dishevelled, dsh homolog 3 (Drosophila) (DVL3) - coding DNA reference sequence

(used for variant description)

(last modified April 1, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_004423.3 in the DVL3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000003.11, covering DVL3 transcript NM_004423.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5020
                                         gaacaagggagctggcgccg       c.-121

 .         .         .         .         .         .                g.5080
 ccagcagccgccgagctgggttgagccgctgggccgcgccgcgcgccgccgccgtctggg       c.-61

 .         .         .         .         .         .                g.5140
 aggctcggcccggccgcccgagcaggccgcgcgcgggccgccgggcccgaggccagagcc       c.-1

          .         .         .         .         .         .       g.5200
 ATGGGCGAGACCAAGATCATCTACCACTTGGATGGGCAGGAGACGCCGTACCTTGTGAAG       c.60
 M  G  E  T  K  I  I  Y  H  L  D  G  Q  E  T  P  Y  L  V  K         p.20

          .         .         .         .         .         .       g.5260
 CTGCCCCTGCCCGCCGAGCGCGTCACCTTGGCGGACTTTAAGGGCGTTTTGCAGCGACCC       c.120
 L  P  L  P  A  E  R  V  T  L  A  D  F  K  G  V  L  Q  R  P         p.40

          .         .         .         .  | 02      .         .    g.13180
 AGCTATAAGTTCTTCTTCAAGTCTATGGACGACGATTTCGG | AGTGGTGAAGGAGGAGATC    c.180
 S  Y  K  F  F  F  K  S  M  D  D  D  F  G  |  V  V  K  E  E  I      p.60

          .         .         .         .         .  | 03      .    g.13780
 TCGGATGACAATGCCAAGCTACCATGCTTCAATGGCCGGGTGGTGTCCTGG | CTGGTGTCA    c.240
 S  D  D  N  A  K  L  P  C  F  N  G  R  V  V  S  W   | L  V  S      p.80

          .         .         .         .         .         .       g.13840
 GCTGAGGGCTCACACCCAGACCCAGCCCCCTTCTGTGCTGATAACCCATCGGAGCTGCCA       c.300
 A  E  G  S  H  P  D  P  A  P  F  C  A  D  N  P  S  E  L  P         p.100

          .         .         .         .         .    | 04    .    g.14003
 CCACCTATGGAGCGCACGGGAGGCATCGGGGACTCCCGACCCCCATCCTTCCA | CCCTCAT    c.360
 P  P  M  E  R  T  G  G  I  G  D  S  R  P  P  S  F  H  |  P  H      p.120

          .         .         .         .         .         .       g.14063
 GCTGGTGGGGGCAGCCAGGAGAACCTGGACAATGACACAGAGACGGACTCTTTGGTGTCT       c.420
 A  G  G  G  S  Q  E  N  L  D  N  D  T  E  T  D  S  L  V  S         p.140

          .         .         .         .    | 05    .         .    g.14317
 GCCCAGCGAGAGCGGCCACGCCGGAGGGATGGCCCAGAGCATG | CAACCCGGCTAAATGGA    c.480
 A  Q  R  E  R  P  R  R  R  D  G  P  E  H  A |   T  R  L  N  G      p.160

          .         .         .         .         .         .       g.14377
 ACTGCGAAGGGGGAACGGCGGCGAGAACCAGGGGGTTATGATAGCTCATCCACCCTTATG       c.540
 T  A  K  G  E  R  R  R  E  P  G  G  Y  D  S  S  S  T  L  M         p.180

          .         .         .         .         .          | 06    g.14618
 AGCAGTGAGCTGGAGACCACCAGCTTCTTTGACTCAGATGAGGATGACTCCACCAGCAG | G    c.600
 S  S  E  L  E  T  T  S  F  F  D  S  D  E  D  D  S  T  S  R  |      p.200

