eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1) - coding DNA reference sequence

(used for variant description)

(last modified April 5, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_014413.3 in the EIF2AK1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000007.13, covering EIF2AK1 transcript NM_014413.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5026
                                   ccccagtgaaggtgcgcgcgtggcgg       c.-121

 .         .         .         .         .         .                g.5086
 aggctggttttccgtctggtgaggggttacttccgggtcggacggcgctagctgcagcat       c.-61

 .         .         .         .         .         .                g.5146
 cggagtgtggcagtgctgggctggccggcgggctgggctgcggcccgcgcgcggccggcg       c.-1

          .         .         .         .         .         .       g.5206
 ATGCAGGGGGGCAACTCCGGGGTCCGCAAGCGCGAAGAGGAGGGCGACGGGGCTGGGGCT       c.60
 M  Q  G  G  N  S  G  V  R  K  R  E  E  E  G  D  G  A  G  A         p.20

          .         .         .         .         .         | 02    g.9527
 GTGGCTGCGCCGCCGGCCATCGACTTTCCCGCCGAGGGCCCGGACCCCGAATATGACG | AA    c.120
 V  A  A  P  P  A  I  D  F  P  A  E  G  P  D  P  E  Y  D  E |       p.40

          .         .         .         .         .         .       g.9587
 TCTGATGTTCCAGCAGAAATCCAGGTGTTAAAAGAACCCCTACAACAGCCAACCTTCCCT       c.180
 S  D  V  P  A  E  I  Q  V  L  K  E  P  L  Q  Q  P  T  F  P         p.60

          .         .         .         .         .         .       g.9647
 TTTGCAGTTGCAAACCAACTCTTGCTGGTTTCTTTGCTGGAGCACTTGAGCCACGTGCAT       c.240
 F  A  V  A  N  Q  L  L  L  V  S  L  L  E  H  L  S  H  V  H         p.80

          .         .         .        | 03.         .         .    g.14207
 GAACCAAACCCACTTCGTTCAAGACAGGTGTTTAAGC | TACTTTGCCAGACGTTTATCAAA    c.300
 E  P  N  P  L  R  S  R  Q  V  F  K  L |   L  C  Q  T  F  I  K      p.100

          .         .         .         .         .         .       g.14267
 ATGGGGCTGCTGTCTTCTTTCACTTGTAGTGACGAGTTTAGCTCATTGAGACTACATCAC       c.360
 M  G  L  L  S  S  F  T  C  S  D  E  F  S  S  L  R  L  H  H         p.120

          .         .         .         .         .  | 04      .    g.15394
 AACAGAGCTATTACTCACTTAATGAGGTCTGCTAAAGAGAGAGTTCGTCAG | GATCCTTGT    c.420
 N  R  A  I  T  H  L  M  R  S  A  K  E  R  V  R  Q   | D  P  C      p.140

          .         .          | 05        .         .         .    g.17169
 GAGGATATTTCTCGTATCCAGAAAATCAG | ATCAAGGGAAGTAGCCTTGGAAGCACAAACT    c.480
 E  D  I  S  R  I  Q  K  I  R  |  S  R  E  V  A  L  E  A  Q  T      p.160

          .         .         .         .         .         .       g.17229
 TCACGTTACTTAAATGAATTTGAAGAACTTGCCATCTTAGGAAAAGGTGGATACGGAAGA       c.540
 S  R  Y  L  N  E  F  E  E  L  A  I  L  G  K  G  G  Y  G  R         p.180

           | 06        .         .         .         .         .    g.18129
 GTATACAAG | GTCAGGAATAAATTAGATGGTCAGTATTATGCAATAAAAAAAATCCTGATT    c.600
 V  Y  K   | V  R  N  K  L  D  G  Q  Y  Y  A  I  K  K  I  L  I      p.200

          .         .         . | 07       .         .         .    g.19598
 AAGGGTGCAACTAAAACAGTTTGCATGAAG | GTCCTACGGGAAGTGAAGGTGCTGGCAGGT    c.660
 K  G  A  T  K  T  V  C  M  K   | V  L  R  E  V  K  V  L  A  G      p.220

          .         .         .         .         .         .       g.19658
 CTTCAGCACCCCAATATTGTTGGCTATCACACCGCGTGGATAGAACATGTTCATGTGATT       c.720
 L  Q  H  P  N  I  V  G  Y  H  T  A  W  I  E  H  V  H  V  I         p.240

