dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) - coding DNA reference sequence

(used for variant description)

(last modified January 22, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_001396.3 in the DYRK1A gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009366.1, covering DYRK1A transcript NM_001396.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.57758
                                              gttatagttttgccg       c.-61

 .         .         .         .         .         .                g.57818
 ctggactcttccctcccttcccccaccccatcaggatgatatgagacttgaaagaagacg       c.-1

          . | 02       .         .         .         .         .    g.110177
 ATGCATACAG | GAGGAGAGACTTCAGCATGCAAACCTTCATCTGTTCGGCTTGCACCGTCA    c.60
 M  H  T  G |   G  E  T  S  A  C  K  P  S  S  V  R  L  A  P  S      p.20

          .         .         .         .         .         .       g.110237
 TTTTCATTCCATGCTGCTGGCCTTCAGATGGCTGGACAGATGCCCCATTCACATCAGTAC       c.120
 F  S  F  H  A  A  G  L  Q  M  A  G  Q  M  P  H  S  H  Q  Y         p.40

          .         .         .         .         .         .       g.110297
 AGTGACCGTCGCCAGCCAAACATAAGTGACCAACAGGTTTCTGCCTTATCATATTCTGAC       c.180
 S  D  R  R  Q  P  N  I  S  D  Q  Q  V  S  A  L  S  Y  S  D         p.60

          .         .        | 03.         .         .         .    g.115657
 CAGATTCAGCAACCTCTAACTAACCAG | GTGATGCCTGATATTGTCATGTTACAGAGGCGG    c.240
 Q  I  Q  Q  P  L  T  N  Q   | V  M  P  D  I  V  M  L  Q  R  R      p.80

          .         .         .         .         .         .       g.115717
 ATGCCCCAAACCTTCCGTGACCCAGCAACTGCTCCCCTGAGAAAACTTTCTGTTGACTTG       c.300
 M  P  Q  T  F  R  D  P  A  T  A  P  L  R  K  L  S  V  D  L         p.100

          .         .        | 04.         .         .         .    g.118114
 ATCAAAACATACAAGCATATTAATGAG | GTTTACTATGCAAAAAAGAAGCGAAGACACCAA    c.360
 I  K  T  Y  K  H  I  N  E   | V  Y  Y  A  K  K  K  R  R  H  Q      p.120

          .         .         .         .         .         .       g.118174
 CAGGGCCAGGGAGACGATTCTAGTCATAAGAAGGAACGGAAGGTTTACAATGATGGTTAT       c.420
 Q  G  Q  G  D  D  S  S  H  K  K  E  R  K  V  Y  N  D  G  Y         p.140

          .         .         .         .         .         .       g.118234
 GATGATGATAACTATGATTATATTGTAAAAAACGGAGAAAAGTGGATGGATCGTTACGAA       c.480
 D  D  D  N  Y  D  Y  I  V  K  N  G  E  K  W  M  D  R  Y  E         p.160

          .         .         .       | 05 .         .         .    g.123934
 ATTGACTCCTTGATAGGCAAAGGTTCCTTTGGACAG | GTTGTAAAGGCATATGATCGTGTG    c.540
 I  D  S  L  I  G  K  G  S  F  G  Q   | V  V  K  A  Y  D  R  V      p.180

          .         .         .         .         .         .       g.123994
 GAGCAAGAATGGGTTGCCATTAAAATAATAAAGAACAAGAAGGCTTTTCTGAATCAAGCA       c.600
 E  Q  E  W  V  A  I  K  I  I  K  N  K  K  A  F  L  N  Q  A         p.200

          .         .         .         .         .         .       g.124054
 CAGATAGAAGTGCGACTTCTTGAGCTCATGAACAAACATGACACTGAAATGAAATACTAC       c.660
 Q  I  E  V  R  L  L  E  L  M  N  K  H  D  T  E  M  K  Y  Y         p.220

      | 06   .         .         .         .         .         .    g.127674
 ATAG | TGCATTTGAAACGCCACTTTATGTTTCGAAACCATCTCTGTTTAGTTTTTGAAATG    c.720
 I  V |   H  L  K  R  H  F  M  F  R  N  H  L  C  L  V  F  E  M      p.240

