death domain containing 1 (DTHD1) - coding DNA reference sequence

(used for variant description)

(last modified November 13, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_001170700.2 in the DTHD1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_032962.1, covering DTHD1 transcript NM_001170700.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.7465
   ggggagcactgctgcacttctaaagaaagaagaaaaggagatttgtaatttatgcggc       c.-1

          .         .         .         .         .         .       g.7525
 ATGCATGATGAATGTACTCCACAGCAGACAATGTCCTCCATTCAAGATACCAAAGCAGCA       c.60
 M  H  D  E  C  T  P  Q  Q  T  M  S  S  I  Q  D  T  K  A  A         p.20

          .         .         .         .         .         .       g.7585
 GACATTGCTGCAAGAGGGGAACTAAATGTCATAGAAACAGCTACTGTTTCTCCCACAAAT       c.120
 D  I  A  A  R  G  E  L  N  V  I  E  T  A  T  V  S  P  T  N         p.40

          .         .         .         .         .         .       g.7645
 GGAGAGGAAAGTCATTACACAAACCAGGTCCAGTTAGAAAAAAATAAAACACATATGAGT       c.180
 G  E  E  S  H  Y  T  N  Q  V  Q  L  E  K  N  K  T  H  M  S         p.60

          .         .         .         .         .         .       g.7705
 TCAGCATTAGTGGAAAAAGAAAACAATACATCACTGAATGGACGTGTACTGGGGCAAGAA       c.240
 S  A  L  V  E  K  E  N  N  T  S  L  N  G  R  V  L  G  Q  E         p.80

          .         .         .         .         .         .       g.7765
 GAGTCACAGAATAAAATGTTCCCAGATAATGCAGAAAATGAAGATGATAAACAAATAGAA       c.300
 E  S  Q  N  K  M  F  P  D  N  A  E  N  E  D  D  K  Q  I  E         p.100

          .         .         .         .         .         .       g.7825
 CACATGACTGTTGAGAACATAAATGGCAACAGGGAAGAGACTCATGGCATAATTCAGACA       c.360
 H  M  T  V  E  N  I  N  G  N  R  E  E  T  H  G  I  I  Q  T         p.120

          .         .         .         .         .         .       g.7885
 ACAGAGACAGAAATTCAAGAGACTTCAGAAAGCCCAAGAGAAGAGATGACCACATCCTCA       c.420
 T  E  T  E  I  Q  E  T  S  E  S  P  R  E  E  M  T  T  S  S         p.140

          .         .         .         .         .         .       g.7945
 ATAATATGTGATATCTCCAAGAAATATATAAATAGTACTCTTCCCAATGATTCAGAGAAT       c.480
 I  I  C  D  I  S  K  K  Y  I  N  S  T  L  P  N  D  S  E  N         p.160

          .         .         .   | 02     .         .         .    g.13786
 ATAAAGCACAAGAATAACATAATGGAAAAGGA | GTATCTTGATGTGCTGAGTGATGTTACT    c.540
 I  K  H  K  N  N  I  M  E  K  E  |  Y  L  D  V  L  S  D  V  T      p.180

          .         .         .         .         .         .       g.13846
 GGCCCCCAAGTGTCTTGTTATATTACAGCACCATCATATGTTCTACAACAACTAGAATGC       c.600
 G  P  Q  V  S  C  Y  I  T  A  P  S  Y  V  L  Q  Q  L  E  C         p.200

          .         .         .         .         .         .       g.13906
 CGGATAATAAATCACATGAGTTCTTTAATAGTGGGTGATAATGAAGAGTTAGTTAGCAAC       c.660
 R  I  I  N  H  M  S  S  L  I  V  G  D  N  E  E  L  V  S  N         p.220

          .         .         .         .         .         .       g.13966
 GTCATAACTATTGAATGCTCAGATAAGGAAAAGAGAGTTCCATTTCCAATAGGCATTGCA       c.720
 V  I  T  I  E  C  S  D  K  E  K  R  V  P  F  P  I  G  I  A         p.240

          .         .         .         .         .         .       g.14026
 ATTCCATTTACTGCACGTTACAGAGGAAATTACAGAGATATCATGGTGAAAGTGTGTGAC       c.780
 I  P  F  T  A  R  Y  R  G  N  Y  R  D  I  M  V  K  V  C  D         p.260

          .         .         .         .         .         .       g.14086
 ATAAACCTTCAATCAAGTTACCTAAACCCAAATTCACTAGAAGGAATGAAGGGAGGTTAT       c.840
 I  N  L  Q  S  S  Y  L  N  P  N  S  L  E  G  M  K  G  G  Y         p.280

     | 03    .         .         .         .         .         .    g.16968
 AAG | GGGACCTGTGCTTCAGTAAAAGTTTACAAATTGGGTATCTTTTCTGTTGTGTCTTGT    c.900
 K   | G  T  C  A  S  V  K  V  Y  K  L  G  I  F  S  V  V  S  C      p.300

