early B-cell factor 3 (EBF3) - coding DNA reference sequence

(used for variant description)

(last modified April 15, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_001005463.2 in the EBF3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000010.10, covering EBF3 transcript NM_001005463.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5059
  gcgccgctgctcgaggaaacgctttcggccgggagctgcggccgccgccagcagttttc       c.-1

          .         .         .         .         .         .       g.5119
 ATGTTTGGGATTCAGGAGAATATTCCGCGCGGGGGGACGACCATGAAGGAGGAGCCGCTG       c.60
 M  F  G  I  Q  E  N  I  P  R  G  G  T  T  M  K  E  E  P  L         p.20

          .         .         .         .         .         .       g.5179
 GGCAGCGGCATGAACCCGGTGCGCTCGTGGATGCACACGGCGGGCGTGGTGGACGCCAAC       c.120
 G  S  G  M  N  P  V  R  S  W  M  H  T  A  G  V  V  D  A  N         p.40

          .     | 02   .         .         .         .         .    g.5350
 ACGGCCGCCCAGAG | CGGCGTGGGGCTGGCGCGGGCGCACTTCGAGAAGCAGCCGCCTTCC    c.180
 T  A  A  Q  S  |  G  V  G  L  A  R  A  H  F  E  K  Q  P  P  S      p.60

          .         .         .         .         .         .       g.5410
 AACCTCCGGAAATCCAATTTCTTCCACTTCGTGCTGGCGCTCTACGATAGGCAGGGGCAG       c.240
 N  L  R  K  S  N  F  F  H  F  V  L  A  L  Y  D  R  Q  G  Q         p.80

          .         .         .         .         .  | 03      .    g.5831
 CCGGTGGAGATTGAAAGGACCGCTTTTGTGGACTTTGTGGAGAAAGAGAAA | GAGCCAAAC    c.300
 P  V  E  I  E  R  T  A  F  V  D  F  V  E  K  E  K   | E  P  N      p.100

          .         .         .         .         .      | 04  .    g.6606
 AACGAGAAAACCAACAACGGCATCCACTATAAACTCCAGTTATTGTACAGCAACG | GAGTC    c.360
 N  E  K  T  N  N  G  I  H  Y  K  L  Q  L  L  Y  S  N  G |   V      p.120

          .         .         .         .         .  | 05      .    g.9829
 AGAACAGAGCAAGATCTGTATGTTCGCCTCATAGATTCAATGACCAAACAG | GCCATCGTC    c.420
 R  T  E  Q  D  L  Y  V  R  L  I  D  S  M  T  K  Q   | A  I  V      p.140

          .         .         .         .         .         .       g.9889
 TACGAGGGCCAGGACAAGAACCCGGAGATGTGCCGTGTGCTGCTGACCCACGAGATCATG       c.480
 Y  E  G  Q  D  K  N  P  E  M  C  R  V  L  L  T  H  E  I  M         p.160

       | 06  .         .         .         .         .         .    g.11556
 TGCAG | CCGGTGCTGTGACAAGAAAAGTTGTGGCAATAGAAACGAAACGCCCTCAGACCCT    c.540
 C  S  |  R  C  C  D  K  K  S  C  G  N  R  N  E  T  P  S  D  P      p.180

          .     | 07   .         .         .         .         .    g.91024
 GTAATCATTGACAG | ATTCTTTCTAAAGTTTTTCCTCAAGTGCAATCAGAACTGTTTGAAG    c.600
 V  I  I  D  R  |  F  F  L  K  F  F  L  K  C  N  Q  N  C  L  K      p.200

          .         .         .       | 08 .         .         .    g.95255
 AATGCAGGCAACCCTCGAGATATGCGGAGATTCCAG | GTTGTTGTATCGACAACAGTCAAC    c.660
 N  A  G  N  P  R  D  M  R  R  F  Q   | V  V  V  S  T  T  V  N      p.220

          .         .         .         .         .         .       g.95315
 GTGGACGGCCACGTGCTGGCCGTGTCAGACAACATGTTTGTGCACAACAATTCCAAACAC       c.720
 V  D  G  H  V  L  A  V  S  D  N  M  F  V  H  N  N  S  K  H         p.240

