endothelin receptor type B (EDNRB) - coding DNA reference sequence

(used for variant description)

(last modified November 28, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_000115.3 in the EDNRB gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011630.2, covering EDNRB transcript NM_000115.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5054
       acattccggtgggggactctggccagcccgagcaacgtggatcctgagagcact       c.-181

 .         .         .         .         .         .                g.5114
 cccaggtaggcatttgccccggtgggacgccttgccagagcagtgtgtggcaggcccccg       c.-121

 .         .         .         .         .         .                g.5174
 tggaggatcaacacagtggctgaacactgggaaggaactggtacttggagtctggacatc       c.-61

 .         | 02         .         .         .         .             g.61956
 tgaaacttg | gctctgaaactgcggagcggccaccggacgccttctggagcaggtagcagc    c.-1

          .         .         .         .         .         .       g.62016
 ATGCAGCCGCCTCCAAGTCTGTGCGGACGCGCCCTGGTTGCGCTGGTTCTTGCCTGCGGC       c.60
 M  Q  P  P  P  S  L  C  G  R  A  L  V  A  L  V  L  A  C  G         p.20

          .         .         .         .         .         .       g.62076
 CTGTCGCGGATCTGGGGAGAGGAGAGAGGCTTCCCGCCTGACAGGGCCACTCCGCTTTTG       c.120
 L  S  R  I  W  G  E  E  R  G  F  P  P  D  R  A  T  P  L  L         p.40

          .         .         .         .         .         .       g.62136
 CAAACCGCAGAGATAATGACGCCACCCACTAAGACCTTATGGCCCAAGGGTTCCAACGCC       c.180
 Q  T  A  E  I  M  T  P  P  T  K  T  L  W  P  K  G  S  N  A         p.60

          .         .         .         .         .         .       g.62196
 AGTCTGGCGCGGTCGTTGGCACCTGCGGAGGTGCCTAAAGGAGACAGGACGGCAGGATCT       c.240
 S  L  A  R  S  L  A  P  A  E  V  P  K  G  D  R  T  A  G  S         p.80

          .         .         .         .         .         .       g.62256
 CCGCCACGCACCATCTCCCCTCCCCCGTGCCAAGGACCCATCGAGATCAAGGAGACTTTC       c.300
 P  P  R  T  I  S  P  P  P  C  Q  G  P  I  E  I  K  E  T  F         p.100

          .         .         .         .         .         .       g.62316
 AAATACATCAACACGGTTGTGTCCTGCCTTGTGTTCGTGCTGGGGATCATCGGGAACTCC       c.360
 K  Y  I  N  T  V  V  S  C  L  V  F  V  L  G  I  I  G  N  S         p.120

          .         .         .         .         .         .       g.62376
 ACACTTCTGAGAATTATCTACAAGAACAAGTGCATGCGAAACGGTCCCAATATCTTGATC       c.420
 T  L  L  R  I  I  Y  K  N  K  C  M  R  N  G  P  N  I  L  I         p.140

          .         .         .         .         .         .       g.62436
 GCCAGCTTGGCTCTGGGAGACCTGCTGCACATCGTCATTGACATCCCTATCAATGTCTAC       c.480
 A  S  L  A  L  G  D  L  L  H  I  V  I  D  I  P  I  N  V  Y         p.160

     | 03    .         .         .         .         .         .    g.76979
 AAG | CTGCTGGCAGAGGACTGGCCATTTGGAGCTGAGATGTGTAAGCTGGTGCCTTTCATA    c.540
 K   | L  L  A  E  D  W  P  F  G  A  E  M  C  K  L  V  P  F  I      p.180

          .         .         .         .         .       | 04 .    g.77173
 CAGAAAGCCTCTGTGGGAATCACTGTGCTGAGTCTATGTGCTCTGAGTATTGACAG | ATAT    c.600
 Q  K  A  S  V  G  I  T  V  L  S  L  C  A  L  S  I  D  R  |  Y      p.200

          .         .         .         .         .         .       g.77233
 CGAGCTGTTGCTTCTTGGAGTAGAATTAAAGGAATTGGGGTTCCAAAATGGACAGCAGTA       c.660
 R  A  V  A  S  W  S  R  I  K  G  I  G  V  P  K  W  T  A  V         p.220

          .         .         .         .         .         .       g.77293
 GAAATTGTTTTGATTTGGGTGGTCTCTGTGGTTCTGGCTGTCCCTGAAGCCATAGGTTTT       c.720
 E  I  V  L  I  W  V  V  S  V  V  L  A  V  P  E  A  I  G  F         p.240

          .         .         .         .         .         .       g.77353
 GATATAATTACGATGGACTACAAAGGAAGTTATCTGCGAATCTGCTTGCTTCATCCCGTT       c.780
 D  I  I  T  M  D  Y  K  G  S  Y  L  R  I  C  L  L  H  P  V         p.260

