enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (EHHADH) - coding DNA reference sequence

(used for variant description)

(last modified September 7, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_001966.3 in the EHHADH gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_015999.1, covering EHHADH transcript NM_001966.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5016
                                             gaggaggccgggcgcg       c.-61

 .         .         .         .         .         .                g.5076
 cccggaaaagtggtttgcctgacggcgagaggcagaggtgccctcggtgatagaggaaac       c.-1

          .         .         .         .         .         .       g.5136
 ATGGCCGAGTATACGCGGCTGCACAACGCCTTGGCGCTAATCCGCCTCCGAAACCCGCCG       c.60
 M  A  E  Y  T  R  L  H  N  A  L  A  L  I  R  L  R  N  P  P         p.20

          .     | 02   .         .         .         .         .    g.10627
 GTCAACGCGATCAG | TACGACTTTACTCCGTGACATAAAAGAAGGACTACAGAAAGCTGTA    c.120
 V  N  A  I  S  |  T  T  L  L  R  D  I  K  E  G  L  Q  K  A  V      p.40

          .         .         .         .         .         | 03    g.23638
 ATAGACCATACAATAAAAGCCATTGTGATTTGTGGAGCAGAGGGCAAATTTTCTGCAG | GT    c.180
 I  D  H  T  I  K  A  I  V  I  C  G  A  E  G  K  F  S  A  G |       p.60

          .         .         .         .         .         .       g.23698
 GCTGATATTCGTGGCTTCAGTGCTCCTAGGACATTTGGCCTTACACTGGGACATGTAGTA       c.240
 A  D  I  R  G  F  S  A  P  R  T  F  G  L  T  L  G  H  V  V         p.80

          .         .         .         .         .         .       g.23758
 GATGAAATACAGAGAAATGAGAAGCCCGTGGTGGCAGCAATCCAAGGCATGGCTTTCGGA       c.300
 D  E  I  Q  R  N  E  K  P  V  V  A  A  I  Q  G  M  A  F  G         p.100

          .         .         .         .         .  | 04      .    g.29564
 GGGGGACTAGAGCTGGCCCTGGGCTGTCACTATAGGATTGCCCACGCAGAG | GCTCAAGTT    c.360
 G  G  L  E  L  A  L  G  C  H  Y  R  I  A  H  A  E   | A  Q  V      p.120

          .         .         .         .         .         .       g.29624
 GGCTTACCAGAAGTTACACTGGGACTTCTCCCTGGTGCAAGAGGAACCCAGCTTCTCCCC       c.420
 G  L  P  E  V  T  L  G  L  L  P  G  A  R  G  T  Q  L  L  P         p.140

          .         .         .         .    | 05    .         .    g.40875
 AGACTCACTGGAGTTCCTGCTGCACTTGACTTAATTACCTCAG | GAAGACGTATTTTAGCA    c.480
 R  L  T  G  V  P  A  A  L  D  L  I  T  S  G |   R  R  I  L  A      p.160

          .         .         .         .         .         .       g.40935
 GATGAAGCACTCAAGCTGGGCATTCTAGATAAAGTTGTAAACTCAGACCCGGTTGAAGAA       c.540
 D  E  A  L  K  L  G  I  L  D  K  V  V  N  S  D  P  V  E  E         p.180

          .         .         | 06         .         .         .    g.54373
 GCAATCAGATTTGCTCAGAGAGTTTCAG | ATCAACCTCTAGAATCCCGTAGACTCTGCAAC    c.600
 A  I  R  F  A  Q  R  V  S  D |   Q  P  L  E  S  R  R  L  C  N      p.200

          .         .         .         .         .         .       g.54433
 AAGCCAATTCAGAGCTTGCCCAACATGGACAGCATTTTTAGTGAGGCCCTCTTGAAGATG       c.660
 K  P  I  Q  S  L  P  N  M  D  S  I  F  S  E  A  L  L  K  M         p.220