          .         .         .     | 09   .         .         .    g.100941
 GGGAGGCGGGCCCGCCGCCTAGACCCGTCAGAAG | CCACTCCGTGCATCAAGGCCATCAGT    c.780
 G  R  R  A  R  R  L  D  P  S  E  A |   T  P  C  I  K  A  I  S      p.260

          .         .         .         .         .         .       g.101001
 CCCAGTGAAGGCTGGACCACGGGGGGTGCCACCGTCATCATAATTGGCGACAACTTCTTT       c.840
 P  S  E  G  W  T  T  G  G  A  T  V  I  I  I  G  D  N  F  F         p.280

          .         .         .         .      | 10  .         .    g.101575
 GACGGGCTGCAAGTTGTATTCGGAACTATGTTGGTGTGGAGCGAG | CTGATAACTCCCCAT    c.900
 D  G  L  Q  V  V  F  G  T  M  L  V  W  S  E   | L  I  T  P  H      p.300

          .         .         .         .         .         .       g.101635
 GCCATCCGAGTCCAGACCCCGCCGAGGCACATTCCTGGCGTCGTCGAAGTGACCCTCTCC       c.960
 A  I  R  V  Q  T  P  P  R  H  I  P  G  V  V  E  V  T  L  S         p.320

          .         .         .         .         .   | 11     .    g.120355
 TACAAATCCAAGCAGTTCTGCAAAGGTGCTCCTGGGCGCTTTGTCTACACCG | CCCTTAAT    c.1020
 Y  K  S  K  Q  F  C  K  G  A  P  G  R  F  V  Y  T  A |   L  N      p.340

          .         .         .         .         .         .       g.120415
 GAACCAACCATAGATTACGGCTTTCAGAGGTTGCAGAAAGTGATCCCAAGACATCCGGGT       c.1080
 E  P  T  I  D  Y  G  F  Q  R  L  Q  K  V  I  P  R  H  P  G         p.360

          .         .  | 12      .         .         .         .    g.125664
 GATCCCGAAAGGTTACCCAAG | GAGGTGTTACTGAAGCGGGCGGCGGACCTGGTGGAAGCC    c.1140
 D  P  E  R  L  P  K   | E  V  L  L  K  R  A  A  D  L  V  E  A      p.380

          .         .        | 13.         .         .         .    g.126567
 TTATACGGAATGCCTCACAACAACCAG | GAGATCATCTTGAAGCGAGCGGCGGACATCGCC    c.1200
 L  Y  G  M  P  H  N  N  Q   | E  I  I  L  K  R  A  A  D  I  A      p.400

          .         .         .         .         .         .       g.126627
 GAGGCGCTGTACAGCGTTCCCCGCAATCACAACCAGATCCCCACCCTGGGCAACAACCCT       c.1260
 E  A  L  Y  S  V  P  R  N  H  N  Q  I  P  T  L  G  N  N  P         p.420

          .         .         .         .         .         .       g.126687
 GCACACACGGGCATGATGGGCGTCAACTCCTTCAGCAGCCAGCTAGCCGTCAACGTGTCA       c.1320
 A  H  T  G  M  M  G  V  N  S  F  S  S  Q  L  A  V  N  V  S         p.440

          .         .      | 14  .         .         .         .    g.127830
 GAGACGTCACAAGCCAACGACCAAG | TCGGCTACAGTCGCAATACAAGCAGCGTGTCCCCG    c.1380
 E  T  S  Q  A  N  D  Q  V |   G  Y  S  R  N  T  S  S  V  S  P      p.460

          .         .         .         .         .         .       g.127890
 CGAGGCTACGTCCCCAGCAGTACTCCCCAGCAGTCCAATTACAACACAGTCAGCACTAGC       c.1440
 R  G  Y  V  P  S  S  T  P  Q  Q  S  N  Y  N  T  V  S  T  S         p.480

          .         .         .         .         .         .       g.127950
 ATGAATGGATATGGAAGTGGCGCCATGGCCAGTCTAGGGGTCCCTGGCTCGCCTGGATTT       c.1500
 M  N  G  Y  G  S  G  A  M  A  S  L  G  V  P  G  S  P  G  F         p.500

