eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa (EIF2B4) - coding DNA reference sequence

(used for variant description)

(last modified February 18, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_001034116.1 in the EIF2B4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009305.1, covering EIF2B4 transcript NM_001034116.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5023
                                      gaaattgtagtccgattggggct       c.-121

 .         .         .         .         .         .                g.5083
 gcgcgcttcgcttctgcggctcagcctccagcccaggtggcgctgtggaccctgcagccg       c.-61

 .         .         .         .         .         .                g.5143
 cggagcgaggcagcggggcggctccgtgaccacggcgggcggagcctaggactgagggcg       c.-1

          .         .         .  | 02      .         .         .    g.5567
 ATGGCTGCTGTGGCCGTGGCTGTTCGCGAGG | ACTCGGGATCCGGGATGAAGGCGGAGCTT    c.60
 M  A  A  V  A  V  A  V  R  E  D |   S  G  S  G  M  K  A  E  L      p.20

          .      | 03  .         .         .         .         .    g.5953
 CCCCCTGGGCCTGGG | GCAGTGGGGAGGGAAATGACCAAAGAAGAAAAGCTGCAGCTTCGG    c.120
 P  P  G  P  G   | A  V  G  R  E  M  T  K  E  E  K  L  Q  L  R      p.40

          .         .         .         .         .         .       g.6013
 AAGGAAAAGAAACAGCAGAAGAAGAAACGGAAGGAAGAAAAGGGGGCAGAACCAGAGACT       c.180
 K  E  K  K  Q  Q  K  K  K  R  K  E  E  K  G  A  E  P  E  T         p.60

          .         .         .  | 04      .         .         .    g.6274
 GGCTCTGCTGTATCTGCAGCCCAATGTCAAG | TAGGCCCAACCAGAGAACTGCCAGAATCG    c.240
 G  S  A  V  S  A  A  Q  C  Q  V |   G  P  T  R  E  L  P  E  S      p.80

          .         .         .         .         .         .       g.6334
 GGCATTCAGTTGGGCACTCCTCGGGAGAAAGTTCCAGCTGGTCGGAGTAAGGCCGAACTT       c.300
 G  I  Q  L  G  T  P  R  E  K  V  P  A  G  R  S  K  A  E  L         p.100

          .         .         .         .         .         .       g.6394
 CGGGCTGAGCGTCGAGCCAAGCAGGAGGCCGAGCGGGCCCTGAAACAGGCAAGAAAAGGG       c.360
 R  A  E  R  R  A  K  Q  E  A  E  R  A  L  K  Q  A  R  K  G         p.120

          .         .         .         .         .         | 05    g.6726
 GAACAAGGAGGACCACCTCCTAAGGCCAGCCCCAGCACAGCTGGAGAAACCCCCTCAG | GA    c.420
 E  Q  G  G  P  P  P  K  A  S  P  S  T  A  G  E  T  P  S  G |       p.140

          .         .         .         .         .         .       g.6786
 GTGAAGCGTCTCCCTGAGTACCCTCAGGTTGATGACCTACTTCTGAGAAGGCTTGTTAAA       c.480
 V  K  R  L  P  E  Y  P  Q  V  D  D  L  L  L  R  R  L  V  K         p.160

          .         | 06         .         .         .         .    g.7036
 AAACCAGAGCGTCAACAG | GTTCCTACACGAAAGGATTATGGATCCAAAGTCAGTCTCTTC    c.540
 K  P  E  R  Q  Q   | V  P  T  R  K  D  Y  G  S  K  V  S  L  F      p.180

          .         .         .         .         . | 07       .    g.7328
 TCTCACCTACCCCAGTACAGCAGACAAAACTCTCTGACCCAGTTTATGAG | CATCCCATCC    c.600
 S  H  L  P  Q  Y  S  R  Q  N  S  L  T  Q  F  M  S  |  I  P  S      p.200

          .         .         .         .         .         .       g.7388
 TCTGTGATCCACCCAGCCATGGTGCGACTCGGCCTGCAGTACTCCCAGGGCCTGGTCAGT       c.660
 S  V  I  H  P  A  M  V  R  L  G  L  Q  Y  S  Q  G  L  V  S         p.220

          .         .         .         .      | 08  .         .    g.7650
 GGCTCCAATGCCCGGTGTATTGCCCTGCTTCGTGCCTTGCAGCAG | GTGATTCAGGATTAC    c.720
 G  S  N  A  R  C  I  A  L  L  R  A  L  Q  Q   | V  I  Q  D  Y      p.240

