGAC       c.2280
 S  D  S  S  D  S  S  D  S  S  N  S  S  D  S  S  D  S  S  D         p.760

          .         .         .         .         .         .       g.11474
 AGCAGCAACAGCAGTGACAGCAGTGATAGCAGTGACAGCAGTGATAGTAGTGACAGCAGC       c.2340
 S  S  N  S  S  D  S  S  D  S  S  D  S  S  D  S  S  D  S  S         p.780

          .         .         .         .         .         .       g.11534
 AACAGCAGTGATAGCAACGACAGCAGCAATAGCAGTGACAGCAGTGATAGCAGCAACAGC       c.2400
 N  S  S  D  S  N  D  S  S  N  S  S  D  S  S  D  S  S  N  S         p.800

          .         .         .         .         .         .       g.11594
 AGTGATAGCAGCAACAGCAGTGATAGCAGTGATAGCAGTGACAGCAGTGATAGCGACAGC       c.2460
 S  D  S  S  N  S  S  D  S  S  D  S  S  D  S  S  D  S  D  S         p.820

          .         .         .         .         .         .       g.11654
 AGCAATAGCAGTGACAGCAGTAATAGTAGTGACAGCAGCGATAGCAGCAACAGCAGTGAT       c.2520
 S  N  S  S  D  S  S  N  S  S  D  S  S  D  S  S  N  S  S  D         p.840

          .         .         .         .         .         .       g.11714
 AGCAGCGACAGCAGCGATAGCAGTGACGGCAGTGATAGCGACAGCAGCAATAGAAGTGAC       c.2580
 S  S  D  S  S  D  S  S  D  G  S  D  S  D  S  S  N  R  S  D         p.860

          .         .         .         .         .         .       g.11774
 AGTAGTAATAGTAGTGACAGCAGCGATAGCAGTGACAGCAGCAACAGCAGTGACAGCAGT       c.2640
 S  S  N  S  S  D  S  S  D  S  S  D  S  S  N  S  S  D  S  S         p.880

          .         .         .         .         .         .       g.11834
 GATAGCAGTGACAGCAACGAAAGCAGCAATAGCAGTGACAGCAGTGATAGCAGCAACAGC       c.2700
 D  S  S  D  S  N  E  S  S  N  S  S  D  S  S  D  S  S  N  S         p.900

          .         .         .         .         .         .       g.11894
 AGTGATAGTGACAGCAGTGATAGCAGCAACAGCAGTGACAGCAGTGATAGCAGCAACAGC       c.2760
 S  D  S  D  S  S  D  S  S  N  S  S  D  S  S  D  S  S  N  S         p.920

          .         .         .         .         .         .       g.11954
 AGTGATAGCAGTGAAAGCAGTAATAGTAGTGACAACAGCAATAGCAGTGACAGCAGCAAC       c.2820
 S  D  S  S  E  S  S  N  S  S  D  N  S  N  S  S  D  S  S  N         p.940

          .         .         .         .         .         .       g.12014
 AGCAGTGACAGCAGTGATAGCAGTGACAGCAGTAATAGTAGTGACAGCAGCAATAGCAGT       c.2880
 S  S  D  S  S  D  S  S  D  S  S  N  S  S  D  S  S  N  S  S         p.960

          .         .         .         .         .         .       g.12074
 GACAGCAGCAACAGCAGTGACAGCAGTGATAGCAATAGCAGCGACAGCAGTGACAGCAGC       c.2940
 D  S  S  N  S  S  D  S  S  D  S  N  S  S  D  S  S  D  S  S         p.980

          .         .         .         .         .         .       g.12134
 AACAGCAGCGATAGCAGTGACAGCAGTGATAGCAGTGACAGCAGTGACAGCAGTGATAGC       c.3000
 N  S  S  D  S  S  D  S  S  D  S  S  D  S  S  D  S  S  D  S         p.1000

          .         .         .         .         .         .       g.12194
 AGCAACAGCAGTGATAGCAGTGACAGCAGTGACAGCAGTGATAGCAGTAATAGTAGTGAC       c.3060
 S  N  S  S  D  S  S  D  S  S  D  S  S  D  S  S  N  S  S  D         p.1020

          .         .         .         .         .         .       g.12254
 AGCAGCAATAGCAGTGACAGCAGCAACAGCAGTGACAGCAGCGATAGCAGTGACAGCAGC       c.3120
 S  S  N  S  S  D  S  S  N  S  S  D  S  S  D  S  S  D  S  S         p.1040

          .         .         .         .         .         .       g.12314
 GATAGCAGTGACAGCAGCGATAGCAGTGACAGCAGTGACAGCAGCAATAGCAGTGACAGC       c.3180
 D  S  S  D  S  S  D  S  S  D  S  S  D  S  S  N  S  S  D  S         p.1060

