endothelial PAS domain protein 1 (EPAS1) - coding DNA reference sequence

(used for variant description)

(last modified November 25, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_001430.4 in the EPAS1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016000.1, covering EPAS1 transcript NM_001430.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5030
                               gctttacactcgcgagcggaccgccacacg       c.-481

 .         .         .         .         .         .                g.5090
 ggtccggtgcccgctgcgcttccgccccagcgctcctgaggcggccgtacaatcctcggc       c.-421

 .         .         .         .         .         .                g.5150
 agtgtcctgagactgtatggtcagctcagcccggcctccgactccttccgactcccagca       c.-361

 .         .         .         .         .         .                g.5210
 ttcgagccacttttttttttctttgaaaactcagaaaagtgactccttttccagggaaaa       c.-301

 .         .         .         .         .         .                g.5270
 aggaacttgggttcccttctctccgtcctcttttcgggtctgacagcctccacccactcc       c.-241

 .         .         .         .         .         .                g.5330
 ttccccggaccccgcctccgcgcgcaggttcctcccagtcacctttctccacccccgccc       c.-181

 .         .         .         .         .         .                g.5390
 ccgcacctagcccgccgcgcgccaccttccacctgactgcgcggggcgctcgggacctgc       c.-121

 .         .         .         .         .         .                g.5450
 gcgcacctcggaccttcaccacccgcccgggccgcggggagcggacgagggccacagccc       c.-61

 .         .         .         .         .         .                g.5510
 cccacccgccagggagcccaggtgctcggcgtctgaacgtctcaaagggccacagcgaca       c.-1

          .         .       | 02 .         .         .         .    g.54505
 ATGACAGCTGACAAGGAGAAGAAAAG | GAGTAGCTCGGAGAGGAGGAAGGAGAAGTCCCGG    c.60
 M  T  A  D  K  E  K  K  R  |  S  S  S  E  R  R  K  E  K  S  R      p.20

          .         .         .         .         .         .       g.54565
 GATGCTGCGCGGTGCCGGCGGAGCAAGGAGACGGAGGTGTTCTATGAGCTGGCCCATGAG       c.120
 D  A  A  R  C  R  R  S  K  E  T  E  V  F  Y  E  L  A  H  E         p.40

          .         .         .         .         .         .       g.54625
 CTGCCTCTGCCCCACAGTGTGAGCTCCCATCTGGACAAGGCCTCCATCATGCGACTGGCA       c.180
 L  P  L  P  H  S  V  S  S  H  L  D  K  A  S  I  M  R  L  A         p.60

          .         .         .        | 03.         .         .    g.63772
 ATCAGCTTCCTGCGAACACACAAGCTCCTCTCCTCAG | TTTGCTCTGAAAACGAGTCCGAA    c.240
 I  S  F  L  R  T  H  K  L  L  S  S  V |   C  S  E  N  E  S  E      p.80

          .         .         .         .         .         .       g.63832
 GCCGAAGCTGACCAGCAGATGGACAACTTGTACCTGAAAGCCTTGGAGGGTTTCATTGCC       c.300
 A  E  A  D  Q  Q  M  D  N  L  Y  L  K  A  L  E  G  F  I  A         p.100

          .         .         .         .         .         .       g.63892
 GTGGTGACCCAAGATGGCGACATGATCTTTCTGTCAGAAAACATCAGCAAGTTCATGGGA       c.360
 V  V  T  Q  D  G  D  M  I  F  L  S  E  N  I  S  K  F  M  G         p.120

           | 04        .         .         .         .         .    g.64373
 CTTACACAG | GTGGAGCTAACAGGACATAGTATCTTTGACTTCACTCATCCCTGCGACCAT    c.420
 L  T  Q   | V  E  L  T  G  H  S  I  F  D  F  T  H  P  C  D  H      p.140

          .         .         .     | 05   .         .         .    g.68262
 GAGGAGATTCGTGAGAACCTGAGTCTCAAAAATG | GCTCTGGTTTTGGGAAAAAAAGCAAA    c.480
 E  E  I  R  E  N  L  S  L  K  N  G |   S  G  F  G  K  K  S  K      p.160

