eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa (EIF2B5) - coding DNA reference sequence

(used for variant description)

(last modified February 18, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_003907.2 in the EIF2B5 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_015826.1, covering EIF2B5 transcript NM_003907.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5004
                                                         gatt       c.-361

 .         .         .         .         .         .                g.5064
 cccgatggagctggccccttcgtggcgaccacaagtcctatcacgccacaagaatctcgg       c.-301

 .         .         .         .         .         .                g.5124
 cttgttcacctacaaatgaaggccgacgatacttgcagaccgagtctgacatctatggga       c.-241

 .         .         .         .         .         .                g.5184
 ccccactcctaccctgcgcctcaggggccgggacaaccgtgacccgtaccgactcctcgc       c.-181

 .         .         .         .         .         .                g.5244
 gcctccgggatcaacctcagacccctgtgggctcccggggaagacgcatgcgcactgctc       c.-121

 .         .         .         .         .         .                g.5304
 cctcctcgtctccttcccttcgttaattagtccatcgcatttcaagtgctggatcctttt       c.-61

 .         .         .         .         .         .                g.5364
 tgtcccctactgcgtgcggtggcagcttccttgcggaagtggtgaccgtgagagaagaag       c.-1

          .         .         .         .         .         .       g.5424
 ATGGCGGCCCCTGTAGTGGCGCCGCCTGGTGTGGTGGTTAGTCGGGCTAACAAGCGCAGC       c.60
 M  A  A  P  V  V  A  P  P  G  V  V  V  S  R  A  N  K  R  S         p.20

          .         .         .         .         .         .       g.5484
 GGCGCGGGGCCGGGAGGCAGCGGTGGCGGGGGAGCCAGAGGGGCGGAGGAGGAACCGCCG       c.120
 G  A  G  P  G  G  S  G  G  G  G  A  R  G  A  E  E  E  P  P         p.40

          .         .         .         .         .         .       g.5544
 CCGCCCCTACAAGCAGTTCTGGTGGCCGATAGCTTCGATCGCCGCTTCTTCCCCATCTCC       c.180
 P  P  L  Q  A  V  L  V  A  D  S  F  D  R  R  F  F  P  I  S         p.60

          .      | 02  .         .         .         .         .    g.6635
 AAGGACCAGCCTCGG | GTCCTCTTGCCCCTGGCCAATGTGGCATTAATTGACTACACTCTG    c.240
 K  D  Q  P  R   | V  L  L  P  L  A  N  V  A  L  I  D  Y  T  L      p.80

          .         .         .         .         .         .       g.6695
 GAATTCCTGACTGCCACAGGTGTACAGGAAACATTTGTCTTTTGTTGCTGGAAAGCTGCT       c.300
 E  F  L  T  A  T  G  V  Q  E  T  F  V  F  C  C  W  K  A  A         p.100

          .         . | 03       .         .         .         .    g.7638
 CAAATCAAAGAACATTTACT | GAAGTCAAAGTGGTGCCGCCCTACATCTCTCAATGTGGTT    c.360
 Q  I  K  E  H  L  L  |  K  S  K  W  C  R  P  T  S  L  N  V  V      p.120

          .         .         .         .         .         .       g.7698
 CGAATAATTACATCAGAGCTCTATCGATCACTGGGAGATGTCCTCCGTGATGTTGATGCC       c.420
 R  I  I  T  S  E  L  Y  R  S  L  G  D  V  L  R  D  V  D  A         p.140

          .         .         .         .         .         .       g.7758
 AAGGCTTTGGTGCGCTCTGACTTTCTTCTGGTGTATGGGGATGTCATCTCAAACATCAAT       c.480
 K  A  L  V  R  S  D  F  L  L  V  Y  G  D  V  I  S  N  I  N         p.160

          .         .       | 04 .         .         .         .    g.7910
 ATCACCAGAGCCCTTGAGGAACACAG | GTTGAGACGGAAGCTAGAAAAAAATGTTTCTGTG    c.540
 I  T  R  A  L  E  E  H  R  |  L  R  R  K  L  E  K  N  V  S  V      p.180

          .         .         .         .         .         .       g.7970
 ATGACGATGATCTTCAAGGAGTCATCCCCCAGCCACCCAACTCGTTGCCACGAAGACAAT       c.600
 M  T  M  I  F  K  E  S  S  P  S  H  P  T  R  C  H  E  D  N         p.200

          .         .         .         .         .         .       g.8030
 GTGGTAGTGGCTGTGGATAGTACCACAAACAGGGTTCTCCATTTTCAGAAGACCCAGGGT       c.660
 V  V  V  A  V  D  S  T  T  N  R  V  L  H  F  Q  K  T  Q  G         p.220

