eukaryotic elongation factor, selenocysteine-tRNA-specific (EEFSEC) - coding DNA reference sequence

(used for variant description)

(last modified January 4, 2025)


This file was created to facilitate the description of sequence variants on transcript NM_021937.3 in the EEFSEC gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000003.11, covering EEFSEC transcript NM_021937.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5038
                       gggcgggccgggcgggtgtccgaggcggcggcggcggc       c.-1

          .         .         .         .         .         .       g.5098
 ATGGCAGGGCGGCGGGTGAACGTGAACGTGGGCGTGCTGGGCCACATCGACAGCGGCAAG       c.60
 M  A  G  R  R  V  N  V  N  V  G  V  L  G  H  I  D  S  G  K         p.20

          .         .         .         .         .         .       g.5158
 ACGGCGCTGGCGCGGGCGCTAAGCACCACAGCCTCCACCGCCGCCTTTGACAAGCAGCCG       c.120
 T  A  L  A  R  A  L  S  T  T  A  S  T  A  A  F  D  K  Q  P         p.40

          .         .         .         .         .         .       g.5218
 CAGAGCCGCGAGCGCGGCATCACGCTCGATCTGGGCTTCTCGTGCTTCTCGGTGCCGCTG       c.180
 Q  S  R  E  R  G  I  T  L  D  L  G  F  S  C  F  S  V  P  L         p.60

          .         .         .         .         .         .       g.5278
 CCCGCGCGCCTGCGGTCGTCTTTGCCCGAGTTCCAGGCAGCGCCCGAGGCCGAGCCCGAG       c.240
 P  A  R  L  R  S  S  L  P  E  F  Q  A  A  P  E  A  E  P  E         p.80

          .         .         .         .         .         .       g.5338
 CCCGGCGAGCCACTGCTTCAGGTCACGCTGGTCGACTGCCCCGGGCACGCCTCCCTCATC       c.300
 P  G  E  P  L  L  Q  V  T  L  V  D  C  P  G  H  A  S  L  I         p.100

          .       | 02 .         .         .         .         .    g.98410
 CGGACCATCATCGGCG | GGGCCCAGATCATTGATCTGATGATGCTGGTCATCGATGTGACC    c.360
 R  T  I  I  G  G |   A  Q  I  I  D  L  M  M  L  V  I  D  V  T      p.120

          .         .         .         .         .         .       g.98470
 AAGGGGATGCAGACCCAGTCAGCGGAATGCCTTGTGATCGGCCAGATTGCCTGCCAGAAG       c.420
 K  G  M  Q  T  Q  S  A  E  C  L  V  I  G  Q  I  A  C  Q  K         p.140

          .         .         .         .         .         .       g.98530
 CTGGTCGTGGTGCTGAACAAAATAGACCTCTTACCTGAAGGAAAGAGACAGGCAGCAATT       c.480
 L  V  V  V  L  N  K  I  D  L  L  P  E  G  K  R  Q  A  A  I         p.160

          .         .         .         .     | 03   .         .    g.113674
 GATAAAATGACCAAGAAAATGCAGAAGACCCTAGAGAACACCAA | GTTCCGAGGTGCACCG    c.540
 D  K  M  T  K  K  M  Q  K  T  L  E  N  T  K  |  F  R  G  A  P      p.180

          .         .         .         .         .         .       g.113734
 ATTATACCCGTGGCGGCCAAGCCGGGGGGACCAGAGGCCCCCGAAACTGAAGCTCCACAG       c.600
 I  I  P  V  A  A  K  P  G  G  P  E  A  P  E  T  E  A  P  Q         p.200

          .         .  | 04      .         .         .         .    g.116186
 GGCATTCCAGAGCTCATTGAG | CTCCTGACGTCCCAGATTTCCATCCCAACGAGAGATCCC    c.660
 G  I  P  E  L  I  E   | L  L  T  S  Q  I  S  I  P  T  R  D  P      p.220

          .         .         .         .         .         .       g.116246
 TCGGGACCGTTCCTCATGTCTGTGGACCACTGTTTCTCCATCAAAGGCCAAGGCACTGTG       c.720
 S  G  P  F  L  M  S  V  D  H  C  F  S  I  K  G  Q  G  T  V         p.240

          .         .         .         .         .         .       g.116306
 ATGACAGGGACCATCCTTTCAGGCTCCATCAGCCTCGGTGACAGTGTGGAGATCCCTGCC       c.780
 M  T  G  T  I  L  S  G  S  I  S  L  G  D  S  V  E  I  P  A         p.260

        | 05 .         .         .         .         .         .    g.192817
 CTCAAG | GTGGTGAAGAAGGTGAAGTCCATGCAGATGTTCCACATGCCCATCACTTCAGCC    c.840
 L  K   | V  V  K  K  V  K  S  M  Q  M  F  H  M  P  I  T  S  A      p.280

          .         .         .         .         .         .       g.192877
 ATGCAAGGAGACCGGCTGGGCATCTGCGTCACCCAGTTTGACCCTAAGCTGCTGGAGCGC       c.900
 M  Q  G  D  R  L  G  I  C  V  T  Q  F  D  P  K  L  L  E  R         p.300

          .         .         .         .         .         .       g.192937
 GGGTTGGTGTGTGCCCCCGAGTCCCTGCACACTGTCCATGCGGCCCTCATCTCTGTGGAA       c.960
 G  L  V  C  A  P  E  S  L  H  T  V  H  A  A  L  I  S  V  E         p.320

