early growth response 2 (EGR2) - coding DNA reference sequence

(used for variant description)

(last modified February 5, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_000399.3 in the EGR2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008936.2, covering EGR2 transcript NM_000399.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.108571
                        aactgagcgaggagcaattgattaatagctcggcgag       c.-301

 .         .         .         .         .         .                g.108631
 gggactcactgactgttataataacactacaccagcaactcctggcttcccagcagccgg       c.-241

 .         .         .         .         .         .                g.108691
 aacacagacaggagagagtcagtggcaaatagacatttttcttatttcttaaaaaacagc       c.-181

 .         .         .         .         .         .                g.108751
 aacttgtttgctacttttatttctgttgatttttttttcttggtgtgtgtggtggttgtt       c.-121

 .         .         .         .         .         .                g.108811
 tttaagtgtggagggcaaaaggagataccatcccaggctcagtccaacccctctccaaaa       c.-61

 .         .         .         .         .         .                g.108871
 cggcttttctgacactccaggtagcgagggagttgggtctccaggttgtgcgaggagcaa       c.-1

          .         .         .         .         .         .       g.108931
 ATGATGACCGCCAAGGCCGTAGACAAAATCCCAGTAACTCTCAGTGGTTTTGTGCACCAG       c.60
 M  M  T  A  K  A  V  D  K  I  P  V  T  L  S  G  F  V  H  Q         p.20

          .         .         .         .         .         .       g.108991
 CTGTCTGACAACATCTACCCGGTGGAGGACCTCGCCGCCACGTCGGTGACCATCTTTCCC       c.120
 L  S  D  N  I  Y  P  V  E  D  L  A  A  T  S  V  T  I  F  P         p.40

          .         .         .         .          | 02        .    g.110443
 AATGCCGAACTGGGAGGCCCCTTTGACCAGATGAACGGAGTGGCCGGAG | ATGGCATGATC    c.180
 N  A  E  L  G  G  P  F  D  Q  M  N  G  V  A  G  D |   G  M  I      p.60

          .         .         .         .         .         .       g.110503
 AACATTGACATGACTGGAGAGAAGAGGTCGTTGGATCTCCCATATCCCAGCAGCTTTGCT       c.240
 N  I  D  M  T  G  E  K  R  S  L  D  L  P  Y  P  S  S  F  A         p.80

          .         .         .         .         .         .       g.110563
 CCCGTCTCTGCACCTAGAAACCAGACCTTCACTTACATGGGCAAGTTCTCCATTGACCCT       c.300
 P  V  S  A  P  R  N  Q  T  F  T  Y  M  G  K  F  S  I  D  P         p.100

          .         .         .         .         .         .       g.110623
 CAGTACCCTGGTGCCAGCTGCTACCCAGAAGGCATAATCAATATTGTGAGTGCAGGCATC       c.360
 Q  Y  P  G  A  S  C  Y  P  E  G  I  I  N  I  V  S  A  G  I         p.120

          .         .         .         .         .         .       g.110683
 TTGCAAGGGGTCACTTCCCCAGCTTCAACCACAGCCTCATCCAGCGTCACCTCTGCCTCC       c.420
 L  Q  G  V  T  S  P  A  S  T  T  A  S  S  S  V  T  S  A  S         p.140

          .         .         .         .         .         .       g.110743
 CCCAACCCACTGGCCACAGGACCCCTGGGTGTGTGCACCATGTCCCAGACCCAGCCTGAC       c.480
 P  N  P  L  A  T  G  P  L  G  V  C  T  M  S  Q  T  Q  P  D         p.160

          .         .         .         .         .         .       g.110803
 CTGGACCACCTGTACTCTCCGCCACCGCCTCCTCCTCCTTATTCTGGCTGTGCAGGAGAC       c.540
 L  D  H  L  Y  S  P  P  P  P  P  P  P  Y  S  G  C  A  G  D         p.180

