dishevelled, dsh homolog 1 (Drosophila) (DVL1) - coding DNA reference sequence

(used for variant description)

(last modified September 29, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_004421.2 in the DVL1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008048.2, covering DVL1 transcript NM_004421.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5047
              ccccgggccgggccctgagcgcgcgggctccgcgccgccgccgcgcc       c.-1

          .         .         .         .         .         .       g.5107
 ATGGCGGAGACCAAGATTATCTACCACATGGACGAGGAGGAGACGCCGTACCTGGTCAAG       c.60
 M  A  E  T  K  I  I  Y  H  M  D  E  E  E  T  P  Y  L  V  K         p.20

          .         .         .         .         .         .       g.5167
 CTGCCCGTGGCCCCCGAGCGCGTCACGCTGGCCGACTTCAAGAACGTGCTCAGCAACCGG       c.120
 L  P  V  A  P  E  R  V  T  L  A  D  F  K  N  V  L  S  N  R         p.40

          .         .         .         .         . | 02       .    g.11364
 CCCGTGCACGCCTACAAATTCTTCTTTAAGTCCATGGACCAGGACTTCGG | GGTGGTGAAG    c.180
 P  V  H  A  Y  K  F  F  F  K  S  M  D  Q  D  F  G  |  V  V  K      p.60

          .         .         .         .         .         .       g.11424
 GAGGAGATCTTTGATGACAATGCCAAGCTTCCCTGCTTCAACGGCCGCGTGGTCTCCTGG       c.240
 E  E  I  F  D  D  N  A  K  L  P  C  F  N  G  R  V  V  S  W         p.80

  | 03       .         .         .         .         .         .    g.11688
  | CTGGTCCTGGCTGAGGGTGCTCACTCGGATGCGGGGTCCCAGGGCACGGACAGCCACACA    c.300
  | L  V  L  A  E  G  A  H  S  D  A  G  S  Q  G  T  D  S  H  T      p.100

          .         .         .         .         .         .       g.11748
 GACCTGCCCCCGCCTCTTGAGCGGACAGGCGGCATCGGGGACTCCCGGCCCCCCTCCTTC       c.360
 D  L  P  P  P  L  E  R  T  G  G  I  G  D  S  R  P  P  S  F         p.120

    | 04     .         .         .         .         .         .    g.12014
 CA | CCCAAATGTGGCCAGCAGCCGTGACGGGATGGACAACGAGACAGGCACGGAGTCCATG    c.420
 H  |  P  N  V  A  S  S  R  D  G  M  D  N  E  T  G  T  E  S  M      p.140

          .         .         .         .       | 05 .         .    g.12321
 GTCAGTCACCGGCGGGAGCGTGCCCGACGCCGGAACCGCGAGGAGG | CCGCCCGGACCAAT    c.480
 V  S  H  R  R  E  R  A  R  R  R  N  R  E  E  A |   A  R  T  N      p.160

          .         .         .         .         .         .       g.12381
 GGGCACCCAAGGGGAGACCGACGGCGGGATGTGGGGCTGCCCCCAGACAGCGCGTCCACC       c.540
 G  H  P  R  G  D  R  R  R  D  V  G  L  P  P  D  S  A  S  T         p.180

          .         .         .         .         .         .       g.12441
 GCCCTCAGCAGCGAGCTTGAGTCCAGCAGCTTTGTGGACTCGGACGAGGATGGCAGCACG       c.600
 A  L  S  S  E  L  E  S  S  S  F  V  D  S  D  E  D  G  S  T         p.200

       | 06  .         .         .         .         .         .    g.13664
 AGCAG | GCTCAGCAGCTCCACGGAGCAGAGCACCTCATCCAGACTCATCCGGAAGCACAAA    c.660
 S  R  |  L  S  S  S  T  E  Q  S  T  S  S  R  L  I  R  K  H  K      p.220

          .         .         .          | 07        .         .    g.13817
 CGCCGGCGGAGGAAGCAGCGCCTTCGGCAGGCGGACCGG | GCCTCCTCCTTCAGCAGCATA    c.720
 R  R  R  R  K  Q  R  L  R  Q  A  D  R   | A  S  S  F  S  S  I      p.240

          .         .         .         .          | 08        .    g.13946
 ACCGACTCCACCATGTCCCTCAACATCGTCACTGTCACGCTCAACATGG | AAAGACATCAC    c.780
 T  D  S  T  M  S  L  N  I  V  T  V  T  L  N  M  E |   R  H  H      p.260

