elaC homolog 2 (E. coli) (ELAC2) - coding DNA reference sequence

(used for variant description)

(last modified November 26, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_018127.6 in the ELAC2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_015808.1, covering ELAC2 transcript NM_018127.6.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5057
    agctcggtgcacggcgcgctgattggctggatccgccatgcggagcggctaggtggt       c.-61

 .         .         .         .         .         .                g.5117
 gcacgggaaacgcgggcgtaggtgaccggcggctttctcagttttggtggagacgggcgc       c.-1

          .         .         .         .         .         .       g.5177
 ATGTGGGCGCTTTGCTCGCTGCTGCGGTCCGCGGCCGGACGCACCATGTCGCAGGGACGC       c.60
 M  W  A  L  C  S  L  L  R  S  A  A  G  R  T  M  S  Q  G  R         p.20

          .         .         .         .         .         .       g.5237
 ACCATATCGCAGGCACCCGCCCGCCGCGAGCGGCCGCGCAAGGACCCGCTGCGGCACCTG       c.120
 T  I  S  Q  A  P  A  R  R  E  R  P  R  K  D  P  L  R  H  L         p.40

          .         .         .         .         .         .       g.5297
 CGCACGCGAGAGAAGCGCGGACCGTCGGGGTGCTCCGGCGGCCCAAACACCGTGTACCTG       c.180
 R  T  R  E  K  R  G  P  S  G  C  S  G  G  P  N  T  V  Y  L         p.60

          .         .         .         .         .         .       g.5357
 CAGGTGGTGGCAGCGGGTAGCCGGGACTCGGGCGCCGCGCTCTACGTCTTCTCCGAGTTC       c.240
 Q  V  V  A  A  G  S  R  D  S  G  A  A  L  Y  V  F  S  E  F         p.80

       | 02  .         .         .         .         .       | 03 . g.6136
 AACCG | GTATCTCTTCAACTGTGGAGAAGGCGTTCAGAGACTCATGCAGGAGCACAA | GTTA c.300
 N  R  |  Y  L  F  N  C  G  E  G  V  Q  R  L  M  Q  E  H  K  |  L   p.100

          .         .         .         .         .         .       g.6196
 AAGGTTGCTCGCCTGGACAACATATTCCTGACACGAATGCACTGGTCTAATGTTGGGGGC       c.360
 K  V  A  R  L  D  N  I  F  L  T  R  M  H  W  S  N  V  G  G         p.120

         | 04.         .         .         .         .         .    g.7285
 TTAAGTG | GAATGATTCTTACTTTAAAGGAAACCGGGCTTCCAAAGTGTGTACTTTCTGGA    c.420
 L  S  G |   M  I  L  T  L  K  E  T  G  L  P  K  C  V  L  S  G      p.140

          .   | 05     .         .         .         .         .    g.8616
 CCTCCACAACTG | GAAAAATACCTCGAAGCAATCAAAATATTTTCTGGTCCATTGAAAGGA    c.480
 P  P  Q  L   | E  K  Y  L  E  A  I  K  I  F  S  G  P  L  K  G      p.160

          . | 06       .         .         .         .         .    g.9839
 ATAGAACTGG | CTGTGCGGCCCCACTCTGCCCCAGAATACGAGGATGAAACCATGACAGTT    c.540
 I  E  L  A |   V  R  P  H  S  A  P  E  Y  E  D  E  T  M  T  V      p.180

          .          | 07        .         .         .         .    g.11323
 TACCAGATCCCCATACACA | GTGAACAGAGGAGGGGAAAGCACCAACCATGGCAGAGTCCA    c.600
 Y  Q  I  P  I  H  S |   E  Q  R  R  G  K  H  Q  P  W  Q  S  P      p.200

          .         .         .         .         .         .       g.11383
 GAAAGGCCTCTCAGCAGGCTCAGTCCAGAGCGATCTTCAGACTCCGAGTCGAATGAAAAT       c.660
 E  R  P  L  S  R  L  S  P  E  R  S  S  D  S  E  S  N  E  N         p.220

          .          | 08        .         .         .         .    g.12434
 GAGCCACACCTTCCACATG | GTGTTAGCCAGAGAAGAGGGGTCAGGGACTCTTCCCTGGTC    c.720
 E  P  H  L  P  H  G |   V  S  Q  R  R  G  V  R  D  S  S  L  V      p.240

