dynein, cytoplasmic 1, intermediate chain 2 (DYNC1I2) - coding DNA reference sequence

(used for variant description)

(last modified June 7, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_001378.2 in the DYNC1I2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.11, covering DYNC1I2 transcript NM_001378.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.4985
             aattcccagaacgcactgctcgtcgcacgcaggttttccttgttgccg       c.-181

 .         .         .         .         .         .                g.5045
 gggtttgtagttcttctcgatcgtgtcagtttgtaaggcgagggcggaagttggattcct       c.-121

 .         .         .         .         .         .                g.5105
 ggcctgagaatattaggcgtagttttccagtttttggcaaagcggaaatacttaaggccc       c.-61

 .         .         .         .         .         . | 02           g.7684
 ctgggttgactgggttctttgttttatctaccggcttctgctttacgacag | gtcacaaac    c.-1

          .         .         .         .         .         .       g.7744
 ATGTCAGACAAAAGTGAATTAAAGGCTGAGTTGGAACGTAAGAAGCAGCGACTGGCCCAA       c.60
 M  S  D  K  S  E  L  K  A  E  L  E  R  K  K  Q  R  L  A  Q         p.20

          .         .         .         .         | 03         .    g.10317
 ATCAGAGAGGAAAAGAAGAGAAAAGAAGAAGAAAGGAAAAAAAAAGAA | ACAGACCAGAAG    c.120
 I  R  E  E  K  K  R  K  E  E  E  R  K  K  K  E   | T  D  Q  K      p.40

          .         .         .         .         .         .       g.10377
 AAGGAAGCTGTTGCTCCTGTGCAAGAAGAATCAGATCTTGAAAAAAAAAGGAGAGAAGCT       c.180
 K  E  A  V  A  P  V  Q  E  E  S  D  L  E  K  K  R  R  E  A         p.60

          .         .         .         .       | 04 .         .    g.24089
 GAAGCATTGCTTCAAAGCATGGGGCTAACTCCAGAATCCCCCATTG | TTTTTTCTGAATAC    c.240
 E  A  L  L  Q  S  M  G  L  T  P  E  S  P  I  V |   F  S  E  Y      p.80

      | 05   .         .         .         .         .         .    g.24871
 TGGG | TCCCTCCTCCTATGTCTCCATCCTCCAAATCTGTGAGCACTCCAAGTGAAGCTGGA    c.300
 W  V |   P  P  P  M  S  P  S  S  K  S  V  S  T  P  S  E  A  G      p.100

          .         .         .      | 06  .         .         .    g.30320
 AGCCAAGACTCTGGAGATGGCGCCGTGGGATCTAG | GACGCTGCATTGGGATACAGATCCA    c.360
 S  Q  D  S  G  D  G  A  V  G  S  R  |  T  L  H  W  D  T  D  P      p.120

          .         .         .      | 07  .         .         .    g.32881
 TCAGTTCTTCAGCTTCACTCAGATTCCGATTTGGG | ACGAGGACCTATTAAACTTGGAATG    c.420
 S  V  L  Q  L  H  S  D  S  D  L  G  |  R  G  P  I  K  L  G  M      p.140

          .         .         .         .         .         .       g.32941
 GCTAAAATCACGCAAGTCGACTTTCCTCCTCGAGAAATTGTCACGTATACAAAGGAAACT       c.480
 A  K  I  T  Q  V  D  F  P  P  R  E  I  V  T  Y  T  K  E  T         p.160

          .         .         .  | 08      .         .         .    g.43175
 CAGACTCCAGTTATGGCTCAACCCAAAGAAG | ATGAAGAGGAAGATGATGATGTAGTGGCT    c.540
 Q  T  P  V  M  A  Q  P  K  E  D |   E  E  E  D  D  D  V  V  A      p.180

          .         .         .         .         .         .       g.43235
 CCTAAACCACCTATTGAACCTGAAGAAGAGAAAACTTTAAAGAAAGATGAGGAAAATGAT       c.600
 P  K  P  P  I  E  P  E  E  E  K  T  L  K  K  D  E  E  N  D         p.200

         | 09.         .         .         .         .         .    g.43500
 AGTAAAG | CTCCCCCTCATGAGCTGACTGAAGAAGAAAAGCAACAAATCTTGCACTCTGAG    c.660
 S  K  A |   P  P  H  E  L  T  E  E  E  K  Q  Q  I  L  H  S  E      p.220

