eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa (EIF2B2) - coding DNA reference sequence

(used for variant description)

(last modified January 23, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_014239.3 in the EIF2B2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_013333.1, covering EIF2B2 transcript NM_014239.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5022
                                       ctcgcccgccccggaagtgcaa       c.-61

 .         .         .         .         .         .                g.5082
 actgtgtggtctggcaggtgtggattccgccggtgaaggctgaaggcagctaccttaaag       c.-1

          .         .         .         .         .         .       g.5142
 ATGCCGGGATCCGCAGCGAAGGGCTCGGAGTTGTCAGAGAGGATCGAGAGCTTCGTGGAG       c.60
 M  P  G  S  A  A  K  G  S  E  L  S  E  R  I  E  S  F  V  E         p.20

          .         .         .         .         .         .       g.5202
 ACCCTGAAGCGGGGTGGTGGGCCGCGCAGCTCCGAGGAAATGGCTCGGGAGACCCTAGGG       c.120
 T  L  K  R  G  G  G  P  R  S  S  E  E  M  A  R  E  T  L  G         p.40

          .         .         .         .    | 02    .         .    g.5383
 TTGCTGCGCCAGATCATCACGGACCACCGCTGGAGCAACGCGG | GGGAGCTGATGGAGCTG    c.180
 L  L  R  Q  I  I  T  D  H  R  W  S  N  A  G |   E  L  M  E  L      p.60

          .         .         .         .         .         .       g.5443
 ATCCGCAGAGAGGGCAGGAGGATGACGGCCGCTCAGCCCTCCGAGACCACCGTGGGCAAC       c.240
 I  R  R  E  G  R  R  M  T  A  A  Q  P  S  E  T  T  V  G  N         p.80

          .         .         .         .     | 03   .         .    g.5658
 ATGGTGCGGAGAGTGCTCAAGATTATCCGGGAGGAGTATGGCAG | ACTCCATGGACGCAGC    c.300
 M  V  R  R  V  L  K  I  I  R  E  E  Y  G  R  |  L  H  G  R  S      p.100

          .         .         .         .         .         .       g.5718
 GACGAGAGTGATCAGCAGGAGTCCCTGCACAAACTGTTGACATCCGGAGGCCTAAACGAG       c.360
 D  E  S  D  Q  Q  E  S  L  H  K  L  L  T  S  G  G  L  N  E         p.120

          .         .         .         .         .         .       g.5778
 GATTTCAGCTTCCATTATGCCCAACTCCAGTCCAACATCATTGAGGCGATTAATGAGCTG       c.420
 D  F  S  F  H  Y  A  Q  L  Q  S  N  I  I  E  A  I  N  E  L         p.140

          .    | 04    .         .         .         .         .    g.6875
 CTAGTGGAGCTGG | AAGGGACAATGGAGAACATTGCAGCCCAGGCTCTGGAGCACATTCAC    c.480
 L  V  E  L  E |   G  T  M  E  N  I  A  A  Q  A  L  E  H  I  H      p.160

          .         .         .         .         .         .       g.6935
 TCCAATGAGGTGATCATGACCATTGGCTTCTCCCGAACAGTAGAGGCCTTCCTCAAAGAG       c.540
 S  N  E  V  I  M  T  I  G  F  S  R  T  V  E  A  F  L  K  E         p.180

          .         .         .         .         .        | 05.    g.7960
 GCTGCCCGAAAGAGGAAATTCCATGTCATTGTAGCAGAGTGTGCTCCTTTCTGCCAG | GGT    c.600
 A  A  R  K  R  K  F  H  V  I  V  A  E  C  A  P  F  C  Q   | G      p.200

          .         .         .         .         .         .       g.8020
 CATGAAATGGCTGTGAATTTGTCCAAAGCAGGTATTGAGACAACTGTCATGACTGATGCT       c.660
 H  E  M  A  V  N  L  S  K  A  G  I  E  T  T  V  M  T  D  A         p.220

          .         .         .    | 06    .         .         .    g.8695
 GCCATTTTTGCCGTTATGTCAAGAGTCAACAAG | GTGATCATTGGCACGAAGACCATCCTG    c.720
 A  I  F  A  V  M  S  R  V  N  K   | V  I  I  G  T  K  T  I  L      p.240

          .         .         .         .         .         .       g.8755
 GCCAATGGGGCCCTGAGAGCTGTGACAGGAACTCACACTCTGGCACTGGCAGCAAAACAC       c.780
 A  N  G  A  L  R  A  V  T  G  T  H  T  L  A  L  A  A  K  H         p.260

          .         .         .         .         .  | 07      .    g.9822
 CATTCCACCCCACTCATCGTCTGTGCACCTATGTTCAAACTTTCTCCACAG | TTCCCCAAT    c.840
 H  S  T  P  L  I  V  C  A  P  M  F  K  L  S  P  Q   | F  P  N      p.280

          .         .         .         .         .         | 08    g.11124
 GAAGAAGACTCATTTCATAAGTTTGTGGCTCCTGAAGAAGTCCTGCCATTCACAGAAG | GG    c.900
 E  E  D  S  F  H  K  F  V  A  P  E  E  V  L  P  F  T  E  G |       p.300

          .         .         .         .         .         .       g.11184
 GACATTCTGGAGAAGGTCAGCGTGCATTGCCCTGTGTTTGACTACGTTCCCCCAGAGCTC       c.960
 D  I  L  E  K  V  S  V  H  C  P  V  F  D  Y  V  P  P  E  L         p.320

          .         .         .         .         .         .       g.11244
 ATTACCCTCTTTATCTCCAACATTGGTGGGAATGCACCTTCCTACATCTACCGCCTGATG       c.1020
 I  T  L  F  I  S  N  I  G  G  N  A  P  S  Y  I  Y  R  L  M         p.340

          .         .         .                                     g.11280
 AGTGAACTCTACCATCCTGATGATCATGTTTTATGA                               c.1056
 S  E  L  Y  H  P  D  D  H  V  L  X                                 p.351

          .         .         .         .         .         .       g.11340
 ccgaccacacgtgtcctaagcagattgcttaggcagatacagaatgaagaggagacttga       c.*60

          .         .         .         .         .         .       g.11400
 gtgttgctgctgaagcacatccttgcaatgtgggagtgcacaggagtccacctaaaaaaa       c.*120

          .         .         .         .         .         .       g.11460
 aaatccttgatactgttgcctgcctttttagtcaccccgtaacaagggcacacatccagg       c.*180

          .         .         .         .         .         .       g.11520
 actgtgtcttgcctttcagatcttaacagagcagcagggcttaacttgttgattttggag       c.*240

          .         .         .         .         .         .       g.11580
 cctcttagtgacctggttgcgtctgtgtcaggaacttaaactttctggttcagtagtgtg       c.*300

          .         .         .         .         .         .       g.11640
 ttaaacataacactgaataccttactgggatacagatttttgctcagaaatggctatgac       c.*360

          .         .         .         .                           g.11683
 actttttctaggctctaccaataaaagccacttgaaggttcca                        c.*403

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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