elastin microfibril interfacer 1 (EMILIN1) - coding DNA reference sequence

(used for variant description)

(last modified June 9, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_007046.3 in the EMILIN1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_046849.1, covering EMILIN1 transcript NM_007046.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5019
                                          gggaggggagccagcaggg       c.-481

 .         .         .         .         .         .                g.5079
 aggaggaggccagggcccgccccacagccactctcgcgcctccgaacagccacaggggca       c.-421

 .         .         .         .         .         .                g.5139
 aagccctgtcacccccaggatccggtcatcagggaaagaggacagggagaccagaagagg       c.-361

 .         .         .         .         .         .                g.5199
 gccagctgggacgagggggcggacgcccaggaggcaacttctgagacgcagctcctgaga       c.-301

 .         .         .         .         .         .                g.5259
 ggggcagggaccaggcgcgggaggccagagggggcacagagaacaaaccccctcagaagt       c.-241

 .         .         .         .         .         .                g.5319
 gaagaggagagcggaaggaaccgagaggggacggacaggagctgaggaggaaagaggagg       c.-181

 .         .         .         .         .         .                g.5379
 ggagaggggtcaggccaggcagccaaggagaagacgtgtggccgggggctatcagaagga       c.-121

 .         .         .         .         .         .                g.5439
 aactgggacggacgggccgggctcgggctgtcctgtggagcagcagcatccccggggccg       c.-61

 .         .         .         .         .         .                g.5499
 gcagaggcgccagtggctgggcgggatgagtctctgagggccactgtggagcgccccgcc       c.-1

          .         .         .         .         .         .       g.5559
 ATGGCCCCCCGCACCCTCTGGAGCTGCTACCTCTGCTGCCTGCTGACGGCAGCTGCAGGG       c.60
 M  A  P  R  T  L  W  S  C  Y  L  C  C  L  L  T  A  A  A  G         p.20

          .         .         .         .         .         .       g.5619
 GCCGCCAGCTACCCTCCTCGAGGTTTCAGCCTCTACACAGGTTCCAGTGGGGCCCTCAGC       c.120
 A  A  S  Y  P  P  R  G  F  S  L  Y  T  G  S  S  G  A  L  S         p.40

          .         .         .         .         . | 02       .    g.6594
 CCCGGGGGGCCCCAGGCCCAGATTGCCCCCCGGCCAGCCAGCCGCCACAG | GAACTGGTGT    c.180
 P  G  G  P  Q  A  Q  I  A  P  R  P  A  S  R  H  R  |  N  W  C      p.60

          .         .         .         .         .         .       g.6654
 GCCTACGTGGTGACCCGGACAGTGAGCTGTGTCCTTGAGGATGGAGTGGAGACATATGTC       c.240
 A  Y  V  V  T  R  T  V  S  C  V  L  E  D  G  V  E  T  Y  V         p.80

          .         .         .         .         . | 03       .    g.7175
 AAGTACCAGCCTTGTGCCTGGGGCCAGCCCCAGTGTCCCCAAAGCATCAT | GTACCGCCGC    c.300
 K  Y  Q  P  C  A  W  G  Q  P  Q  C  P  Q  S  I  M  |  Y  R  R      p.100

          .         .         .         .         .         .       g.7235
 TTCCTCCGCCCTCGCTACCGTGTGGCCTACAAGACAGTGACCGACATGGAGTGGAGGTGC       c.360
 F  L  R  P  R  Y  R  V  A  Y  K  T  V  T  D  M  E  W  R  C         p.120

          .         .         .         .         .         .       g.7295
 TGTCAGGGTTATGGGGGCGATGACTGTGCTGAGAGTCCCGCTCCAGCGCTGGGGCCTGCG       c.420
 C  Q  G  Y  G  G  D  D  C  A  E  S  P  A  P  A  L  G  P  A         p.140

          .         .         .         .         .         .       g.7355
 TCTTCCACACCACGGCCCCTGGCCCAGCCTGCCCGCCCCAACCTCTCTGGCTCCAGTGCA       c.480
 S  S  T  P  R  P  L  A  Q  P  A  R  P  N  L  S  G  S  S  A         p.160

          .         .         .  | 04      .         .         .    g.8545
 GGCAGCCCCCTCAGTGGACTGGGGGGAGAAG | GTCCTGGGGAGTCAGAGAAGGTGCAGCAG    c.540
 G  S  P  L  S  G  L  G  G  E  G |   P  G  E  S  E  K  V  Q  Q      p.180

          .         .         .         .         .         .       g.8605
 CTGGAGGAACAGGTGCAGAGCCTGACCAAGGAGCTGCAAGGCCTGCGGGGCGTCCTGCAA       c.600
 L  E  E  Q  V  Q  S  L  T  K  E  L  Q  G  L  R  G  V  L  Q         p.200