          .         .         .         .         .         .       g.43560
 GAATTTTTAAGTTTCTTTGACCATTCTACAAGAATTGTAGAAAGAGCTCTTTCTGAGCAG       c.720
 E  F  L  S  F  F  D  H  S  T  R  I  V  E  R  A  L  S  E  Q         p.240

          .         .         .         .         . | 10       .    g.43732
 ATTAACATCTTCTTTGACTATAGTGGGAGAGATTTGGAAGACAAAGAAGG | AGAGATTCAA    c.780
 I  N  I  F  F  D  Y  S  G  R  D  L  E  D  K  E  G  |  E  I  Q      p.260

          .         .         .         .         .         .       g.43792
 GCAGGTGCTAAACTGTCATTAAATCGACAATTTTTTGACGAACGTTGGTCAAAGCATCGG       c.840
 A  G  A  K  L  S  L  N  R  Q  F  F  D  E  R  W  S  K  H  R         p.280

          .         .         . | 11       .         .         .    g.44349
 GTGGTTAGTTGTTTGGATTGGTCATCTCAG | TATCCGGAGTTACTCGTGGCTTCCTATAAC    c.900
 V  V  S  C  L  D  W  S  S  Q   | Y  P  E  L  L  V  A  S  Y  N      p.300

          .         .         .         .         .         .       g.44409
 AACAATGAAGATGCCCCTCATGAGCCTGATGGTGTGGCCCTTGTATGGAATATGAAATAC       c.960
 N  N  E  D  A  P  H  E  P  D  G  V  A  L  V  W  N  M  K  Y         p.320

          .         .         .       | 12 .         .         .    g.45373
 AAAAAAACTACCCCAGAGTATGTGTTTCACTGCCAG | TCAGCTGTGATGTCTGCCACATTT    c.1020
 K  K  T  T  P  E  Y  V  F  H  C  Q   | S  A  V  M  S  A  T  F      p.340

          .         .         .         .         .         .       g.45433
 GCAAAATTTCATCCAAATCTTGTTGTTGGTGGTACATATTCAGGCCAAATTGTGCTTTGG       c.1080
 A  K  F  H  P  N  L  V  V  G  G  T  Y  S  G  Q  I  V  L  W         p.360

          .         .         .         .         .         .       g.45493
 GATAACCGTAGCAATAAAAGAACTCCAGTGCAAAGAACTCCACTGTCAGCAGCTGCACAC       c.1140
 D  N  R  S  N  K  R  T  P  V  Q  R  T  P  L  S  A  A  A  H         p.380

     | 13    .         .         .         .         .         .    g.45890
 ACA | CACCCTGTATATTGTGTAAATGTTGTTGGAACACAAAATGCTCACAATCTGATTAGC    c.1200
 T   | H  P  V  Y  C  V  N  V  V  G  T  Q  N  A  H  N  L  I  S      p.400

          .         .         .         .         .        | 14.    g.46248
 ATCTCTACTGATGGAAAAATTTGTTCATGGAGTCTGGACATGCTTTCCCATCCACAG | GAT    c.1260
 I  S  T  D  G  K  I  C  S  W  S  L  D  M  L  S  H  P  Q   | D      p.420

          .         .         .         .         .         .       g.46308
 AGCATGGAGTTGGTTCATAAACAGTCAAAAGCAGTAGCTGTGACATCTATGTCCTTCCCT       c.1320
 S  M  E  L  V  H  K  Q  S  K  A  V  A  V  T  S  M  S  F  P         p.440

          .         .         .         .         .         .       g.46368
 GTTGGAGATGTCAACAACTTTGTTGTTGGGAGTGAAGAAGGTTCTGTGTACACAGCATGC       c.1380
 V  G  D  V  N  N  F  V  V  G  S  E  E  G  S  V  Y  T  A  C         p.460

          .  | 15      .         .         .         .         .    g.47286
 CGCCATGGCAG | CAAAGCTGGAATCAGTGAGATGTTTGAGGGGCATCAAGGACCAATCACT    c.1440
 R  H  G  S  |  K  A  G  I  S  E  M  F  E  G  H  Q  G  P  I  T      p.480