          .         .         .     | 15   .         .         .    g.128519
 CTTAATGGCTCCTCCGCTAACTCTCCCTACGGCA | TGAAACAGAAGAGCGCCTTCGCGCCC    c.1560
 L  N  G  S  S  A  N  S  P  Y  G  M |   K  Q  K  S  A  F  A  P      p.520

          .         .         .         .         .         .       g.128579
 GTGGTCCGGCCCCAAGCCTCTCCTCCTCCTTCCTGCACCAGCGCCAACGGGAATGGACTG       c.1620
 V  V  R  P  Q  A  S  P  P  P  S  C  T  S  A  N  G  N  G  L         p.540

      | 16   .         .         .                                  g.130923
 CAAG | CTATGTCTGGGCTGGTAGTCCCGCCAATGTGA                            c.1656
 Q  A |   M  S  G  L  V  V  P  P  M  X                              p.551

          .         .         .         .         .         .       g.130983
 gggacttctgtttaccttccgcagcacccagcatcaaaggacggacttcaggggacacgt       c.*60

          .         .         .         .         .         .       g.131043
 ttagtatattaagacatgctgatggaaacagtatcttcaaaaaaatcagcagcaattgaa       c.*120

          .         .         .         .         .         .       g.131103
 atgctacaaaagactttgtttaaagattttatttaaactattaagaatcaacatgcaaac       c.*180

          .         .         .         .         .         .       g.131163
 agcctacttcttcatgaacaattccattttattgactgaacttttctcatattttcacat       c.*240

          .         .         .         .         .         .       g.131223
 ttctcagtcctgaagaataaggaaaacaaagcgacgcctattttgtataaagtttccgac       c.*300

          .         .         .         .         .         .       g.131283
 tccgtcttggccatgtctagtaattgctatgtgttgggagaaactttgtgaatgcaccat       c.*360

          .         .         .         .         .         .       g.131343
 tttgatgatcatgaaacgctgatgaaaaatgcctccaaacatttttctgtactcatactt       c.*420

          .         .         .         .         .         .       g.131403
 agattcacaatggttgtgtatctctataatgtgaaatatttttttgtggtgataaaaaga       c.*480

          .         .         .         .         .         .       g.131463
 gggccaaggaggtatgagccatcagactggaaaaaaggatgactatatgatgaggagaaa       c.*540

          .         .         .         .         .         .       g.131523
 ctggggtggcagggagggagggagggtttatcactgcttaacttcatcttcatgaaatga       c.*600

          .         .         .         .         .         .       g.131583
 aactttgtaacttattgtagttagaaattgtaactttgatattgaattctcttgccttca       c.*660

          .         .         .         .         .         .       g.131643
 acaagcacactgacagagaaaaaatgctactgtctgttggttccaatattctcccactgc       c.*720

          .         .         .         .         .         .       g.131703
 tagagcttcctgttaagcaagtgtgatctgcaacattttttcaacttttgctagcactgt       c.*780

          .         .         .         .         .         .       g.131763
 atactattgcattcttaggctactgtgaggtctatgtttcttgtaccagaaattgtcctt       c.*840

          .         .         .         .         .         .       g.131823
 ttgacttctagatccttcttccctaatgtgttttgtatgtggttataaaattgtagactt       c.*900

          .         .         .         .         .         .       g.131883
 ttgtgattttgccaaagttgtagctaaatatttatacacttgtcttgaatttttttcaga       c.*960

          .         .         .         .         .         .       g.131943
 tccacttaaaatatttagaaaaacaagttttattccttatgtgtcttataaggaataaaa       c.*1020

          .         .         .         .         .         .       g.132003
 tggtcttcatttgacacttactttcccatgaacacttgcagttgctaagggactttattt       c.*1080

          .         .         .         .         .         .       g.132063
 tgtaacatatcaattataaatattgtatttatctttgaaattttgtacattgcttttccc       c.*1140

          .         .         .         .         .         .       g.132123
 accttttcctttttcttctttcttgtctgtattggtttttgatcacggcctggtgttgtg       c.*1200