          .         .         .         .         .         .       g.68322
 GACATGTCCACAGAGCGGGACTTCTTCATGAGGATGAAGTGCACGGTCACCAACAGAGGC       c.540
 D  M  S  T  E  R  D  F  F  M  R  M  K  C  T  V  T  N  R  G         p.180

          .         .         .    | 06    .         .         .    g.68510
 CGTACTGTCAACCTCAAGTCAGCCACCTGGAAG | GTCTTGCACTGCACGGGCCAGGTGAAA    c.600
 R  T  V  N  L  K  S  A  T  W  K   | V  L  H  C  T  G  Q  V  K      p.200

          .         .         .         .         .         .       g.68570
 GTCTACAACAACTGCCCTCCTCACAATAGTCTGTGTGGCTACAAGGAGCCCCTGCTGTCC       c.660
 V  Y  N  N  C  P  P  H  N  S  L  C  G  Y  K  E  P  L  L  S         p.220

          .         .         .         .         .         .       g.68630
 TGCCTCATCATCATGTGTGAACCAATCCAGCACCCATCCCACATGGACATCCCCCTGGAT       c.720
 C  L  I  I  M  C  E  P  I  Q  H  P  S  H  M  D  I  P  L  D         p.240

          .         .         .         .         .          | 07    g.77426
 AGCAAGACCTTCCTGAGCCGCCACAGCATGGACATGAAGTTCACCTACTGTGATGACAG | A    c.780
 S  K  T  F  L  S  R  H  S  M  D  M  K  F  T  Y  C  D  D  R  |      p.260

          .         .         .         .         .         .       g.77486
 ATCACAGAACTGATTGGTTACCACCCTGAGGAGCTGCTTGGCCGCTCAGCCTATGAATTC       c.840
 I  T  E  L  I  G  Y  H  P  E  E  L  L  G  R  S  A  Y  E  F         p.280

          .         .         .         .       | 08 .         .    g.83302
 TACCATGCGCTAGACTCCGAGAACATGACCAAGAGTCACCAGAACT | TGTGCACCAAGGGT    c.900
 Y  H  A  L  D  S  E  N  M  T  K  S  H  Q  N  L |   C  T  K  G      p.300

          .         .         .         .         .         .       g.83362
 CAGGTAGTAAGTGGCCAGTACCGGATGCTCGCAAAGCATGGGGGCTACGTGTGGCTGGAG       c.960
 Q  V  V  S  G  Q  Y  R  M  L  A  K  H  G  G  Y  V  W  L  E         p.320

          .         .         .         .         .         .       g.83422
 ACCCAGGGGACGGTCATCTACAACCCTCGCAACCTGCAGCCCCAGTGCATCATGTGTGTC       c.1020
 T  Q  G  T  V  I  Y  N  P  R  N  L  Q  P  Q  C  I  M  C  V         p.340

          .     | 09   .         .         .         .         .    g.84183
 AACTACGTCCTGAG | TGAGATTGAGAAGAATGACGTGGTGTTCTCCATGGACCAGACTGAA    c.1080
 N  Y  V  L  S  |  E  I  E  K  N  D  V  V  F  S  M  D  Q  T  E      p.360

          .         .         .         .         .         .       g.84243
 TCCCTGTTCAAGCCCCACCTGATGGCCATGAACAGCATCTTTGATAGCAGTGGCAAGGGG       c.1140
 S  L  F  K  P  H  L  M  A  M  N  S  I  F  D  S  S  G  K  G         p.380

          .         .         .         .         .         .       g.84303
 GCTGTGTCTGAGAAGAGTAACTTCCTATTCACCAAGCTAAAGGAGGAGCCCGAGGAGCTG       c.1200
 A  V  S  E  K  S  N  F  L  F  T  K  L  K  E  E  P  E  E  L         p.400

          .         .         .         .          | 10        .    g.85503
 GCCCAGCTGGCTCCCACCCCAGGAGACGCCATCATCTCTCTGGATTTCG | GGAATCAGAAC    c.1260
 A  Q  L  A  P  T  P  G  D  A  I  I  S  L  D  F  G |   N  Q  N      p.420

