eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa (EIF2S3) - coding DNA reference sequence

(used for variant description)

(last modified October 6, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_001415.3 in the EIF2S3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016387.1, covering EIF2S3 transcript NM_001415.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5021
                                        tttccttcctcttttggcaac       c.-1

          .         .         .         .         .         .       g.5081
 ATGGCGGGCGGAGAAGCTGGAGTGACTCTAGGGCAGCCGCATCTTTCGCGTCAGGATCTC       c.60
 M  A  G  G  E  A  G  V  T  L  G  Q  P  H  L  S  R  Q  D  L         p.20

           | 02        .         .         .         .         .    g.5718
 ACCACCTTG | GATGTTACCAAGTTGACGCCACTTTCACACGAAGTTATCAGCAGACAAGCC    c.120
 T  T  L   | D  V  T  K  L  T  P  L  S  H  E  V  I  S  R  Q  A      p.40

          .    | 03    .         .         .         .         .    g.7520
 ACAATTAACATAG | GTACAATTGGTCATGTAGCTCATGGGAAATCCACAGTCGTCAAAGCT    c.180
 T  I  N  I  G |   T  I  G  H  V  A  H  G  K  S  T  V  V  K  A      p.60

          .         .         .         .         .         .       g.7580
 ATTTCTGGAGTTCATACTGTCAGGTTCAAAAATGAACTAGAAAGAAATATTACAATCAAG       c.240
 I  S  G  V  H  T  V  R  F  K  N  E  L  E  R  N  I  T  I  K         p.80

          .         .  | 04      .         .         .         .    g.7724
 CTTGGATATGCTAATGCTAAG | ATTTATAAGCTTGATGACCCAAGTTGCCCTCGGCCAGAA    c.300
 L  G  Y  A  N  A  K   | I  Y  K  L  D  D  P  S  C  P  R  P  E      p.100

          .         .         .         .         .         .       g.7784
 TGTTATAGATCTTGTGGGAGCAGTACACCTGACGAGTTTCCTACGGACATTCCAGGGACC       c.360
 C  Y  R  S  C  G  S  S  T  P  D  E  F  P  T  D  I  P  G  T         p.120

          .         .    | 05    .         .         .         .    g.10177
 AAAGGGAACTTCAAATTAGTCAG | ACATGTTTCCTTTGTTGACTGTCCTGGCCACGATATT    c.420
 K  G  N  F  K  L  V  R  |  H  V  S  F  V  D  C  P  G  H  D  I      p.140

          .         .         .         .         .         | 06    g.12470
 TTGATGGCTACTATGCTGAACGGTGCAGCAGTGATGGATGCAGCTCTTCTGTTGATAG | CT    c.480
 L  M  A  T  M  L  N  G  A  A  V  M  D  A  A  L  L  L  I  A |       p.160

          .         .         .         .         .         .       g.12530
 GGTAATGAATCTTGCCCTCAGCCTCAGACATCGGAACACCTGGCTGCTATAGAGATCATG       c.540
 G  N  E  S  C  P  Q  P  Q  T  S  E  H  L  A  A  I  E  I  M         p.180

          .         .         .         .         .         .       g.12590
 AAACTGAAGCATATTTTGATTCTACAAAATAAAATTGATTTGGTAAAAGAAAGTCAGGCT       c.600
 K  L  K  H  I  L  I  L  Q  N  K  I  D  L  V  K  E  S  Q  A         p.200

          .         .         .        | 07.         .         .    g.14276
 AAAGAACAATACGAGCAGATCCTTGCATTTGTCCAAG | GTACAGTAGCAGAGGGAGCTCCC    c.660
 K  E  Q  Y  E  Q  I  L  A  F  V  Q  G |   T  V  A  E  G  A  P      p.220

          .         .         .         .         .         .       g.14336
 ATTATTCCAATTTCAGCTCAGCTGAAATACAATATTGAAGTTGTTTGTGAGTACATAGTA       c.720
 I  I  P  I  S  A  Q  L  K  Y  N  I  E  V  V  C  E  Y  I  V         p.240

          .         .         .         .         .   | 08     .    g.16058
 AAGAAAATTCCAGTACCCCCAAGAGACTTTACTTCAGAGCCCCGGCTTATTG | TTATTAGA    c.780
 K  K  I  P  V  P  P  R  D  F  T  S  E  P  R  L  I  V |   I  R      p.260

