eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa (EIF2B3) - coding DNA reference sequence

(used for variant description)

(last modified February 18, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_020365.4 in the EIF2B3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_015864.1, covering EIF2B3 transcript NM_020365.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5026
  ctctccgctgagtgtgcttcccctccgtcatccatcgctcggcggtcttctcttctcca       c.-181

 .         .         .         .         .         .                g.5086
 tgggtctgctctgcgcgttccatcgagtttctcggccatcgcgcgcctgcgccattgggc       c.-121

 .         .         .         .         .         .                g.5146
 tgtcagtcagaggcggcgtggagatcgctgggagcggttgcggcgtgccgggagctgagt       c.-61

 .         .         .         .         .         . | 02           g.10521
 tatagctgtgacttctgccctgccaggccgcacacaagctggctgacccgg | tttgtaaaa    c.-1

          .         .         .         .         .         .       g.10581
 ATGGAATTTCAAGCAGTAGTGATGGCAGTAGGTGGAGGATCTCGGATGACAGACCTAACT       c.60
 M  E  F  Q  A  V  V  M  A  V  G  G  G  S  R  M  T  D  L  T         p.20

          .         .         .         .         .         .       g.10641
 TCCAGCATTCCCAAACCTCTGCTTCCAGTTGGGAACAAACCTTTAATTTGGTACCCATTG       c.120
 S  S  I  P  K  P  L  L  P  V  G  N  K  P  L  I  W  Y  P  L         p.40

          .         .         | 03         .         .         .    g.13261
 AACCTGCTTGAGCGTGTTGGATTTGAAG | AAGTCATTGTGGTTACAACCAGGGATGTTCAA    c.180
 N  L  L  E  R  V  G  F  E  E |   V  I  V  V  T  T  R  D  V  Q      p.60

          .         .         .         .         .         .       g.13321
 AAGGCTCTATGTGCAGAATTCAAGATGAAAATGAAGCCAGATATTGTGTGTATTCCTGAT       c.240
 K  A  L  C  A  E  F  K  M  K  M  K  P  D  I  V  C  I  P  D         p.80

          .         .         .         .         .     | 04   .    g.50030
 GACGCTGACATGGGAACTGCAGATTCTTTGCGCTACATATATCCAAAACTTAAG | ACAGAT    c.300
 D  A  D  M  G  T  A  D  S  L  R  Y  I  Y  P  K  L  K   | T  D      p.100

          .         .         .         .         .         .       g.50090
 GTGCTGGTGCTGAGCTGTGATCTGATAACAGACGTTGCCTTACATGAGGTTGTGGACCTG       c.360
 V  L  V  L  S  C  D  L  I  T  D  V  A  L  H  E  V  V  D  L         p.120

          .         .         .         .         .         .       g.50150
 TTTAGAGCTTATGATGCATCACTTGCTATGTTGATGAGAAAAGGCCAAGATAGCATAGAA       c.420
 F  R  A  Y  D  A  S  L  A  M  L  M  R  K  G  Q  D  S  I  E         p.140

          .         .         .     | 05   .         .         .    g.64976
 CCTGTTCCCGGTCAAAAGGGGAAAAAAAAAGCAG | TGGAGCAGCGTGACTTCATTGGAGTG    c.480
 P  V  P  G  Q  K  G  K  K  K  A  V |   E  Q  R  D  F  I  G  V      p.160

          .         .         .         .         .         .       g.65036
 GACAGCACAGGAAAGAGGCTGCTCTTCATGGCTAATGAAGCAGACTTGGATGAAGAGCTG       c.540
 D  S  T  G  K  R  L  L  F  M  A  N  E  A  D  L  D  E  E  L         p.180

          .         .       | 06 .         .         .         .    g.94279
 GTCATTAAGGGATCCATCCTACAGAA | GCATCCTAGAATACGTTTCCACACGGGTCTTGTG    c.600
 V  I  K  G  S  I  L  Q  K  |  H  P  R  I  R  F  H  T  G  L  V      p.200

          .         .         .         .         .       | 07 .    g.109954
 GATGCCCACCTCTACTGTTTGAAAAAATACATCGTGGATTTCCTAATGGAAAATGG | GTCA    c.660
 D  A  H  L  Y  C  L  K  K  Y  I  V  D  F  L  M  E  N  G  |  S      p.220

          .         .         .         .         .         .       g.110014
 ATAACTTCTATCCGGAGTGAACTGATTCCATATTTAGTGAGAAAACAGTTTTCCTCAGCT       c.720
 I  T  S  I  R  S  E  L  I  P  Y  L  V  R  K  Q  F  S  S  A         p.240