          .         .         .         .         .         .       g.127734
 CTGTCCTACAACCTCTATGACTTGCTGAGAAACACCAATTTCCGAGGGGTCTCTTTGAAC       c.780
 L  S  Y  N  L  Y  D  L  L  R  N  T  N  F  R  G  V  S  L  N         p.260

          .         .         .         .         .         .       g.127794
 CTAACACGAAAGTTTGCGCAACAGATGTGCACTGCACTGCTTTTCCTTGCGACTCCAGAA       c.840
 L  T  R  K  F  A  Q  Q  M  C  T  A  L  L  F  L  A  T  P  E         p.280

          .         .         .         .         .         .       g.127854
 CTTAGTATCATTCACTGTGATCTAAAACCTGAAAATATCCTTCTTTGTAACCCCAAACGC       c.900
 L  S  I  I  H  C  D  L  K  P  E  N  I  L  L  C  N  P  K  R         p.300

          .         .         .         .         .  | 07      .    g.130469
 AGTGCAATCAAGATAGTTGACTTTGGCAGTTCTTGTCAGTTGGGGCAGAGG | ATATACCAG    c.960
 S  A  I  K  I  V  D  F  G  S  S  C  Q  L  G  Q  R   | I  Y  Q      p.320

          .         .         .         .         .         .       g.130529
 TATATTCAGAGTCGCTTTTATCGGTCTCCAGAGGTGCTACTGGGAATGCCTTATGACCTT       c.1020
 Y  I  Q  S  R  F  Y  R  S  P  E  V  L  L  G  M  P  Y  D  L         p.340

          .         .         .         .         .         .       g.130589
 GCCATTGATATGTGGTCCCTCGGGTGTATTTTGGTTGAAATGCACACTGGAGAACCTCTG       c.1080
 A  I  D  M  W  S  L  G  C  I  L  V  E  M  H  T  G  E  P  L         p.360

          .         | 08         .         .         .         .    g.133603
 TTCAGTGGTGCCAATGAG | GTAGATCAGATGAATAAAATAGTGGAAGTTCTGGGTATTCCA    c.1140
 F  S  G  A  N  E   | V  D  Q  M  N  K  I  V  E  V  L  G  I  P      p.380

          .         .         .         .         .         .       g.133663
 CCTGCTCATATTCTTGACCAAGCACCAAAAGCAAGAAAGTTCTTTGAGAAGTTGCCAGAT       c.1200
 P  A  H  I  L  D  Q  A  P  K  A  R  K  F  F  E  K  L  P  D         p.400

          .         .         .          | 09        .         .    g.142748
 GGCACTTGGAACTTAAAGAAGACCAAAGATGGAAAACGG | GAGTACAAACCACCAGGAACC    c.1260
 G  T  W  N  L  K  K  T  K  D  G  K  R   | E  Y  K  P  P  G  T      p.420

          .         .         .         .         .         .       g.142808
 CGTAAACTTCATAACATTCTTGGAGTGGAAACAGGAGGACCTGGTGGGCGACGTGCTGGG       c.1320
 R  K  L  H  N  I  L  G  V  E  T  G  G  P  G  G  R  R  A  G         p.440

          .         .         .         .         .         .       g.142868
 GAGTCAGGTCATACGGTCGCTGACTACTTGAAGTTCAAAGACCTCATTTTAAGGATGCTT       c.1380
 E  S  G  H  T  V  A  D  Y  L  K  F  K  D  L  I  L  R  M  L         p.460

          .         .         .         .         .         .       g.142928
 GATTATGACCCCAAAACTCGAATTCAACCTTATTATGCTCTGCAGCACAGTTTCTTCAAG       c.1440
 D  Y  D  P  K  T  R  I  Q  P  Y  Y  A  L  Q  H  S  F  F  K         p.480

