ELOVL fatty acid elongase 5 (ELOVL5) - coding DNA reference sequence

(used for variant description)

(last modified December 24, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_021814.4 in the ELOVL5 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering ELOVL5 transcript NM_021814.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5011
                                                  aaaaaaatttc       c.-361

 .         .         .         .         .         .                g.5071
 ccagagacacgtggaaccgaggggccaaccccggcctaggctctccaccgcatcggattc       c.-301

 .         .         .         .         .         .                g.5131
 tggaatttacgatcacgaaagttctattgtcccgcgattggctcccgggccgcatgacat       c.-241

 .         .         .         .         .         .                g.5191
 catagcgcttgattcatccttcgggtcccgattggctggccgcgccattgtgacgtcacg       c.-181

 .         .         .         .         .         .                g.5251
 gtcagcccacgttctgattgtagatagccggcgccttcctcttcccatcgcgcgggtcct       c.-121

 .         .         .         .         .         .                g.5311
 agccaccggtgtctccttctacatccgcctctgcgccggctgccacccgcgctccctccg       c.-61

 .         .         .         .         .         .  | 02          g.58480
 ccgccgccgccttgctgctgctcaaagctgctgccgccccttgggctaaaag | gttttcaa    c.-1

          .         .         .         .         .         | 03    g.62218
 ATGGAACATTTTGATGCATCACTTAGTACCTATTTCAAGGCATTGCTAGGCCCTCGAG | AT    c.60
 M  E  H  F  D  A  S  L  S  T  Y  F  K  A  L  L  G  P  R  D |       p.20

          .         .         .         .         .         .       g.62278
 ACTAGAGTAAAAGGATGGTTTCTTCTGGACAATTATATACCCACATTTATCTGCTCTGTC       c.120
 T  R  V  K  G  W  F  L  L  D  N  Y  I  P  T  F  I  C  S  V         p.40

          .         .         .         .         .         .       g.62338
 ATATATTTACTAATTGTATGGCTGGGACCAAAATACATGAGGAATAAACAGCCATTCTCT       c.180
 I  Y  L  L  I  V  W  L  G  P  K  Y  M  R  N  K  Q  P  F  S         p.60

          .         .         .         .         .         .       g.62398
 TGCCGGGGGATTTTAGTGGTGTATAACCTTGGACTCACACTGCTGTCTCTGTATATGTTC       c.240
 C  R  G  I  L  V  V  Y  N  L  G  L  T  L  L  S  L  Y  M  F         p.80

        | 04 .         .         .         .         .         .    g.77977
 TGTGAG | TTAGTAACAGGAGTATGGGAAGGCAAATACAACTTCTTCTGTCAGGGCACACGC    c.300
 C  E   | L  V  T  G  V  W  E  G  K  Y  N  F  F  C  Q  G  T  R      p.100

          .         .     | 05   .         .         .         .    g.78954
 ACCGCAGGAGAATCAGATATGAAG | ATTATCCGTGTCCTCTGGTGGTACTACTTCTCCAAA    c.360
 T  A  G  E  S  D  M  K   | I  I  R  V  L  W  W  Y  Y  F  S  K      p.120

          .         .         .         .         .         .       g.79014
 CTCATAGAATTTATGGACACTTTCTTCTTCATCCTGCGCAAGAACAACCACCAGATCACG       c.420
 L  I  E  F  M  D  T  F  F  F  I  L  R  K  N  N  H  Q  I  T         p.140

          .         .         .         .         .         .       g.79074
 GTCCTGCACGTCTACCACCATGCCTCGATGCTGAACATCTGGTGGTTTGTGATGAACTGG       c.480
 V  L  H  V  Y  H  H  A  S  M  L  N  I  W  W  F  V  M  N  W         p.160

          .       | 06 .         .         .         .         .    g.80879
 GTCCCCTGCGGCCACT | CTTATTTTGGTGCCACACTTAATAGCTTCATCCACGTCCTCATG    c.540
 V  P  C  G  H  S |   Y  F  G  A  T  L  N  S  F  I  H  V  L  M      p.180

          .         .         .         .         .         .       g.80939
 TACTCTTACTATGGTTTGTCGTCAGTCCCTTCCATGCGTCCATACCTCTGGTGGAAGAAG       c.600
 Y  S  Y  Y  G  L  S  S  V  P  S  M  R  P  Y  L  W  W  K  K         p.200

          .         .  | 07      .         .         .         .    g.83491
 TACATCACTCAGGGGCAGCTG | CTTCAGTTTGTGCTGACAATCATCCAGACCAGCTGCGGG    c.660
 Y  I  T  Q  G  Q  L   | L  Q  F  V  L  T  I  I  Q  T  S  C  G      p.220

          .         .         .         .         .         .       g.83551
 GTCATCTGGCCGTGCACATTCCCTCTTGGTTGGTTGTATTTCCAGATTGGATACATGATT       c.720
 V  I  W  P  C  T  F  P  L  G  W  L  Y  F  Q  I  G  Y  M  I         p.240

          .         .         .       | 08 .         .         .    g.84933
 TCCCTGATTGCTCTCTTCACAAACTTCTACATTCAG | ACCTACAACAAGAAAGGGGCCTCC    c.780
 S  L  I  A  L  F  T  N  F  Y  I  Q   | T  Y  N  K  K  G  A  S      p.260

