eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa (EIF2B1) - coding DNA reference sequence

(used for variant description)

(last modified February 18, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_001414.3 in the EIF2B1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_015862.1, covering EIF2B1 transcript NM_001414.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5039
                      aagtgacgcacgaggtgctgtgactcgtgccagccccct       c.-181

 .         .         .         .         .         .                g.5099
 aatctgcggaagtggagtgcggggagtgcgccggaagaggggtacggaagtgcgccggaa       c.-121

 .         .         .         .         .         .                g.5159
 gtggggtgcggaggtgtgcagcgcgctgtcagactggctcgcaggcggcgcggccggcgg       c.-61

 .         .         .         .         .         .                g.5219
 acccgttcgagacagcgcgggcggctcgggtcccctggggctccgcagcaggaggacgcc       c.-1

          .    | 02    .         .         .         .         .    g.6377
 ATGGACGACAAGG | AGTTAATTGAATACTTTAAGTCTCAGATGAAAGAAGATCCTGACATG    c.60
 M  D  D  K  E |   L  I  E  Y  F  K  S  Q  M  K  E  D  P  D  M      p.20

          .         .         .         .         .      | 03  .    g.8248
 GCCTCAGCAGTGGCTGCCATCCGGACGTTGCTGGAGTTCTTGAAGAGAGATAAAG | GGGAG    c.120
 A  S  A  V  A  A  I  R  T  L  L  E  F  L  K  R  D  K  G |   E      p.40

          .         .         .         .         .         .       g.8308
 ACAATCCAGGGTCTGAGGGCGAATCTCACCAGTGCCATAGAAACCCTGTGTGGTGTGGAC       c.180
 T  I  Q  G  L  R  A  N  L  T  S  A  I  E  T  L  C  G  V  D         p.60

          .         .         .         .         .         .       g.8368
 TCCTCTGTGGCAGTGTCCTCTGGCGGGGAGCTCTTCCTCCGCTTCATCAGTCTTGCCTCC       c.240
 S  S  V  A  V  S  S  G  G  E  L  F  L  R  F  I  S  L  A  S         p.80

          .   | 04     .         .         .         .         .    g.8539
 CTGGAATACTCC | GATTACTCCAAATGTAAAAAGATCATGATTGAGCGGGGAGAACTTTTT    c.300
 L  E  Y  S   | D  Y  S  K  C  K  K  I  M  I  E  R  G  E  L  F      p.100

          .         .         .         .         .         .       g.8599
 CTCAGGAGAATATCACTGTCAAGAAACAAAATTGCAGATCTGTGCCATACTTTCATCAAA       c.360
 L  R  R  I  S  L  S  R  N  K  I  A  D  L  C  H  T  F  I  K         p.120

           | 05        .         .         .         .         .    g.11671
 GATGGAGCG | ACAATATTGACTCACGCCTACTCCAGAGTGGTCCTGAGAGTCCTGGAAGCA    c.420
 D  G  A   | T  I  L  T  H  A  Y  S  R  V  V  L  R  V  L  E  A      p.140

          .         .         .         .         .         .       g.11731
 GCCGTGGCGGCCAAGAAGCGATTTAGTGTATACGTCACAGAGTCACAGCCTGATTTGTCA       c.480
 A  V  A  A  K  K  R  F  S  V  Y  V  T  E  S  Q  P  D  L  S         p.160

    | 06     .         .         .         .         .         .    g.12341
 GG | TAAGAAAATGGCCAAAGCCCTCTGCCACCTCAACGTCCCTGTCACTGTGGTGCTAGAT    c.540
 G  |  K  K  M  A  K  A  L  C  H  L  N  V  P  V  T  V  V  L  D      p.180

          .  | 07      .         .         .         .         .    g.13963
 GCTGCTGTCGG | CTACATCATGGAGAAAGCAGATCTTGTCATAGTTGGTGCTGAAGGAGTT    c.600
 A  A  V  G  |  Y  I  M  E  K  A  D  L  V  I  V  G  A  E  G  V      p.200

