E4F transcription factor 1 (E4F1) - coding DNA reference sequence

(used for variant description)

(last modified September 23, 2024)


This file was created to facilitate the description of sequence variants on transcript NM_004424.3 in the E4F1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000016.9, covering E4F1 transcript NM_004424.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5048
             atgacgacatggtcgtaaatccgccatcttcctgcggcgcgttgcgac       c.-1

          .         .         .         .         .         .       g.5108
 ATGGAGGGCGCGATGGCAGTGCGGGTGACGGCCGCTCATACGGCAGAAGCCCAGGCCGAA       c.60
 M  E  G  A  M  A  V  R  V  T  A  A  H  T  A  E  A  Q  A  E         p.20

          .         .         .         .         .         .       g.5168
 GCCGGGCGGGAAGCGGGCGAGGGTGCAGTTGCGGCGGTGGCGGCGGCCTTGGCCCCCAGC       c.120
 A  G  R  E  A  G  E  G  A  V  A  A  V  A  A  A  L  A  P  S         p.40

          .         .         .        | 02.         .         .    g.9829
 GGCTTCCTCGGCCTCCCGGCGCCCTTCAGCGAGGAAG | ATGAGGACGATGTGCACAGATGC    c.180
 G  F  L  G  L  P  A  P  F  S  E  E  D |   E  D  D  V  H  R  C      p.60

          .         .         .         .         .         .       g.9889
 GGCCGCTGCCAGGCAGAGTTCACCGCCTTGGAGGATTTTGTTCAGCACAAGATTCAGAAG       c.240
 G  R  C  Q  A  E  F  T  A  L  E  D  F  V  Q  H  K  I  Q  K         p.80

          .         .         .         .         .         .       g.9949
 GCCTGCCAGCGGGCCCCTCCGGAGGCCCTGCCTGCCACCCCTGCCACCACAGCGTTGCTG       c.300
 A  C  Q  R  A  P  P  E  A  L  P  A  T  P  A  T  T  A  L  L         p.100

           | 03        .         .         .         .         .    g.11055
 GGCCAGGAG | GTGGTGCCGGCAGCACCAGGCCCAGAGGAGCCCATCACTGTGGCCCACATC    c.360
 G  Q  E   | V  V  P  A  A  P  G  P  E  E  P  I  T  V  A  H  I      p.120

          .         .         .         .         .      | 04  .    g.13610
 GTGGTGGAGGCGGCCTCTCTGGCAGCAGACATCAGCCACGCATCTGACCTTGTTG | GTGGT    c.420
 V  V  E  A  A  S  L  A  A  D  I  S  H  A  S  D  L  V  G |   G      p.140

          .         .         .         .         .         .       g.13670
 GGGCACATCAAAGAGGTCATCGTGGCTGCTGAGGCGGAGCTGGGAGACGGTGAGATGGCC       c.480
 G  H  I  K  E  V  I  V  A  A  E  A  E  L  G  D  G  E  M  A         p.160

          .         .         .         .         .         .       g.13730
 GAGGCCCCGGGCAGCCCCCGCCAGCAGGGGCTGGGGCTCGCAGGGGAGGGTGAGCAGGCC       c.540
 E  A  P  G  S  P  R  Q  Q  G  L  G  L  A  G  E  G  E  Q  A         p.180

          .         .         .         .         .         .       g.13790
 CAGGTGAAGCTACTGGTGAACAAGGATGGCCGCTATGTGTGTGCGCTGTGCCACAAGACC       c.600
 Q  V  K  L  L  V  N  K  D  G  R  Y  V  C  A  L  C  H  K  T         p.200

           | 05        .         .         .         .         .    g.13941
 TTCAAGACG | GGCAGCATCCTCAAGGCCCACATGGTCACTCACAGCAGCCGCAAGGACCAC    c.660
 F  K  T   | G  S  I  L  K  A  H  M  V  T  H  S  S  R  K  D  H      p.220

          .         .         .         .         .         .       g.14001
 GAGTGCAAGCTCTGTGGGGCCTCCTTCCGCACCAAGGGCTCACTCATCCGGCACCACCGG       c.720
 E  C  K  L  C  G  A  S  F  R  T  K  G  S  L  I  R  H  H  R         p.240

          . | 06       .         .         .         .         .    g.14240
 CGGCACACGG | ATGAGCGCCCCTACAAGTGCTCCAAGTGTGGAAAGAGCTTCCGGGAGTCG    c.780
 R  H  T  D |   E  R  P  Y  K  C  S  K  C  G  K  S  F  R  E  S      p.260