          .         .         .         .         .         .       g.54493
 CGGAGGCAGCACCCTGGGTGTCTTGCACAGGAGGCTTGTGTCCGTGCAGTCCAGGCTGCT       c.720
 R  R  Q  H  P  G  C  L  A  Q  E  A  C  V  R  A  V  Q  A  A         p.240

          .         .         .         .         .         .       g.54553
 GTGCAGTATCCCTATGAAGTGGGCATCAAGAAGGAGGAGGAGCTGTTTCTATATCTTTTG       c.780
 V  Q  Y  P  Y  E  V  G  I  K  K  E  E  E  L  F  L  Y  L  L         p.260

          .         .         .         .         .         .       g.54613
 CAATCAGGGCAGGCTAGAGCCCTGCAATATGCTTTCTTCGCTGAAAGGAAAGCAAATAAG       c.840
 Q  S  G  Q  A  R  A  L  Q  Y  A  F  F  A  E  R  K  A  N  K         p.280

          .         .         .         .         .         .       g.54673
 TGGTCAACTCCCTCCGGAGCATCGTGGAAAACAGCATCAGCGCGGCCTGTCTCCTCAGTT       c.900
 W  S  T  P  S  G  A  S  W  K  T  A  S  A  R  P  V  S  S  V         p.300

          . | 07       .         .         .         .         .    g.65661
 GGTGTTGTTG | GCTTGGGAACAATGGGCCGAGGCATTGTCATTTCTTTTGCAAGGGCCAGG    c.960
 G  V  V  G |   L  G  T  M  G  R  G  I  V  I  S  F  A  R  A  R      p.320

          .         .         .         .         .         .       g.65721
 ATTCCTGTGATTGCTGTAGACTCGGACAAAAACCAGCTAGCAACTGCAAACAAGATGATA       c.1020
 I  P  V  I  A  V  D  S  D  K  N  Q  L  A  T  A  N  K  M  I         p.340

          .         .         .         .         .         .       g.65781
 ACCTCTGTCTTGGAAAAAGAAGCCTCCAAAATGCAACAGAGCGGCCACCCTTGGTCAGGA       c.1080
 T  S  V  L  E  K  E  A  S  K  M  Q  Q  S  G  H  P  W  S  G         p.360

          .         .         .         .         .         .       g.65841
 CCAAAACCCAGGTTAACTTCATCTGTGAAGGAGCTTGGTGGTGTAGATTTAGTCATTGAA       c.1140
 P  K  P  R  L  T  S  S  V  K  E  L  G  G  V  D  L  V  I  E         p.380

          .         .         .         .         .         .       g.65901
 GCAGTATTTGAGGAAATGAGCCTGAAGAAGCAGGTCTTTGCTGAACTCTCAGCTGTGTGC       c.1200
 A  V  F  E  E  M  S  L  K  K  Q  V  F  A  E  L  S  A  V  C         p.400

          .         .         .         .         .         .       g.65961
 AAACCAGAAGCATTTTTGTGCACTAATACTTCAGCCCTGGATGTTGATGAGATTGCTTCT       c.1260
 K  P  E  A  F  L  C  T  N  T  S  A  L  D  V  D  E  I  A  S         p.420

          .         .         .         .         .         .       g.66021
 TCCACTGATCGTCCTCACTTGGTCATTGGCACCCACTTCTTTTCGCCAGCTCATGTCATG       c.1320
 S  T  D  R  P  H  L  V  I  G  T  H  F  F  S  P  A  H  V  M         p.440

          .         .         .         .         .         .       g.66081
 AAGTTGTTAGAGGTTATTCCCAGCCAATACTCTTCCCCCACTACCATTGCCACTGTTATG       c.1380
 K  L  L  E  V  I  P  S  Q  Y  S  S  P  T  T  I  A  T  V  M         p.460

          .         .         .         .         .         .       g.66141
 AACTTATCAAAAAAGATTAAAAAGATTGGAGTCGTTGTAGGCAACTGTTTTGGATTTGTG       c.1440
 N  L  S  K  K  I  K  K  I  G  V  V  V  G  N  C  F  G  F  V         p.480