          .         .         .         .         .         .       g.14678
 TTCAGCAGCTCCACAGAACAGAGCAGTGCCTCACGCCTGATGAGAAGACACAAGCGGCGG       c.660
 F  S  S  S  T  E  Q  S  S  A  S  R  L  M  R  R  H  K  R  R         p.220

          .         .         .    | 07    .         .         .    g.14953
 CGGCGGAAGCAGAAGGTTTCTCGGATTGAGCGG | TCCTCGTCCTTCAGCAGCATCACGGAC    c.720
 R  R  K  Q  K  V  S  R  I  E  R   | S  S  S  F  S  S  I  T  D      p.240

          .         .         .         .    | 08    .         .    g.15647
 TCCACCATGTCACTCAACATCATCACGGTCACTCTCAACATGG | AAAAATATAACTTCTTG    c.780
 S  T  M  S  L  N  I  I  T  V  T  L  N  M  E |   K  Y  N  F  L      p.260

          .         .         .         .         .         .       g.15707
 GGCATCTCCATTGTGGGCCAAAGCAACGAGCGTGGTGACGGCGGCATCTACATTGGCTCT       c.840
 G  I  S  I  V  G  Q  S  N  E  R  G  D  G  G  I  Y  I  G  S         p.280

          .         .         .         .         .         .       g.15767
 ATCATGAAGGGTGGGGCCGTGGCTGCTGATGGACGCATCGAGCCAGGAGATATGTTGTTA       c.900
 I  M  K  G  G  A  V  A  A  D  G  R  I  E  P  G  D  M  L  L         p.300

     | 09    .         .         .         .         .         .    g.16007
 CAG | GTAAACGAGATCAACTTTGAGAACATGAGTAATGACGATGCAGTCCGGGTACTGCGG    c.960
 Q   | V  N  E  I  N  F  E  N  M  S  N  D  D  A  V  R  V  L  R      p.320

          .         . | 10       .         .         .         .    g.16150
 GAGATTGTGCACAAACCGGG | GCCCATCACCCTGACTGTAGCCAAGTGCTGGGACCCAAGT    c.1020
 E  I  V  H  K  P  G  |  P  I  T  L  T  V  A  K  C  W  D  P  S      p.340

          .         .         | 11         .         .         .    g.16362
 CCACGTGGTTGCTTCACATTGCCCAGGA | GCGAGCCCATCCGGCCCATTGACCCTGCGGCC    c.1080
 P  R  G  C  F  T  L  P  R  S |   E  P  I  R  P  I  D  P  A  A      p.360

          .         .         .         .         .         .       g.16422
 TGGGTCTCCCACACTGCAGCCATGACCGGCACCTTCCCTGCATACGGCATGAGCCCCTCC       c.1140
 W  V  S  H  T  A  A  M  T  G  T  F  P  A  Y  G  M  S  P  S         p.380

          .         .         .         .         .         | 12    g.17086
 CTGAGCACCATCACCTCCACCAGCTCCTCCATCACCAGTTCCATCCCTGACACAGAGC | GC    c.1200
 L  S  T  I  T  S  T  S  S  S  I  T  S  S  I  P  D  T  E  R |       p.400

          .         .         .         .         .         .       g.17146
 CTAGACGACTTCCACTTGTCCATCCACAGTGACATGGCTGCCATCGTAAAAGCCATGGCC       c.1260
 L  D  D  F  H  L  S  I  H  S  D  M  A  A  I  V  K  A  M  A         p.420

          .         .         .         .         .         .       g.17206
 TCCCCTGAATCAGGGTTGGAGGTCCGTGACCGCATGTGGCTCAAGATTACCATCCCTAAT       c.1320
 S  P  E  S  G  L  E  V  R  D  R  M  W  L  K  I  T  I  P  N         p.440

          . | 13       .         .         .         .         .    g.17452
 GCTTTCATCG | GCTCAGATGTGGTGGACTGGCTGTACCACAATGTGGAAGGCTTCACGGAC    c.1380
 A  F  I  G |   S  D  V  V  D  W  L  Y  H  N  V  E  G  F  T  D      p.460