          .         .         .         .         .         .       g.14300
 GGTGCACTGACCCGGCACCTCAAGTCTCTCACCCCCTGCACAGAGAAAATCCGCTTCAGT       c.840
 G  A  L  T  R  H  L  K  S  L  T  P  C  T  E  K  I  R  F  S         p.280

          .         .         .         .    | 07    .         .    g.14462
 GTGAGCAAGGACGTGGTTGTCAGCAAAGAGGACGCACGTGCAG | GTTCTGGAGCTGGAGCT    c.900
 V  S  K  D  V  V  V  S  K  E  D  A  R  A  G |   S  G  A  G  A      p.300

          .         .         .         .         .         .       g.14522
 GCCGGCTTGGGGACAGCCACATCATCGGTGACAGGCGAGCCTATAGAGACTTCACCCGTG       c.960
 A  G  L  G  T  A  T  S  S  V  T  G  E  P  I  E  T  S  P  V         p.320

          .         .         .         .         .         .       g.14582
 ATTCACCTGGTGACAGATGCCAAGGGCACCGTCATCCACGAAGTCCACGTCCAGATGCAG       c.1020
 I  H  L  V  T  D  A  K  G  T  V  I  H  E  V  H  V  Q  M  Q         p.340

          .         .         .       | 08 .         .         .    g.14896
 GAGCTGTCCCTGGGCATGAAAGCCCTGGCCCCAGAG | CCCCCCGTCTCCCAGGAGCTCCCC    c.1080
 E  L  S  L  G  M  K  A  L  A  P  E   | P  P  V  S  Q  E  L  P      p.360

          .         .         .         .         .         .       g.14956
 TGCTCCAGCGAGGGCAGCCGTGAGAACCTGCTGCACCAGGCCATGCAGAACTCCGGCATC       c.1140
 C  S  S  E  G  S  R  E  N  L  L  H  Q  A  M  Q  N  S  G  I         p.380

          .         .         .         .         .         .       g.15016
 GTCCTTGAGCGCGCTGCTGGGGAGGAGGGTGCCCTGGAGCCAGCTCCTGCTGCCGGGTCC       c.1200
 V  L  E  R  A  A  G  E  E  G  A  L  E  P  A  P  A  A  G  S         p.400

          .         .         .         .         .         .       g.15076
 AGTCCCCAGCCCCTGGCAGTGGCAGCCCCGCAGCTGCCGGTACTGGAAGTGCAGCCGCTG       c.1260
 S  P  Q  P  L  A  V  A  A  P  Q  L  P  V  L  E  V  Q  P  L         p.420

        | 09 .         .         .         .         .         .    g.15370
 GAGACA | CAGGTGGCCAGCGAGGCCTCAGCGGTGCCCAGGACCCACCCATGTCCTCAGTGC    c.1320
 E  T   | Q  V  A  S  E  A  S  A  V  P  R  T  H  P  C  P  Q  C      p.440

          .         .         .         .         .      | 10  .    g.15610
 AGTGAGACCTTCCCGACAGCAGCCACCCTGGAGGCCCACAAGAGGGGCCACACCG | GGCCG    c.1380
 S  E  T  F  P  T  A  A  T  L  E  A  H  K  R  G  H  T  G |   P      p.460

          .         .         .         .         .         .       g.15670
 AGGCCGTTCGCCTGCGCGCAGTGTGGCAAGGCCTTCCCCAAGGCCTACCTGCTCAAGAAG       c.1440
 R  P  F  A  C  A  Q  C  G  K  A  F  P  K  A  Y  L  L  K  K         p.480

          .         .         .         .         .         .       g.15730
 CACCAGGAGGTGCACGTGCGTGAGCGCCGCTTCCGCTGTGGCGACTGCGGGAAGCTCTAC       c.1500
 H  Q  E  V  H  V  R  E  R  R  F  R  C  G  D  C  G  K  L  Y         p.500

          .         .         .         .         .         .       g.15790
 AAGACCATTGCCCATGTGCGTGGCCACCGGCGCGTCCACTCAGACGAGCGGCCCTACCCT       c.1560
 K  T  I  A  H  V  R  G  H  R  R  V  H  S  D  E  R  P  Y  P         p.520

          .         .         .    | 11    .         .         .    g.16044
 TGTCCCAAGTGTGGCAAGCGCTACAAGACTAAG | AACGCACAGCAGGTGCACTTCAGGACA    c.1620
 C  P  K  C  G  K  R  Y  K  T  K   | N  A  Q  Q  V  H  F  R  T      p.540