          .         .         .         .         .         .       g.66201
 GGGAATCGAATGTTGAATCCTTACTACAATCAGGCATATTTCTTGTTAGAAGAAGGCAGC       c.1500
 G  N  R  M  L  N  P  Y  Y  N  Q  A  Y  F  L  L  E  E  G  S         p.500

          .         .         .         .         .         .       g.66261
 AAACCAGAGGAGGTAGATCAGGTGCTGGAAGAGTTTGGTTTTAAAATGGGACCTTTTAGA       c.1560
 K  P  E  E  V  D  Q  V  L  E  E  F  G  F  K  M  G  P  F  R         p.520

          .         .         .         .         .         .       g.66321
 GTGTCTGATCTTGCTGGGTTGGATGTGGGCTGGAAATCTAGAAAGGGGCAAGGTCTTACT       c.1620
 V  S  D  L  A  G  L  D  V  G  W  K  S  R  K  G  Q  G  L  T         p.540

          .         .         .         .         .         .       g.66381
 GGACCTACATTGCTTCCAGGAACTCCTGCCCGAAAAAGGGGTAATAGGAGGTACTGCCCA       c.1680
 G  P  T  L  L  P  G  T  P  A  R  K  R  G  N  R  R  Y  C  P         p.560

          .         .         .         .         .         .       g.66441
 ATTCCTGATGTGCTCTGTGAATTAGGACGATTTGGCCAGAAGACAGGTAAGGGTTGGTAT       c.1740
 I  P  D  V  L  C  E  L  G  R  F  G  Q  K  T  G  K  G  W  Y         p.580

          .         .         .         .         .         .       g.66501
 CAATATGACAAGCCATTGGGTAGGATTCACAAACCTGATCCCTGGCTTTCCAAATTCCTA       c.1800
 Q  Y  D  K  P  L  G  R  I  H  K  P  D  P  W  L  S  K  F  L         p.600

          .         .         .         .         .         .       g.66561
 TCACGGTATAGAAAAACCCATCACATTGAACCACGTACCATTAGCCAGGATGAGATCCTT       c.1860
 S  R  Y  R  K  T  H  H  I  E  P  R  T  I  S  Q  D  E  I  L         p.620

          .         .         .         .         .         .       g.66621
 GAACGCTGCTTATATTCACTTATCAATGAAGCATTCCGTATCTTGGGAGAAGGGATAGCT       c.1920
 E  R  C  L  Y  S  L  I  N  E  A  F  R  I  L  G  E  G  I  A         p.640

          .         .         .         .         .         .       g.66681
 GCTAGCCCAGAGCACATTGATGTTGTCTATTTACATGGATATGGATGGCCAAGGCACAAG       c.1980
 A  S  P  E  H  I  D  V  V  Y  L  H  G  Y  G  W  P  R  H  K         p.660

          .         .         .         .         .         .       g.66741
 GGCGGGCCCATGTTCTATGCTTCCACAGTTGGGTTGCCCACAGTTCTAGAGAAATTGCAG       c.2040
 G  G  P  M  F  Y  A  S  T  V  G  L  P  T  V  L  E  K  L  Q         p.680

          .         .         .         .         .         .       g.66801
 AAATATTACAGGCAGAACCCTGATATTCCCCAACTGGAGCCAAGTGACTATCTAAAAAAA       c.2100
 K  Y  Y  R  Q  N  P  D  I  P  Q  L  E  P  S  D  Y  L  K  K         p.700

          .         .         .         .         .         .       g.66861
 CTGGCTTCTCAGGGAAACCCTCCCCTGAAAGAATGGCAAAGCTTGGCAGGCTCCCCTAGC       c.2160
 L  A  S  Q  G  N  P  P  L  K  E  W  Q  S  L  A  G  S  P  S         p.720

          .                                                         g.66873
 AGTAAATTGTGA                                                       c.2172
 S  K  L  X                                                         p.723

          .         .         .         .         .         .       g.66933
 ttcagtcttccagattatgcctcacatgctagcatcaggtaatgctgactgaatttcagt       c.*60