          .         .         .         .         .         .       g.12374
 AGTGACAGCAGCGACAGCAGTGATAGCAGTGACAGCAGTGACAGCAGCGACAGCAGTGAT       c.3240
 S  D  S  S  D  S  S  D  S  S  D  S  S  D  S  S  D  S  S  D         p.1080

          .         .         .         .         .         .       g.12434
 AGCAGTGAAAGCAGTGATAGCAGTGACAGCAGCAATAGCAGTGACAGCAGCGATAGCAGC       c.3300
 S  S  E  S  S  D  S  S  D  S  S  N  S  S  D  S  S  D  S  S         p.1100

          .         .         .         .         .         .       g.12494
 GACAGCAGCGACAGCAGCGATAGCAGTGACAGCAGCGATAGCAGTGACAGCAGTGACAGC       c.3360
 D  S  S  D  S  S  D  S  S  D  S  S  D  S  S  D  S  S  D  S         p.1120

          .         .         .         .         .         .       g.12554
 AGCAATAGCAGTGACAGCAGTGACAGCAGCGACAGCAGTGATAGCAGTGACAGCAGCAAC       c.3420
 S  N  S  S  D  S  S  D  S  S  D  S  S  D  S  S  D  S  S  N         p.1140

          .         .         .         .         .         .       g.12614
 AGCAGTGACAGCAGTGACAGCAGTGAAAGCAGCGACAGCAGTGACAGCAGCGACAGCAGT       c.3480
 S  S  D  S  S  D  S  S  E  S  S  D  S  S  D  S  S  D  S  S         p.1160

          .         .         .         .         .         .       g.12674
 GACAGCAGCGATAGCAGCGACAGCAGCGACAGCAGCGATAGCAGTGACAGCAGCAATAGC       c.3540
 D  S  S  D  S  S  D  S  S  D  S  S  D  S  S  D  S  S  N  S         p.1180

          .         .         .         .         .         .       g.12734
 AGTGATAGCAGCGACAGCAGTGATAGCAGTGACAGCAGCGACAGCAGCGATAGCAGCGAC       c.3600
 S  D  S  S  D  S  S  D  S  S  D  S  S  D  S  S  D  S  S  D         p.1200

          .         .         .         .         .         .       g.12794
 AGCAGCGATAGTAGTGATAGCAGTGACAGCAGTGACAGCAGCGACAGCAGTGACAGCAGC       c.3660
 S  S  D  S  S  D  S  S  D  S  S  D  S  S  D  S  S  D  S  S         p.1220

          .         .         .         .         .         .       g.12854
 GACAGCAGTGACAGCAGCGACAGCAGTGACAGCAATGAAAGCAGCGACAGCAGTGACAGC       c.3720
 D  S  S  D  S  S  D  S  S  D  S  N  E  S  S  D  S  S  D  S         p.1240

          .         .         .         .         .         .       g.12914
 AGCGATAGCAGTGACAGCAGCAACAGCAGTGACAGCAGCGACAGCAGTGATAGCAGTGAC       c.3780
 S  D  S  S  D  S  S  N  S  S  D  S  S  D  S  S  D  S  S  D         p.1260

          .         .         .         .         .         .       g.12974
 AGCACATCTGACAGCAATGATGAGAGTGACAGCCAGAGCAAGTCTGGTAACGGTAACAAC       c.3840
 S  T  S  D  S  N  D  E  S  D  S  Q  S  K  S  G  N  G  N  N         p.1280

          .         .         .         .         .         .       g.13034
 AATGGAAGTGACAGTGACAGTGACAGTGAAGGCAGTGACAGTAACCACTCAACCAGTGAT       c.3900
 N  G  S  D  S  D  S  D  S  E  G  S  D  S  N  H  S  T  S  D         p.1300

                                                                    g.13040
 GATTAG                                                             c.3906
 D  X                                                               p.1301

          .         .         .         .         .         .       g.13100
 aacaaaagaaaaacccgtaagattccttttgtgaaaagtttggtaatgggataggaaaaa       c.*60

          .         .         .         .         .         .       g.13160
 aagatttccaagaaagtaaagaaaggggagaaataaacataagacgtatgtaaacaaaaa       c.*120

          .         .         .         .         .         .       g.13220
 caactgggggaatcaaatcaaacagttggattcagaaccaagacctaactcctgcagaga       c.*180

          .         .         .         .         .         .       g.13280
 cagactctgaatgcatgacctttggtacatgcctgttaatattcatgttctgaaaatatt       c.*240

          .         .         .         .         .         .       g.13340
 ttgttaaaagtgtaaatctaaacataaaagaacaattaaaatattctttaatacttcaca       c.*300

                                                                    g.13345
 cagaa                                                              c.*305

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Dentin sialophosphoprotein protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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