          . | 08       .         .         .         .         .    g.21286
 CAGCCACGAG | CAGACAGAGCTGCCATTGAGTTGCCATCTCTGGAAGTGCTCTCCGACCAG    c.780
 Q  P  R  A |   D  R  A  A  I  E  L  P  S  L  E  V  L  S  D  Q      p.260

          .  | 09      .         .         .         .         .    g.23059
 GAAGAGGACAG | AGAGCAATGTGGTGTTAAAAATGATGAAAGTAGCAGCTCATCCATTATC    c.840
 E  E  D  R  |  E  Q  C  G  V  K  N  D  E  S  S  S  S  S  I  I      p.280

          .         .         .         .         .         .       g.23119
 TTTGCTGAGCCCACCCCAGAAAAAGAAAAACGCTTTGGAGAATCTGACACTGAAAATCAG       c.900
 F  A  E  P  T  P  E  K  E  K  R  F  G  E  S  D  T  E  N  Q         p.300

          .         .         .         .         .         .       g.23179
 AATAACAAGTCGGTGAAGTACACCACCAATTTAGTCATAAGAGAATCTGGTGAACTTGAG       c.960
 N  N  K  S  V  K  Y  T  T  N  L  V  I  R  E  S  G  E  L  E         p.320

          .         .         .         .         .         .       g.23239
 TCGACCCTGGAGCTCCAGGAAAATGGCTTGGCTGGTTTGTCTGCCAGTTCAATTGTGGAA       c.1020
 S  T  L  E  L  Q  E  N  G  L  A  G  L  S  A  S  S  I  V  E         p.340

          .         .         .         .         .         .       g.23299
 CAGCAGCTGCCACTCAGGCGTAATTCCCACCTAGAGGAGAGTTTCACATCCACCGAAGAA       c.1080
 Q  Q  L  P  L  R  R  N  S  H  L  E  E  S  F  T  S  T  E  E         p.360

          .         .         .          | 10        .         .    g.25579
 TCTTCCGAAGAAAATGTCAACTTTTTGGGTCAGACAGAG | GCACAGTACCACCTGATGCTG    c.1140
 S  S  E  E  N  V  N  F  L  G  Q  T  E   | A  Q  Y  H  L  M  L      p.380

          .         .         .         .         .         .       g.25639
 CACATCCAGATGCAGCTGTGTGAGCTCTCGCTGTGGGATTGGATAGTCGAGAGAAACAAG       c.1200
 H  I  Q  M  Q  L  C  E  L  S  L  W  D  W  I  V  E  R  N  K         p.400

          .         .         .  | 11      .         .         .    g.26734
 CGGGGCCGGGAGTATGTGGACGAGTCTGCCT | GTCCTTATGTTATGGCCAATGTTGCAACA    c.1260
 R  G  R  E  Y  V  D  E  S  A  C |   P  Y  V  M  A  N  V  A  T      p.420

          .         .         .         .         .         .       g.26794
 AAAATTTTTCAAGAATTGGTAGAAGGTGTGTTTTACATACATAACATGGGAATTGTGCAC       c.1320
 K  I  F  Q  E  L  V  E  G  V  F  Y  I  H  N  M  G  I  V  H         p.440

          .   | 12     .         .         .         .         .    g.35245
 CGAGATCTGAAG | CCAAGAAATATTTTTCTTCATGGCCCTGATCAGCAAGTAAAAATAGGA    c.1380
 R  D  L  K   | P  R  N  I  F  L  H  G  P  D  Q  Q  V  K  I  G      p.460

          .         .         .         .         .         .       g.35305
 GACTTTGGTCTGGCCTGCACAGACATCCTACAGAAGAACACAGACTGGACCAACAGAAAC       c.1440
 D  F  G  L  A  C  T  D  I  L  Q  K  N  T  D  W  T  N  R  N         p.480

         | 13.         .         .         .         .         .    g.35585
 GGGAAGA | GAACACCAACACATACGTCCAGAGTGGGTACTTGTCTGTACGCTTCACCCGAA    c.1500
 G  K  R |   T  P  T  H  T  S  R  V  G  T  C  L  Y  A  S  P  E      p.500

