ELOVL fatty acid elongase 4 (ELOVL4) - coding DNA reference sequence

(used for variant description)

(last modified November 13, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_022726.3 in the ELOVL4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009108.2, covering ELOVL4 transcript NM_022726.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5019
                                          acgtgacgccggctgagga       c.-301

 .         .         .         .         .         .                g.5079
 gattggaggggcggctgcgcgaggctgcagactggtgcagcgcactgtgctggcggctgg       c.-241

 .         .         .         .         .         .                g.5139
 gcctcctccacctcctcgtctttctcccgggaaccttgacgacgccttccgcttggccct       c.-181

 .         .         .         .         .         .                g.5199
 gccttctgccgcatccccgccgccgcggcgccttgaggagcaggagaagacgcagccggg       c.-121

 .         .         .         .         .         .                g.5259
 ccgccgccgttagaggggttcccggccgccgctcgccccgtcggccgccaccgcctccgg       c.-61

 .         .         .         .         .         .                g.5319
 ggtcagccctctctctgggtctccgctttctcctgccgccagcgcccgctcatcgccgcg       c.-1

          .         .         .         .         .         .       g.5379
 ATGGGGCTCCTGGACTCGGAGCCGGGTAGTGTCCTAAACGTAGTGTCCACGGCACTCAAC       c.60
 M  G  L  L  D  S  E  P  G  S  V  L  N  V  V  S  T  A  L  N         p.20

          .         .         .         . | 02       .         .    g.26237
 GACACGGTAGAGTTCTACCGCTGGACCTGGTCCATCGCAG | ATAAGCGTGTGGAAAATTGG    c.120
 D  T  V  E  F  Y  R  W  T  W  S  I  A  D |   K  R  V  E  N  W      p.40

          .         .         .         .         .         .       g.26297
 CCTCTGATGCAGTCTCCTTGGCCTACACTAAGTATAAGCACTCTTTATCTCCTGTTTGTG       c.180
 P  L  M  Q  S  P  W  P  T  L  S  I  S  T  L  Y  L  L  F  V         p.60

          .         .         .         .         .         .       g.26357
 TGGCTGGGTCCAAAATGGATGAAGGACCGAGAACCTTTTCAGATGCGTCTAGTGCTCATT       c.240
 W  L  G  P  K  W  M  K  D  R  E  P  F  Q  M  R  L  V  L  I         p.80

          .         .         .         .         | 03         .    g.27578
 ATCTATAATTTTGGGATGGTTTTGCTTAACCTCTTTATCTTCAGAGAG | TTATTCATGGGA    c.300
 I  Y  N  F  G  M  V  L  L  N  L  F  I  F  R  E   | L  F  M  G      p.100

          .         .         .         .         .         .       g.27638
 TCATATAATGCGGGATATAGCTATATTTGCCAGAGTGTGGATTATTCTAATAATGTTCAT       c.360
 S  Y  N  A  G  Y  S  Y  I  C  Q  S  V  D  Y  S  N  N  V  H         p.120

           | 04        .         .         .         .         .    g.30853
 GAAGTCAGG | ATAGCTGCTGCTCTGTGGTGGTACTTTGTATCTAAAGGAGTTGAGTATTTG    c.420
 E  V  R   | I  A  A  A  L  W  W  Y  F  V  S  K  G  V  E  Y  L      p.140

          .         .         .         .         .         .       g.30913
 GACACAGTGTTTTTTATTCTGAGAAAGAAAAACAACCAAGTTTCTTTCCTTCATGTGTAT       c.480
 D  T  V  F  F  I  L  R  K  K  N  N  Q  V  S  F  L  H  V  Y         p.160

          .         .         .         .         .         .       g.30973
 CATCACTGTACGATGTTTACCTTGTGGTGGATTGGAATTAAGTGGGTTGCAGGAGGACAA       c.540
 H  H  C  T  M  F  T  L  W  W  I  G  I  K  W  V  A  G  G  Q         p.180

   | 05      .         .         .         .         .         .    g.33110
 G | CATTTTTTGGAGCCCAGTTGAATTCCTTTATCCATGTGATTATGTACTCATACTATGGG    c.600
 A |   F  F  G  A  Q  L  N  S  F  I  H  V  I  M  Y  S  Y  Y  G      p.200

          .         .         .         .         .         .       g.33170
 TTAACTGCATTTGGCCCATGGATTCAGAAATATCTTTGGTGGAAACGATACCTGACTATG       c.660
 L  T  A  F  G  P  W  I  Q  K  Y  L  W  W  K  R  Y  L  T  M         p.220

           | 06        .         .         .         .         .    g.35766
 TTGCAACTG | ATTCAATTCCATGTGACCATTGGGCACACGGCACTGTCTCTTTACACTGAC    c.720
 L  Q  L   | I  Q  F  H  V  T  I  G  H  T  A  L  S  L  Y  T  D      p.240

          .         .         .         .         .         .       g.35826
 TGCCCCTTCCCCAAATGGATGCACTGGGCTCTAATTGCCTATGCAATCAGCTTCATATTT       c.780
 C  P  F  P  K  W  M  H  W  A  L  I  A  Y  A  I  S  F  I  F         p.260

          .         .         .         .         .         .       g.35886
 CTCTTTCTTAACTTCTACATTCGGACATACAAAGAGCCTAAGAAACCAAAAGCTGGAAAA       c.840
 L  F  L  N  F  Y  I  R  T  Y  K  E  P  K  K  P  K  A  G  K         p.280