          .         .         .         .         .         .       g.47346
 GGCATCCATTGTCATGCAGCTGTTGGAGCAGTAGACTTCTCACATCTTTTTGTCACTTCA       c.1500
 G  I  H  C  H  A  A  V  G  A  V  D  F  S  H  L  F  V  T  S         p.500

          .         .         .       | 16 .         .         .    g.61601
 TCGTTTGACTGGACAGTAAAGCTTTGGACAACTAAG | AATAACAAGCCTTTGTATTCATTT    c.1560
 S  F  D  W  T  V  K  L  W  T  T  K   | N  N  K  P  L  Y  S  F      p.520

          .         .         .         .         .         .       g.61661
 GAAGATAATGCAGACTATGTTTATGATGTTATGTGGTCACCTACCCACCCAGCCCTGTTT       c.1620
 E  D  N  A  D  Y  V  Y  D  V  M  W  S  P  T  H  P  A  L  F         p.540

          .         .         .         .         .        | 17.    g.63333
 GCCTGTGTGGATGGCATGGGGAGATTGGATTTGTGGAATCTCAATAATGACACAGAG | GTA    c.1680
 A  C  V  D  G  M  G  R  L  D  L  W  N  L  N  N  D  T  E   | V      p.560

          .         .         .         .         .         .       g.63393
 CCAACTGCCAGCATTTCTGTGGAGGGTAATCCTGCTCTTAATCGTGTGAGATGGACCCAT       c.1740
 P  T  A  S  I  S  V  E  G  N  P  A  L  N  R  V  R  W  T  H         p.580

          .         .         .         .         .         .       g.63453
 TCTGGCAGAGAGATTGCTGTGGGTGATTCTGAAGGACAGATTGTTATATACGATGTGGGA       c.1800
 S  G  R  E  I  A  V  G  D  S  E  G  Q  I  V  I  Y  D  V  G         p.600

     | 18    .         .         .         .         .         .    g.65361
 GAG | CAGATTGCTGTTCCCCGCAATGATGAATGGGCACGGTTTGGCCGAACACTTGCAGAA    c.1860
 E   | Q  I  A  V  P  R  N  D  E  W  A  R  F  G  R  T  L  A  E      p.620

          .         .         .         .         .                 g.65418
 ATTAATGCAAACCGAGCTGATGCAGAGGAGGAAGCAGCTACCCGAATACCTGCTTAG          c.1917
 I  N  A  N  R  A  D  A  E  E  E  A  A  T  R  I  P  A  X            p.638

          .         .         .         .         .         .       g.65478
 ttcctgaaaaggggagtgtaactagtggatttgggaaaggttcttaagtagatcctgaga       c.*60

          .         .         .         .         .         .       g.65538
 ctatttgcatgcttctgtctaaatgataattaaaaggaaatttcatggattaaaccatgg       c.*120

          .         .         .         .         .         .       g.65598
 gtttaatgcagcaaggaaacttacaatgtccctttatatataacatgcatcttgttttgg       c.*180

          .         .         .         .         .         .       g.65658
 atttgtgtcattttttaatatagctgattgacttcacagaaagcagcttttttgaattct       c.*240

          .         .         .         .         .         .       g.65718
 aatacataggtgtatatttggtattagttattttgagttcttttcaacttataacactgt       c.*300

          .         .         .         .         .         .       g.65778
 atacagttatttctaaagcacagatgaaataagttctgcatatttttaaataatcacagt       c.*360

          .         .         .         .         .         .       g.65838
 tccctgttatacagataatgttctcactacccataatatgtaggaacattgtttctcctt       c.*420

          .         .         .         .         .         .       g.65898
 agccgtagtatgcatacacctatccatgttcattctgacatcctttgttgtctttataat       c.*480

          .         .         .         .         .         .       g.65958
 tcatgtggtagttacctataaataaaaacaaatatgcgttaacttttcaaattttcattt       c.*540

          .         .         .         .         .         .       g.66018
 ttactccttacaacttgaatttttccatcttttataaaatatattttttccatatctttc       c.*600

          .         .         .         .         .         .       g.66078
 tttaagctcctgctgtgagcagccatctcaaatcctatagagctgtgtaccctaaatata       c.*660