          .         .  | 05      .         .         .         .    g.79361
 CAGAAGACAGCTTTCATGCAG | TTTTACAAGACAGCAAAAGATTGGTGGCTATTCAGTTTC    c.840
 Q  K  T  A  F  M  Q   | F  Y  K  T  A  K  D  W  W  L  F  S  F      p.280

          .         .         .         .         .         .       g.79421
 TATTTCTGCTTGCCATTGGCCATCACTGCATTTTTTTATACACTAATGACCTGTGAAATG       c.900
 Y  F  C  L  P  L  A  I  T  A  F  F  Y  T  L  M  T  C  E  M         p.300

          .         .         .         .         .  | 06      .    g.79884
 TTGAGAAAGAAAAGTGGCATGCAGATTGCTTTAAATGATCACCTAAAGCAG | AGACGGGAA    c.960
 L  R  K  K  S  G  M  Q  I  A  L  N  D  H  L  K  Q   | R  R  E      p.320

          .         .         .         .         .         .       g.79944
 GTGGCCAAAACCGTCTTTTGCCTGGTCCTTGTCTTTGCCCTCTGCTGGCTTCCCCTTCAC       c.1020
 V  A  K  T  V  F  C  L  V  L  V  F  A  L  C  W  L  P  L  H         p.340

          .         .         .         .         .         .       g.80004
 CTCAGCAGGATTCTGAAGCTCACTCTTTATAATCAGAATGATCCCAATAGATGTGAACTT       c.1080
 L  S  R  I  L  K  L  T  L  Y  N  Q  N  D  P  N  R  C  E  L         p.360

       | 07  .         .         .         .         .         .    g.80617
 TTGAG | CTTTCTGTTGGTATTGGACTATATTGGTATCAACATGGCTTCACTGAATTCCTGC    c.1140
 L  S  |  F  L  L  V  L  D  Y  I  G  I  N  M  A  S  L  N  S  C      p.380

          .         .         .         .         .     | 08   .    g.82201
 ATTAACCCAATTGCTCTGTATTTGGTGAGCAAAAGATTCAAAAACTGCTTTAAG | TCATGC    c.1200
 I  N  P  I  A  L  Y  L  V  S  K  R  F  K  N  C  F  K   | S  C      p.400

          .         .         .         .         .         .       g.82261
 TTATGCTGCTGGTGCCAGTCATTTGAAGAAAAACAGTCCTTGGAGGAAAAGCAGTCGTGC       c.1260
 L  C  C  W  C  Q  S  F  E  E  K  Q  S  L  E  E  K  Q  S  C         p.420

          .         .         .         .         .         .       g.82321
 TTAAAGTTCAAAGCTAATGATCACGGATATGACAACTTCCGTTCCAGTAATAAATACAGC       c.1320
 L  K  F  K  A  N  D  H  G  Y  D  N  F  R  S  S  N  K  Y  S         p.440

                                                                    g.82330
 TCATCTTGA                                                          c.1329
 S  S  X                                                            p.442

          .         .         .         .         .         .       g.82390
 aagaagaactattcactgtatttcattttctttatattggaccgaagtcattaaaacaaa       c.*60

          .         .         .         .         .         .       g.82450
 atgaaacatttgccaaaacaaaacaaaaaactatgtatttgcacagcacactattaaaat       c.*120

          .         .         .         .         .         .       g.82510
 attaagtgtaattattttaacactcacagctacatatgacattttatgagctgtttacgg       c.*180

          .         .         .         .         .         .       g.82570
 catggaaagaaaatcagtgggaattaagaaagcctcgtcgtgaaagcacttaatttttta       c.*240

          .         .         .         .         .         .       g.82630
 cagttagcacttcaacatagctcttaacaacttccaggatattcacacaacacttaggct       c.*300

          .         .         .         .         .         .       g.82690
 taaaaatgagctcactcagaatttctattctttctaaaaagagatttatttttaaatcaa       c.*360

          .         .         .         .         .         .       g.82750
 tgggactctgatataaaggaagaataagtcactgtaaaacagaacttttaaatgaagctt       c.*420

          .         .         .         .         .         .       g.82810
 aaattactcaatttaaaattttaaaatcctttaaaacaacttttcaattaatattatcac       c.*480

          .         .         .         .         .         .       g.82870
 actattatcagattgtaattagatgcaaatgagagagcagtttagttgttgcatttttcg       c.*540

          .         .         .         .         .         .       g.82930
 gacactggaaacatttaaatgatcaggagggagtaacagaaagagcaaggctgtttttga       c.*600

          .         .         .         .         .         .       g.82990
 aaatcattacactttcactagaagcccaaacctcagcattctgcaatatgtaaccaacat       c.*660

          .         .         .         .         .         .       g.83050
 gtcacaaacaagcagcatgtaacagactggcacatgtgccagctgaatttaaaatataat       c.*720

          .         .         .         .         .         .       g.83110
 acttttaaaaagaaaattattacatcctttacattcagttaagatcaaacctcacaaaga       c.*780

          .         .         .         .         .         .       g.83170
 gaaatagaatgtttgaaaggctatcccaaaagacttttttgaatctgtcattcacatacc       c.*840

