EF-hand domain (C-terminal) containing 2 (EFHC2) - coding DNA reference sequence

(used for variant description)

(last modified October 28, 2013)


This file was created to facilitate the description of sequence variants on transcript NM_025184.3 in the EFHC2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_021391.1, covering EFHC2 transcript NM_025184.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5029
                                aacgtgggggccaaacaacacggccggga       c.-61

 .         .         .         .         .         .                g.5089
 ggcgccgctgcctgccgggccctctcttctgggaccctggattttcggacactgagcgcc       c.-1

          .         .         .         .   | 02     .         .    g.35939
 ATGGCCCTGCCTCTGCTGCCGGGCAACAGCTTCAACCGCAAC | GTGGGAAAGGAGAAGTTT    c.60
 M  A  L  P  L  L  P  G  N  S  F  N  R  N   | V  G  K  E  K  F      p.20

          .         .         .         .         .         .       g.35999
 CACAAATCCCAACATTGGGGCTTTTGCAACAATGTTATGATGTTGGTGAGTGATGAAAAG       c.120
 H  K  S  Q  H  W  G  F  C  N  N  V  M  M  L  V  S  D  E  K         p.40

          .         .         .         .         .         .       g.36059
 CCTGGAATAGGTGGAGAACCACTTCTGGGGCAAAAGATAAAGCCTAAATGTAGCATATAT       c.180
 P  G  I  G  G  E  P  L  L  G  Q  K  I  K  P  K  C  S  I  Y         p.60

          .         .         .         .         .  | 03      .    g.75850
 CCTAAAGGAGATGGAAGTGATGTACCATCATGGGTAGCCTTTGATAAACAG | GTATTATCT    c.240
 P  K  G  D  G  S  D  V  P  S  W  V  A  F  D  K  Q   | V  L  S      p.80

          .         .         .         .         .         .       g.75910
 TTTGATGCCTATTTGGAAGAGGAAGTACTTGATAAAAGCCAAACCAACTACAGAATAAGA       c.300
 F  D  A  Y  L  E  E  E  V  L  D  K  S  Q  T  N  Y  R  I  R         p.100

          .         .         .         .         .         .       g.75970
 TACTATAAAATCTACTTCTACCCTGAAGATGACACAATTCAAGTAAATGAACCAGAGGTG       c.360
 Y  Y  K  I  Y  F  Y  P  E  D  D  T  I  Q  V  N  E  P  E  V         p.120

          .         .   | 04     .         .         .         .    g.87417
 AAAAATAGTGGATTACTTCAAG | GGACTTCTATCCGGCGTCATCGGATTACTCTTCCGCCT    c.420
 K  N  S  G  L  L  Q  G |   T  S  I  R  R  H  R  I  T  L  P  P      p.140

          .         .         .         .         .         .       g.87477
 CCTGATGAGGATCAGTTTTATACTGTGTATCATTTTAATGTCGGCACAGAGGTTGTCTTC       c.480
 P  D  E  D  Q  F  Y  T  V  Y  H  F  N  V  G  T  E  V  V  F         p.160

          .         .         .         .         .         .       g.87537
 TATGGCCGGACATTCAAGATTTATGACTGTGATGCATTCACAAGAAACTTTTTGAGGAAA       c.540
 Y  G  R  T  F  K  I  Y  D  C  D  A  F  T  R  N  F  L  R  K         p.180

          .         .         .         .         .         .       g.87597
 ATAGGGGTCAAAGTGAATCCCCCAGTGCAATGTCCAGAAGATCCTTACATGAAGATTCGG       c.600
 I  G  V  K  V  N  P  P  V  Q  C  P  E  D  P  Y  M  K  I  R         p.200

        | 05 .         .         .         .         .         .    g.98286
 AGAGAG | GTTGTAGAACACGTAGAGCCCTTACGTCCCTACGAATCCCTCGACACCCTGAAA    c.660
 R  E   | V  V  E  H  V  E  P  L  R  P  Y  E  S  L  D  T  L  K      p.220

          .         .         .         .         .         .       g.98346
 CAGTTCCTCCAGTATCATGGCAAGATTTTGTGTTTCTTCTGCCTGTGGGATGACTCAGTC       c.720
 Q  F  L  Q  Y  H  G  K  I  L  C  F  F  C  L  W  D  D  S  V         p.240

          .         .         .         .         .         .       g.98406
 TCAATGTTTGGAGACCGTAGAGAACTCATCCTGCATTACTTCTTGTGTGATGATACTATT       c.780
 S  M  F  G  D  R  R  E  L  I  L  H  Y  F  L  C  D  D  T  I         p.260

          .         .         .         .         .         .       g.98466
 GAAATCAAAGAATTGCTTCCACACAGCTCAGGCCGAGATGCTCTAAAAATGTTCCTCCGG       c.840
 E  I  K  E  L  L  P  H  S  S  G  R  D  A  L  K  M  F  L  R         p.280