          .         .         .         .         .         .       g.17028
 TTAAAGAAAGAGTCGTTCACAGTAACAAAGAAAGGCCTCGCTCTTAAGTCAAGCATGGAT       c.960
 L  K  K  E  S  F  T  V  T  K  K  G  L  A  L  K  S  S  M  D         p.320

          .         .         .         .         .         .       g.17088
 TCCCGAATATCCTTAAATTACCCTCCAGGAGTTTTTACCTCTCCAGTGCTGGTGCAGTTA       c.1020
 S  R  I  S  L  N  Y  P  P  G  V  F  T  S  P  V  L  V  Q  L         p.340

     | 04    .         .         .         .         .         .    g.18237
 AAG | ATCCAACCAGTTGACCCAGCTCTGGTGGCACATTTAAAAGCACAGCAAGATACTTTC    c.1080
 K   | I  Q  P  V  D  P  A  L  V  A  H  L  K  A  Q  Q  D  T  F      p.360

          .         .         .         .         .         .       g.18297
 TACTCAGTCCAATCCACAAGCCCTCTGATTCACATTCAGCACCCATCAACTTATCCTTTT       c.1140
 Y  S  V  Q  S  T  S  P  L  I  H  I  Q  H  P  S  T  Y  P  F         p.380

          .         .         .         .         .         .       g.18357
 CAGAAGCCAGTCACTTTGTTTTTACCTTGTTCTCCATACCTTGATAAAAACAACCTTGGT       c.1200
 Q  K  P  V  T  L  F  L  P  C  S  P  Y  L  D  K  N  N  L  G         p.400

          .         .         .         .         .         .       g.18417
 TCTGAGATAGATCATAAAAGAAGAGCAAGTGCCACAATAAATAGGATTACACCTTCGTAT       c.1260
 S  E  I  D  H  K  R  R  A  S  A  T  I  N  R  I  T  P  S  Y         p.420

          | 05         .         .         .         .         .    g.29628
 TTCAACCG | GACAAAAATTGCCTCCATAAGAAAACCTAGGAAAAATGCCAGTGAATGTTTG    c.1320
 F  N  R  |  T  K  I  A  S  I  R  K  P  R  K  N  A  S  E  C  L      p.440

          .         .         .         .         .         .       g.29688
 AAATTACTGGGATTCAGAAGCCAAGACAGTGGTTGGTGTGGGCTTGATGATGTTGTGAAA       c.1380
 K  L  L  G  F  R  S  Q  D  S  G  W  C  G  L  D  D  V  V  K         p.460

          .         .         .         .         . | 06       .    g.31599
 ACCATACAGAGCGGCTTGGTATCAGTTGAATTGTATGAACATTTGGAGAG | GTTTATTGTA    c.1440
 T  I  Q  S  G  L  V  S  V  E  L  Y  E  H  L  E  R  |  F  I  V      p.480

          .         .         .         .         .         .       g.31659
 CTTCACCTCTCTTCCACCATGGACAATAGTCATTTGGTTACTTTTGTGAAATCTTTAGAG       c.1500
 L  H  L  S  S  T  M  D  N  S  H  L  V  T  F  V  K  S  L  E         p.500

          .         .         .         .         .         .       g.31719
 GAAGCCATGCTCAGCACCACTGCCTGCATAGTACTGTCTCACCAGAAGGACAATCCACAT       c.1560
 E  A  M  L  S  T  T  A  C  I  V  L  S  H  Q  K  D  N  P  H         p.520

          .         .         .         .         .         .       g.31779
 AGAATAGCTGTTTTAGTGGTGCCTTCCAAAGATTTAAGCCAGGTGCTTAAGGACCTGCAC       c.1620
 R  I  A  V  L  V  V  P  S  K  D  L  S  Q  V  L  K  D  L  H         p.540

          .         .         .         .         .         .       g.31839
 TTGGAAGGGTTTGGAGGACCTCCAGAGCCATCTCGTCATTTCCAAGTTCGAGAAGGAGAA       c.1680
 L  E  G  F  G  G  P  P  E  P  S  R  H  F  Q  V  R  E  G  E         p.560

          .         .         .         . | 07       .         .    g.39647
 CAACTTCTTTTAAGATTTACTGGAAACATATTTGCTTCAA | GCAACGGGAAGGATTATGGA    c.1740
 Q  L  L  L  R  F  T  G  N  I  F  A  S  S |   N  G  K  D  Y  G      p.580

          .         .         .         .         .         .       g.39707
 AAAGACTACACACTTATTTTTCACTTGCAAAGAAAACCTAGGCTGGAACTCCAAATCAAA       c.1800
 K  D  Y  T  L  I  F  H  L  Q  R  K  P  R  L  E  L  Q  I  K         p.600

          .         .         .         .         .         .       g.39767
 GAAGTGGACGAATTTGGAAACTATAGTTGCCCTCATTACAAAGGCACCATTGTCGTTTAT       c.1860
 E  V  D  E  F  G  N  Y  S  C  P  H  Y  K  G  T  I  V  V  Y         p.620