          .         .         .         .         .         .       g.192997
 AAGATACCGTATTTCCGGGGGCCCCTGCAAACCAAGGCCAAGTTCCACATTACAGTGGGC       c.1020
 K  I  P  Y  F  R  G  P  L  Q  T  K  A  K  F  H  I  T  V  G         p.340

          .         .         .         .         .         .       g.193057
 CATGAAACAGTCATGGGCCGGTTGATGTTCTTCAGTCCTGCTCCAGATAACTTTGACCAG       c.1080
 H  E  T  V  M  G  R  L  M  F  F  S  P  A  P  D  N  F  D  Q         p.360

          .         .         .         .         .         .       g.193117
 GAGCCTATACTGGACTCTTTCAACTTCTCTCAAGAATACCTTTTCCAGGAGCAGTACCTG       c.1140
 E  P  I  L  D  S  F  N  F  S  Q  E  Y  L  F  Q  E  Q  Y  L         p.380

          .         .         .         .         .         .       g.193177
 TCCAAGGATTTGACACCAGCAGTGACAGACAATGATGAGGCCGACAAGAAGGCCGGCCAG       c.1200
 S  K  D  L  T  P  A  V  T  D  N  D  E  A  D  K  K  A  G  Q         p.400

          .         .         .         .         .         .       g.193237
 GCCACAGAGGGCCATTGTCCTCGGCAGCAGTGGGCCCTGGTGGAGTTTGAGAAGCCCGTC       c.1260
 A  T  E  G  H  C  P  R  Q  Q  W  A  L  V  E  F  E  K  P  V         p.420

          .         .         .         .         .         .       g.193297
 ACCTGCCCTCGGCTGTGCCTGGTGATTGGCTCCAGGCTAGATGCGGACATTCACACCAAC       c.1320
 T  C  P  R  L  C  L  V  I  G  S  R  L  D  A  D  I  H  T  N         p.440

          .         .         .         .         .         .       g.193357
 ACGTGCCGGCTAGCCTTCCATGGCATCCTGCTCCACGGGCTAGAGGACAGGAACTACGCC       c.1380
 T  C  R  L  A  F  H  G  I  L  L  H  G  L  E  D  R  N  Y  A         p.460

          .         .         .         .         .         .       g.193417
 GACAGCTTCCTGCCCAGGCTGAAGGTGTACAAGCTGAAGCACAAGCATGGCCTTGTGGAG       c.1440
 D  S  F  L  P  R  L  K  V  Y  K  L  K  H  K  H  G  L  V  E         p.480

     | 06    .         .         .         .         .         .    g.209804
 CGG | GCGATGGATGACTACAGTGTGATCGGCCGCTCCCTGTTCAAAAAGGAAACCAACATC    c.1500
 R   | A  M  D  D  Y  S  V  I  G  R  S  L  F  K  K  E  T  N  I      p.500

          .         .         .         .         .         .       g.209864
 CAGCTCTTCGTGGGGCTCAAGGTGCACTTGTCCACTGGGGAACTGGGCATCATCGACAGT       c.1560
 Q  L  F  V  G  L  K  V  H  L  S  T  G  E  L  G  I  I  D  S         p.520

          .         .         .         . | 07       .         .    g.259619
 GCCTTCGGCCAGAGCGGCAAGTTCAAGATCCACATCCCAG | GTGGCCTCAGCCCCGAGTCC    c.1620
 A  F  G  Q  S  G  K  F  K  I  H  I  P  G |   G  L  S  P  E  S      p.540

          .         .         .         .         .         .       g.259679
 AAGAAGATCCTGACACCCGCCCTCAAGAAGCGGGCCCGGGCTGGCCGTGGGGAGGCCACC       c.1680
 K  K  I  L  T  P  A  L  K  K  R  A  R  A  G  R  G  E  A  T         p.560

          .         .         .         .         .         .       g.259739
 AGGCAGGAGGAGAGCGCCGAGCGGAGCGAGCCCTCACAGCATGTGGTGCTCAGCCTGACT       c.1740
 R  Q  E  E  S  A  E  R  S  E  P  S  Q  H  V  V  L  S  L  T         p.580

          .         .         .         .         .                 g.259790
 TTCAAGCGTTATGTCTTCGACACCCACAAGCGCATGGTTCAGTCTCCCTGA                c.1791
 F  K  R  Y  V  F  D  T  H  K  R  M  V  Q  S  P  X                  p.596

          .         .         .         .         .         .       g.259850
 gtgtccggtgacctcccccagggcctccttgcccagcccagtccaggctgctgtgccaaa       c.*60

          .         .         .         .         .         .       g.259910
 tcccaaccagccacgcctcagcctctcccagtctctccctgcagtcctgcagcagcagcc       c.*120

          .         .         .         .         .         .       g.259970
 cccacccccaagcttggtgctgagccctggtgaggagctgagggggatgggttgctgggg       c.*180

          .         .         .         .         .         .       g.260030
 ccaggagggtctctcctccagcccctgcacactcccacccaggacagcccccagcccaac       c.*240

          .         .         .         .         .         .       g.260090
 taggaaagggccatgggcagagggctggtagccagtatcttccactgccccatctgttgg       c.*300

          .         .         .         .         .         .       g.260150
 ccacctgcaggccagtctcaaccctcccccaggtgggcaggcacttgatggctacaaata       c.*360

          .         .                                               g.260177
 aatgtcccgtggccccagcccactcta                                        c.*387

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Eukaryotic elongation factor, selenocysteine-tRNA-specific protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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