          .         .         .         .         .         .       g.142988
 AAAACAGCTGATGAAGGTACAAATACAAGTAATAGTGTATCTACAAGCCCCGCCATGGAG       c.1500
 K  T  A  D  E  G  T  N  T  S  N  S  V  S  T  S  P  A  M  E         p.500

          .         .         .         .       | 10 .         .    g.143557
 CAGTCTCAGTCTTCGGGCACCACCTCCAGTACATCGTCAAGCTCAG | GTGGCTCATCGGGG    c.1560
 Q  S  Q  S  S  G  T  T  S  S  T  S  S  S  S  G |   G  S  S  G      p.520

          .         .         .         .         .         .       g.143617
 ACAAGCAACAGTGGGAGAGCCCGGTCGGATCCGACGCACCAGCATCGGCACAGTGGTGGG       c.1620
 T  S  N  S  G  R  A  R  S  D  P  T  H  Q  H  R  H  S  G  G         p.540

          .         .         .         .         .  | 11      .    g.149364
 CACTTCACAGCTGCCGTGCAGGCCATGGACTGCGAGACACACAGTCCCCAG | GTGCGTCAG    c.1680
 H  F  T  A  A  V  Q  A  M  D  C  E  T  H  S  P  Q   | V  R  Q      p.560

          .         .         .         .         .         .       g.149424
 CAATTTCCTGCTCCTCTTGGTTGGTCAGGCACTGAAGCTCCTACACAGGTCACTGTTGAA       c.1740
 Q  F  P  A  P  L  G  W  S  G  T  E  A  P  T  Q  V  T  V  E         p.580

          .         .         .         .         .         .       g.149484
 ACTCATCCTGTTCAAGAAACAACCTTTCATGTAGCCCCTCAACAGAATGCATTGCATCAT       c.1800
 T  H  P  V  Q  E  T  T  F  H  V  A  P  Q  Q  N  A  L  H  H         p.600

          .         .         .         .         .         .       g.149544
 CACCATGGTAACAGTTCCCATCACCATCACCACCACCACCACCATCACCACCACCATGGA       c.1860
 H  H  G  N  S  S  H  H  H  H  H  H  H  H  H  H  H  H  H  G         p.620

          .         .         .         .         .         .       g.149604
 CAACAAGCCTTGGGTAACCGGACCAGGCCAAGGGTCTACAATTCTCCAACGAATAGCTCC       c.1920
 Q  Q  A  L  G  N  R  T  R  P  R  V  Y  N  S  P  T  N  S  S         p.640

          .         .         .         .         .         .       g.149664
 TCTACCCAAGATTCTATGGAGGTTGGCCACAGTCACCACTCCATGACATCCCTGTCTTCC       c.1980
 S  T  Q  D  S  M  E  V  G  H  S  H  H  S  M  T  S  L  S  S         p.660

          .         .         .         .         .         .       g.149724
 TCAACGACTTCTTCCTCGACATCTTCCTCCTCTACTGGTAACCAAGGCAATCAGGCCTAC       c.2040
 S  T  T  S  S  S  T  S  S  S  S  T  G  N  Q  G  N  Q  A  Y         p.680

          .         .         .         .         .         .       g.149784
 CAGAATCGCCCAGTGGCTGCTAATACCTTGGACTTTGGACAGAATGGAGCTATGGACGTT       c.2100
 Q  N  R  P  V  A  A  N  T  L  D  F  G  Q  N  G  A  M  D  V         p.700

          .         .         .         .         .         .       g.149844
 AATTTGACCGTCTACTCCAATCCCCGCCAAGAGACTGGCATAGCTGGACATCCAACATAC       c.2160
 N  L  T  V  Y  S  N  P  R  Q  E  T  G  I  A  G  H  P  T  Y         p.720

          .         .         .         .         .         .       g.149904
 CAATTTTCTGCTAATACAGGTCCTGCACATTACATGACTGAAGGACATCTGACAATGAGG       c.2220
 Q  F  S  A  N  T  G  P  A  H  Y  M  T  E  G  H  L  T  M  R         p.740