          .         .         .         .         .         .       g.110863
 CTCTACCAGGACCCTTCTGCGTTCCTGTCAGCAGCCACCACCTCCACCTCTTCCTCTCTG       c.600
 L  Y  Q  D  P  S  A  F  L  S  A  A  T  T  S  T  S  S  S  L         p.200

          .         .         .         .         .         .       g.110923
 GCCTACCCACCACCTCCTTCCTATCCATCCCCCAAGCCAGCCACGGACCCAGGTCTCTTC       c.660
 A  Y  P  P  P  P  S  Y  P  S  P  K  P  A  T  D  P  G  L  F         p.220

          .         .         .         .         .         .       g.110983
 CCAATGATCCCAGACTATCCTGGATTCTTTCCATCTCAGTGCCAGAGAGACCTACATGGT       c.720
 P  M  I  P  D  Y  P  G  F  F  P  S  Q  C  Q  R  D  L  H  G         p.240

          .         .         .         .         .         .       g.111043
 ACAGCTGGCCCAGACCGTAAGCCCTTTCCCTGCCCACTGGACACCCTGCGGGTGCCCCCT       c.780
 T  A  G  P  D  R  K  P  F  P  C  P  L  D  T  L  R  V  P  P         p.260

          .         .         .         .         .         .       g.111103
 CCACTCACTCCACTCTCTACAATCCGTAACTTTACCCTGGGGGGCCCCAGTGCTGGGGTG       c.840
 P  L  T  P  L  S  T  I  R  N  F  T  L  G  G  P  S  A  G  V         p.280

          .         .         .         .         .         .       g.111163
 ACCGGACCAGGGGCCAGTGGAGGCAGCGAGGGACCCCGGCTGCCTGGTAGCAGCTCAGCA       c.900
 T  G  P  G  A  S  G  G  S  E  G  P  R  L  P  G  S  S  S  A         p.300

          .         .         .         .         .         .       g.111223
 GCAGCAGCAGCCGCCGCCGCCGCCGCCTATAACCCACACCACCTGCCACTGCGGCCCATT       c.960
 A  A  A  A  A  A  A  A  A  Y  N  P  H  H  L  P  L  R  P  I         p.320

          .         .         .         .         .         .       g.111283
 CTGAGGCCTCGCAAGTACCCCAACAGACCCAGCAAGACGCCGGTGCACGAGAGGCCCTAC       c.1020
 L  R  P  R  K  Y  P  N  R  P  S  K  T  P  V  H  E  R  P  Y         p.340

          .         .         .         .         .         .       g.111343
 CCGTGCCCAGCAGAAGGCTGCGACCGGCGGTTCTCCCGCTCTGACGAGCTGACACGGCAC       c.1080
 P  C  P  A  E  G  C  D  R  R  F  S  R  S  D  E  L  T  R  H         p.360

          .         .         .         .         .         .       g.111403
 ATCCGAATCCACACTGGGCATAAGCCCTTCCAGTGTCGGATCTGCATGCGCAACTTCAGC       c.1140
 I  R  I  H  T  G  H  K  P  F  Q  C  R  I  C  M  R  N  F  S         p.380

          .         .         .         .         .         .       g.111463
 CGCAGTGACCACCTCACCACCCATATCCGCACCCACACCGGTGAGAAGCCCTTCGCCTGT       c.1200
 R  S  D  H  L  T  T  H  I  R  T  H  T  G  E  K  P  F  A  C         p.400

          .         .         .         .         .         .       g.111523
 GACTACTGTGGCCGAAAGTTTGCCCGGAGTGATGAGAGGAAGCGCCACACCAAGATCCAC       c.1260
 D  Y  C  G  R  K  F  A  R  S  D  E  R  K  R  H  T  K  I  H         p.420

          .         .         .         .         .         .       g.111583
 CTGAGACAGAAAGAGCGGAAAAGCAGTGCCCCCTCTGCATCGGTGCCAGCCCCCTCTACA       c.1320
 L  R  Q  K  E  R  K  S  S  A  P  S  A  S  V  P  A  P  S  T         p.440