          .         | 06         .         .         .         .    g.99803
 AGGAGTAAGCTACCCAAG | AATTGCCCACCTAGAGTCTATCAACCAGGCCAGATAACAGAT    c.900
 R  S  K  L  P  K   | N  C  P  P  R  V  Y  Q  P  G  Q  I  T  D      p.300

          .         .         .         .         .         .       g.99863
 CGAGCAGTTCTCAATTCATATGGTGACTTTATAAAGAACCAAGCGGATGGCTACCTGTTC       c.960
 R  A  V  L  N  S  Y  G  D  F  I  K  N  Q  A  D  G  Y  L  F         p.320

          .   | 07     .         .         .         .         .    g.100315
 GATAGATATAAG | CTAGGAAAAGTAGACCAAGAGTTTTACAAAGATAGTGACCTGTCCCTA    c.1020
 D  R  Y  K   | L  G  K  V  D  Q  E  F  Y  K  D  S  D  L  S  L      p.340

          .         .         .         .         .         .       g.100375
 GGAGTCACCATCAATGTGTGGGGAAGAAAAGTGCTCCTTTATGACTGTGATGAATTTACG       c.1080
 G  V  T  I  N  V  W  G  R  K  V  L  L  Y  D  C  D  E  F  T         p.360

          .         .         .  | 08      .         .         .    g.106417
 AAGTCTTATTATAAGTCTAAATATGGAATTG | AGAACTTTACCTCAGTTTCATGCAAGCCT    c.1140
 K  S  Y  Y  K  S  K  Y  G  I  E |   N  F  T  S  V  S  C  K  P      p.380

          .         .         .         .         .         .       g.106477
 CCTTCTCCTCCTCCAAAAATAGAAAGGAAATTTCCACCTTACAACGGTTTTGGTTCTGAA       c.1200
 P  S  P  P  P  K  I  E  R  K  F  P  P  Y  N  G  F  G  S  E         p.400

          .         .         .         .         .         .       g.106537
 GAGGATTCTCTCCGTAACTGCATAGACCTCAAGCCCACACCTCATCGGAGGAACTTCAAG       c.1260
 E  D  S  L  R  N  C  I  D  L  K  P  T  P  H  R  R  N  F  K         p.420

          .         . | 09       .         .         .         .    g.113270
 AAGTTTATGGAAAAAGACAG | CTATGGCTCCAAAAGCAATATACTCCGTTTTTTTGCAAAA    c.1320
 K  F  M  E  K  D  S  |  Y  G  S  K  S  N  I  L  R  F  F  A  K      p.440

          .         .         .         .         .         .       g.113330
 CTAGTCACAGACAAATGTGTTGACTTGGACAGGATGTTTGTTATTTCATATTATCTCGGT       c.1380
 L  V  T  D  K  C  V  D  L  D  R  M  F  V  I  S  Y  Y  L  G         p.460

          .         .         .         .    | 10    .         .    g.116017
 GATGACACCATTTCAGTGTTTGAACCTATAGAGAGGAATTCAG | GAATTGCTGGTGGGATG    c.1440
 D  D  T  I  S  V  F  E  P  I  E  R  N  S  G |   I  A  G  G  M      p.480

          .         .         .         .         .         .       g.116077
 TTCTTGAAAAGAAGTCGCGTTAAGAAGCCTGGACAAGAAGTCTTTAAAAGTGAACTATCT       c.1500
 F  L  K  R  S  R  V  K  K  P  G  Q  E  V  F  K  S  E  L  S         p.500

          .         .         .         .         .         .       g.116137
 GAATATATCAAGGCCGAGGAGCTGTACATTGGAGTCACGGTGAATGTGAATGGTTACCTA       c.1560
 E  Y  I  K  A  E  E  L  Y  I  G  V  T  V  N  V  N  G  Y  L         p.520

          .         .         .         .         .         .       g.116197
 TTTCGTTTGCTCAATGCTGATGAGTATACCTTAAACTACATGGAGCAGAATACAGATAAG       c.1620
 F  R  L  L  N  A  D  E  Y  T  L  N  Y  M  E  Q  N  T  D  K         p.540

  | 11       .         .         .         .         .         .    g.118958
  | TATCCTTTCAGTAACCTCAAACTTGCCCTACAAAAGCTGAAGCAAGAAGAAGGAAAATCC    c.1680
  | Y  P  F  S  N  L  K  L  A  L  Q  K  L  K  Q  E  E  G  K  S      p.560

          .         .         .         .         .         .       g.119018
 AGAGAGCTCAAGCAGGTATTTAAAGCTGCTGACTCTAAGCACACAAATATGGTGGATTAT       c.1740
 R  E  L  K  Q  V  F  K  A  A  D  S  K  H  T  N  M  V  D  Y         p.580

          .  | 12      .         .         .         .         .    g.170162
 AATACATTCAG | AGACATATTGATGTCTTTGACTGTTGGAAACCTTGCAGAGCAAGAATTT    c.1800
 N  T  F  R  |  D  I  L  M  S  L  T  V  G  N  L  A  E  Q  E  F      p.600