          .         .         . | 14       .         .         .    g.37298
 CAGTTGGAAGGATCTGAGTATGATGCCAAG | TCAGATATGTACAGCTTGGGTGTGGTCCTG    c.1560
 Q  L  E  G  S  E  Y  D  A  K   | S  D  M  Y  S  L  G  V  V  L      p.520

          .         .         .         .         .         .       g.37358
 CTAGAGCTCTTTCAGCCGTTTGGAACAGAAATGGAGCGAGCAGAAGTTCTAACAGGTTTA       c.1620
 L  E  L  F  Q  P  F  G  T  E  M  E  R  A  E  V  L  T  G  L         p.540

          .         .         .         .         .         .       g.37418
 AGAACTGGTCAGTTGCCGGAATCCCTCCGTAAAAGGTGTCCAGTGCAAGCCAAGTATATC       c.1680
 R  T  G  Q  L  P  E  S  L  R  K  R  C  P  V  Q  A  K  Y  I         p.560

          .         .         .         .         .         .       g.37478
 CAGCACTTAACGAGAAGGAACTCATCGCAGAGACCATCTGCCATTCAGCTGCTGCAGAGT       c.1740
 Q  H  L  T  R  R  N  S  S  Q  R  P  S  A  I  Q  L  L  Q  S         p.580

          .         .     | 15   .         .         .         .    g.39464
 GAACTTTTCCAAAATTCTGGAAAT | GTTAACCTCACCCTACAGATGAAGATAATAGAGCAA    c.1800
 E  L  F  Q  N  S  G  N   | V  N  L  T  L  Q  M  K  I  I  E  Q      p.600

          .         .         .         .         .         .       g.39524
 GAAAAAGAAATTGCAGAACTAAAGAAGCAGCTAAACCTCCTTTCTCAAGACAAAGGGGTG       c.1860
 E  K  E  I  A  E  L  K  K  Q  L  N  L  L  S  Q  D  K  G  V         p.620

          .         .         .                                     g.39557
 AGGGATGACGGAAAGGATGGGGGCGTGGGATGA                                  c.1893
 R  D  D  G  K  D  G  G  V  G  X                                    p.630

          .         .         .         .         .         .       g.39617
 aagtggacttaacttttaaggtagttaactggaatgtaaatttttaatctttattagggt       c.*60

          .         .         .         .         .         .       g.39677
 atagttggtacaatgcttcgttgtatttagtaagcctttacaagacttgttaaagatgtc       c.*120

          .         .         .         .         .         .       g.39737
 agagtgccccaagctgccgttccttcccttcctgccccacaagctccttttcctgaattt       c.*180

          .         .         .         .         .         .       g.39797
 cctacctaaatattaaccatatgcctagtctctgaaactaaaaacttggacctcatcctc       c.*240

          .         .         .         .         .         .       g.39857
 aattattttctcctttcaactctgttgaccctctgtctggtcttcctctagaaggtaccg       c.*300

          .         .         .         .         .         .       g.39917
 cagaaattgatgtgtgctccctgccctcgtcactgcccaagcccgggcctgcacatactc       c.*360

          .         .         .         .         .         .       g.39977
 actggactgttccagttttgacagctgccagtcttcctgcccctttcacactgcagctga       c.*420

          .         .         .         .         .         .       g.40037
 agttcattacctgaaggacgcctcatcatttcattccttggctccaaaccttctgctgcc       c.*480

          .         .         .         .         .         .       g.40097
 tctaagataaaagctcaacttcttaacagtgtacagtgtgcaacttccaacctttttatc       c.*540

          .         .         .         .         .         .       g.40157
 tgttctctccaccttcagtttagcgtcattccaaaaccacacccttgcaaagctttgtac       c.*600

          .         .         .         .         .         .       g.40217
 tccgcaccccagatgatctccaggcagctcagatctctttcctgcctttgccctgcactg       c.*660

          .         .         .         .         .         .       g.40277
 ttccccggtacttcctcctttattgtagcactcagctccccagccaatctgtacatccct       c.*720

          .         .         .         .         .         .       g.40337
 cagaggcagcgatctgatgaattggtttttgaatcccagaaagggtctgccatggagttg       c.*780

          .         .         .         .         .         .       g.40397
 gcagtcatcacggtagatggcgtatgattttgctgaattttaaataaaatgaaaaccata       c.*840