          .         .         .         .         .         .       g.8665
 GGACTGAGCGGGCGCCTGGCAGAGGATGTGCAGAGGGCTGTGGAGACGGCCTTCAACGGG       c.660
 G  L  S  G  R  L  A  E  D  V  Q  R  A  V  E  T  A  F  N  G         p.220

          .         .         .         .         .         .       g.8725
 AGGCAGCAGCCAGCTGACGCGGCTGCCCGCCCTGGGGTGCATGAAACCCTCAATGAGATC       c.720
 R  Q  Q  P  A  D  A  A  A  R  P  G  V  H  E  T  L  N  E  I         p.240

          .         .         .         .         .         .       g.8785
 CAGCACCAGCTGCAGCTCCTGGACACCCGCGTCTCCACCCACGACCAGGAGCTGGGTCAC       c.780
 Q  H  Q  L  Q  L  L  D  T  R  V  S  T  H  D  Q  E  L  G  H         p.260

          .         .         .         .         .         .       g.8845
 CTCAACAACCATCATGGCGGCAGCAGCAGCAGTGGGGGCAGCAGGGCCCCAGCCCCAGCC       c.840
 L  N  N  H  H  G  G  S  S  S  S  G  G  S  R  A  P  A  P  A         p.280

          .         .         .         .         .         .       g.8905
 TCAGCCCCTCCGGGCCCCAGTGAGGAGCTGCTGCGGCAGCTGGAGCAGCGGTTGCAGGAG       c.900
 S  A  P  P  G  P  S  E  E  L  L  R  Q  L  E  Q  R  L  Q  E         p.300

          .         .         .         .         .         .       g.8965
 TCCTGCTCCGTGTGCCTGGCCGGGCTAGATGGCTTCCGCCGGCAGCAGCAGGAGGACAGG       c.960
 S  C  S  V  C  L  A  G  L  D  G  F  R  R  Q  Q  Q  E  D  R         p.320

          .         .         .         .         .         .       g.9025
 GAGCGGCTGCGAGCGATGGAGAAGCTGCTGGCCTCGGTGGAGGAGCGGCAACGGCACCTC       c.1020
 E  R  L  R  A  M  E  K  L  L  A  S  V  E  E  R  Q  R  H  L         p.340

          .         .         .         .         .         .       g.9085
 GCAGGGCTGGCGGTGGGCCGCAGGCCCCCTCAGGAATGCTGCTCTCCAGAGCTGGGCCGG       c.1080
 A  G  L  A  V  G  R  R  P  P  Q  E  C  C  S  P  E  L  G  R         p.360

          .         .         .         .         .         .       g.9145
 CGACTGGCAGAGCTGGAGCGCAGGCTGGATGTCGTGGCCGGCTCAGTGACAGTGCTGAGT       c.1140
 R  L  A  E  L  E  R  R  L  D  V  V  A  G  S  V  T  V  L  S         p.380

          .         .         .         .         .         .       g.9205
 GGGCGGCGAGGCACAGAGCTGGGAGGAGCCGCGGGGCAGGGAGGCCACCCCCCAGGCTAC       c.1200
 G  R  R  G  T  E  L  G  G  A  A  G  Q  G  G  H  P  P  G  Y         p.400

          .         .         .         .         .         .       g.9265
 ACCAGCTTGGCCTCCCGCCTGTCTCGCCTGGAGGACCGCTTCAACTCCACCCTGGGCCCT       c.1260
 T  S  L  A  S  R  L  S  R  L  E  D  R  F  N  S  T  L  G  P         p.420

          .         .         .         .         .         .       g.9325
 TCGGAGGAGCAGGAGGAGAGCTGGCCTGGGGCTCCTGGGGGGCTGAGCCACTGGCTGCCT       c.1320
 S  E  E  Q  E  E  S  W  P  G  A  P  G  G  L  S  H  W  L  P         p.440

          .         .         .         .         .         .       g.9385
 GCTGCCCGGGGCCGACTAGAGCAGTTGGGGGGGCTGCTGGCCAATGTGAGCGGGGAGCTG       c.1380
 A  A  R  G  R  L  E  Q  L  G  G  L  L  A  N  V  S  G  E  L         p.460

          .         .         .         .         .         .       g.9445
 GGGGGGCGGTTGGATCTGTTGGAGGAGCAGGTGGCAGGGGCCATGCAGGCATGCGGGCAG       c.1440
 G  G  R  L  D  L  L  E  E  Q  V  A  G  A  M  Q  A  C  G  Q         p.480

          .         .         .         .         .         .       g.9505
 CTCTGCTCTGGGGCCCCTGGGGAGCAGGACTCTCAAGTCAGCGAGATCCTCAGTGCCTTG       c.1500
 L  C  S  G  A  P  G  E  Q  D  S  Q  V  S  E  I  L  S  A  L         p.500