          .         | 09         .         .         .         .    g.17127
 GTAGCTTTCATCTGTAAG | CTTCACTTAAAGAGAGGAAACTTCTTGGTGCTCAAAGCAAAG    c.780
 V  A  F  I  C  K   | L  H  L  K  R  G  N  F  L  V  L  K  A  K      p.260

          .        | 10.         .         .         .         .    g.17282
 GAGATGGGCCTCCCAGT | TGGGACAGCTGCCATCGCTCCCATCATTGCTGCTGTCAAGGAC    c.840
 E  M  G  L  P  V  |  G  T  A  A  I  A  P  I  I  A  A  V  K  D      p.280

          .         .         . | 11       .         .         .    g.17993
 GGGAAAAGCATCACTCATGAAGGAAGAGAG | ATTTTGGCTGAAGAGCTGTGTACTCCTCCA    c.900
 G  K  S  I  T  H  E  G  R  E   | I  L  A  E  E  L  C  T  P  P      p.300

          .         .         .         .         .         .       g.18053
 GATCCTGGTGCTGCTTTTGTGGTGGTAGAATGTCCAGATGAAAGCTTCATTCAACCCATC       c.960
 D  P  G  A  A  F  V  V  V  E  C  P  D  E  S  F  I  Q  P  I         p.320

          .         .    | 12    .         .         .         .    g.19527
 TGTGAGAATGCCACCTTTCAGAG | GTACCAAGGAAAGGCAGATGCCCCCGTGGCCTTGGTG    c.1020
 C  E  N  A  T  F  Q  R  |  Y  Q  G  K  A  D  A  P  V  A  L  V      p.340

          .         .         .         .         .          | 13    g.20486
 GTTCACATGGCCCCAGCATCTGTGCTTGTGGACAGCAGGTACCAGCAGTGGATGGAGAG | G    c.1080
 V  H  M  A  P  A  S  V  L  V  D  S  R  Y  Q  Q  W  M  E  R  |      p.360

          .         .         .         .         .         .       g.20546
 TTTGGGCCTGACACCCAGCACTTGGTCCTGAATGAGAACTGTGCCTCAGTTCACAACCTT       c.1140
 F  G  P  D  T  Q  H  L  V  L  N  E  N  C  A  S  V  H  N  L         p.380

          .         .         .         .         .         .       g.20606
 CGCAGCCACAAGATTCAAACCCAGCTCAACCTCATCCACCCGGACATCTTCCCCCTGCTC       c.1200
 R  S  H  K  I  Q  T  Q  L  N  L  I  H  P  D  I  F  P  L  L         p.400

          .         | 14         .         .         .         .    g.20747
 ACCAGTTTCCGCTGTAAG | AAGGAGGGCCCCACCCTCAGTGTGCCCATGGTTCAGGGTGAA    c.1260
 T  S  F  R  C  K   | K  E  G  P  T  L  S  V  P  M  V  Q  G  E      p.420

          .         .         .         .     | 15   .         .    g.22806
 TGCCTCCTCAAGTACCAGCTCCGTCCCAGGAGGGAGTGGCAGAG | GGATGCCATTATTACT    c.1320
 C  L  L  K  Y  Q  L  R  P  R  R  E  W  Q  R  |  D  A  I  I  T      p.440

          .         .         .         .         .         .       g.22866
 TGCAATCCTGAGGAATTCATAGTTGAGGCGCTGCAGCTTCCCAACTTCCAGCAGAGCGTG       c.1380
 C  N  P  E  E  F  I  V  E  A  L  Q  L  P  N  F  Q  Q  S  V         p.460

          .         .         .         .    | 16    .         .    g.24573
 CAGGAGTACAGGAGGAGTGCGCAGGACGGCCCAGCCCCAGCAG | AGAAAAGAAGTCAGTAC    c.1440
 Q  E  Y  R  R  S  A  Q  D  G  P  A  P  A  E |   K  R  S  Q  Y      p.480

          .         .         .         .         .         .       g.24633
 CCAGAAATCATCTTCCTTGGAACAGGGTCTGCCATCCCGATGAAGATTCGAAATGTCAGT       c.1500
 P  E  I  I  F  L  G  T  G  S  A  I  P  M  K  I  R  N  V  S         p.500