          .         .         .         .         .         .       g.17512
 CGGAGGGAGGCCCGCAAGTATGCCAGCAACCTGCTGAAAGCTGGCTTCATCCGCCATACC       c.1440
 R  R  E  A  R  K  Y  A  S  N  L  L  K  A  G  F  I  R  H  T         p.480

          .         .         .         .         .         | 14    g.19512
 GTCAACAAGATCACCTTCTCCGAGCAGTGCTACTACATCTTCGGTGACCTCTGCGGCA | AC    c.1500
 V  N  K  I  T  F  S  E  Q  C  Y  Y  I  F  G  D  L  C  G  N |       p.500

          .         .         .         .         .         .       g.19572
 ATGGCCAACCTGTCTCTCCACGATCACGATGGCTCCAGTGGCGCCTCTGACCAGGACACA       c.1560
 M  A  N  L  S  L  H  D  H  D  G  S  S  G  A  S  D  Q  D  T         p.520

          .         .         .         .         .         .       g.19632
 CTGGCCCCTTTGCCGCACCCGGGGGCCGCCCCTTGGCCCATGGCTTTCCCGTACCAGTAC       c.1620
 L  A  P  L  P  H  P  G  A  A  P  W  P  M  A  F  P  Y  Q  Y         p.540

          .         .         .         .         .         .       g.19692
 CCGCCACCCCCGCACCCATACAACCCGCACCCGGGCTTCCCGGAGCTGGGCTACAGCTAC       c.1680
 P  P  P  P  H  P  Y  N  P  H  P  G  F  P  E  L  G  Y  S  Y         p.560

          .         .         .     | 15   .         .         .    g.19849
 GGCGGGGGCAGCGCCAGCAGTCAGCACAGCGAAG | GCAGTCGGAGCAGTGGCTCCAACCGT    c.1740
 G  G  G  S  A  S  S  Q  H  S  E  G |   S  R  S  S  G  S  N  R      p.580

          .         .         .         .         .         .       g.19909
 AGCGGCAGCGATCGGAGGAAGGAGAAGGACCCGAAGGCCGGGGACTCCAAGTCCGGGGGC       c.1800
 S  G  S  D  R  R  K  E  K  D  P  K  A  G  D  S  K  S  G  G         p.600

          .         .         .         .         .         .       g.19969
 AGCGGCAGCGAATCGGACCACACCACACGCAGCAGCCTGCGGGGGCCGCGGGAGCGGGCG       c.1860
 S  G  S  E  S  D  H  T  T  R  S  S  L  R  G  P  R  E  R  A         p.620

          .         .         .         .         .         .       g.20029
 CCCAGCGAGCGCTCAGGGCCGGCGGCCAGCGAGCACAGCCACCGCAGCCACCATTCCCTG       c.1920
 P  S  E  R  S  G  P  A  A  S  E  H  S  H  R  S  H  H  S  L         p.640

          .         .         .         .         .         .       g.20089
 GCCAGCAGCCTTCGCAGCCACCACACACACCCGAGCTACGGTCCTCCCGGAGTGCCCCCT       c.1980
 A  S  S  L  R  S  H  H  T  H  P  S  Y  G  P  P  G  V  P  P         p.660

          .         .         .         .         .         .       g.20149
 CTCTACGGCCCCCCCATGCTGATGATGCCCCCGCCGCCCGCGGCCATGGGGCCCCCAGGA       c.2040
 L  Y  G  P  P  M  L  M  M  P  P  P  P  A  A  M  G  P  P  G         p.680

          .         .         .         .         .         .       g.20209
 GCCCCTCCGGGCCGCGACCTGGCCTCAGTGCCCCCGGAACTGACCGCCAGCAGACAGTCC       c.2100
 A  P  P  G  R  D  L  A  S  V  P  P  E  L  T  A  S  R  Q  S         p.700