          .         .         .         .         .         .       g.84993
 CGAAGGAAAGACCACCTGAAGGACCACCAGAATGGGTCCATGGCTGCTGTGAATGGACAC       c.840
 R  R  K  D  H  L  K  D  H  Q  N  G  S  M  A  A  V  N  G  H         p.280

          .         .         .         .         .         .       g.85053
 ACCAACAGCTTTTCACCCCTGGAAAACAATGTGAAGCCAAGGAAGCTGCGGAAGGATTGA       c.900
 T  N  S  F  S  P  L  E  N  N  V  K  P  R  K  L  R  K  D  X         p.299

          .         .         .         .         .         .       g.85113
 agtcaaagaattgaaaccctccaaaccacgtcatctgattgtaagcacaatatgagttgt       c.*60

          .         .         .         .         .         .       g.85173
 gccccaatgctcgttaacagctgctgtaactagtctggcctacaatagtgtgattcatgt       c.*120

          .         .         .         .         .         .       g.85233
 aggacttctttcatcaattcaaaacccctagaaaacgtatacagattatataagtaggga       c.*180

          .         .         .         .         .         .       g.85293
 taagatttctaacatttctgggctctctgacccctgcgctagactgtggaaagggagtat       c.*240

          .         .         .         .         .         .       g.85353
 tattatagtatacaacactgctgttgccttattagttataacatgataggtgctgaattg       c.*300

          .         .         .         .         .         .       g.85413
 tgattcacaatttaaaaacactgtaatccaaacttttttttttaactgtagatcatgcat       c.*360

          .         .         .         .         .         .       g.85473
 gtgattgtaaatgtaaatttgtacaatgttgttatggtagagaaacacacatgccttaaa       c.*420

          .         .         .         .         .         .       g.85533
 atttaaaaagcagggcccaaagcttattagtttaaattagggtatgtttcaagtttgtat       c.*480

          .         .         .         .         .         .       g.85593
 taatttgtaatagctctgtttagaaaaaatcaaagaccatgatttatgaaactaatgtga       c.*540

          .         .         .         .         .         .       g.85653
 cataatttccagtgacttgttgatgtgaaatcagacacggcaccttcagttttgtactat       c.*600

          .         .         .         .         .         .       g.85713
 tggctttgaatcaagcaggctcaaatctagtggaacagtcagtttaactttttaacagat       c.*660

          .         .         .         .         .         .       g.85773
 cttatttttttattttgagtgccactattaatgtaaaaaggggggggctctacagcagtc       c.*720

          .         .         .         .         .         .       g.85833
 gtgatgaaacttaaatatatattctttgtcctcgagattttaggaagggtgtagggtgag       c.*780

          .         .         .         .         .         .       g.85893
 taggccatttttaatttctgaagtgctaagtgtttttatacagcaaacaaaaagtcaatt       c.*840

          .         .         .         .         .         .       g.85953
 ttgctttccaccagtgcgagagaggatgtatacttttcaagagagatgattgcctattta       c.*900

          .         .         .         .         .         .       g.86013
 ccgtttgacagagtcccgtagatgagcaatggggaactggttgccagggtctaaatttgg       c.*960

          .         .         .         .         .         .       g.86073
 attgatttatgcactgttatctgttttgacacagatttccttgtaaaatgtgcctagttt       c.*1020

          .         .         .         .         .         .       g.86133
 accaaaattaacaaagggggggaaaggaccttagaactttttaaggtaaaatcaaatata       c.*1080

          .         .         .         .         .         .       g.86193
 gctacagcataagagaatcgagaaatttgatagaggtaacttgtttaatgtaaatctaat       c.*1140

          .         .         .         .         .         .       g.86253
 agtacttgtaatttctttctgcttagaatctaaagatgtgtttagaacctcttgtttaaa       c.*1200

          .         .         .         .         .         .       g.86313
 aataatagactgcttatcataaaatcacatctcacacatttgaggcagtggtcaaacagg       c.*1260

          .         .         .         .         .         .       g.86373
 taaagcctatgatgtgtgtcattttaaagtgtcggaatttagcctctgaataccttctcc       c.*1320

          .         .         .         .         .         .       g.86433
 attgggggaaagatattcttggaaccactcatgacatatcttagaaggtcattgacaatg       c.*1380

          .         .         .         .         .         .       g.86493
 tataaactaattgttggtttgatatttatgtaaatatcagtttaccatgctttaattttg       c.*1440

          .         .         .         .         .         .       g.86553
 cacattcgtactatagggagcctattggttctctattagtcttgtgggttttctgtttga       c.*1500

          .         .         .         .         .         .       g.86613
 aaaggagtcatggcatctgtttacatttaccttatcaaacctagaatgtgtatatttata       c.*1560

          .         .         .         .         .         .       g.86673
 aatgtatgtcttcattgctaggtactaatttgcagatgtctttacatatttcaatacaga       c.*1620

          .         .         .         .         .         .       g.86733
 aactataacattcaatagtgtgctgtcaaagtgtgcttagctcacctggatatacctaca       c.*1680

          .         .         .         .                           g.86782
 ttgttaaatgtctaaacagtaatcattaaaacatttttgattacctgtg                  c.*1729

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The ELOVL fatty acid elongase 5 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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