          .         .         .         .         .         .       g.9565
 GAGCGCAGGGTGCTGGACAGTGAGGGGCAGCTGCGGCTGGTGGGCTCCGGCCTGCACACG       c.1560
 E  R  R  V  L  D  S  E  G  Q  L  R  L  V  G  S  G  L  H  T         p.520

          .         .         .         .         .         .       g.9625
 GTGGAAGCAGCGGGGGAGGCCCGGCAGGCCACGCTGGAGGGATTACAAGAGGTTGTGGGC       c.1620
 V  E  A  A  G  E  A  R  Q  A  T  L  E  G  L  Q  E  V  V  G         p.540

          .         .         .         .         .         .       g.9685
 CGGCTCCAGGATCGTGTGGATGCCCAGGATGAGACAGCTGCAGAGTTCACACTACGGCTG       c.1680
 R  L  Q  D  R  V  D  A  Q  D  E  T  A  A  E  F  T  L  R  L         p.560

          .         .         .         .         .         .       g.9745
 AATCTCACTGCGGCCCGGCTAGGCCAACTGGAGGGGCTGCTGCAGGCCCATGGGGATGAG       c.1740
 N  L  T  A  A  R  L  G  Q  L  E  G  L  L  Q  A  H  G  D  E         p.580

          .         .         .         .         .         .       g.9805
 GGCTGTGGGGCCTGTGGCGGAGTCCAAGAGGAACTAGGCCGCCTTCGGGATGGTGTGGAG       c.1800
 G  C  G  A  C  G  G  V  Q  E  E  L  G  R  L  R  D  G  V  E         p.600

          .         .         .         .         .         .       g.9865
 CGCTGCTCCTGCCCCCTGTTGCCTCCTCGGGGTCCTGGGGCTGGTCCAGGTGTTGGGGGC       c.1860
 R  C  S  C  P  L  L  P  P  R  G  P  G  A  G  P  G  V  G  G         p.620

          .         .         .         .         .         .       g.9925
 CCAAGCCGTGGGCCCCTGGACGGCTTCAGCGTGTTTGGGGGCAGCTCAGGCTCAGCCCTG       c.1920
 P  S  R  G  P  L  D  G  F  S  V  F  G  G  S  S  G  S  A  L         p.640

          .         .         .         .         .         .       g.9985
 CAGGCCCTGCAAGGAGAGCTCTCTGAGGTTATTCTCAGCTTCAGCTCCCTCAATGACTCA       c.1980
 Q  A  L  Q  G  E  L  S  E  V  I  L  S  F  S  S  L  N  D  S         p.660

          .         .         .         .         .         .       g.10045
 CTGAATGAGCTCCAGACCACTGTGGAGGGCCAGGGCGCTGATCTGGCTGACCTGGGGGCA       c.2040
 L  N  E  L  Q  T  T  V  E  G  Q  G  A  D  L  A  D  L  G  A         p.680

          .         .         .         .         .         .       g.10105
 ACCAAGGACCGTATCATTTCTGAGATTAACAGGCTGCAGCAGGAGGCCACAGAGCATGCT       c.2100
 T  K  D  R  I  I  S  E  I  N  R  L  Q  Q  E  A  T  E  H  A         p.700

          .         .         .         .         .         .       g.10165
 ACAGAGAGTGAAGAGCGCTTCCGAGGCCTAGAGGAGGGACAAGCACAGGCCGGCCAGTGC       c.2160
 T  E  S  E  E  R  F  R  G  L  E  E  G  Q  A  Q  A  G  Q  C         p.720

          .         .         .         .         .         .       g.10225
 CCCAGCTTAGAGGGGCGATTGGGCCGTCTTGAGGGTGTCTGTGAACGGTTGGACACTGTG       c.2220
 P  S  L  E  G  R  L  G  R  L  E  G  V  C  E  R  L  D  T  V         p.740

          .         .         .         .         .         .       g.10285
 GCTGGGGGACTGCAGGGCCTGCGCGAGGGCCTTTCCAGACACGTGGCTGGGCTCTGGGCT       c.2280
 A  G  G  L  Q  G  L  R  E  G  L  S  R  H  V  A  G  L  W  A         p.760

          .         .         .         .         .         .       g.10345
 GGGCTCCGGGAAACCAACACCACCAGCCAGATGCAGGCAGCCCTGCTGGAGAAGCTGGTC       c.2340
 G  L  R  E  T  N  T  T  S  Q  M  Q  A  A  L  L  E  K  L  V         p.780

          .         .         .         .         .         .       g.10405
 GGGGGACAGGCGGGCCTGGGCAGGCGGCTGGGTGCCCTTAACAGCTCCCTGCAGCTCCTG       c.2400
 G  G  Q  A  G  L  G  R  R  L  G  A  L  N  S  S  L  Q  L  L         p.800