          .         .         .         .         .         .       g.16118
 TCTTTTGATGTCAACAAACCTGGCTGTGAAGTTGATGACCTTAAGGGAGGTGTAGCTGGT       c.840
 S  F  D  V  N  K  P  G  C  E  V  D  D  L  K  G  G  V  A  G         p.280

          .         .        | 09.         .         .         .    g.18049
 GGTAGTATCCTAAAAGGAGTATTAAAG | GTGGGCCAGGAGATAGAAGTAAGACCTGGTATT    c.900
 G  S  I  L  K  G  V  L  K   | V  G  Q  E  I  E  V  R  P  G  I      p.300

          .         .         .         .         .         .       g.18109
 GTTTCCAAAGATAGTGAAGGAAAACTCATGTGTAAACCAATCTTTTCCAAAATTGTATCA       c.960
 V  S  K  D  S  E  G  K  L  M  C  K  P  I  F  S  K  I  V  S         p.320

          .         .         .         .         .   | 10     .    g.21618
 CTTTTTGCGGAGCATAATGATCTGCAATATGCTGCTCCAGGCGGTCTTATTG | GAGTTGGA    c.1020
 L  F  A  E  H  N  D  L  Q  Y  A  A  P  G  G  L  I  G |   V  G      p.340

          .         .         .         .         .         .       g.21678
 ACAAAAATTGACCCCACTTTGTGCCGGGCTGACAGAATGGTGGGGCAAGTACTTGGTGCA       c.1080
 T  K  I  D  P  T  L  C  R  A  D  R  M  V  G  Q  V  L  G  A         p.360

          .         .         .         .         .         .       g.21738
 GTCGGAGCTTTACCTGAGATATTCACAGAATTGGAAATTTCCTATTTCCTGCTTAGACGG       c.1140
 V  G  A  L  P  E  I  F  T  E  L  E  I  S  Y  F  L  L  R  R         p.380

          .         .         .         .   | 11     .         .    g.23161
 CTTCTAGGTGTACGCACTGAAGGAGACAAGAAAGCAGCAAAG | GTTCAAAAGCTGTCTAAG    c.1200
 L  L  G  V  R  T  E  G  D  K  K  A  A  K   | V  Q  K  L  S  K      p.400

          .         .         .         .         .         .       g.23221
 AATGAAGTGCTCATGGTGAACATAGGATCCCTGTCAACAGGAGGGAGAGTTAGTGCTGTC       c.1260
 N  E  V  L  M  V  N  I  G  S  L  S  T  G  G  R  V  S  A  V         p.420

          .         .         .         .         .         .       g.23281
 AAGGCCGATTTGGGTAAAATTGTTTTGACCAATCCAGTGTGCACAGAGGTAGGAGAAAAA       c.1320
 K  A  D  L  G  K  I  V  L  T  N  P  V  C  T  E  V  G  E  K         p.440

          .         .         .      | 12  .         .         .    g.26799
 ATTGCCCTTAGCCGAAGAGTTGAAAAACACTGGCG | TTTAATTGGTTGGGGTCAGATAAGA    c.1380
 I  A  L  S  R  R  V  E  K  H  W  R  |  L  I  G  W  G  Q  I  R      p.460

          .         .         .                                     g.26838
 AGAGGAGTGACAATCAAGCCAACAGTAGATGATGACTGA                            c.1419
 R  G  V  T  I  K  P  T  V  D  D  D  X                              p.472

          .         .         .         .         .         .       g.26898
 agaataccagttaaataatacattcggatggatttggaagttggaattcctcttaacaac       c.*60

          .         .         .         .         .         .       g.26958
 caaggggtttattttcaaagcaatattggggaattgatttcacagttcgttaccttagta       c.*120

          .         .         .         .         .         .       g.27018
 ggtaacggtaaggttattctctttttttttttttttttttttggttatgaaaacttaggg       c.*180

          .         .         .         .         .         .       g.27078
 actaaaattaatataaaaattggcataatgttggattgaatctacattttggcagaagtt       c.*240

          .         .         .         .         .         .       g.27138
 aaacattcccacataatgtcaaaattatacatcatgcagttctgtttttttgtttgtttt       c.*300

          .         .         .         .         .         .       g.27198
 attttgttttgtttttgagtctggctctgtcacccaggctggagtgcagtggcgtgatct       c.*360

