egl nine homolog 1 (C. elegans) (EGLN1) - coding DNA reference sequence

(used for variant description)

(last modified November 25, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_022051.2 in the EGLN1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_015865.1, covering EGLN1 transcript NM_022051.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5036
                         ttaggggcagaaaaacatttgtaataattaatggct       c.-3121

 .         .         .         .         .         .                g.5096
 ttgagagacacaaggctttgtttgccccagagtattagttaacccacctagtgctcctaa       c.-3061

 .         .         .         .         .         .                g.5156
 tcatacaatattaaggattgggagggacattcattgcctcactctctatttgtttcacct       c.-3001

 .         .         .         .         .         .                g.5216
 tctgtaaaattggtagaataatagtacccacttcatagcattgtatgatgattaaattgg       c.-2941

 .         .         .         .         .         .                g.5276
 ttaatatttttaaaatgcttagaacacagattgggcacataacagcaagcaccacatgtg       c.-2881

 .         .         .         .         .         .                g.5336
 tttataagataaattcctttgtgttgccttccgttaaagtttaaataagtaaataaataa       c.-2821

 .         .         .         .         .         .                g.5396
 ataaatacttgcatgacattttgaagtctctctataacatctgagtaagtggcggctgcg       c.-2761

 .         .         .         .         .         .                g.5456
 acaatgctactggagttccagaatcgtgttggtgacaagattgttcaccagcatatggtg       c.-2701

 .         .         .         .         .         .                g.5516
 tggtgaaaactcactaatttggaattagttcagattattaagcctgaataggtgaaaatc       c.-2641

 .         .         .         .         .         .                g.5576
 ctgaaatcaaggatctttggaactatttgaaatcagtattttatattttcctgttgtatt       c.-2581

 .         .         .         .         .         .                g.5636
 cattaaagtgttgcaagtgttctatttgatggattaagtatatttaggatatacatgttc       c.-2521

 .         .         .         .         .         .                g.5696
 aatttgtgattttgtatacttaattggaacaagaaagctaataaaggttttgatatggac       c.-2461

 .         .         .         .         .         .                g.5756
 atctattcttttaagtaaacttcaatgaaaatatatgagtagagcatatagagatgtaaa       c.-2401

 .         .         .         .         .         .                g.5816
 taatttgtggacacaccacagactgaaatagcaaatttaaaagaaattgttggaagaatc       c.-2341

 .         .         .         .         .         .                g.5876
 aagtgtttgtggaatgagtcctcctagtaaagttcctgctcttgtgaataattaagcctc       c.-2281

 .         .         .         .         .         .                g.5936
 atgtataattactatagcaaaaggaagcctaagaagtattagactctacttgtatttaaa       c.-2221

 .         .         .         .         .         .                g.5996
 ttacattttacataatttatgtgtatgaaaaatgttttaaatgcttattttcgtaagcca       c.-2161

 .         .         .         .         .         .                g.6056
 tgagatagctcctttatattttaagaatttctgaattaatttgcttggattttattagtg       c.-2101

 .         .         .         .         .         .                g.6116
 caaatggcagagctagcaattcctttttctgtgttcccattccatcctattcatccctct       c.-2041

 .         .         .         .         .         .                g.6176
 tttaggaaactctgaactctggattgtccttgtttacatacctgcctcctgcattggact       c.-1981

 .         .         .         .         .         .                g.6236
 atgtgtctctgagtgtagtatgactaattcatttgtttgtcaaggactctcaatgcattt       c.-1921

 .         .         .         .         .         .                g.6296
 gttgaacagcctaattagtaatgtctgcaacaatgacattttactgtatttaataaagct       c.-1861

 .         .         .         .         .         .                g.6356
 ctgggaaagtaggatacacataagacaggtctaggtctaaattctttacagaaacttgga       c.-1801

 .         .         .         .         .         .                g.6416
 tttttagttcggtttgaaatttgaagatgtgagtatatttatctcagtttcccaaaggac       c.-1741

 .         .         .         .         .         .                g.6476
 aagctaattggaattatcatcctctttcacttgattggatccccagaatgccatttacgc       c.-1681

 .         .         .         .         .         .                g.6536
 atgcagcaggattttataacagttttaaattctgtatatttgatgaagaggttttatatt       c.-1621

 .         .         .         .         .         .                g.6596
 tttggattcaagcctctttttaaacttctacaatatggtttacaataattccttatatcc       c.-1561

 .         .         .         .         .         .                g.6656
 tgcttttgaaatacatattacaactttttaagtttggaaggctatatttcaaggactgaa       c.-1501