          .         .         .         .         .         .       g.39827
 AAAGTACCTAAAGGAAAGATAGTCCCCAACTTGAATCAATCTCTCGTAATTAATGAAAAC       c.1920
 K  V  P  K  G  K  I  V  P  N  L  N  Q  S  L  V  I  N  E  N         p.640

          .         .         .         .      | 08  .         .    g.62512
 CATTCTCAGTTGCCAATTTGCAAATTACCATTGAAATTGCCAAAG | CATAAGAAATTAATC    c.1980
 H  S  Q  L  P  I  C  K  L  P  L  K  L  P  K   | H  K  K  L  I      p.660

          .         .         .         .    | 09    .         .    g.66904
 AACCGTCCACAGAGTACCAAAAGAGTTTCTAAGGATCCTGTAG | AAGCCCTTTGGGATAAC    c.2040
 N  R  P  Q  S  T  K  R  V  S  K  D  P  V  E |   A  L  W  D  N      p.680

          .         .         .         .         .         .       g.66964
 TTGCTCCATTGGCTGGCTGAGGAGCTCTCAGAAGAAAATGCTGAGTCTCTTTCCTCAACT       c.2100
 L  L  H  W  L  A  E  E  L  S  E  E  N  A  E  S  L  S  S  T         p.700

          .         .         .         .         .         .       g.67024
 CTCCCTCTGCGCCGTAGCACCATTCAGCTCATCAAACTCAAGAACCCTGATGATCTCACA       c.2160
 L  P  L  R  R  S  T  I  Q  L  I  K  L  K  N  P  D  D  L  T         p.720

          .         .         .         .         .         .       g.67084
 GAACAGATCCACGAGTTTCTTTGCTTCTGGAAAAAATCGCTTCCAACTTTCACCGACAAA       c.2220
 E  Q  I  H  E  F  L  C  F  W  K  K  S  L  P  T  F  T  D  K         p.740

          .         .         .         .         .         .       g.67144
 CTTCGCCTCCTGGCTCGACATCTCCGCAAGATTGGCAGGAGTGATCTTGCAGAAGAGCTC       c.2280
 L  R  L  L  A  R  H  L  R  K  I  G  R  S  D  L  A  E  E  L         p.760

          .         .         .         .         .         .       g.67204
 AAATTCAAGTGGGAAAATAAAGTGTTCACTGAACCACAGCAGTGTTTTGATGTAGCCCCT       c.2340
 K  F  K  W  E  N  K  V  F  T  E  P  Q  Q  C  F  D  V  A  P         p.780

                                                                    g.67210
 GAGTAA                                                             c.2346
 E  X                                                               p.781

          .         .         .         .         .         .       g.67270
 aagcctgatctctcttcctttacccctaggaaaaggcacacggtgggtttttgtttctgt       c.*60

          .         .         .         .         .         .       g.67330
 caacattttcctggaagtttccgaatgatattatttgaagtcagtctatttaatgatgtg       c.*120

          .         .         .         .         .         .       g.67390
 ctatttaatgatgtgagacaaagggagaagcacggatcagataatagaaagcattcctgg       c.*180

          .         .         .         .         .         .       g.67450
 gtgtgagcgctcctctctggttgagtgattatgttttgcaaccatgactgtcttgagttt       c.*240

          .         .         .         .         .         .       g.67510
 ggcctcacttaatagcatttgcaattgagtttgacttgttcacattttaaaagctaagtg       c.*300

          .         .         .         .         .         .       g.67570
 tgaagaaaagatctgatatatgtaattacttattaattggtatctacataaaattaaact       c.*360

          .         .         .         .         .         .       g.67630
 agttttctgtgacttcaagtgtgagcccaaaaatatctgagacagttctcaatcaattta       c.*420

          .         .         .         .         .         .       g.67690
 gaaagattattttgccaaggttaaggacaggcccgtaacagcctcagaagatcctgatga       c.*480

          .         .         .         .         .         .       g.67750
 catatgcccaaggtgttcggggtagagcttgcttttatgcattttagggagttataatat       c.*540

          .         .         .         .         .         .       g.67810
 atcaatcaatacatgtaaggtgtacattggctcaatctggaaaggtaggacaactcaaag       c.*600

          .         .         .         .         .         .       g.67870
 caggggcttccagatcacaggtagatttaaagattcttgattggcattgattgaacagtt       c.*660

          .         .         .         .         .         .       g.67930
 attatctaaagacctggaatcaataggaaggaaatgcctgggctatgataagaagttatg       c.*720

          .         .         .         .         .         .       g.67990
 gagaccaaagttttataatgcagatgaagcctccaggtagcagactttagagggaataga       c.*780

          .         .         .         .         .         .       g.68050
 ttgtaaatatttctgatcagtcctaaggtctgttgaaatttatgctggccagcttttcct       c.*840

          .         .         .         .         .         .       g.68110
 gaattccaaaagagaggagggtattatggagtcatgtccaacctccccttcccagcatgg       c.*900

          .         .         .         .         .         .       g.68170
 cctaaactagtttttcaggataactttgaaatgcccttggctgagagaaggggcttgttc       c.*960

                                                                    g.68171
 a                                                                  c.*961

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Death domain containing 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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