          .         .         .         .         .         .       g.85563
 TTCGAGGAGTCCTCAGCCTATGGCAAGGCCATCCTGCCCCCGAGCCAGCCATGGGCCACG       c.1320
 F  E  E  S  S  A  Y  G  K  A  I  L  P  P  S  Q  P  W  A  T         p.440

          .         .         .         .         .         .       g.85623
 GAGTTGAGGAGCCACAGCACCCAGAGCGAGGCTGGGAGCCTGCCTGCCTTCACCGTGCCC       c.1380
 E  L  R  S  H  S  T  Q  S  E  A  G  S  L  P  A  F  T  V  P         p.460

          .         .         .         .         .         .       g.85683
 CAGGCAGCTGCCCCGGGCAGCACCACCCCCAGTGCCACCAGCAGCAGCAGCAGCTGCTCC       c.1440
 Q  A  A  A  P  G  S  T  T  P  S  A  T  S  S  S  S  S  C  S         p.480

     | 11    .         .         .         .         .         .    g.86312
 ACG | CCCAATAGCCCTGAAGACTATTACACATCTTTGGATAACGACCTGAAGATTGAAGTG    c.1500
 T   | P  N  S  P  E  D  Y  Y  T  S  L  D  N  D  L  K  I  E  V      p.500

          .         .         .         .         .     | 12   .    g.87831
 ATTGAGAAGCTCTTCGCCATGGACACAGAGGCCAAGGACCAATGCAGTACCCAG | ACGGAT    c.1560
 I  E  K  L  F  A  M  D  T  E  A  K  D  Q  C  S  T  Q   | T  D      p.520

          .         .         .         .         .         .       g.87891
 TTCAATGAGCTGGACTTGGAGACACTGGCACCCTATATCCCCATGGACGGGGAAGACTTC       c.1620
 F  N  E  L  D  L  E  T  L  A  P  Y  I  P  M  D  G  E  D  F         p.540

          .         .         .         .         .         .       g.87951
 CAGCTAAGCCCCATCTGCCCCGAGGAGCGGCTCTTGGCGGAGAACCCACAGTCCACCCCC       c.1680
 Q  L  S  P  I  C  P  E  E  R  L  L  A  E  N  P  Q  S  T  P         p.560

          .         .         .         .         .         .       g.88011
 CAGCACTGCTTCAGTGCCATGACAAACATCTTCCAGCCACTGGCCCCTGTAGCCCCGCAC       c.1740
 Q  H  C  F  S  A  M  T  N  I  F  Q  P  L  A  P  V  A  P  H         p.580

          .         .         .         .         .         .       g.88071
 AGTCCCTTCCTCCTGGACAAGTTTCAGCAGCAGCTGGAGAGCAAGAAGACAGAGCCCGAG       c.1800
 S  P  F  L  L  D  K  F  Q  Q  Q  L  E  S  K  K  T  E  P  E         p.600

          .         .         .         .         .         .       g.88131
 CACCGGCCCATGTCCTCCATCTTCTTTGATGCCGGAAGCAAAGCATCCCTGCCACCGTGC       c.1860
 H  R  P  M  S  S  I  F  F  D  A  G  S  K  A  S  L  P  P  C         p.620

          .         .         .         .         .         .       g.88191
 TGTGGCCAGGCCAGCACCCCTCTCTCTTCCATGGGGGGCAGATCCAATACCCAGTGGCCC       c.1920
 C  G  Q  A  S  T  P  L  S  S  M  G  G  R  S  N  T  Q  W  P         p.640

          .         .         .         .         .         .       g.88251
 CCAGATCCACCATTACATTTTGGGCCCACAAAGTGGGCCGTCGGGGATCAGCGCACAGAG       c.1980
 P  D  P  P  L  H  F  G  P  T  K  W  A  V  G  D  Q  R  T  E         p.660

          .         .         .         .         .         .       g.88311
 TTCTTGGGAGCAGCGCCGTTGGGGCCCCCTGTCTCTCCACCCCATGTCTCCACCTTCAAG       c.2040
 F  L  G  A  A  P  L  G  P  P  V  S  P  P  H  V  S  T  F  K         p.680

       | 13  .         .         .         .         .         .    g.89249
 ACAAG | GTCTGCAAAGGGTTTTGGGGCTCGAGGCCCAGACGTGCTGAGTCCGGCCATGGTA    c.2100
 T  R  |  S  A  K  G  F  G  A  R  G  P  D  V  L  S  P  A  M  V      p.700