          .         .         .         .         .         .       g.7710
 ACAACACCGCCTAATGAAGAACTCTCCAGGGATCTAGTGAATAAACTAAAACCCTACATG       c.780
 T  T  P  P  N  E  E  L  S  R  D  L  V  N  K  L  K  P  Y  M         p.260

    | 09     .         .         .         .         .         .    g.7956
 AG | CTTCCTGACTCAGTGCCGTCCCCTGTCAGCGAGCATGCACAACGCCATCAAGTTCCTT    c.840
 S  |  F  L  T  Q  C  R  P  L  S  A  S  M  H  N  A  I  K  F  L      p.280

          .         .         .         .      | 10  .         .    g.8271
 AACAAGGAAATCACCAGTGTGGGCAGTTCCAAGCGGGAAGAGGAG | GCCAAGTCAGAACTT    c.900
 N  K  E  I  T  S  V  G  S  S  K  R  E  E  E   | A  K  S  E  L      p.300

          .         .         .         .         .         .       g.8331
 CGAGCAGCCATTGATCGGTATGTGCAAGAGAAGATTGTGCTAGCAGCTCAGGCAATTTCA       c.960
 R  A  A  I  D  R  Y  V  Q  E  K  I  V  L  A  A  Q  A  I  S         p.320

          .         .         .         .         .    | 11    .    g.8528
 CGCTTTGCTTACCAGAAGATCAGTAATGGAGATGTGATCCTGGTATATGGATG | CTCATCT    c.1020
 R  F  A  Y  Q  K  I  S  N  G  D  V  I  L  V  Y  G  C  |  S  S      p.340

          .         .         .         .         .         .       g.8588
 CTGGTATCACGAATTCTTCAGGAGGCTTGGACAGAGGGCCGGCGGTTTCGGGTGGTAGTG       c.1080
 L  V  S  R  I  L  Q  E  A  W  T  E  G  R  R  F  R  V  V  V         p.360

          .         .         .         .         .         .       g.8648
 GTGGACAGCCGGCCATGGCTGGAAGGAAGGCACACACTACGTTCTCTAGTCCATGCTGGT       c.1140
 V  D  S  R  P  W  L  E  G  R  H  T  L  R  S  L  V  H  A  G         p.380

          .         .         .         .         .  | 12      .    g.10568
 GTCCCAGCCTCCTACCTGCTGATTCCTGCAGCCTCCTATGTGCTCCCAGAG | GTTTCCAAG    c.1200
 V  P  A  S  Y  L  L  I  P  A  A  S  Y  V  L  P  E   | V  S  K      p.400

          .         .         .         .         .         .       g.10628
 GTGCTATTGGGAGCTCATGCACTCTTGGCCAACGGGTCTGTGATGTCACGGGTAGGGACA       c.1260
 V  L  L  G  A  H  A  L  L  A  N  G  S  V  M  S  R  V  G  T         p.420

          .         .         .         .         .         .       g.10688
 GCACAGTTAGCCCTGGTGGCTCGAGCCCATAATGTACCAGTGCTGGTTTGCTGTGAAACA       c.1320
 A  Q  L  A  L  V  A  R  A  H  N  V  P  V  L  V  C  C  E  T         p.440

          .         .         .         .         .   | 13     .    g.10866
 TACAAGTTCTGTGAGCGTGTGCAGACTGATGCCTTTGTCTCTAATGAGCTAG | ATGACCCT    c.1380
 Y  K  F  C  E  R  V  Q  T  D  A  F  V  S  N  E  L  D |   D  P      p.460

          .         .         .         .         .         .       g.10926
 GATGATCTGCAATGTAAGCGGGGAGAACATGTTGCGCTGGCTAACTGGCAGAACCACGCA       c.1440
 D  D  L  Q  C  K  R  G  E  H  V  A  L  A  N  W  Q  N  H  A         p.480

          .         .         .         .         .         .       g.10986
 TCCCTACGGTTGTTGAATCTAGTCTATGATGTGACTCCCCCAGAGCTTGTGGATCTGGTG       c.1500
 S  L  R  L  L  N  L  V  Y  D  V  T  P  P  E  L  V  D  L  V         p.500

          .         .         .         .         .         .       g.11046
 ATCACGGAGCTGGGGATGATCCCTTGCAGTTCTGTACCTGTTGTTCTACGAGTCAAGAGC       c.1560
 I  T  E  L  G  M  I  P  C  S  S  V  P  V  V  L  R  V  K  S         p.520

          .                                                         g.11058
 AGTGACCAGTGA                                                       c.1572
 S  D  Q  X                                                         p.523

          .         .         .         .                           g.11106
 cgggggaaacacagggttaataaatgccatactccctaccctcagcaa                   c.*48

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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