          .         .         .         .         .         .       g.83230
 ctgtgaagacaatactatctacaattttttcaggattattaaaatcttcttctttcacta       c.*900

          .         .         .         .         .         .       g.83290
 tcgtagcttaaactctgtttggttttgtcatctgtaaatacttacctacatacactgcat       c.*960

          .         .         .         .         .         .       g.83350
 gtagatgattaaatgagggcaggccctgtgctcatagctttacgatggagagatgccagt       c.*1020

          .         .         .         .         .         .       g.83410
 gacctcataataaagactgtgaactgcctggtgcagtgtccacatgacaaaggggcaggt       c.*1080

          .         .         .         .         .         .       g.83470
 agcaccctctctcacccatgctgtggttaaaatggtttctagcatatgtataatgctata       c.*1140

          .         .         .         .         .         .       g.83530
 gttaaaatactatttttcaaaatcatacagattagtacatttaacagctacctgtaaagc       c.*1200

          .         .         .         .         .         .       g.83590
 ttattactaatttttgtattatttttgtaaatagccaatagaaaagtttgcttgacatgg       c.*1260

          .         .         .         .         .         .       g.83650
 tgcttttctttcatctagaggcaaaactgctttttgagaccgtaagaacctcttagcttt       c.*1320

          .         .         .         .         .         .       g.83710
 gtgcgttcctgcctaatttttatatcttctaagcaaagtgccttaggatagcttgggatg       c.*1380

          .         .         .         .         .         .       g.83770
 agatgtgtgtgaaagtatgtacaagagaaaacggaagagagaggaaatgaggtggggttg       c.*1440

          .         .         .         .         .         .       g.83830
 gaggaaacccatggggacagattcccattcttagcctaacgttcgtcattgcctcgtcac       c.*1500

          .         .         .         .         .         .       g.83890
 atcaatgcaaaaggtcctgattttgttccagcaaaacacagtgcaatgttctcagagtga       c.*1560

          .         .         .         .         .         .       g.83950
 ctttcgaaataaattgggcccaagagctttaactcggtcttaaaatatgcccaaattttt       c.*1620

          .         .         .         .         .         .       g.84010
 actttgtttttcttttaataggctgggccacatgttggaaataagctagtaatgttgttt       c.*1680

          .         .         .         .         .         .       g.84070
 tctgtcaatattgaatgtgatggtacagtaaaccaaaacccaacaatgtggccagaaaga       c.*1740

          .         .         .         .         .         .       g.84130
 aagagcaataataattaattcacacaccatatggattctatttataaatcacccacaaac       c.*1800

          .         .         .         .         .         .       g.84190
 ttgttctttaatttcatcccaatcactttttcagaggcctgttatcatagaagtcatttt       c.*1860

          .         .         .         .         .         .       g.84250
 agactctcaattttaaattaattttgaatcactaatattttcacagtttattaatatatt       c.*1920

          .         .         .         .         .         .       g.84310
 taatttctatttaaattttagattatttttattaccatgtactgaatttttacatcctga       c.*1980

          .         .         .         .         .         .       g.84370
 taccttttccttctccatgtcagtatcatgttctctaattatcttgccaaattttgaaac       c.*2040

          .         .         .         .         .         .       g.84430
 tacacacaaaaagcatacttgcattatttataataaaattgcattcagtggctttttaaa       c.*2100

          .         .         .         .         .         .       g.84490
 aaaatgtttgattcaaaactttaacatactgataagtaagaaacaattataatttcttta       c.*2160

          .         .         .         .         .         .       g.84550
 catactcaaaaccaagatagaaaaaggtgctatcgttcaacttcaaaacatgtttcctag       c.*2220

          .         .         .         .         .         .       g.84610
 tattaaggactttaatatagcaacagacaaaattattgttaacatggatgttacagctca       c.*2280

          .         .         .         .         .         .       g.84670
 aaagatttataaaagattttaacctattttctcccttattatccactgctaatgtggatg       c.*2340

          .         .         .         .         .         .       g.84730
 tatgttcaaacaccttttagtattgatagcttacatatggccaaaggaatacagtttata       c.*2400

          .         .         .         .         .         .       g.84790
 gcaaaacatgggtatgctgtagctaactttataaaagtgtaatataacaatgtaaaaaat       c.*2460

          .         .         .         .         .         .       g.84850
 tatatatctgggaggattttttggttgcctaaagtggctatagttactgattttttatta       c.*2520

          .         .         .         .         .         .       g.84910
 tgtaagcaaaaccaataaaaatttaagtttttttaacaactaccttatttttcactgtac       c.*2580

          .         .         .         .         .         .       g.84970
 agacactaattcattaaatactaattgattgtttaaaagaaatataaatgtgacaagtgg       c.*2640

          .         .         .         .         .         .       g.85030
 acattatttatgttaaatatacaattatcaagcaagtatgaagttattcaattaaaatgc       c.*2700

          .                                                         g.85049
 cacatttctggtctctggg                                                c.*2719

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Endothelin receptor type B protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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