          .         .         .         .         .         .       g.16104
 CACCTGGAGGAGAAGCCGCACGTGTGCCAGTTCTGCAGCCGTGGCTTCCGAGAGAAGGGC       c.1680
 H  L  E  E  K  P  H  V  C  Q  F  C  S  R  G  F  R  E  K  G         p.560

          .         .         .         .         .         .       g.16164
 TCACTGGTGCGGCACGTGCGACACCACACAGGCGAGAAGCCGTTCAAGTGCTACAAGTGC       c.1740
 S  L  V  R  H  V  R  H  H  T  G  E  K  P  F  K  C  Y  K  C         p.580

          .         .         .         .         .   | 12     .    g.16301
 GGCCGTGGCTTCGCCGAGCACGGCACGCTGAACCGGCACCTGCGCACCAAAG | GGGGCTGC    c.1800
 G  R  G  F  A  E  H  G  T  L  N  R  H  L  R  T  K  G |   G  C      p.600

          .         .         .         .         .         .       g.16361
 CTGCTGGAGGTGGAGGAGTTGCTGGTGTCTGAGGACAGCCCCGCGGCAGCCACCACCGTC       c.1860
 L  L  E  V  E  E  L  L  V  S  E  D  S  P  A  A  A  T  T  V         p.620

          .         .         .         .         .         .       g.16421
 CTCACGGAAGACCCGCACACAGTGTTGGTGGAGTTCTCGTCCGTGGTAGCTGACACCCAG       c.1920
 L  T  E  D  P  H  T  V  L  V  E  F  S  S  V  V  A  D  T  Q         p.640

          .      | 13  .         .         .         .         .    g.16560
 GAGTATATCATCGAG | GCCACTGCGGACGATGCGGAGACCAGTGAGGCCACGGAGATCATC    c.1980
 E  Y  I  I  E   | A  T  A  D  D  A  E  T  S  E  A  T  E  I  I      p.660

          .         | 14         .         .         .         .    g.16692
 GAGGGCACCCAGACAGAG | GTGGACAGCCACATCATGAAGGTGGTGCAGCAGATCGTGCAC    c.2040
 E  G  T  Q  T  E   | V  D  S  H  I  M  K  V  V  Q  Q  I  V  H      p.680

          .         .         .         .         .         .       g.16752
 CAGGCTAGCGCCGGCCACCAGATCATCGTGCAGAACGTCACCATGGACGAGGAGACGGCG       c.2100
 Q  A  S  A  G  H  Q  I  I  V  Q  N  V  T  M  D  E  E  T  A         p.700

          .         .         .         .         .         .       g.16812
 CTGGGCCCAGAGGCGGCTGCCGCCGACACCATCACCATCGCCACCCCCGAGAGCCTGACA       c.2160
 L  G  P  E  A  A  A  A  D  T  I  T  I  A  T  P  E  S  L  T         p.720

          .         .         .         .         .         .       g.16872
 GAGCAGGTGGCCATGACGCTGGCCTCGGCCATCAGCGAGGGCACTGTGCTTGCCGCCCGG       c.2220
 E  Q  V  A  M  T  L  A  S  A  I  S  E  G  T  V  L  A  A  R         p.740

          .         .         .         .         .         .       g.16932
 GCAGGGACAAGTGGCACTGAACAGGCCACTGTGACCATGGTGTCATCAGAGGACATCGAG       c.2280
 A  G  T  S  G  T  E  Q  A  T  V  T  M  V  S  S  E  D  I  E         p.760

          .         .         .         .         .         .       g.16992
 ATCCTGGAGCATGCAGGCGAGCTGGTCATCGCCTCGCCGGAGGGCCAGCTGGAGGTGCAG       c.2340
 I  L  E  H  A  G  E  L  V  I  A  S  P  E  G  Q  L  E  V  Q         p.780

          .                                                         g.17007
 ACGGTCATCGTCTAG                                                    c.2355
 T  V  I  V  X                                                      p.784

          .         .         .         .         .         .       g.17067
 catgaggtctgcggggtcctggccgggcagggacagggcagaggactctgagcgccccac       c.*60

          .         .         .         .         .         .       g.17127
 ccatgcctgcctggcctggtagagaagatggcacaggatggaggcgccccaagacggaca       c.*120

          .         .         .         .         .                 g.17177
 gtgtacataagagtttcttgttgctttacaataaaacatgagaacctgca                 c.*170

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The E4F transcription factor 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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