          .         . | 17       .         .         .         .    g.26419
 GCCACACTTGTCAACATAAG | CCCCGACACGTCTCTGCTACTGGACTGTGGTGAGGGCACA    c.1560
 A  T  L  V  N  I  S  |  P  D  T  S  L  L  L  D  C  G  E  G  T      p.520

          .         .         .         .         .         .       g.26479
 TTTGGGCAGCTGTGCCGTCATTACGGAGACCAGGTGGACAGGGTCCTGGGCACCCTGGCT       c.1620
 F  G  Q  L  C  R  H  Y  G  D  Q  V  D  R  V  L  G  T  L  A         p.540

          .         .         .          | 18        .         .    g.27107
 GCTGTGTTTGTGTCCCACCTGCACGCAGATCACCACACG | GGCTTGCCAAGTATCTTGCTG    c.1680
 A  V  F  V  S  H  L  H  A  D  H  H  T   | G  L  P  S  I  L  L      p.560

          .         | 19         .         .         .         .    g.27294
 CAGAGAGAACGCGCCTTG | GCATCTTTGGGAAAGCCGCTTCACCCTTTGCTGGTGGTTGCC    c.1740
 Q  R  E  R  A  L   | A  S  L  G  K  P  L  H  P  L  L  V  V  A      p.580

          .         .         .         .         .         .       g.27354
 CCCAACCAGCTCAAAGCCTGGCTCCAGCAGTACCACAACCAGTGCCAGGAGGTCCTGCAC       c.1800
 P  N  Q  L  K  A  W  L  Q  Q  Y  H  N  Q  C  Q  E  V  L  H         p.600

          | 20         .         .         .         .         .    g.28054
 CACATCAG | TATGATTCCTGCCAAATGCCTTCAGGAAGGGGCTGAGATCTCCAGTCCTGCA    c.1860
 H  I  S  |  M  I  P  A  K  C  L  Q  E  G  A  E  I  S  S  P  A      p.620

          .         .         .         .         | 21         .    g.28192
 GTGGAAAGATTGATCAGTTCGCTGTTGCGAACATGTGATTTGGAAGAG | TTTCAGACCTGT    c.1920
 V  E  R  L  I  S  S  L  L  R  T  C  D  L  E  E   | F  Q  T  C      p.640

          .         .         .         .         .         .       g.28252
 CTGGTGCGGCACTGCAAGCATGCGTTTGGCTGTGCGCTGGTGCACACCTCTGGCTGGAAA       c.1980
 L  V  R  H  C  K  H  A  F  G  C  A  L  V  H  T  S  G  W  K         p.660

          .         .         .         .          | 22        .    g.28572
 GTGGTCTATTCCGGGGACACCATGCCCTGCGAGGCTCTGGTCCGGATGG | GGAAAGATGCC    c.2040
 V  V  Y  S  G  D  T  M  P  C  E  A  L  V  R  M  G |   K  D  A      p.680

          .         .         .         .         .         .       g.28632
 ACCCTCCTGATACATGAAGCCACCCTGGAAGATGGTTTGGAAGAGGAAGCAGTGGAAAAG       c.2100
 T  L  L  I  H  E  A  T  L  E  D  G  L  E  E  E  A  V  E  K         p.700

          | 23         .         .         .         .         .    g.29285
 ACACACAG | CACAACGTCCCAAGCCATCAGCGTGGGGATGCGGATGAACGCGGAGTTCATT    c.2160
 T  H  S  |  T  T  S  Q  A  I  S  V  G  M  R  M  N  A  E  F  I      p.720

          .         .         .         .         .         .       g.29345
 ATGCTGAACCACTTCAGCCAGCGCTATGCCAAGGTCCCCCTCTTCAGCCCCAACTTCAGC       c.2220
 M  L  N  H  F  S  Q  R  Y  A  K  V  P  L  F  S  P  N  F  S         p.740

          .         .         .    | 24    .         .         .    g.30046
 GAGAAAGTGGGAGTTGCCTTTGACCACATGAAG | GTCTGCTTTGGAGACTTTCCAACAATG    c.2280
 E  K  V  G  V  A  F  D  H  M  K   | V  C  F  G  D  F  P  T  M      p.760