          .         .         .         .         .         .       g.89309
 GCCCTCTCCAACAAGCTGAAGCTGAAGCGACAGCTGGAGTATGAAGAGCAAGCCTTCCAG       c.2160
 A  L  S  N  K  L  K  L  K  R  Q  L  E  Y  E  E  Q  A  F  Q         p.720

          .   | 14     .         .         .         .         .    g.89621
 GACCTGAGCGGG | GGGGACCCACCTGGTGGCAGCACCTCACATTTGATGTGGAAACGGATG    c.2220
 D  L  S  G   | G  D  P  P  G  G  S  T  S  H  L  M  W  K  R  M      p.740

          .         .         .         .         .         .       g.89681
 AAGAACCTCAGGGGTGGGAGCTGCCCTTTGATGCCGGACAAGCCACTGAGCGCAAATGTA       c.2280
 K  N  L  R  G  G  S  C  P  L  M  P  D  K  P  L  S  A  N  V         p.760

         | 15.         .         .         .         .         .    g.90076
 CCCAATG | ATAAGTTCACCCAAAACCCCATGAGGGGCCTGGGCCATCCCCTGAGACATCTG    c.2340
 P  N  D |   K  F  T  Q  N  P  M  R  G  L  G  H  P  L  R  H  L      p.780

          .         .         .         .         .         .       g.90136
 CCGCTGCCACAGCCTCCATCTGCCATCAGTCCCGGGGAGAACAGCAAGAGCAGGTTCCCC       c.2400
 P  L  P  Q  P  P  S  A  I  S  P  G  E  N  S  K  S  R  F  P         p.800

          .         .         .         .         .         .       g.90196
 CCACAGTGCTACGCCACCCAGTACCAGGACTACAGCCTGTCGTCAGCCCACAAGGTGTCA       c.2460
 P  Q  C  Y  A  T  Q  Y  Q  D  Y  S  L  S  S  A  H  K  V  S         p.820

   | 16      .         .         .         .         .         .    g.92166
 G | GCATGGCAAGCCGGCTGCTCGGGCCCTCATTTGAGTCCTACCTGCTGCCCGAACTGACC    c.2520
 G |   M  A  S  R  L  L  G  P  S  F  E  S  Y  L  L  P  E  L  T      p.840

          .         .         .         .         .         .       g.92226
 AGATATGACTGTGAGGTGAACGTGCCCGTGCTGGGAAGCTCCACGCTCCTGCAAGGAGGG       c.2580
 R  Y  D  C  E  V  N  V  P  V  L  G  S  S  T  L  L  Q  G  G         p.860

          .         .         .                                     g.92259
 GACCTCCTCAGAGCCCTGGACCAGGCCACCTGA                                  c.2613
 D  L  L  R  A  L  D  Q  A  T  X                                    p.870

          .         .         .         .         .         .       g.92319
 gccaggccttctacctgggcagcacctctgccgacgccgtcccaccagcttcactctctc       c.*60

          .         .         .         .         .         .       g.92379
 cgtctgtttttgcaactaggtatttctaacgccagcacactatttacaagatggacttac       c.*120

          .         .         .         .         .         .       g.92439
 ctggcagacttgcccaggtcaccaagcagtggcctttttctgagatgctcactttattat       c.*180

          .         .         .         .         .         .       g.92499
 ccctatttttaaagtacacaattgttttacctgttctgaaatgttcttaaattttgtagg       c.*240

          .         .         .         .         .         .       g.92559
 atttttttcctccccaccttcaatgacttctaatttatattatccataggtttctctccc       c.*300

          .         .         .         .         .         .       g.92619
 tccttctccttctcacacacaactgtccatactaacaagtttggtgcatgtctgttcttc       c.*360

          .         .         .         .         .         .       g.92679
 tgtagggagaagctttagcttcattttactaaaaagattcctcgttattgttgttgccaa       c.*420

          .         .         .         .         .         .       g.92739
 agagaaacaaaaatgattttgctttccaagcttggtttgtggcgtctccctcgcagagcc       c.*480