          .         .         .         .         .         .       g.14006
 TTTCTGGGCATCAGCATCGTGGGGCAGAGCAACGACCGTGGAGACGGCGGCATCTACATT       c.840
 F  L  G  I  S  I  V  G  Q  S  N  D  R  G  D  G  G  I  Y  I         p.280

          .         .         .         .         .         .       g.14066
 GGCTCCATCATGAAGGGCGGGGCTGTGGCCGCTGACGGCCGCATCGAGCCCGGCGACATG       c.900
 G  S  I  M  K  G  G  A  V  A  A  D  G  R  I  E  P  G  D  M         p.300

           | 09        .         .         .         .         .    g.14351
 TTGCTGCAG | GTGAATGACGTGAACTTTGAGAACATGAGCAATGACGATGCCGTGCGGGTG    c.960
 L  L  Q   | V  N  D  V  N  F  E  N  M  S  N  D  D  A  V  R  V      p.320

          .         .       | 10 .         .         .         .    g.14497
 CTGCGGGAGATCGTTTCCCAGACGGG | GCCCATCAGCCTCACTGTGGCCAAGTGCTGGGAC    c.1020
 L  R  E  I  V  S  Q  T  G  |  P  I  S  L  T  V  A  K  C  W  D      p.340

          .         .         .     | 11   .         .         .    g.14699
 CCAACGCCCCGAAGCTACTTCACCGTCCCACGGG | CTGACCCGGTGCGGCCCATCGACCCC    c.1080
 P  T  P  R  S  Y  F  T  V  P  R  A |   D  P  V  R  P  I  D  P      p.360

          .         .         .         .         .   | 12     .    g.15467
 GCCGCCTGGCTGTCCCACACGGCGGCACTGACAGGAGCCCTGCCCCGCTACG | AGCTGGAA    c.1140
 A  A  W  L  S  H  T  A  A  L  T  G  A  L  P  R  Y  E |   L  E      p.380

          .         .         .         .         .         .       g.15527
 GAGGCGCCGCTGACGGTGAAGAGTGACATGAGCGCCGTCGTCCGGGTCATGCAGCTGCCA       c.1200
 E  A  P  L  T  V  K  S  D  M  S  A  V  V  R  V  M  Q  L  P         p.400

          .         .         .         .         .         .       g.15587
 GACTCGGGACTGGAGATCCGCGACCGCATGTGGCTCAAGATCACCATCGCCAATGCCGTC       c.1260
 D  S  G  L  E  I  R  D  R  M  W  L  K  I  T  I  A  N  A  V         p.420

      | 13   .         .         .         .         .         .    g.15732
 ATCG | GGGCGGACGTGGTGGACTGGCTGTACACACACGTGGAGGGCTTCAAGGAGCGGCGG    c.1320
 I  G |   A  D  V  V  D  W  L  Y  T  H  V  E  G  F  K  E  R  R      p.440

          .         .         .         .         .         .       g.15792
 GAGGCCCGGAAGTACGCCAGCAGCTTGCTGAAGCACGGCTTCCTGCGGCACACGGTCAAC       c.1380
 E  A  R  K  Y  A  S  S  L  L  K  H  G  F  L  R  H  T  V  N         p.460

          .         .         .         .         .   | 14     .    g.15937
 AAGATCACCTTCTCCGAGCAGTGCTACTACGTCTTCGGGGATCTCTGCAGCA | ATCTCGCC    c.1440
 K  I  T  F  S  E  Q  C  Y  Y  V  F  G  D  L  C  S  N |   L  A      p.480

          .         .         .         .         .         .       g.15997
 ACCCTGAACCTCAACAGTGGCTCCAGTGGGACTTCGGATCAGGACACGCTGGCCCCGCTG       c.1500
 T  L  N  L  N  S  G  S  S  G  T  S  D  Q  D  T  L  A  P  L         p.500

          .         .         .         .         .         .       g.16057
 CCCCACCCGGCTGCCCCCTGGCCTCTGGGTCAGGGCTACCCCTACCAGTACCCGGGACCC       c.1560
 P  H  P  A  A  P  W  P  L  G  Q  G  Y  P  Y  Q  Y  P  G  P         p.520

          .         .         .         .         .         .       g.16117
 CCACCCTGCTTCCCGCCTGCCTACCAGGACCCGGGCTTTAGCTATGGCAGCGGCAGCACC       c.1620
 P  P  C  F  P  P  A  Y  Q  D  P  G  F  S  Y  G  S  G  S  T         p.540