 .         .         .         .         .         .                g.6716
 gttacagtatactcaagtgatacacaagcctagcaccccactttccacatagtgttcgat       c.-1441

 .         .         .         .         .         .                g.6776
 aaagattgataaactcgaaatcacagaccttttaattcttaagacaaatagcagcagaaa       c.-1381

 .         .         .         .         .         .                g.6836
 gaaacatctttggcttatttctggtaaggtttttatgctctgtaaaacaaagaattgtat       c.-1321

 .         .         .         .         .         .                g.6896
 tcatccgcgcagcacagattctattaaaaataaatgtgagagtcgttaatgtagtactgc       c.-1261

 .         .         .         .         .         .                g.6956
 tcatttaccatcaaaattcacttttcaggaataatcccatcagtttaaattggatattgg       c.-1201

 .         .         .         .         .         .                g.7016
 aatgagcattgattacatttaacttggtagcccaaaatttcttcatggggttttgaactc       c.-1141

 .         .         .         .         .         .                g.7076
 ggcgggatttcaaaggttttaaaaatgagtttttgattttttttaaaaccctcaaatttc       c.-1081

 .         .         .         .         .         .                g.7136
 attacctttaaactaggtcgaaacggggcgcaagagattggattaacaccatagtaatac       c.-1021

 .         .         .         .         .         .                g.7196
 ttattttgttcttaaccatttcagggcttcttgaaatagaggctgtatggtgtaatggaa       c.-961

 .         .         .         .         .         .                g.7256
 aaaacagccttggaatctgggagcctgattcctggattcagtcccagttttgcgtgacct       c.-901

 .         .         .         .         .         .                g.7316
 tgggcaagttactttacttctctgaatttccgtttcctcctctgcaaaatgaggatcgca       c.-841

 .         .         .         .         .         .                g.7376
 atagccaccttgcaaccttgactggagcgagcctcgcacaccccgcgccggcctggagga       c.-781

 .         .         .         .         .         .                g.7436
 agagcagccatgattacgccgccttcgctccgctacccgcttgcggctggcgccctcctc       c.-721

 .         .         .         .         .         .                g.7496
 cagcaggtgtaggcgctgccgcgctgccccacgcctttccgccgctcgcgggcctgcgcc       c.-661

 .         .         .         .         .         .                g.7556
 tcggcgtccccgaggaggccgctgcgggctgaggtagcgcaccggcctctcggcgtccca       c.-601

 .         .         .         .         .         .                g.7616
 gtccggtcccgggcggagggaaagcgggcgacccacctccgaggcagaagccgaggcccg       c.-541

 .         .         .         .         .         .                g.7676
 gccccgccgagtgcggaggagcgcaggcagcccccgcccctcggccctccccccggccct       c.-481

 .         .         .         .         .         .                g.7736
 cccggccctccctccgccccctccgccctcgcgcgccgcccgcccgggtcgccgcggggc       c.-421

 .         .         .         .         .         .                g.7796
 cgtggtgtacgtgcagagcgcgcagagcgagtggcgcccgtatgccctgcgctcctccac       c.-361

 .         .         .         .         .         .                g.7856
 agcctgggccgggccgcccgggacgctgaggcggcggcggcggccgagggggccggtctt       c.-301

 .         .         .         .         .         .                g.7916
 gcgctccccaggcccgcgcgcctgagcccaggttgccattcgccgcacaggccctattct       c.-241

 .         .         .         .         .         .                g.7976
 ctcagccctcggcggcgatgaggcgctgaggcggctgccggcgctgcgccggagcttagg       c.-181

 .         .         .         .         .         .                g.8036
 actcggaagcggccgggccgagggcgtggggtgccggcctccctgaggcgagggtagcgg       c.-121

 .         .         .         .         .         .                g.8096
 gtgcatggcgcagtaacggcccctatctctctccccgctccccagcctcgggcgaggccg       c.-61

 .         .         .         .         .         .                g.8156
 tccggccgctacccctcctgctcggccgccgcagtcgccgtcgccgccgccgccgccgcc       c.-1

          .         .         .         .         .         .       g.8216
 ATGGCCAATGACAGCGGCGGGCCCGGCGGGCCGAGCCCGAGCGAGCGAGACCGGCAGTAC       c.60
 M  A  N  D  S  G  G  P  G  G  P  S  P  S  E  R  D  R  Q  Y         p.20