          .         .         .         .         .         .       g.35946
 ACAGCCATGAATGGTATTTCAGCAAATGGTGTGAGCAAATCAGAAAAACAACTCATGATA       c.900
 T  A  M  N  G  I  S  A  N  G  V  S  K  S  E  K  Q  L  M  I         p.300

          .         .         .         .                           g.35991
 GAAAATGGAAAAAAGCAGAAAAATGGAAAAGCAAAAGGAGATTAA                      c.945
 E  N  G  K  K  Q  K  N  G  K  A  K  G  D  X                        p.314

          .         .         .         .         .         .       g.36051
 attgaactgggccttaactgttgttgacagtgaggaaaaactcccatatcatataaaatt       c.*60

          .         .         .         .         .         .       g.36111
 tcagggaaaacagaagcaaaggagagcttgggggtggggagaaaagacaaatgtgctcta       c.*120

          .         .         .         .         .         .       g.36171
 tgtcctagtaactcttagactgagtaaagtgttaataccatacccagatgttttatttat       c.*180

          .         .         .         .         .         .       g.36231
 gaagtttttattttaaacattttttttaaaaattagccttgatattctccagaccaaagc       c.*240

          .         .         .         .         .         .       g.36291
 aatcattaagtgactttggggattctccccctgttcacatccagttgtctaaaggatgag       c.*300

          .         .         .         .         .         .       g.36351
 atttttcatgtatcttatagtcactcattcttcggtctgaattttagacgatcacagaaa       c.*360

          .         .         .         .         .         .       g.36411
 cggtctttatgaattattttgataaattactaattatcttatctactgactgaaatcagt       c.*420

          .         .         .         .         .         .       g.36471
 ggtgttacattttcttgtccaaagctgaaaatgtgtatacacttaaacttgcacatttga       c.*480

          .         .         .         .         .         .       g.36531
 attcatttgctgaccggaatggtcaaatctctccacctctagtcagagtataattttggt       c.*540

          .         .         .         .         .         .       g.36591
 tgtaattaaatttttaaaatctgctgatctctgtagaatcttagaggcttgatgatgatg       c.*600

          .         .         .         .         .         .       g.36651
 gtgttggtgaaaataagaaagaattgcagtaaagtcttgtctggtgacccagagatcacc       c.*660

          .         .         .         .         .         .       g.36711
 atgacttgaggcacaaatcactgtggggaaacaattttttgtgatgaaaaggcagcattt       c.*720

          .         .         .         .         .         .       g.36771
 gaatactcctgttagtagcagaaatatattatgaaaattaagattattgtctgattgaaa       c.*780

          .         .         .         .         .         .       g.36831
 catgaaacaactcatgtctttattagtaacatcataagatagttacatttatgtgctgtt       c.*840

          .         .         .         .         .         .       g.36891
 agaatatgttgatttttatcaggctttccttgttttgatttatggctgttcctgattttt       c.*900

          .         .         .         .         .         .       g.36951
 catatgtggaaatatacctacctcttccgttggaaagaacatttaaaattaaataaattt       c.*960

          .         .         .         .         .         .       g.37011
 taattaaaaaatcaaggagtcttctaatgtaaattttaatgttaactttcaaatccacta       c.*1020

          .         .         .         .         .         .       g.37071
 gtattttttttgcttttatgacaaatagcatacaccaaacatttctgtgaaactatcctt       c.*1080

          .         .         .         .         .         .       g.37131
 ctctttcaatgtgtttaattttggagtaacgttttccttgtgactaagttgcaagatctt       c.*1140

          .         .         .         .         .         .       g.37191
 atttattaactaggtatgaagtataaacccattttggtgcaatattcttgactccttggt       c.*1200

          .         .         .         .         .         .       g.37251
 gctaaagattgttaaattcaatgcttgatgttacaaggtgttgttaaaacacaaaatgaa       c.*1260

          .         .         .         .         .         .       g.37311
 taaaagtgagagtagtcagaactataacattcaatttgctatttacaaatgaagtatttc       c.*1320

          .         .         .         .         .         .       g.37371
 atgtaatataagtgaacaactggaaataaagtaggaaagaatttgtatcatgttttacta       c.*1380

          .         .         .         .         .         .       g.37431
 cataggttaattttttaagggatgttgcaaagggattactagagaaagacaaaatgtgac       c.*1440

          .         .         .         .         .         .       g.37491
 caaaaaaaagcatgaatatttcttaagtatctcaacaacatgtcaaagctgcatgtgtag       c.*1500

          .         .         .         .         .         .       g.37551
 gatgtatgctgtttgtacaaactatttcagaatattttgtaagctataacatatttattg       c.*1560

          .         .         .         .         .         .       g.37611
 tgcattaaaattaaatactttttccccaaaggcatgcagtcatgagaattacagaaaatt       c.*1620

          .         .         .         .         .         .       g.37671
 tgcaacatataaagtagtttgatctaagaggattcaacacctttgttttgttgctcagtg       c.*1680

          .         .         .         .         .         .       g.37731
 tgtaatgactgagatttgtaaatctttgtgaacattctgtactggttcccaagagctatt       c.*1740

          .         .         .         .         .                 g.37787
 cattccctgctacctgatttcagcacaataaatatacttctgctgtgggaaaaata           c.*1796

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The ELOVL fatty acid elongase 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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