          .          | 15        .         .         .         .    g.17638
 GGGAGTCAGCAGAGTGAAG | GGAGCAAAAGCAGTGGGTCCACCCGGAGCAGCCGCCGGGCC    c.1680
 G  S  Q  Q  S  E  G |   S  K  S  S  G  S  T  R  S  S  R  R  A      p.560

          .         .         .         .         .         .       g.17698
 CCGGGCCGTGAGAAGGAGCGTCGGGCGGCGGGAGCTGGGGGCAGTGGCAGTGAATCGGAT       c.1740
 P  G  R  E  K  E  R  R  A  A  G  A  G  G  S  G  S  E  S  D         p.580

          .         .         .         .         .         .       g.17758
 CACACGGCACCGAGTGGGGTGGGGAGCAGCTGGCGAGAGCGTCCGGCCGGCCAGCTCAGC       c.1800
 H  T  A  P  S  G  V  G  S  S  W  R  E  R  P  A  G  Q  L  S         p.600

          .         .         .         .         .         .       g.17818
 CGTGGCAGCAGCCCACGCAGTCAGGCCTCGGCTACCGCCCCGGGGCTCCCCCCGCCCCAC       c.1860
 R  G  S  S  P  R  S  Q  A  S  A  T  A  P  G  L  P  P  P  H         p.620

          .         .         .         .         .         .       g.17878
 CCCACGACCAAGGCCTATACAGTGGTGGGGGGGCCACCCGGGGGACCCCCTGTCCGGGAG       c.1920
 P  T  T  K  A  Y  T  V  V  G  G  P  P  G  G  P  P  V  R  E         p.640

          .         .         .         .         .         .       g.17938
 CTGGCTGCCGTCCCCCCGGAATTGACAGGCAGCCGCCAGTCCTTCCAGAAGGCTATGGGG       c.1980
 L  A  A  V  P  P  E  L  T  G  S  R  Q  S  F  Q  K  A  M  G         p.660

          .         .         .                                     g.17971
 AACCCCTGCGAGTTCTTCGTGGACATCATGTGA                                  c.2013
 N  P  C  E  F  F  V  D  I  M  X                                    p.670

          .         .         .         .         .         .       g.18031
 ctcgtggcgcatgccccagccctgcctgaggtggggagctggcggtcctgccgcatgcag       c.*60

          .         .         .         .         .         .       g.18091
 agctcgcgtgggcttgccttcgtgggggccaggacgggaggcagggtggggggcaggctg       c.*120

          .         .         .         .         .         .       g.18151
 gaccaccaccatctgccctggcagcctggctgctccagctcctgacagcacctgtgtctg       c.*180

          .         .         .         .         .         .       g.18211
 agcagccgtgttgggggcgctccctctctgcccctcagcgagagcctcggacctcccaac       c.*240

          .         .         .         .         .         .       g.18271
 cccttgtgtctggtggggatccctcctgggatgaggaagaccccctcgggctctcggctg       c.*300

          .         .         .         .         .         .       g.18331
 acccccacctcctgcacagctgtgcccaggcccccagggtggtccatgcggggcaacccc       c.*360

          .         .         .         .         .         .       g.18391
 ctgcggtgcacaggccccctgtctggagtagggatctaatttatttatttattgcctggc       c.*420

          .         .         .         .         .         .       g.18451
 cggtgactcgggggaggaggcgaccctgtcatctgtcccacctgctgctgccccttggag       c.*480

          .         .         .         .         .         .       g.18511
 cagcctgcaccttctctcctcccatccggcaacagtctgaaagtacgtggaggacgggac       c.*540

          .         .         .         .         .         .       g.18571
 cggaagacgagagagggctggacatcctgcccaccgtgtcccagccagggcagggaggga       c.*600

          .         .         .         .         .         .       g.18631
 ccatggcccgcagggtcaaggggccccgatgtgcacagctgccacagggagggaggtctt       c.*660

          .         .         .         .         .         .       g.18691
 ggggagatgggcagtcaggtggcccgtccttggtgagtgcacacactgcgcgcacacatc       c.*720

          .         .         .         .         .         .       g.18751
 gcggccttcctggcttctctggcccccacgtgtctgtgctgtagatactgtatcaaagtc       c.*780

          .         .         .         .         .         .       g.18811
 ccagcgtttagatggttaacatagagctgcttctgtgtaaatgctgcttattttaaacac       c.*840

          .         .                                               g.18835
 taaaaagcgtttaattttatggga                                           c.*864

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Dishevelled, dsh homolog 1 (Drosophila) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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