          .         .         .         .         .                 g.20260
 TTCCGCATGGCCATGGGAAACCCCAGTGAGTTCTTTGTGGATGTGATGTGA                c.2151
 F  R  M  A  M  G  N  P  S  E  F  F  V  D  V  M  X                  p.716

          .         .         .         .         .         .       g.20320
 gcagggcccctcccccagctccattccgctcccaccccagccggctgcgttcctctctcc       c.*60

          .         .         .         .         .         .       g.20380
 atccgtccgtcttttttactttgtctggtacctgaaagggaaataaaaggaactaaatcc       c.*120

          .         .         .         .         .         .       g.20440
 aggtgcgctaactgctcgcagggtgctgcgagggtggggtgcacctaccgattggctctg       c.*180

          .         .         .         .         .         .       g.20500
 cagccccctaacctgcctctggccccagttcgtttcctctgcccactaatccctgcgcag       c.*240

          .         .         .         .         .         .       g.20560
 gacttcccaggaccccttttgtctctgggaccagacttgttggtgctaccccttactccc       c.*300

          .         .         .         .         .         .       g.20620
 ctctgcaacccccattttgggagttgaccccagcaatgaccttggtggcacgctcactcc       c.*360

          .         .         .         .         .         .       g.20680
 ctcattctctcgtttcccctttagctccctttcaccatttattcagctacatcatccctc       c.*420

          .         .         .         .         .         .       g.20740
 tattaaccccaccccatcaggcacgtgtgcaaacctcttgactttaccccacattactga       c.*480

          .         .         .         .         .         .       g.20800
 aaccaaaatatatttgcttcatctgcccctactaaccatccccctgcctgctgcctcagt       c.*540

          .         .         .         .         .         .       g.20860
 cctgcaacctaaagctgtagtcgcctccaatagccatccatgccatccctgcctgtgcct       c.*600

          .         .         .         .         .         .       g.20920
 agatcagaggcccagagggccccctcagttgcctgagcagctggtggcttccagggagca       c.*660

          .         .         .         .         .         .       g.20980
 tctctgctctacccctgccccatgcctgccctgcgtgctggttccttcagacccctaacc       c.*720

          .         .         .         .         .         .       g.21040
 ctactaaccagcaggctcatctcacctccaggcctgaaacatttcttttctttctttttt       c.*780

          .         .         .         .         .         .       g.21100
 cctcccccaatttaccctgggcctggagcagccaagaatttcgggctgtttgactttctg       c.*840

          .         .         .         .         .         .       g.21160
 tgagcccccagcgaggggaggcccagcctccgaggagaccaggaaccctgcttcagcagc       c.*900

          .         .         .         .         .         .       g.21220
 ccctcagggcttcccaaggatgtccagcccccacacccacacgttaacataatgagtcac       c.*960

          .         .         .         .         .         .       g.21280
 taggcttctggggagggcccaacttcacccatgcatgagagactctcctcctttccagag       c.*1020

          .         .         .         .         .         .       g.21340
 agaatcggatcgcaccacgtgtggcagcctgcggcggggggaggggggcctctttagctc       c.*1080

          .         .         .         .         .         .       g.21400
 tctttatctttctctctcactcatgtatgcatacatgcacagagatgcatacacaggtgc       c.*1140

          .         .         .         .         .         .       g.21460
 ctatgcaagttcatttaagcctcagggctggtccctgcccaaagggctggaccctcctaa       c.*1200

          .         .         .         .         .         .       g.21520
 tcctctcctaggttgtggggctggtcccctgacacccttctccccttcctggtagacctt       c.*1260

          .         .         .         .         .         .       g.21580
 aaacctcgcacacatgtccccagcattttctcacctggataaagcccataagctgggtct       c.*1320

          .         .         .         .         .         .       g.21640
 caggctgggctcagcaaaggactcgccttgcaaccgacaggccattcccacccccacaca       c.*1380