          .         .         .         .         .         .       g.66138
 ccatgtggtatatactatagatctcccagtgcattatgaattgatgtctagataatctgt       c.*720

          .         .         .         .         .         .       g.66198
 tggtgaaaaaatttcccctaggttaacttttgctttactactttatattctttccatcta       c.*780

          .         .         .         .         .         .       g.66258
 agacatatttcctttaaaggataaatagaaagctgcctataattttcactgattaagaac       c.*840

          .         .         .         .         .         .       g.66318
 tatgtatgtgacctcactgagagtaaaatctttgagagaaattgatttcatgatttcagt       c.*900

          .         .         .         .         .         .       g.66378
 agccataaaggcaaagtgctcaaatggacccatactttggcattaaaatctacatcttga       c.*960

          .         .         .         .         .         .       g.66438
 gatctgttgccacagcattgtctacaagtccgaaaggtaggtgacaaatatctaagaatc       c.*1020

          .         .         .         .         .         .       g.66498
 agtattgaaatcagtgaatttcaggaatagaggaaaggactatgatcagatcttgatttt       c.*1080

          .         .         .         .         .         .       g.66558
 atctactttaaattgtctatttatttgatcccaaccttttgtacttctgaagtgtaactg       c.*1140

          .         .         .         .         .         .       g.66618
 tcttttattcaacagaacatgaactaggaagagagattagaaaacagaatgtgaacattt       c.*1200

          .         .         .         .         .         .       g.66678
 ttcttttaataattgtaacaaagatttgttgggagagaaatttccaaataatgagtagtg       c.*1260

          .         .         .         .         .         .       g.66738
 tatagtgtaaggaataattgacctggaattattggccccaaactctgattcttgctgaag       c.*1320

          .         .         .         .         .         .       g.66798
 catctatgagaagtgtgattttagccaagtctgtgccgcattctttatatgtaggaatta       c.*1380

          .         .         .         .         .         .       g.66858
 agttttgatttaatgatttctgaattttctttcagctctactcaattaaggggtatcagt       c.*1440

          .         .         .         .         .         .       g.66918
 atgtgaaatggaatatagaaaagtaggcaattctttacttttctatattcagtttcataa       c.*1500

          .         .         .         .         .         .       g.66978
 attaataccccataattgcccattatataccaaagacaatatctcaagttatctcattgt       c.*1560

          .         .         .         .         .         .       g.67038
 agcagtgtctgtgagtcaaaacttcaattttagtagagtcacactttctttatatagaaa       c.*1620

          .         .         .         .         .         .       g.67098
 aattcatgtactcactactcatgtagttactgtatctttaccttcagtttgtaaaaatga       c.*1680

          .         .         .         .         .         .       g.67158
 ctaaaagtagggaaaacaagtgttaaaacataatggataagaaaaggttggaaatcatat       c.*1740

          .         .         .         .         .         .       g.67218
 ggcaaatcacatgttcctcagcctcaaggtgtgtttagttgtgaaagaaagaataaaatt       c.*1800

          .         .         .         .         .         .       g.67278
 gtttaaatatttcactttttgggaatgacttctcccctactcccccagaaaatgcgatgt       c.*1860

          .         .         .         .         .         .       g.67338
 atacctttgcccattcaactttagtccatatttttaggaacacacaaatttactttaagg       c.*1920

          .         .         .         .         .         .       g.67398
 aattacctttaaagttgactatataatagcaaaagagaaagtattgagactgtcagtgtt       c.*1980

          .         .         .         .         .         .       g.67458
 gataaagcttctagcaagattaggttgactagaagtgcatcacagttctttatactttta       c.*2040

          .         .         .         .         .         .       g.67518
 gaactaaaagccttataattttgaaaaatatccagttacagaaattgtaccttatcagtt       c.*2100

          .         .         .         .         .         .       g.67578
 atactttttttctgagtaagaaaacaagctatagctttctggttaatttcttatttttcg       c.*2160

          .         .         .         .         .         .       g.67638
 ttgtttggtttttgtctttttgagtggaacgttaaagtttattaccttcatgttaaggaa       c.*2220

          .         .         .         .                           g.67687
 tatccagcttcacagacaattaacttgcaataaatctctgaaataatca                  c.*2269

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Dynein, cytoplasmic 1, intermediate chain 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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