          .         .         .         .         .         .       g.110074
 TCCTCACAACAGGGACAAGAAGAAAAAGAGGAGGATCTAAAGAAAAAGGAGCTGAAGTCC       c.780
 S  S  Q  Q  G  Q  E  E  K  E  E  D  L  K  K  K  E  L  K  S         p.260

      | 08   .         .         .         .         .         .    g.111737
 TTAG | ATATCTACAGTTTTATAAAAGAAGCCAATACACTGAACCTGGCTCCCTATGATGCC    c.840
 L  D |   I  Y  S  F  I  K  E  A  N  T  L  N  L  A  P  Y  D  A      p.280

          .         .         .         .         .         .       g.111797
 TGCTGGAATGCCTGTCGAGGAGACAGGTGGGAAGACTTGTCCAGATCACAGGTGCGCTGC       c.900
 C  W  N  A  C  R  G  D  R  W  E  D  L  S  R  S  Q  V  R  C         p.300

          .         .         .         .         .         .       g.111857
 TATGTCCACATCATGAAAGAGGGGCTCTGCTCTCGAGTGAGCACACTGGGACTCTACATG       c.960
 Y  V  H  I  M  K  E  G  L  C  S  R  V  S  T  L  G  L  Y  M         p.320

          .      | 09  .         .         .         .         .    g.116039
 GAAGCAAACAGACAG | GTGCCCAAATTGCTGTCTGCTCTCTGTCCAGAAGAACCACCAGTC    c.1020
 E  A  N  R  Q   | V  P  K  L  L  S  A  L  C  P  E  E  P  P  V      p.340

          .         .         .    | 10    .         .         .    g.116890
 CATTCGTCAGCCCAGATTGTCAGCAAACACCTG | GTTGGAGTTGACAGCCTCATTGGGCCA    c.1080
 H  S  S  A  Q  I  V  S  K  H  L   | V  G  V  D  S  L  I  G  P      p.360

          .         .         .         .         .         .       g.116950
 GAGACACAGATTGGAGAGAAGTCATCCATTAAGCGCTCAGTCATTGGCTCATCCTGTCTC       c.1140
 E  T  Q  I  G  E  K  S  S  I  K  R  S  V  I  G  S  S  C  L         p.380

          .         .         .         .         .         .       g.117010
 ATAAAAGATAGAGTGACTATTACCAATTGCCTTCTCATGAACTCAGTCACTGTGGAGGAA       c.1200
 I  K  D  R  V  T  I  T  N  C  L  L  M  N  S  V  T  V  E  E         p.400

    | 11     .         .         .         .         .         .    g.133940
 GG | AAGCAATATCCAAGGCAGTGTCATCTGCAACAATGCTGTGATCGAGAAGGGTGCAGAC    c.1260
 G  |  S  N  I  Q  G  S  V  I  C  N  N  A  V  I  E  K  G  A  D      p.420

          .         .         .         .       | 12 .         .    g.140700
 ATCAAGGACTGCTTGATTGGAAGTGGCCAGAGGATTGAAGCCAAAG | CTAAACGAGTGAAT    c.1320
 I  K  D  C  L  I  G  S  G  Q  R  I  E  A  K  A |   K  R  V  N      p.440

          .         .         .                                     g.140739
 GAGGTGATCGTGGGGAATGACCAGCTCATGGAGATCTGA                            c.1359
 E  V  I  V  G  N  D  Q  L  M  E  I  X                              p.452

          .         .         .         .         .         .       g.140799
 gttctgagcaagtcagactccttccttttggcctccaaagccacagatgttggccggccc       c.*60

          .         .         .         .         .         .       g.140859
 acctgtttaactctgtatttatttcccaataaagaagggcttccaaaggcatgctggaga       c.*120

          .         .         .         .         .         .       g.140919
 cttgtggagcagtccaaagctccatgtcaggtgggctccaggtgtacacagtgtatgttc       c.*180

          .         .         .         .         .         .       g.140979
 atgtgtcatgtggtaaagatcatctggagcaagtgtgtgggacaggacagatacagtggc       c.*240

          .         .         .         .         .         .       g.141039
 ctaactcttgtgtgccaagatgtatcggtggggcagcagctgtccaatgtaaagctccta       c.*300

          .         .         .         .         .         .       g.141099
 ggaaggctactttctgactggctgacccaacccagtcctgaaagtatccctcacctaaaa       c.*360

          .         .         .         .         .         .       g.141159
 ggacctgggagtacttcagtcccttatcctaatcagcctttctagacccataggcctagc       c.*420

                                                                    g.141168
 tgctggcag                                                          c.*429

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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