          .         .         .         . | 05       .         .    g.10868
 GAGGACCGTCTGCACCAGCTCAGCCTGAAGGACCTCACTG | GGCCTGCAGGAGAGGCTGGG    c.2460
 E  D  R  L  H  Q  L  S  L  K  D  L  T  G |   P  A  G  E  A  G      p.820

          .         .         .         .         .         .       g.10928
 CCCCCAGGGCCTCCTGGGCTGCAGGGACCCCCAGGCCCTGCTGGACCTCCAGGATCACCA       c.2520
 P  P  G  P  P  G  L  Q  G  P  P  G  P  A  G  P  P  G  S  P         p.840

          .         .         .        | 06.         .      | 07  . g.11598
 GGCAAGGACGGGCAAGAGGGCCCCATCGGGCCACCAG | GTCCTCAAGGTGAACAGG | GAGTG c.2580
 G  K  D  G  Q  E  G  P  I  G  P  P  G |   P  Q  G  E  Q  G |   V   p.860

          .         .         .         .         .         .       g.11658
 GAGGGGGCACCAGCAGCCCCTGTGCCCCAAGTGGCATTTTCAGCTGCTCTGAGTTTGCCC       c.2640
 E  G  A  P  A  A  P  V  P  Q  V  A  F  S  A  A  L  S  L  P         p.880

          .         .         .         .         .         .       g.11718
 CGGTCTGAACCAGGCACGGTCCCCTTCGACAGAGTCCTGCTCAATGATGGAGGCTATTAT       c.2700
 R  S  E  P  G  T  V  P  F  D  R  V  L  L  N  D  G  G  Y  Y         p.900

          .    | 08    .         .         .         .         .    g.12158
 GATCCAGAGACAG | GCGTGTTCACAGCGCCACTGGCTGGACGCTACTTGCTGAGCGCGGTG    c.2760
 D  P  E  T  G |   V  F  T  A  P  L  A  G  R  Y  L  L  S  A  V      p.920

          .         .         .         .         .         .       g.12218
 CTGACTGGGCACCGGCACGAGAAAGTGGAGGCCGTGCTGTCCCGCTCCAACCAGGGCGTG       c.2820
 L  T  G  H  R  H  E  K  V  E  A  V  L  S  R  S  N  Q  G  V         p.940

          .         .         .         .         .         .       g.12278
 GCCCGCGTAGACTCCGGTGGCTACGAGCCTGAGGGCCTGGAGAATAAGCCGGTGGCCGAG       c.2880
 A  R  V  D  S  G  G  Y  E  P  E  G  L  E  N  K  P  V  A  E         p.960

          .         .         .         .         .         .       g.12338
 AGCCAGCCCAGCCCGGGCACCCTGGGCGTCTTCAGCCTCATCCTGCCGCTGCAGGCCGGG       c.2940
 S  Q  P  S  P  G  T  L  G  V  F  S  L  I  L  P  L  Q  A  G         p.980

          .         .         .         .         .         .       g.12398
 GACACGGTCTGCGTCGACCTGGTCATGGGGCAGCTGGCGCACTCGGAGGAGCCGCTCACC       c.3000
 D  T  V  C  V  D  L  V  M  G  Q  L  A  H  S  E  E  P  L  T         p.1000

          .         .         .         .         .                 g.12449
 ATCTTCAGCGGGGCCCTGCTCTATGGGGACCCAGAGCTTGAACACGCGTAG                c.3051
 I  F  S  G  A  L  L  Y  G  D  P  E  L  E  H  A  X                  p.1016

          .         .         .         .         .         .       g.12509
 actggggtcccgcccgacgtgtctacgtcggctgaagagacagcgggggcggcgggctcc       c.*60

          .         .         .         .         .         .       g.12569
 tggggtctcgcctgagacggggcacctagccctgggcgagcgccgcacccgggcccgcag       c.*120

          .         .         .         .         .         .       g.12629
 cggcaccgcgcccagagcggcctctccccacgcccggggcgcgccggctcagggaggctc       c.*180

          .         .         .         .         .         .       g.12689
 ggggccgcccatgcagacttttggcctggcgcgatcccccaagaacccctccagggccgg       c.*240

          .         .         .         .         .         .       g.12749
 cctgcggaggagccgatcctcgcaccctccgctccctccactggccctccaggtcgattc       c.*300

          .         .         .         .         .         .       g.12809
 cctgggctccaggctcccccgcgcgggcgccgcccaccgccatactaaacgatcgaggaa       c.*360

          .         .                                               g.12837
 taaagacacttggtttttctaaaaaaaa                                       c.*388

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Elastin microfibril interfacer 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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