          .         .         .         .         .         .       g.149964
 CAAGGGGCTGATAGAGAAGAGTCCCCCATGACAGGAGTTTGTGTGCAACAGAGTCCTGTA       c.2280
 Q  G  A  D  R  E  E  S  P  M  T  G  V  C  V  Q  Q  S  P  V         p.760

          .                                                         g.149976
 GCTAGCTCGTGA                                                       c.2292
 A  S  S  X                                                         p.763

          .         .         .         .         .         .       g.150036
 ctacattgaaacttgagtttgtttcttgtgtgtttttatagaagtggtgttttttttcca       c.*60

          .         .         .         .         .         .       g.150096
 aaaacaaagtgcaaagctgcttgaatcaggaggagattaacacactgaaccgctacaaga       c.*120

          .         .         .         .         .         .       g.150156
 gggcaaagctgattttttttttaacttgaaaagattgcaaagggacattgaagtgtttaa       c.*180

          .         .         .         .         .         .       g.150216
 aagagccatgtccaaacccatcttcatggatagctcagaggtatcctctttttgctcccc       c.*240

          .         .         .         .         .         .       g.150276
 cattttaacttgccacatcccagtcacagtggggtttttttgtctttctattcagcaaaa       c.*300

          .         .         .         .         .         .       g.150336
 gttaatattcagatgttggtcttggtcatttgccaactaattttaaagtaaaaggcactg       c.*360

          .         .         .         .         .         .       g.150396
 cacataatttgcataaagggccccatgagggtgttttttttttttctttttgtccccccc       c.*420

          .         .         .         .         .         .       g.150456
 atccccctttttttttgttttgttctgttttgttttgggtgggagggtgggaaatttggg       c.*480

          .         .         .         .         .         .       g.150516
 tttttaagtcctctaaacacacttgggcacggaaatgcagtactgtaaggaagagggacc       c.*540

          .         .         .         .         .         .       g.150576
 tccagcttccacaaacaccatcttcagctgtatgaaagggacggttgtggtgaagtttgt       c.*600

          .         .         .         .         .         .       g.150636
 caggcacagtaagcatgctgagtggcggggatcagaactctcctatctgaacctactgag       c.*660

          .         .         .         .         .         .       g.150696
 gagcaaagcagcaattacatgggatcctgtggctctcccgttgcagaggccacaggaaga       c.*720

          .         .         .         .         .         .       g.150756
 taggatggaacgtgactggtctcctaaccaaggtgcactgagaagcaatcaacgggtcgg       c.*780

          .         .         .         .         .         .       g.150816
 tcgtggccagtcctggggaggtctgagtggtggtctttgggataacctttggccttatgg       c.*840

          .         .         .         .         .         .       g.150876
 atttggactcgaaattagaagagcctaccatttcagatgcaatcacttttggacatgctt       c.*900

          .         .         .         .         .         .       g.150936
 ttgcagacagtccttaatgctgaaaacacagagaatgggtaattcaagaggcctttcttt       c.*960

          .         .         .         .         .         .       g.150996
 taaaatagacttttgtgacccactaattgtaaggtattgcaaggtcactttgcgtgtgtc       c.*1020

          .         .         .         .         .         .       g.151056
 ataaagttgacttccttattggttgaaggtcacagaagtagtggtttgctttgatggaaa       c.*1080

          .         .         .         .         .         .       g.151116
 tagctacagctgtgtcccttcctgctttttactttttcttttgctttttctcggcacgtg       c.*1140

          .         .         .         .         .         .       g.151176
 gtatctccaccatttcttctgcacaaagatgtcttctgttcatcctgaacatttttaaaa       c.*1200

          .         .         .         .         .         .       g.151236
 aatgcagaattttatgtgactgcttttttgcctcacaattatgctgtgaattttacaaaa       c.*1260

          .         .         .         .         .         .       g.151296
 atttattttcttttttgataatttattgtaccaaagctgtttttatagcacatagatgtc       c.*1320

          .         .         .         .         .         .       g.151356
 tgtaaccaataatgtagcagttctgcactttgacacaaggtgtaactagaccatttttaa       c.*1380