          .         .         .         .         .         .       g.8276
 TGCGAGCTGTGCGGGAAGATGGAGAACCTGCTGCGCTGCAGCCGCTGCCGCAGCTCCTTC       c.120
 C  E  L  C  G  K  M  E  N  L  L  R  C  S  R  C  R  S  S  F         p.40

          .         .         .         .         .         .       g.8336
 TACTGCTGCAAGGAGCACCAGCGTCAGGACTGGAAGAAGCACAAGCTCGTGTGCCAGGGC       c.180
 Y  C  C  K  E  H  Q  R  Q  D  W  K  K  H  K  L  V  C  Q  G         p.60

          .         .         .         .         .         .       g.8396
 AGCGAGGGCGCCCTCGGCCACGGAGTGGGCCCACACCAGCATTCCGGCCCCGCGCCGCCG       c.240
 S  E  G  A  L  G  H  G  V  G  P  H  Q  H  S  G  P  A  P  P         p.80

          .         .         .         .         .         .       g.8456
 GCTGCAGTGCCGCCGCCCAGGGCCGGGGCCCGGGAGCCCAGGAAGGCAGCGGCGCGCCGG       c.300
 A  A  V  P  P  P  R  A  G  A  R  E  P  R  K  A  A  A  R  R         p.100

          .         .         .         .         .         .       g.8516
 GACAACGCCTCCGGGGACGCGGCCAAGGGAAAAGTAAAGGCCAAGCCCCCGGCCGACCCA       c.360
 D  N  A  S  G  D  A  A  K  G  K  V  K  A  K  P  P  A  D  P         p.120

          .         .         .         .         .         .       g.8576
 GCGGCGGCCGCGTCGCCGTGTCGTGCGGCCGCCGGCGGCCAGGGCTCGGCGGTGGCTGCC       c.420
 A  A  A  A  S  P  C  R  A  A  A  G  G  Q  G  S  A  V  A  A         p.140

          .         .         .         .         .         .       g.8636
 GAAGCCGAGCCCGGCAAGGAGGAGCCGCCGGCCCGCTCATCGCTGTTCCAGGAGAAGGCG       c.480
 E  A  E  P  G  K  E  E  P  P  A  R  S  S  L  F  Q  E  K  A         p.160

          .         .         .         .         .         .       g.8696
 AACCTGTACCCCCCAAGCAACACGCCCGGGGATGCGCTGAGCCCCGGCGGCGGCCTGCGG       c.540
 N  L  Y  P  P  S  N  T  P  G  D  A  L  S  P  G  G  G  L  R         p.180

          .         .         .         .         .         .       g.8756
 CCCAACGGGCAGACGAAGCCCCTGCCGGCGCTGAAGCTGGCGCTCGAGTACATCGTGCCG       c.600
 P  N  G  Q  T  K  P  L  P  A  L  K  L  A  L  E  Y  I  V  P         p.200

          .         .         .         .         .         .       g.8816
 TGCATGAACAAGCACGGCATCTGTGTGGTGGACGACTTCCTCGGCAAGGAGACCGGACAG       c.660
 C  M  N  K  H  G  I  C  V  V  D  D  F  L  G  K  E  T  G  Q         p.220

          .         .         .         .         .         .       g.8876
 CAGATCGGCGACGAGGTGCGCGCCCTGCACGACACCGGGAAGTTCACGGACGGGCAGCTG       c.720
 Q  I  G  D  E  V  R  A  L  H  D  T  G  K  F  T  D  G  Q  L         p.240

          .         .         .         .         .         .       g.8936
 GTCAGCCAGAAGAGTGACTCGTCCAAGGACATCCGAGGCGATAAGATCACCTGGATCGAG       c.780
 V  S  Q  K  S  D  S  S  K  D  I  R  G  D  K  I  T  W  I  E         p.260

          .         .         .         .         .         .       g.8996
 GGCAAGGAGCCCGGCTGCGAAACCATTGGGCTGCTCATGAGCAGCATGGACGACCTGATA       c.840
 G  K  E  P  G  C  E  T  I  G  L  L  M  S  S  M  D  D  L  I         p.280

          .         .         .         .         .  | 02      .    g.55954
 CGCCACTGTAACGGGAAGCTGGGCAGCTACAAAATCAATGGCCGGACGAAA | GCCATGGTT    c.900
 R  H  C  N  G  K  L  G  S  Y  K  I  N  G  R  T  K   | A  M  V      p.300

          .         .         .         .         .         .       g.56014
 GCTTGTTATCCGGGCAATGGAACGGGTTATGTACGTCATGTTGATAATCCAAATGGAGAT       c.960
 A  C  Y  P  G  N  G  T  G  Y  V  R  H  V  D  N  P  N  G  D         p.320