          .         .         .         .         .         .       g.170222
 GTAACCATTGCACGTCACTACCGTGTGCCTGAGGGCACATGTTCAGATATGGATTTCTTA       c.1860
 V  T  I  A  R  H  Y  R  V  P  E  G  T  C  S  D  M  D  F  L         p.620

          .         .         .         .         .         .       g.170282
 ATCGCACTGGCCCACGAAAAGTTCAAGAAAAATATGTTTGAGAATTTCGACACTTTCATT       c.1920
 I  A  L  A  H  E  K  F  K  K  N  M  F  E  N  F  D  T  F  I         p.640

          .         .          | 13        .         .         .    g.172324
 TATTCCTGTGTGTATGAAGATCGAGAAAA | AAAAAATGTATTACCCACCAAAGACATTAAA    c.1980
 Y  S  C  V  Y  E  D  R  E  K  |  K  N  V  L  P  T  K  D  I  K      p.660

          .         .         .         .         .         .       g.172384
 AGGCTGTGCAAATCCTCCAGATTACCTTTGAGTGATGATCTTCTAGAATCCTTATTGTCA       c.2040
 R  L  C  K  S  S  R  L  P  L  S  D  D  L  L  E  S  L  L  S         p.680

    | 14     .         .         .         .         .         .    g.184708
 AG | GTTTGAAGACAGTGAAAAACAAATAGATTATAAGTCATTTTTCTCTGCCCTGAACTGG    c.2100
 R  |  F  E  D  S  E  K  Q  I  D  Y  K  S  F  F  S  A  L  N  W      p.700

          .         .         .         .         | 15         .    g.199793
 AGAAAGAATCCAGTGCCTGAATTGCAACCAGCATCATACCTTAAAGAG | AGATGTGAAGAT    c.2160
 R  K  N  P  V  P  E  L  Q  P  A  S  Y  L  K  E   | R  C  E  D      p.720

          .         .         .         .         .         .       g.199853
 GTTTGGCTTGGTATGCCATCACCTATTCCTGCGAAATACATTGACTACTGGACCTTTTTG       c.2220
 V  W  L  G  M  P  S  P  I  P  A  K  Y  I  D  Y  W  T  F  L         p.740

          .         .         .                                     g.199883
 AAGGACGCGTTTGGCTTAGAGGAGGAATAA                                     c.2250
 K  D  A  F  G  L  E  E  E  X                                       p.749

          .         .         .         .         .         .       g.199943
 ccatgccagttttggtcaattctctatgatttacttctctcattttgccacatttacttt       c.*60

          .         .         .         .         .         .       g.200003
 agtagatataatttcattaaaaacaaaaaagaaacaaggtttatattaaatggaaatcca       c.*120

          .         .         .         .         .         .       g.200063
 taaaccacaattaatcctattttgtcatgttagttttacagaacatcatgttacattgcc       c.*180

          .         .         .         .         .         .       g.200123
 gacgtactgttactatttaaaatgccatcttaaaacatgttgaatatttttattatatgt       c.*240

          .         .         .         .         .         .       g.200183
 atggtttattaataccaaaaaatcttctgataatttttgatccaacataatttgattcat       c.*300

          .         .         .         .         .         .       g.200243
 tactatatgaacagaaaatgacttttgaaggttatacatgacaatacaaaatcaaattat       c.*360

          .         .         .         .         .         .       g.200303
 atcacagcaataagttgtgattctattaaacatttttgaaacctttttgacacgtttatt       c.*420

          .         .         .         .         .         .       g.200363
 acttacataattaagttttgtagcaacccacctcatcaaaataattcttaaacctctcta       c.*480

          .         .         .         .         .         .       g.200423
 gagtaaatatatttatcttttgaacttagtaaagctatgggaagaaaaagaacctccaac       c.*540

          .         .         .         .         .         .       g.200483
 acacacacacacacacacacacacgcacgtgcacacacactggaaacatatgcagtattt       c.*600

          .         .         .         .         .         .       g.200543
 atatttgtaatgcccttttttctatctaaagtcagcttgttagcttaggaatatatgcat       c.*660

          .         .         .         .         .         .       g.200603
 gtgtgtataattatagtttgaccaaaactttattatgtctaaaatatttacaaatgtgaa       c.*720

          .         .         .         .         .         .       g.200663
 agctgaagattttgagatttttgttttttttttggtttgttttacacacacatcccacgc       c.*780

          .         .         .         .         .         .       g.200723
 gccccaccctagaggtttaaatattcagaaactacaacatttttcccctgcatttttcta       c.*840

          .         .         .         .         .         .       g.200783
 gttctatttttatttttcttcagcagaactcttgtcatgtagtgtacatttgattaaaac       c.*900

          .                                                         g.200796
 ccatagccatgta                                                      c.*913

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The EF-hand domain (C-terminal) containing 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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