embryonic ectoderm development (EED) - coding DNA reference sequence

(used for variant description)

(last modified October 26, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_003797.3 in the EED gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_029595.1, covering EED transcript NM_003797.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5046
               tttcgctccctagcagcgggtcggagatcgaaggaacgggccaatt       c.-421

 .         .         .         .         .         .                g.5106
 gcggctgaaacgtctttggaaggaggaagggggtgagggagcatccctttgagtttcgcc       c.-361

 .         .         .         .         .         .                g.5166
 tcttctcgaggcggtggtgggaagggagacatacttaatactgccctcttaatccaacgg       c.-301

 .         .         .         .         .         .                g.5226
 accttacatcgtgtagactgccgggagggcggcgggaaaagggcaagacgggagttgggg       c.-241

 .         .         .         .         .         .                g.5286
 aagggaaggagccaggaagccgcgcgggagggcgcgcgcgcgcgcccctttttcagcagt       c.-181

 .         .         .         .         .         .                g.5346
 gtggcggggtcgcacgcacgcccgcctcggcggctgggcgcgatttgcgacagtgggggg       c.-121

 .         .         .         .         .         .                g.5406
 ggcggtggaggtggcggcggcagcggcaactttgcggcaagctcgggccgggcttgcttg       c.-61

 .         .         .         .         .         .                g.5466
 acggcggtgtggcggaggccccgccccaggcggcaggaacctggagggaggcggaggaat       c.-1

          .         .         .         .         .         .       g.5526
 ATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGGGAACAGACATGCCTGCGGCCAAGAAG       c.60
 M  S  E  R  E  V  S  T  A  P  A  G  T  D  M  P  A  A  K  K         p.20

          .         .         .         .         .     | 02   .    g.10538
 CAGAAGCTGAGCAGTGACGAGAACAGCAATCCAGACCTCTCTGGAGACGAGAAT | GATGAC    c.120
 Q  K  L  S  S  D  E  N  S  N  P  D  L  S  G  D  E  N   | D  D      p.40

          .         .         .         .         .         .       g.10598
 GCTGTCAGTATAGAAAGTGGTACAAACACTGAACGCCCTGATACACCTACAAACACGCCA       c.180
 A  V  S  I  E  S  G  T  N  T  E  R  P  D  T  P  T  N  T  P         p.60

          .         .         .         .         .         .       g.10658
 AATGCACCTGGAAGGAAAAGTTGGGGAAAGGGAAAATGGAAGTCAAAGAAATGCAAATAT       c.240
 N  A  P  G  R  K  S  W  G  K  G  K  W  K  S  K  K  C  K  Y         p.80

          .         .        | 03.         .         .         .    g.12417
 TCTTTCAAATGTGTAAATAGTCTCAAG | GAAGATCATAACCAACCATTGTTTGGAGTTCAG    c.300
 S  F  K  C  V  N  S  L  K   | E  D  H  N  Q  P  L  F  G  V  Q      p.100

          .         .         .         .         .         .       g.12477
 TTTAACTGGCACAGTAAAGAAGGAGATCCATTAGTGTTTGCAACTGTAGGAAGCAACAGA       c.360
 F  N  W  H  S  K  E  G  D  P  L  V  F  A  T  V  G  S  N  R         p.120

  | 04       .         .         .         .         .         .    g.15518
  | GTTACCTTGTATGAATGTCATTCACAAGGAGAAATCCGGTTGTTGCAATCTTACGTGGAT    c.420
  | V  T  L  Y  E  C  H  S  Q  G  E  I  R  L  L  Q  S  Y  V  D      p.140

        | 05 .         .         .         .         .         .    g.16677
 GCTGAT | GCTGATGAAAACTTTTACACTTGTGCATGGACCTATGATAGCAATACGAGCCAT    c.480
 A  D   | A  D  E  N  F  Y  T  C  A  W  T  Y  D  S  N  T  S  H      p.160

          .         .         .         .         .         .       g.16737
 CCTCTGCTGGCTGTAGCTGGATCTAGAGGCATAATTAGGATAATAAATCCTATAACAATG       c.540
 P  L  L  A  V  A  G  S  R  G  I  I  R  I  I  N  P  I  T  M         p.180

          .   | 06     .         .         .         .         .    g.17799
 CAGTGTATAAAG | CACTATGTTGGCCATGGAAATGCTATCAATGAGCTGAAATTCCATCCA    c.600
 Q  C  I  K   | H  Y  V  G  H  G  N  A  I  N  E  L  K  F  H  P      p.200