          .         .     | 05   .         .         .         .    g.8180
 CTCCGGCGTTTTGCATTTCCTCTG | AGCCTGTTTCAGGGCAGTAGTGATGGAGTGGAGGTT    c.720
 L  R  R  F  A  F  P  L   | S  L  F  Q  G  S  S  D  G  V  E  V      p.240

          .         .         .         .      | 06  .         .    g.10073
 CGATATGATTTACTGGATTGTCATATCAGCATCTGTTCTCCTCAG | GTGGCACAACTCTTT    c.780
 R  Y  D  L  L  D  C  H  I  S  I  C  S  P  Q   | V  A  Q  L  F      p.260

          .         .         .         .         .         .       g.10133
 ACAGACAACTTTGACTACCAAACTCGAGATGACTTTGTGCGAGGTCTCTTAGTGAATGAG       c.840
 T  D  N  F  D  Y  Q  T  R  D  D  F  V  R  G  L  L  V  N  E         p.280

     | 07    .         .         .         .         .         .    g.10453
 GAG | ATCCTAGGGAACCAGATCCACATGCACGTAACAGCTAAGGAATATGGTGCCCGTGTC    c.900
 E   | I  L  G  N  Q  I  H  M  H  V  T  A  K  E  Y  G  A  R  V      p.300

          .         .         .         .         .         .       g.10513
 TCCAACCTACACATGTACTCAGCTGTCTGTGCTGACGTCATCCGCCGATGGGTCTACCCT       c.960
 S  N  L  H  M  Y  S  A  V  C  A  D  V  I  R  R  W  V  Y  P         p.320

          .         .         .         .         .         .       g.10573
 CTCACCCCAGAGGCGAACTTCACTGACAGCACCACCCAGAGCTGCACTCATTCCCGGCAC       c.1020
 L  T  P  E  A  N  F  T  D  S  T  T  Q  S  C  T  H  S  R  H         p.340

          .         .         .         .         .         .       g.10633
 AACATCTACCGAGGGCCTGAGGTCAGCCTGGGCCATGGCAGCATCCTAGAGGAAAATGTG       c.1080
 N  I  Y  R  G  P  E  V  S  L  G  H  G  S  I  L  E  E  N  V         p.360

          .         .         .         .         .         .       g.10693
 CTCCTGGGCTCTGGCACTGTCATTGGCAGCAATTGCTTTATCACCAACAGTGTCATTGGC       c.1140
 L  L  G  S  G  T  V  I  G  S  N  C  F  I  T  N  S  V  I  G         p.380

          .       | 08 .         .         .         .         .    g.11947
 CCCGGCTGCCACATTG | GTGATAACGTGGTGCTGGACCAGACCTACCTGTGGCAGGGTGTT    c.1200
 P  G  C  H  I  G |   D  N  V  V  L  D  Q  T  Y  L  W  Q  G  V      p.400

          .         .         .         .         .         .       g.12007
 CGAGTGGCGGCTGGAGCACAGATCCATCAGTCTCTGCTTTGTGACAATGCTGAGGTCAAG       c.1260
 R  V  A  A  G  A  Q  I  H  Q  S  L  L  C  D  N  A  E  V  K         p.420

          .         .         .         .   | 09     .         .    g.12233
 GAACGAGTGACACTGAAACCACGCTCTGTCCTCACTTCCCAG | GTGGTCGTGGGCCCAAAT    c.1320
 E  R  V  T  L  K  P  R  S  V  L  T  S  Q   | V  V  V  G  P  N      p.440

          .         .         .         .         .         .       g.12293
 ATCACGCTGCCTGAGGGCTCGGTGATCTCTTTGCACCCTCCAGATGCAGAGGAAGATGAA       c.1380
 I  T  L  P  E  G  S  V  I  S  L  H  P  P  D  A  E  E  D  E         p.460

          .         .         .         .         .         .       g.12353
 GATGATGGCGAGTTCAGTGATGATTCTGGGGCTGACCAAGAAAAGGACAAAGTGAAGATG       c.1440
 D  D  G  E  F  S  D  D  S  G  A  D  Q  E  K  D  K  V  K  M         p.480

      | 10   .         .         .         .         .         .    g.12536
 AAAG | GTTACAATCCAGCAGAAGTAGGAGCTGCTGGCAAGGGCTACCTCTGGAAAGCTGCA    c.1500
 K  G |   Y  N  P  A  E  V  G  A  A  G  K  G  Y  L  W  K  A  A      p.500