          .         .         .         .         .         .       g.92799
 cttctcgtttcttttttaaactaatcaccatattgtaaatttcagggttttttttttttt       c.*540

          .         .         .         .         .         .       g.92859
 gtttaagctgactctttgctctaattttggaaaaaaagaaatgtgaagggtcaactccaa       c.*600

          .         .         .         .         .         .       g.92919
 cgtatgtggttatctgtgaaagttgcacagcgtggcttttcctaaactggtgtttttccc       c.*660

          .         .         .         .         .         .       g.92979
 ccgcatttggtggattttttattattattcaaaaacataactgagttttttaaaagagga       c.*720

          .         .         .         .         .         .       g.93039
 gaaaatttatatctgggttaagtgtttatcatatatatgggtactttgtaatatctaaaa       c.*780

          .         .         .         .         .         .       g.93099
 acttagaaacggaaatggaatcctgctcacaaaatcactttaagatcttttcgaagctgt       c.*840

          .         .         .         .         .         .       g.93159
 taatttttcttagtgttgtggacactgcagacttgtccagtgctcccacggcctgtacgg       c.*900

          .         .         .         .         .         .       g.93219
 acactgtggaaggcctccctctgtcggctttttgccatctgtgatatgccataggtgtga       c.*960

          .         .         .         .         .         .       g.93279
 caatccgagcagtggagtcattcagcgggagcactgcgcgctatcccctcacattctcta       c.*1020

          .         .         .         .         .         .       g.93339
 tgtactatgtatgtatgtattattattattgctgccaagagggtctgatggcacgttgtg       c.*1080

          .         .         .         .         .         .       g.93399
 gggtcggggggtggggcggggaagtgctctaacttttcttaaggttttgttgctagccct       c.*1140

          .         .         .         .         .         .       g.93459
 tcaagtgcactgagctatgtgactcggatggtctttcacacggcacatttggacatttcc       c.*1200

          .         .         .         .         .         .       g.93519
 agaactaccatgagatggtttagacgggaattcatgcaaatgaggggtcaaaaatggtat       c.*1260

          .         .         .         .         .         .       g.93579
 agtgaccccgtccacgtcctccaagctcacgaccttggagccccgtggagctggactgag       c.*1320

          .         .         .         .         .         .       g.93639
 gaggaggctgcacagcgggagagcagctggtccagaccagccctgcagcccccactcagc       c.*1380

          .         .         .         .         .         .       g.93699
 cggcagccagatggccccgcaaggcctccagggatggcccctagccacaggccctggctg       c.*1440

          .         .         .         .         .         .       g.93759
 aggtctctgggtcggtcagtgacatgtaggtaggaagcactgaaaatagtgttcccagag       c.*1500

          .         .         .         .         .         .       g.93819
 cactttgcaactccctgggtaagagggacgacacctctggtttttcaataccaattacat       c.*1560

          .         .         .         .         .         .       g.93879
 ggaacttttctgtaatgggtacaatgaagaagtttctaaaaacacacacaaagcacattg       c.*1620

          .         .         .         .         .         .       g.93939
 ggccaactatttagtaagcccggatagacttattgccaaaaacaaaaaatagctttcaaa       c.*1680

          .         .         .         .         .         .       g.93999
 agaaatttaagttctatgagaaattccttagtcatggtgttgcgtaaatcatattttagc       c.*1740

          .         .         .         .         .         .       g.94059
 tgcacggcattaccccacacagggtggcagaacttgaagggttactgacgtgtaaatgct       c.*1800

          .         .         .         .         .         .       g.94119
 ggtatttgatttcctgtgtgtgttgccctggcattaagggcattttacccttgcagtttt       c.*1860

          .         .         .         .         .         .       g.94179
 actaaaacactgaaaaatattccaagcttcatattaaccctacctgtcaacgtaacgatt       c.*1920

          .         .         .         .         .         .       g.94239
 tcatgaacgttattatattgtcgaattcctactgacaacattataactgtatgggagctt       c.*1980

          .         .         .         .         .         .       g.94299
 aactttataaggaaatgtattttgacactggtatcttattaaagtattctgatcctacca       c.*2040

                                                                    g.94302
 ctg                                                                c.*2043

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Endothelial PAS domain protein 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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