          .         .         .         .         .         .       g.132183
 atactgggaagagcattagccaagaacttgtctctttgatctgtttcgttaagctgaacc       c.*1260

          .         .         .         .         .         .       g.132243
 agtgtctttacatttcatttgtacttcaaaaaatatgctattgtttagactttccatcct       c.*1320

          .         .         .         .         .         .       g.132303
 ttttttttttattttgaggaaaagtcaaattcattgtttatttttatattatttttaagt       c.*1380

          .         .         .         .         .         .       g.132363
 tatctgaacaaatacttttgaaaaaaaagtttgttgtatagtcaaaacaaatcggtgcca       c.*1440

          .         .         .         .         .         .       g.132423
 cccggccgtgacaaatcctagtagattctgtgcatgtggagcggccgcgaagaggtgaca       c.*1500

          .         .         .         .         .         .       g.132483
 ccgtttggggctgtgtccttattttattttatttttttgtagaatgtaaaaagtcatttt       c.*1560

          .         .         .         .         .         .       g.132543
 agatgccacccattgactttgccacatagctgaactgtgtttactggaaaaattcagagg       c.*1620

          .         .         .         .         .         .       g.132603
 cctaaagtttaaaataaaatttacttctgatgttttaattaaaatgtttgccacattaac       c.*1680

          .         .         .         .         .         .       g.132663
 ttttctgatgccttaaaagtgaacttctttaaagaacctttgtgctattttatcacaggc       c.*1740

          .         .         .         .         .         .       g.132723
 ttacactacaattgttaataaatacttcatttggagatgtatggtgtaaaacacacaaac       c.*1800

          .         .         .         .         .         .       g.132783
 acacacaaaaaagcacaagcccgctgcatgacccgtctctcctttctgggactatttctg       c.*1860

          .         .         .         .         .         .       g.132843
 ctgcgtcctgcaccctcctgggcccacctccgattcacagaggtttcagggggacccaaa       c.*1920

          .         .         .         .         .         .       g.132903
 tcactgctggttttcaatttttttttaacaatacatttttgtggtcagttccaacagcac       c.*1980

          .         .         .         .         .         .       g.132963
 tgtccgtacttttaaaactggaatgacctccttcagatatcgtgcctcttagtgccaaac       c.*2040

          .         .         .         .         .         .       g.133023
 ccacagtgagaccaaaagtgtcaggtgtttttttttttttctttctcctttgcactaagt       c.*2100

          .         .         .         .         .         .       g.133083
 gctttgcagacacggcacagcaaacattttgcaaactgcagcagaaatcgaatttaaaac       c.*2160

          .         .         .         .         .         .       g.133143
 aaaaaggagggactttaaaataccttcttgacaaaaatcaacaatgcacaacttacaaag       c.*2220

          .         .         .         .         .         .       g.133203
 tgttcattctagggacaaaattaaataaacagaatgtccccaggagtcagcaggtcacag       c.*2280

          .         .         .         .         .         .       g.133263
 tctggctttgtgatggttgacaaggtctagctacatgggaaagcctgagaagtcactttg       c.*2340

          .         .         .         .         .         .       g.133323
 gaactaaattgcctccattttattttgtacgagtaagggtttgatctacaaaagagctca       c.*2400

          .         .         .         .         .         .       g.133383
 catggacgcactgagaacgcctgccagcttccccatgccctcacttggtttgtgttttag       c.*2460

          .         .         .         .         .         .       g.133443
 gttaagtagtcaatgcccacatcacttcactgtctcaagactgagcacttcactaaatgg       c.*2520

          .         .         .         .         .         .       g.133503
 tagattttactgttaaagaccctacaataagattgttttatctgtacattttttcagata       c.*2580

          .         .         .         .         .         .       g.133563
 tttaactgtataaaaatgttcattttacacaatatttaattaaagtatttcttgtctgtg       c.*2640

          .         .         .         .         .                 g.133620
 aatttcacttttggtaattttctctgtttttgattattaaaatgactaaacactaac          c.*2697

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Early B-cell factor 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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