          .         .         .         .         .         .       g.30106
 CCCAAGCTGATTCCCCCACTGAAAGCCCTGTTTGCTGGCGACATCGAGGAGATGGAGGAG       c.2340
 P  K  L  I  P  P  L  K  A  L  F  A  G  D  I  E  E  M  E  E         p.780

          .         .         .         .         .         .       g.30166
 CGCAGGGAGAAGCGGGAGCTGCGGCAGGTGCGGGCGGCCCTCCTGTCCAGGGAGCTGGCA       c.2400
 R  R  E  K  R  E  L  R  Q  V  R  A  A  L  L  S  R  E  L  A         p.800

          .         .         .         .         .         .       g.30226
 GGCGGCCTGGAGGATGGGGAGCCTCAGCAGAAGCGGGCCCACACAGAGGAGCCACAGGCC       c.2460
 G  G  L  E  D  G  E  P  Q  Q  K  R  A  H  T  E  E  P  Q  A         p.820

          .         .                                               g.30247
 AAGAAGGTCAGAGCCCAGTGA                                              c.2481
 K  K  V  R  A  Q  X                                                p.826

          .         .         .         .         .         .       g.30307
 agatctgggagaccctgaactcagaaggctgtgtgtcttctgccccacgcacgcacccgt       c.*60

          .         .         .         .         .         .       g.30367
 atctgccctccttgctggtagaagctgaagagcacggtcccccaggaggcagctcaggat       c.*120

          .         .         .         .         .         .       g.30427
 aggtggtatggagctgtgccgaggcttgggctcccacataagcactagtctatagatgcc       c.*180

          .         .         .         .         .         .       g.30487
 tcttaggactggtgcctggcacagccgcgggccaggaggctgccacacggaagcaagcag       c.*240

          .         .         .         .         .         .       g.30547
 atgaactaatttcatttcaaggcagtttttaaagaagtcttggaaacagacggcggcacc       c.*300

          .         .         .         .         .         .       g.30607
 tttcctctaatccagcaaagtgattccctgcacaccagagacaagcagagtaacaggatc       c.*360

          .         .         .         .         .         .       g.30667
 agtgggtctaagtgtccgagacttaacgaaaatagtatttcagctgcaataaagattgag       c.*420

          .         .         .         .         .         .       g.30727
 tttgcaattgtgagttcttttgcttcctcctgctgctgctacagagcagggtctgctgtg       c.*480

          .         .         .         .         .         .       g.30787
 caccaccttggagaaggctctctgtgctgtagtgtggcagctgcctggtacccgggtggc       c.*540

          .         .         .         .         .         .       g.30847
 ttggaagaagtcagctcccgtcgtagtgagcacctctggaacctgtcctcagagagccac       c.*600

          .         .         .         .         .         .       g.30907
 ccttattcgccaagtctttttgacaactcgagctgtgccagctcacagcagggcgtgctt       c.*660

          .         .         .         .         .         .       g.30967
 tctctatcaatcaatcaatcaatcaatcaaatcaatcagtgagagcctggctgggctggt       c.*720

          .         .         .         .         .         .       g.31027
 gtcattggtcagggaaatgcaagtcttctggtggttctgggtaaaagtggagacaataga       c.*780

          .         .         .         .         .         .       g.31087
 tttgctgtgttgttgcttccatactgagaggagtgaggatcactttgccctcgaaggttt       c.*840

          .         .         .         .         .         .       g.31147
 tgagaaatggcacacggggctggtttccattgtcctccttgcgggatttacagacgtgga       c.*900

          .         .         .         .         .         .       g.31207
 ttagtgctcgacaaatggagagcattttccaaggaagtaagtaagtaaagtaagtaagta       c.*960

          .         .         .         .         .         .       g.31267
 agtaagtaagttgaatctagtatttattgtgtatattccctacccaggagaatgtaaaaa       c.*1020

          .         .         .         .         .         .       g.31327
 gaagagctttaaaaactcaaaagacaagcaagcgagagatcagccagggacctggcttta       c.*1080

          .         .         .         .         .         .       g.31387
 cacaggtggtgaccttcaggctccatcccggtgtgcatttgagattgacggccatgtccc       c.*1140

          .         .         .         .         .         .       g.31447
 cgcaggtttattaaagcaagaacagatgccaagctcagggataataaatctattttaata       c.*1200

                                                                    g.31453
 acgtta                                                             c.*1206

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The ElaC homolog 2 (E. coli) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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