          .         .         .         .         .         .       g.66993
 gaaattaaatcaaaaatccaaagtaagattgttctgaaatacaaagcaaaataaataatc       c.*120

          .         .         .         .         .         .       g.67053
 attagaatcttctgtgtaacgactctaatggtcaaatctttaggaatgtgcttcctatgc       c.*180

          .         .         .         .         .         .       g.67113
 ctctgaatctgtccttatcagataaattcaatgcatgaacttgtgtgaatataataccat       c.*240

          .         .         .         .         .         .       g.67173
 aatagctaatgaaagaggctcaggcataagttgagattctcaaatgcttttatcattgga       c.*300

          .         .         .         .         .         .       g.67233
 taaatgtgtcatcaattaataaatgataaatgcagctaagtcatacattcattttgactc       c.*360

          .         .         .         .         .         .       g.67293
 ctttcaatgtcacacacatagtattgatcagaaatcttatgaatcatacatacactcaac       c.*420

          .         .         .         .         .         .       g.67353
 aaacattaaagttgtaggaaaaagacagttggaaattggtaagggaactgagtacttcaa       c.*480

          .         .         .         .         .         .       g.67413
 accagcacagggaacttaggttagtgtggcaagcctttcctcttctggtctttcctcttc       c.*540

          .         .         .         .         .         .       g.67473
 tgtttatggagaaataatagaaagtagtaagtcgttaacttagtgtaagaagggtcttag       c.*600

          .         .         .         .         .         .       g.67533
 agaacatctaaccttctaggatttcccaattctgtgatagagtaatgacaccagttttcc       c.*660

          .         .         .         .         .         .       g.67593
 tgtcatgacaagcctctgtgatgttacatatggaaatggttgaatcttgaaaaatctaaa       c.*720

          .         .         .         .         .         .       g.67653
 attgttgcaaaacatattttgtatgattttgttgtaagagttcttctctttttacttttt       c.*780

          .         .         .         .         .         .       g.67713
 gccttgtgtagttaaaaattaaggggctggtcaatacaaaaacttgtacacaaatattta       c.*840

          .         .         .         .         .         .       g.67773
 tagcagaattattcataatggccaaaagctgaatacaacccaaatgtctatgaactaatg       c.*900

          .         .         .         .         .         .       g.67833
 aatagataaaccaaatctggtatatccatacaatggactatattattcagccataaaaag       c.*960

          .         .         .         .         .         .       g.67893
 aaataaagggccaggcacagtggctcacacctgtaatcccagcactttgggaggctgagg       c.*1020

          .         .         .         .         .         .       g.67953
 caggaggattgtttgaggccagaaatttgagaccagcctgggcaacatagcaaaaccctg       c.*1080

          .         .         .         .         .         .       g.68013
 tctctacaaaaaatactttccgtacattagtggttgcctaaggctagaattgggggtgat       c.*1140

          .         .         .         .         .         .       g.68073
 gaatggggagtacaggattcatctaatgggtacaggatttctttatggttcatgaaaatg       c.*1200

          .         .         .         .         .         .       g.68133
 gtctaaacttattgtggtaatggtcacataacaatatattaaaaaccattgagttgtata       c.*1260

          .         .         .         .         .         .       g.68193
 ttttaagtgggtgaattatatggtatgtgaattatatctcaataaagttgttagtaaata       c.*1320

          .         .         .         .         .         .       g.68253
 aatggggctgaagatgttatccttcattgtggtgtaaatgaactttcacaatattttcac       c.*1380

          .         .         .         .         .         .       g.68313
 ctgtgaacccaaataaaatgattaaagttctgatggaaaaatcttgaatggagtataagt       c.*1440

          .         .         .         .         .         .       g.68373
 tttccgttgttaaaaagcaaacaaaaaaccaacaaaaaatccaagtgtgccttgaattgt       c.*1500

          .         .         .         .         .         .       g.68433
 acagagcacaattattatgtttgaaatgtgtactacttaattttatataatttggtttgt       c.*1560

          .         .         .         .                           g.68475
 gaaattaaagacatcaataaaaatgattcctgaaagtagtaa                         c.*1602

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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