          .         .         .         .         .  | 03      .    g.59355
 GGAAGATGTGTGACATGTATATATTATCTTAATAAAGACTGGGATGCCAAG | GTAAGTGGA    c.1020
 G  R  C  V  T  C  I  Y  Y  L  N  K  D  W  D  A  K   | V  S  G      p.340

          .         .         .         .         .         .       g.59415
 GGTATACTTCGAATTTTTCCAGAAGGCAAAGCCCAGTTTGCTGACATTGAACCCAAATTT       c.1080
 G  I  L  R  I  F  P  E  G  K  A  Q  F  A  D  I  E  P  K  F         p.360

          .         .         .         .         .         .       g.59475
 GATAGACTGCTGTTTTTCTGGTCTGACCGTCGCAACCCTCATGAAGTACAACCAGCATAT       c.1140
 D  R  L  L  F  F  W  S  D  R  R  N  P  H  E  V  Q  P  A  Y         p.380

          | 04         .         .         .         .         .    g.62460
 GCTACAAG | GTACGCAATAACTGTTTGGTATTTTGATGCAGATGAGAGAGCACGAGCTAAA    c.1200
 A  T  R  |  Y  A  I  T  V  W  Y  F  D  A  D  E  R  A  R  A  K      p.400

          .       | 05 .         .         .         .         .    g.63613
 GTAAAATATCTAACAG | GTGAAAAAGGTGTGAGGGTTGAACTCAATAAACCTTCAGATTCG    c.1260
 V  K  Y  L  T  G |   E  K  G  V  R  V  E  L  N  K  P  S  D  S      p.420

          .         .                                               g.63634
 GTCGGTAAAGACGTCTTCTAG                                              c.1281
 V  G  K  D  V  F  X                                                p.426

          .         .         .         .         .         .       g.63694
 agcctttgatccagcaataccccacttcacctacaatattgttaactatttgttaacttg       c.*60

          .         .         .         .         .         .       g.63754
 tgaatacgaataaatgggataaagaaaaatagacaaccagttcgcattttaataaggaaa       c.*120

          .         .         .         .         .         .       g.63814
 cagaaacaactttttgtgttgcatcaaacagaagattttgactgctgtgactttgtactg       c.*180

          .         .         .         .         .         .       g.63874
 catgatcaacttcaaatctgtgattgcttacaggaggaagataagctactaattgaaaat       c.*240

          .         .         .         .         .         .       g.63934
 ggtttttacatctggatatgaaataagtgccctgtgtagaatttttttcattcttatatt       c.*300

          .         .         .         .         .         .       g.63994
 ttgccagatctgttatctagctgagttcatttcatctctcccttttttatatcaagtttg       c.*360

          .         .         .         .         .         .       g.64054
 aatttgggataatttttctatattaggtacaatttatctaaactgaattgagaaaaaatt       c.*420

          .         .         .         .         .         .       g.64114
 acagtattattcctcaaaataacatcaatctatttttgtaaacctgttcatactattaaa       c.*480

          .         .         .         .         .         .       g.64174
 ttttgccctaaaagacctcttaataatgattgttgccagtgactgatgattaattttatt       c.*540

          .         .         .         .         .         .       g.64234
 ttacttaaaataagaaaaggagcactttaattacaactgaaaaatcagattgttttgtag       c.*600

          .         .         .         .         .         .       g.64294
 tccttccttacactaatttgaactgttaaagattgctgctttttttttgacattgtcaat       c.*660

          .         .         .         .         .         .       g.64354
 aacgaaacctaattgtaaaacagtcaccatttactaccaataacttttagttaatgtttt       c.*720

          .         .         .         .         .         .       g.64414
 acaaggaaaaagacacaagaagagtttaaatttttttgttttgttttgtttttttgagac       c.*780

          .         .         .         .         .         .       g.64474
 agtcttgctctgttacccaggctggaggggagtggtgcattcttggctcactgcaacctc       c.*840

          .         .         .         .         .         .       g.64534
 cgcctcccaggttcaagcaatcctcccacctcagcctcccaactagctgggactgcaggc       c.*900

          .         .         .         .         .         .       g.64594
 acacaccaccatgcctgactaatttttgtatgtttagtagagacggggttttgccatgtt       c.*960

          .         .         .         .         .         .       g.64654
 gcctaggctggggtttaagttaaattttttaaaaaactaaagtgactggcactaagtgaa       c.*1020