          .         .         .         .       | 11 .         .    g.12771
 GGCATGAACATGGAGGAAGAGGAGGAACTGCAGCAGAATCTGTGGG | GACTCAAGATCAAC    c.1560
 G  M  N  M  E  E  E  E  E  L  Q  Q  N  L  W  G |   L  K  I  N      p.520

          .         .         .         .         .         .       g.12831
 ATGGAAGAAGAGAGTGAAAGTGAAAGTGAGCAAAGTATGGATTCTGAGGAGCCGGACAGC       c.1620
 M  E  E  E  S  E  S  E  S  E  Q  S  M  D  S  E  E  P  D  S         p.540

          .         .         .     | 12   .         .         .    g.13056
 CGGGGAGGCTCCCCTCAGATGGATGACATCAAAG | TGTTCCAGAATGAAGTTTTAGGAACA    c.1680
 R  G  G  S  P  Q  M  D  D  I  K  V |   F  Q  N  E  V  L  G  T      p.560

          .         .         .         .         .         .       g.13116
 CTACAGCGGGGCAAAGAGGAGAACATTTCTTGTGACAATCTCGTCCTGGAAATCAACTCT       c.1740
 L  Q  R  G  K  E  E  N  I  S  C  D  N  L  V  L  E  I  N  S         p.580

       | 13  .         .         .         .         .         .    g.13475
 CTCAA | GTATGCCTATAACATAAGTCTAAAGGAGGTGATGCAGGTACTGAGCCACGTGGTC    c.1800
 L  K  |  Y  A  Y  N  I  S  L  K  E  V  M  Q  V  L  S  H  V  V      p.600

          .         .         .         .         .         .       g.13535
 CTGGAGTTCCCCCTGCAACAGATGGATTCCCCGCTTGACTCAAGCCGCTACTGTGCCCTG       c.1860
 L  E  F  P  L  Q  Q  M  D  S  P  L  D  S  S  R  Y  C  A  L         p.620

           | 14        .         .         .         .         .    g.14128
 CTGCTTCCT | CTGCTAAAGGCCTGGAGCCCTGTTTTTAGGAACTACATAAAGCGCGCAGCC    c.1920
 L  L  P   | L  L  K  A  W  S  P  V  F  R  N  Y  I  K  R  A  A      p.640

          .         .         .         .         .         .       g.14188
 GACCATTTGGAAGCGTTAGCAGCCATTGAGGACTTCTTCCTAGAGCATGAAGCTCTTGGT       c.1980
 D  H  L  E  A  L  A  A  I  E  D  F  F  L  E  H  E  A  L  G         p.660

          .      | 15  .         .         .         .         .    g.14620
 ATTTCCATGGCCAAG | GTACTGATGGCTTTCTACCAGCTGGAGATCCTGGCTGAGGAAACA    c.2040
 I  S  M  A  K   | V  L  M  A  F  Y  Q  L  E  I  L  A  E  E  T      p.680

          .         .         .         .         .         .       g.14680
 ATTCTGAGCTGGTTCAGCCAAAGAGATACAACTGACAAGGGCCAGCAGTTGCGCAAGAAT       c.2100
 I  L  S  W  F  S  Q  R  D  T  T  D  K  G  Q  Q  L  R  K  N         p.700

        | 16 .         .         .         .         .         .    g.14916
 CAACAG | CTGCAGAGGTTCATCCAGTGGCTAAAAGAGGCAGAAGAGGAGTCATCTGAAGAT    c.2160
 Q  Q   | L  Q  R  F  I  Q  W  L  K  E  A  E  E  E  S  S  E  D      p.720

                                                                    g.14922
 GACTGA                                                             c.2166
 D  X                                                               p.721

          .         .         .         .         .         .       g.14982
 agtcacactgcctgctcctttgggtgtgattgagtgccctcctggctcctgggctgggac       c.*60

          .         .         .         .         .         .       g.15042
 aagtgaggaactagctgcagagggatgagtgaccaccatccaggctgagactgaaaggag       c.*120

          .         .         .         .         .         .       g.15102
 cagaggctggaactacagtattctttcccctgctagcaaccatgtgcctcccatcctgac       c.*180

          .         .         .         .         .         .       g.15162
 tgtggagttgggatgtggaagtggggctggaacaaagcttctgcctagggaggagctaag       c.*240

          .         .         .         .         .         .       g.15222
 caggcccggcagttggaggaaggccagaggaacagctttgtgctccggctttccctcagg       c.*300

          .         .         .         .         .         .       g.15282
 gaacagcagagagcagttggctctttctgctgcttgtatatgttaatattaaaagagaga       c.*360

                                                                    g.15290
 gtggtgta                                                           c.*368

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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