          .         .         .         .         .         .       g.151416
 atgtcagttgaaaattatggctgtactattgcttaaacaaaactggaactgttgttgaat       c.*1440

          .         .         .         .         .         .       g.151476
 ccatagccaatacatttacagcaatctgtgtactgaacatagtagattgacatctaattc       c.*1500

          .         .         .         .         .         .       g.151536
 aagattacaacatctgttacattctaagtgtgttcaggcttctgaaggtaaagggacact       c.*1560

          .         .         .         .         .         .       g.151596
 ggatccagaagctatggaaccagcagttgattcttgtattcctgattaacctacttgtaa       c.*1620

          .         .         .         .         .         .       g.151656
 acttgaaagcaagaccttgattgcaccaacaggtccagagtatgagtgcaagcaaagcag       c.*1680

          .         .         .         .         .         .       g.151716
 aactctcatgcgtgacctgagcagacaggctggtatttaacaggtgcctcgtgttgagat       c.*1740

          .         .         .         .         .         .       g.151776
 tacgctgccttaatgtaacacagtctggcagttgctaaatttgtgttcccattttaaatt       c.*1800

          .         .         .         .         .         .       g.151836
 gaccaattttggggtgtgacacttttgagcggttgaattgggagaatgaagataagtaat       c.*1860

          .         .         .         .         .         .       g.151896
 ttacctgtccaggatcaaaagaagcctagaaaagaagcagtaatctacctctgccgataa       c.*1920

          .         .         .         .         .         .       g.151956
 cctgtttaagatgactcagcagaacaccgcgtttcattctattggtcaattccatgtggc       c.*1980

          .         .         .         .         .         .       g.152016
 tgactaggtcaattttttttctgaacaaaagcaggtttttatatgtaaacagtgagaaaa       c.*2040

          .         .         .         .         .         .       g.152076
 gaaaggctaaacactatgtaaatgtgaatggaaacttggaaatactcgtttttataaact       c.*2100

          .         .         .         .         .         .       g.152136
 acaaaaactttttgttgtttatcaggaaatccatatttattttgtaattaactgtcaagc       c.*2160

          .         .         .         .         .         .       g.152196
 ctgtggatgatttttttgaacttggtagttcataaaggtttacagtgaataaaaggatat       c.*2220

          .         .         .         .         .         .       g.152256
 catcttgagtatagcaatatcaaaaggaattcagtagttactgctgtttaggaatataag       c.*2280

          .         .         .         .         .         .       g.152316
 gttaagatatcatatgggtcaggtcattttttttttctgtgctggttgccacatcttagc       c.*2340

          .         .         .         .         .         .       g.152376
 aagcaccaaaaaactaaagcagtttttaaaccgatatttacgtaaagaaaatcataaaat       c.*2400

          .         .         .         .         .         .       g.152436
 ccaatgcttctgcatactgtgttatgttacagtccagttttgtgtgctttactacacagt       c.*2460

          .         .         .         .         .         .       g.152496
 ttggttacaggacttctgtgcattgtaaacataaacagcatggaaaaggttaaatacctg       c.*2520

          .         .         .         .         .         .       g.152556
 tgttcagattgtaagatctagtccggacttgctgtgtatattgtaacgttaaatgaaaaa       c.*2580

          .         .         .         .         .         .       g.152616
 agaacccccctttgtattatagtcatgcggtcttatgtatgataaacagttgaataattt       c.*2640

          .         .         .         .         .         .       g.152676
 gtcctcagactctttactatgcttttttaaaaattaatttaagaaaaatgtaaacatagt       c.*2700

          .         .         .         .         .         .       g.152736
 aaaaatcttcctatgcaattaaactggtccaggtctggtaggtatagtatcaaagttgag       c.*2760

          .         .         .         .         .         .       g.152796
 ttaaatgtgtaaaaaggaaactatttgagatacattgacataggcatcagcaatctctga       c.*2820

          .         .                                               g.152821
 aagtaaaaattggaggtttaacaga                                          c.*2845

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 14c
©2004-2016 Leiden University Medical Center