          .         .         .         .         .         .       g.64714
 cttgagattatcctcagcttcaagttcctaagataagggctttcttaagctttcaggtgt       c.*1080

          .         .         .         .         .         .       g.64774
 atgtatcctctagatgtagacaataatgtcccatttctaagtcttttccttttgcttctc       c.*1140

          .         .         .         .         .         .       g.64834
 cttaaattgattgtacttccaaatttgctgttatgtttttttcctaatactgtgatctat       c.*1200

          .         .         .         .         .         .       g.64894
 ctgatctgcagacaagaaccttgtctctgttgaagagcatcaaggggagattatgtacac       c.*1260

          .         .         .         .         .         .       g.64954
 attgaaactgaagtgtggtgttactgacggaatgtgcagtaactcctcagatatctgtta       c.*1320

          .         .         .         .         .         .       g.65014
 aggcatttcccagatgtgatgccagccttcttacctgtactgaaagatgcttagcttaga       c.*1380

          .         .         .         .         .         .       g.65074
 aaaaaacaaaacagatgcaaaatcagataattttattttgtttcatgggttttcttattt       c.*1440

          .         .         .         .         .         .       g.65134
 actttttaaacaaggaaggaatattagaaaatcacacaaggcctcacatacatgttattt       c.*1500

          .         .         .         .         .         .       g.65194
 aaagaatgaattgggacggatgtcttagacttcactttcctaggctttttagcaaaacct       c.*1560

          .         .         .         .         .         .       g.65254
 aaagggtggtatccatattttgcgtgaattatgggtgtaagaccttgcccacttaggttt       c.*1620

          .         .         .         .         .         .       g.65314
 tctatctctgtccttgatcttctttgccaaaatgtgagtatacagaaattttctgtatat       c.*1680

          .         .         .         .         .         .       g.65374
 ttcaacttaagacatttttagcatctgtatagtttgtattcaatttgagaccttttctat       c.*1740

          .         .         .         .         .         .       g.65434
 gggaagctcagtaatttttattaaaagattgccattgctattcatgtaaaacatggaaaa       c.*1800

          .         .         .         .         .         .       g.65494
 aaattgtgtagtgaagccaacagtggacttaggatgggattgaatgttcagtatagtgat       c.*1860

          .         .         .         .         .         .       g.65554
 ctcacttaggagaatttgcaggagaaagtgatagtttattgttttttcctcgcccatatt       c.*1920

          .         .         .         .         .         .       g.65614
 cagttttgttctacttcctccccttccttccagatgataacatcacatctctacagtaag       c.*1980

          .         .         .         .         .         .       g.65674
 tgcctctgccagcccaacccaggagcgcaagttgtctttgccatctggtctatagtacag       c.*2040

          .         .         .         .         .         .       g.65734
 tgcgcggcgttaggccacaactcaaaagcattatcttttttagggttagtagaaattgtt       c.*2100

          .         .         .         .         .         .       g.65794
 ttatgttgatgggaggtttgtttgattgtcaaaatgtacagccacagccttttaatttgg       c.*2160

          .         .         .         .         .         .       g.65854
 gagcccctgttgtcattcaaatgtgtacctctacagttgtaaaaagtattagattctact       c.*2220

          .         .         .         .         .         .       g.65914
 atctgtgggttgtgcttgccagacaggtcttaaattgtatattttttggaaaagtttata       c.*2280

          .         .         .         .         .         .       g.65974
 tactctcttaggaatcattgtgaaaagatcaagaaatcaggatggccatttatttaatat       c.*2340

          .         .         .         .         .         .       g.66034
 ccattcatttcatgttagtgggactattaacttgtcaccaagcaggactctatttcaaac       c.*2400

          .         .         .         .         .         .       g.66094
 aaaatttaaaactgtttgtggcctatatgtgtttaatcctggttaaagataaagcttcat       c.*2460

          .         .         .         .         .         .       g.66154
 aatgctgtttttattcaacacattaaccagctgtaaaacacagacctttatcaagagtag       c.*2520

          .         .         .         .         .         .       g.66214
 gcaaagattttcaggattcatatacagatagactataaagtcatgtaatttgaaaagcag       c.*2580

          .         .         .         .         .         .       g.66274
 tgtttcattatgaaagagctctcaagttgcttgtaaagctaatctaattaaaaagatgta       c.*2640

          .         .                                               g.66294
 taaatgttgttgaaacatta                                               c.*2660

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Egl nine homolog 1 (C. elegans) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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