          .         .        | 08.         .         .         .    g.16048
 GTTGAAAACGGAGGAATTATTAACAAG | ATTGGAACCAACCAGATGGCTGTGTGTGCCAAA    c.660
 V  E  N  G  G  I  I  N  K   | I  G  T  N  Q  M  A  V  C  A  K      p.220

          .         .         .         .         .         .       g.16108
 GCACAGAACAAACCTTTCTATGTGGTTGCAGAAAGTTTCAAGTTTGTCCGGCTCTTTCCA       c.720
 A  Q  N  K  P  F  Y  V  V  A  E  S  F  K  F  V  R  L  F  P         p.240

          .         .         .    | 09    .         .         .    g.16883
 CTAAACCAGCAAGACGTCCCAGATAAGTTTAAG | TATAAGGCAGACACTCTCAAGGTCGCG    c.780
 L  N  Q  Q  D  V  P  D  K  F  K   | Y  K  A  D  T  L  K  V  A      p.260

          .         .         .         .         .         .       g.16943
 CAGACTGGACAAGACCTCAAAGAGGAGCATCCGTGGGTCGACTACACTGCCCCTTCCTTA       c.840
 Q  T  G  Q  D  L  K  E  E  H  P  W  V  D  Y  T  A  P  S  L         p.280

          .         .         .         .         .         .       g.17003
 ATCACTCTGCTGTTTACAGACCTGGGCGTGCTGACACCCTCAGCAGTCAGCGATGAGCTC       c.900
 I  T  L  L  F  T  D  L  G  V  L  T  P  S  A  V  S  D  E  L         p.300

          .                                                         g.17021
 ATCAAGCTCTATCTGTAA                                                 c.918
 I  K  L  Y  L  X                                                   p.305

          .         .         .         .         .         .       g.17081
 cctgtgagccctttcctgccaaggtgcagcttacgtagttgaggcagggtgagtagctgc       c.*60

          .         .         .         .         .         .       g.17141
 ttgacaccccagtgagtcaggccaaaactgagatgtgtttaatgaagatttatggagtaa       c.*120

          .         .         .         .         .         .       g.17201
 ggacttaaaatcatacatcttggagaacctttcttactcatttcagtcccatctaaaaat       c.*180

          .         .         .         .         .         .       g.17261
 gtgtcagctattctaaatcccaacttaaattgttcttacggtttctagaaactttccttt       c.*240

          .         .         .         .         .         .       g.17321
 tcagtttccagaaatacaagttagataattggctacttaactgatgaaagatgagcccaa       c.*300

          .         .         .         .         .         .       g.17381
 gtccacctgtcttcatcctcccctgcactccagactgatctgcctaaagcacgcgagatg       c.*360

          .         .         .         .         .         .       g.17441
 caggcgaaaagcagccacacccctctgccacaaatgaccaacagctggtcaggacgttac       c.*420

          .         .         .         .         .         .       g.17501
 acgcggtgccttgtaagaggcaagaaacacttgccgaatctgcatctggcttccagtggt       c.*480

          .         .         .         .         .         .       g.17561
 aagcacattcctcagcaggatcaagccaaacagtaaaaactaccaagagaacacgaggaa       c.*540

          .         .         .         .         .         .       g.17621
 ggcagaaacgatgtttagcaacagtattctgcatggttcactgcttaagaaaatgccttc       c.*600

          .         .         .         .         .         .       g.17681
 tggaatatttgtaaactgaaattctgtatgtgtaagagatgtttaaatatgtttgggtcc       c.*660

          .         .         .         .         .         .       g.17741
 taaacagctttttaaaattatacttgggaataaattcagcatcttttcaaataaactcta       c.*720

          .                                                         g.17754
 tgaaagacgctga                                                      c.*733

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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