          .         .         .         .         .         .       g.40457
 aattacatgatgcttttattgacacttgacaactggcctaaataaaaagactctgactct       c.*900

          .         .         .         .         .         .       g.40517
 aatacaagtccccttactgataataggcatgaaagagcaccattcttaaaatctaaaccc       c.*960

          .         .         .         .         .         .       g.40577
 tttaaaatcagttacggcaattcacttaaggagcttgagggccgtgttaaaaggagccag       c.*1020

          .         .         .         .         .         .       g.40637
 gttttcacaagacctcatccacctctgcacattggctggcactgtcacactgcagcctcc       c.*1080

          .         .         .         .         .         .       g.40697
 gatctgctggagtacagaccacagcaccacgtctgctacggtgagttcattcccagcgag       c.*1140

          .         .         .         .         .         .       g.40757
 ccaagggctcttcccaagagcagagttcatggagcggaaaacagcggctttttctttact       c.*1200

          .         .         .         .         .         .       g.40817
 gcttccctcttttaactgaaaaatcgcaatatctacccagctatctataagggttgcgtt       c.*1260

          .         .         .         .         .         .       g.40877
 gacagcattatgcttctggccaaacagagagaacaagaaacgtgcaatgttcccttcgcc       c.*1320

          .         .         .         .         .         .       g.40937
 ttcgatggggcacatcgtctggatgctgaatttcatctgcgtcttcggcactgaaaagaa       c.*1380

          .         .         .         .         .         .       g.40997
 aaaacacgccaggtagcatcaccagagcagccctgagggaagtactcgcacagtggggaa       c.*1440

          .         .         .         .         .         .       g.41057
 ggggacagtcaccaaacaccacagactgatgacatgggaaagggtgttttcaagaagaac       c.*1500

          .         .         .         .         .         .       g.41117
 atcacattttcagtctgtctctaagatgcttactactgaaaagggtttaagtgcaaacta       c.*1560

          .         .         .         .         .         .       g.41177
 tgttaaaaaagtaaccaaagagtcattcctggtatttgattatgacacttctgaagctag       c.*1620

          .         .         .         .         .         .       g.41237
 aagggacctcagaccacctgctccaatccctgctgcctaaggttttgggggctgagggct       c.*1680

          .         .         .         .         .         .       g.41297
 ggaaacccaggagctgcatctcccaggctcttggcctcataatcgccttctgtgagactg       c.*1740

          .         .         .         .         .         .       g.41357
 agggcaattaagatatgaatgacatgaactcgcttatctccatatcaacataaaccagaa       c.*1800

          .         .         .         .         .         .       g.41417
 gaggcatacatctgtgggatagtcaatacataacatcctatctttatatggccatatgag       c.*1860

          .         .         .         .         .         .       g.41477
 aagataacttcagtgtccctatgatggtaagttcttgaatgtgagggcaagatggctgtg       c.*1920

          .         .         .         .         .         .       g.41537
 atagccatgactccccgctttgcctggttggacagaacccccttccccaaatgctcacag       c.*1980

          .         .         .         .         .         .       g.41597
 tcccccccttgagctgtgtctcactcagagaccctaaattttgcagacgaacaagggcat       c.*2040

          .         .         .         .         .         .       g.41657
 ctttgcgttgcttcatctctgctcctcctctagaactatcccacaggctttctagactta       c.*2100

          .         .         .         .         .         .       g.41717
 gaatatctgacctgatgcaaatcgctatgtggccagtatgccacagaatgtcctaaaccc       c.*2160

          .         .         .         .         .         .       g.41777
 ttgctgcctcttatcaaaaccatgttgcacatctcatcatatagtacagctaacccttga       c.*2220

          .         .         .         .         .         .       g.41837
 acagtgggggggttagggacactgacccccgactgctgtgcagtcgaaaatccacataaa       c.*2280

          .         .         .         .         .         .       g.41897
 acttctgactccttcaaaacttaagcactaatagcctactattcatgggaagccttaccc       c.*2340

          .         .         .         .         .         .       g.41957
 atcacagttgattaacacgttttgtatggtctgtatattatatgctatattcttacaata       c.*2400

          .         .                                               g.41983
 aacttgagaaaatgttaagaaaataa                                         c.*2426

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Eukaryotic translation initiation factor 2-alpha kinase 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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