          .         .         .         .         .         .       g.27258
 gcaacctctgccccccgggttcaagcgattctcctgcctcagcctcccgagtagctgaga       c.*420

          .         .         .         .         .         .       g.27318
 ttacaggtgcgcgccaccacacttggctaatttttgtattattagtagagacggggtttc       c.*480

          .         .         .         .         .         .       g.27378
 agcatgttggctaggccggtctctcctgacctcagggtgatcagcccacctcggcctcac       c.*540

          .         .         .         .         .         .       g.27438
 aaagtgctgggattacaggcgtgagccaccttgcccagcccacatcatacagtttgaaat       c.*600

          .         .         .         .         .         .       g.27498
 gaaactttgccacaaccagcctttgctgtagcacacacatatatcactgaacctgtttga       c.*660

          .         .         .         .         .         .       g.27558
 aataaagttttttttctttttcatgattcgtctttgagtacctccaggctgaaagactgt       c.*720

          .         .         .         .         .         .       g.27618
 tgtaccagtaaaaacttaaaggcacaaattctccttgaagaccttctcccttttatgtgg       c.*780

          .         .         .         .         .         .       g.27678
 ccccatattttatgttgctttatctttgaaattttgcatgaaaaggaaatgaatggattc       c.*840

          .         .         .         .         .         .       g.27738
 gaatgaaattgtcctttagagcatgattacttgttcccatggacaaatatttttctcccc       c.*900

          .         .         .         .         .         .       g.27798
 ttgctcttcctggcctgaaacacgggaaaccagagtcaaaagttatctccctctccctgt       c.*960

          .         .         .         .         .         .       g.27858
 gatgccttgagatttttttctgcgttgtttaatgcctgaaatccaagtcttcctccatgg       c.*1020

          .         .         .         .         .         .       g.27918
 gaaaatactgttataccaaataattctagatgagtaacaaagatctttttaggccttcat       c.*1080

          .         .         .         .         .         .       g.27978
 tttatgttttttcttaactgttatattatgattgtgacatagattatactactactaatt       c.*1140

          .         .         .         .         .         .       g.28038
 tttggatgtttcaaaaggtcaagaagtaaaagatgttagaaagcaatgagtgagtccttt       c.*1200

          .         .         .         .         .         .       g.28098
 tgatttttaacttattccccatgtccctatacttcgtgtgcttttcctttttttttttga       c.*1260

          .         .         .         .         .         .       g.28158
 gacggaggctcactccgtcacctaggctagagtacagtggcacgatcttggctcgctgca       c.*1320

          .         .         .         .         .         .       g.28218
 acctctgcctccctgattcaagtgattctcgtgcttcagcctcccatgtagctgatatta       c.*1380

          .         .         .         .         .         .       g.28278
 caggcacttgccaccatacccggctaatttttgtatttttagtagagatggggtttcacc       c.*1440

          .         .         .         .         .         .       g.28338
 atgttgcccaggctggtcttgaactcctaacctcaggtgatccgcccgcctctgccttcc       c.*1500

          .         .         .         .         .         .       g.28398
 aaagtgctgggattacaggcgtgagccactctgcccggcttatttttctttatgtttttg       c.*1560

          .         .         .         .         .         .       g.28458
 cttcgtaagaggttctgttgagcagtgatttgcaactcttgctgacgttgctggggaagc       c.*1620

          .         .         .         .         .         .       g.28518
 tttaaaaaaaaaaaagatgccccacagagattctgattttaattgttctgatttaattgg       c.*1680

          .         .         .         .         .         .       g.28578
 cttggagtagaattcaggcattgatatctttaaaaactccccagtgttgagaaacaaatt       c.*1740

          .         .         .         .         .         .       g.28638
 tagagagttgagaagtaggtatattaaattacagaatcttactgagttttggtagactga       c.*1800

          .         .         .         .         .         .       g.28698
 taatacaatttgctttgcttttcttaaatttgcattgagatgggatttgaagcatattgt       c.*1860

          .         .         .         .         .         .       g.28758
 gctcttgtgaatgttgaagttgcattgtagaagtttagaagctctggctatgggttgcct       c.*1920

          .         .         .         .         .         .       g.28818
 aaattgatgttttgaggaagcatattaatgttataaacttcgctgactttgaaggttgtg       c.*1980

          .         .         .         .                           g.28863
 ttgtagcatgaggaacacaaataaaacaattctaaatcaaactaa                      c.*2025

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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