          .         .         .         .         .         .       g.21700
 caacctcccctgttttcacattcaccatggcatcccagagcaaggacacaggagcccaca       c.*1440

          .         .         .         .         .         .       g.21760
 ggccagttgaggttgggcaaggagacttccaggacttccagacagagtaccaggttttat       c.*1500

          .         .         .         .         .         .       g.21820
 ttttcaccttattctctactttaaacaaatcataactttctctttaagcctctgctataa       c.*1560

          .         .         .         .         .         .       g.21880
 attctcctggctctcctgggcttccatattttgggggctggggtgtcaaaagtgagatga       c.*1620

          .         .         .         .         .         .       g.21940
 agttcttagctccaggttttggggtaaaccaaggtaggaacattttggcatttatttcaa       c.*1680

          .         .         .         .         .         .       g.22000
 ttaacaatacttccttggacgggtgcggtggctcacgtctgtaatcccagcactttggga       c.*1740

          .         .         .         .         .         .       g.22060
 ggctgagacaggtggatcacttgaggtcgggagttcgagaccagcctggccaacatagca       c.*1800

          .         .         .         .         .         .       g.22120
 aaaccctgtctctactaaaaatacaaaaattagatgggtgttttggcacctgcctgtaat       c.*1860

          .         .         .         .         .         .       g.22180
 ctcagctactcaggaggctgaggcacaagaatcgcttgaatccaggaagcaagcggaggt       c.*1920

          .         .         .         .         .         .       g.22240
 tgcagtgagttgagatcgcactccagcctgggtgacagagtgagattctgtctcaaaagc       c.*1980

          .         .         .         .         .         .       g.22300
 aaactaacaaagaaaaacaatacttcctggggttttggtgtgcagagggctttgttggaa       c.*2040

          .         .         .         .         .         .       g.22360
 gtgtgactcaatcttgcctgccttctgggagctctagaattgttcccaacccagtccatg       c.*2100

          .         .         .         .         .         .       g.22420
 gcttctagccaccactacagggctgtttcatgtacttctctctctgactctgtcttgtcc       c.*2160

          .         .         .         .         .         .       g.22480
 gactctcttgagaatttctcaacgattgctcatgcctgtcagtatcagtgcttccatcgt       c.*2220

          .         .         .         .         .         .       g.22540
 tccatctttgattcacttctctttcctttctatttactcccaaaatggagtcattcatcc       c.*2280

          .         .         .         .         .         .       g.22600
 tgatgtcctcaattgctgctgatatgctggtgattcccaaatacatagctccaaccccca       c.*2340

          .         .         .         .         .         .       g.22660
 acttcccccagactttagatctgtattggtattacctactggacatctctatggacagtt       c.*2400

          .         .         .         .         .         .       g.22720
 ccgtatagactcaactcatctgcccaaccaagtatgttcctcctgaattcctctcctggt       c.*2460

          .         .         .         .         .         .       g.22780
 tacttcatcacaatctacataggctcaccagctagaaacatttatgagcttacattcctt       c.*2520

          .         .         .         .         .         .       g.22840
 cttcccatatcttatcagcatatcatatccatttcactccaacactctgtcttgaatttg       c.*2580

          .         .         .         .         .         .       g.22900
 gccctccctctcccctctctactttaattcattggagcatgggatttggagttaggtggt       c.*2640

          .         .         .         .         .         .       g.22960
 tttgggtttgaattccagctctactatttttggttgtgtgatagagttatttaacctctc       c.*2700

          .         .         .         .         .         .       g.23020
 tgagcctcagttccctcgtatgtaaaatgatgataataatacctacctcacagggttgtt       c.*2760

          .                                                         g.23031
 gtgaggattta                                                        c.*2771

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Dishevelled, dsh homolog 3 (Drosophila) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 27
©2004-2022 Leiden University Medical Center