          .         .         .     | 07   .         .         .    g.24434
 AGAGATCCAAATCTTCTCCTGTCAGTAAGTAAAG | ATCATGCTTTACGATTATGGAATATC    c.660
 R  D  P  N  L  L  L  S  V  S  K  D |   H  A  L  R  L  W  N  I      p.220

          .         .         .         .         .         .       g.24494
 CAGACGGACACTCTGGTGGCAATATTTGGAGGCGTAGAAGGGCACAGAGATGAAGTTCTA       c.720
 Q  T  D  T  L  V  A  I  F  G  G  V  E  G  H  R  D  E  V  L         p.240

        | 08 .         .         .         .         .         .    g.26373
 AGTGCT | GATTATGATCTTTTGGGTGAAAAAATAATGTCCTGTGGTATGGATCATTCTCTT    c.780
 S  A   | D  Y  D  L  L  G  E  K  I  M  S  C  G  M  D  H  S  L      p.260

          .         .         .         .         .         .       g.26433
 AAACTTTGGAGGATCAATTCAAAGAGAATGATGAATGCAATTAAGGAATCTTATGATTAT       c.840
 K  L  W  R  I  N  S  K  R  M  M  N  A  I  K  E  S  Y  D  Y         p.280

          .         . | 09       .         .         .         .    g.28732
 AATCCAAATAAAACTAACAG | GCCATTTATTTCTCAGAAAATCCATTTTCCTGATTTTTCT    c.900
 N  P  N  K  T  N  R  |  P  F  I  S  Q  K  I  H  F  P  D  F  S      p.300

          .         .         .         .         .         .       g.28792
 ACCAGAGACATACATAGGAATTATGTTGATTGTGTGCGATGGTTAGGCGATTTGATACTT       c.960
 T  R  D  I  H  R  N  Y  V  D  C  V  R  W  L  G  D  L  I  L         p.320

        | 10 .         .         .         .         .         .    g.37270
 TCTAAG | TCTTGTGAAAATGCCATTGTGTGCTGGAAACCTGGCAAGATGGAAGATGATATA    c.1020
 S  K   | S  C  E  N  A  I  V  C  W  K  P  G  K  M  E  D  D  I      p.340

          .         .         .         .         .         .       g.37330
 GATAAAATTAAACCCAGTGAATCTAATGTGACTATTCTTGGGCGATTTGATTACAGCCAG       c.1080
 D  K  I  K  P  S  E  S  N  V  T  I  L  G  R  F  D  Y  S  Q         p.360

          .         .         .         .      | 11  .         .    g.38169
 TGTGACATTTGGTACATGAGGTTTTCTATGGATTTCTGGCAAAAG | ATGCTTGCATTGGGC    c.1140
 C  D  I  W  Y  M  R  F  S  M  D  F  W  Q  K   | M  L  A  L  G      p.380

          .         .         .         .         .          | 12    g.38636
 AATCAAGTTGGCAAACTTTATGTTTGGGATTTAGAAGTAGAAGATCCTCATAAAGCCAA | A    c.1200
 N  Q  V  G  K  L  Y  V  W  D  L  E  V  E  D  P  H  K  A  K  |      p.400

          .         .         .         .         .         .       g.38696
 TGTACAACACTGACTCATCATAAATGTGGTGCTGCTATTCGACAAACCAGTTTTAGCAGG       c.1260
 C  T  T  L  T  H  H  K  C  G  A  A  I  R  Q  T  S  F  S  R         p.420

          .         .         .         .         .         .       g.38756
 GATAGCAGCATTCTTATAGCTGTTTGTGATGATGCCAGTATTTGGCGCTGGGATCGACTT       c.1320
 D  S  S  I  L  I  A  V  C  D  D  A  S  I  W  R  W  D  R  L         p.440

                                                                    g.38762
 CGATAA                                                             c.1326
 R  X                                                               p.441

          .         .         .         .         .         .       g.38822
 aatacttttgcctaatcaaaattagagtgtgtttgttgtctgtgtaaaatagaattaatg       c.*60

          .         .         .         .         .         .       g.38882
 tatcttgctagtaagggcacgtagagcatttagagttgtctttcagcattcaatcaggct       c.*120

          .         .         .         .         .         .       g.38942
 gagctgaatgtagtgatgtttacattgtttacattctttgtactgtcttcctgctcagac       c.*180

          .         .         .                                     g.38980
 tctactgcttttaataaaaatttatttttgtaaagctg                             c.*218

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Embryonic ectoderm development protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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