          .         .         .         .         .         .       g.111643
 GCCTCCTGCTCTGGGGGCGTGCAGCCTGGGGGTACCCTGTGCAGCAGTAACAGCAGCAGT       c.1380
 A  S  C  S  G  G  V  Q  P  G  G  T  L  C  S  S  N  S  S  S         p.460

          .         .         .         .         .                 g.111694
 CTTGGCGGAGGGCCGCTCGCCCCTTGCTCCTCTCGGACCCGGACACCTTGA                c.1431
 L  G  G  G  P  L  A  P  C  S  S  R  T  R  T  P  X                  p.476

          .         .         .         .         .         .       g.111754
 gatgagactcaggctgatacaccagctcccaaaggtcccggaggccctttgtccactgga       c.*60

          .         .         .         .         .         .       g.111814
 gctgcacaacaaacactaccaccctttcctgtccctctctccctttgttgggcaaagggc       c.*120

          .         .         .         .         .         .       g.111874
 tttggtggagctagcactgccccctttccacctagaagcaggttcttcctaaaacttagc       c.*180

          .         .         .         .         .         .       g.111934
 ccattctagtctctcttaggtgagttgactatcaacccaaggcaaaggggaggctcagaa       c.*240

          .         .         .         .         .         .       g.111994
 ggaggtggtgtggggacccctggccaagagggctgaggtctgaccctgctttaaagggtt       c.*300

          .         .         .         .         .         .       g.112054
 gtttgactaggttttgctaccccacttccccttattttgacccatcacaggtttttgacc       c.*360

          .         .         .         .         .         .       g.112114
 ctggatgtcagagttgatctaagacgttttctacaataggttgggagatgctgatccctt       c.*420

          .         .         .         .         .         .       g.112174
 caagtggggacagcaaaaagacaagcaaaactgatgtgcactttatggcttgggactgat       c.*480

          .         .         .         .         .         .       g.112234
 ttgggggacattgtacagtgagtgaagtatagcctttatgccacactctgtggccctaaa       c.*540

          .         .         .         .         .         .       g.112294
 atggtgaatcagagcatatctagttgtctcaacccttgaagcaatatgtattataaactc       c.*600

          .         .         .         .         .         .       g.112354
 agagaacagaagtgcaatgtgatgggaggaacatagcaatatctgctccttttcgagttg       c.*660

          .         .         .         .         .         .       g.112414
 tttgagaaatgtaggctattttttcagtgtatatccactcagattttgtgtatttttgat       c.*720

          .         .         .         .         .         .       g.112474
 gtacactgttctctaaattctgaatctttgggaaaaaatgtaaagcatttatgatctcag       c.*780

          .         .         .         .         .         .       g.112534
 aggttaacttatttaagggggatgtacatatattctctgaaactaggatgcatgcaattg       c.*840

          .         .         .         .         .         .       g.112594
 tgttggaagtgtccttggtgccttgtgtgatgtagacaatgttacaaggtctgcatgtaa       c.*900

          .         .         .         .         .         .       g.112654
 atgggttgccttattatggagaaaaaaatcactccctgagtttagtatggctgtatattt       c.*960

          .         .         .         .         .         .       g.112714
 ctgcctattaatatttggaattttttttagaaagtatatttttgtatgctttgttttgtg       c.*1020

          .         .         .         .         .         .       g.112774
 acttaaaagtgttacctttgtagtcaaatttcagataagaatgtacataatgttaccgga       c.*1080

          .         .         .         .         .         .       g.112834
 gctgatttgtttggtcattagctcttaatagttgtgaaaaaataaatctattctaacgca       c.*1140

          .         .         .         .         .         .       g.112894
 aaaccactaactgaagttcagataatggatggtttgtgactatagtgtaaataaatactt       c.*1200

          .                                                         g.112904
 ttcaacaata                                                         c.*1210

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Early growth response 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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