excision repair cross-complementing rodent repair deficiency, complementation group 2 (ERCC2) - coding DNA reference sequence

(used for variant description)

(last modified February 4, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_000400.3 in the ERCC2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007067.2, covering ERCC2 transcript NM_000400.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5047
              ttcatgagggaggcgggtcgaccccgctgcacagtccggccggcgcc       c.-1

       | 02  .         .         .         .         .         .    g.5410
 ATGAA | GCTCAACGTGGACGGGCTCCTGGTCTACTTCCCGTACGACTACATCTACCCCGAG    c.60
 M  K  |  L  N  V  D  G  L  L  V  Y  F  P  Y  D  Y  I  Y  P  E      p.20

          .         .         .         .      | 03  .         .    g.6455
 CAGTTCTCCTACATGCGGGAGCTCAAACGCACGCTGGACGCCAAG | GGTCATGGAGTCCTG    c.120
 Q  F  S  Y  M  R  E  L  K  R  T  L  D  A  K   | G  H  G  V  L      p.40

          .         .         .         .         .         .       g.6515
 GAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCTGATCATGGCATACCAG       c.180
 E  M  P  S  G  T  G  K  T  V  S  L  L  A  L  I  M  A  Y  Q         p.60

     | 04    .         .         .         .         .         .    g.6652
 AGA | GCATATCCGCTGGAGGTGACCAAACTCATCTACTGCTCAAGAACTGTGCCAGAGATT    c.240
 R   | A  Y  P  L  E  V  T  K  L  I  Y  C  S  R  T  V  P  E  I      p.80

        | 05 .         .         .         .         .         .    g.6898
 GAGAAG | GTGATTGAAGAGCTTCGAAAGTTGCTCAACTTCTATGAGAAGCAGGAGGGCGAG    c.300
 E  K   | V  I  E  E  L  R  K  L  L  N  F  Y  E  K  Q  E  G  E      p.100

          .         .         .         .         .         .       g.6958
 AAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTTGTGTATTCACCCTGAG       c.360
 K  L  P  F  L  G  L  A  L  S  S  R  K  N  L  C  I  H  P  E         p.120

  | 06       .         .         .         .         .         .    g.10489
  | GTGACACCCCTGCGCTTTGGGAAGGACGTCGATGGGAAATGCCACAGCCTCACAGCCTCC    c.420
  | V  T  P  L  R  F  G  K  D  V  D  G  K  C  H  S  L  T  A  S      p.140

          .         .         .         .         .        | 07.    g.10636
 TATGTGCGGGCGCAGTACCAGCATGACACCAGCCTGCCCCACTGCCGATTCTATGAG | GAA    c.480
 Y  V  R  A  Q  Y  Q  H  D  T  S  L  P  H  C  R  F  Y  E   | E      p.160

          .         .         .         .         .         .       g.10696
 TTTGATGCCCATGGGCGTGAGGTGCCCCTCCCCGCTGGCATCTACAACCTGGATGACCTG       c.540
 F  D  A  H  G  R  E  V  P  L  P  A  G  I  Y  N  L  D  D  L         p.180

          .         .         .         .         .     | 08   .    g.11046
 AAGGCCCTGGGGCGGCGCCAGGGCTGGTGCCCATACTTCCTTGCTCGATACTCA | ATCCTG    c.600
 K  A  L  G  R  R  Q  G  W  C  P  Y  F  L  A  R  Y  S   | I  L      p.200

          .         .         .         .         .         .       g.11106
 CATGCCAATGTGGTGGTTTATAGCTACCACTACCTCCTGGACCCCAAGATTGCAGACCTG       c.660
 H  A  N  V  V  V  Y  S  Y  H  Y  L  L  D  P  K  I  A  D  L         p.220

          .         .         .         .         .         | 09    g.11258
 GTGTCCAAGGAACTGGCCCGCAAGGCCGTCGTGGTCTTCGACGAGGCCCACAACATTG | AC    c.720
 V  S  K  E  L  A  R  K  A  V  V  V  F  D  E  A  H  N  I  D |       p.240

          .         .         .         .         .         .       g.11318
 AACGTCTGCATCGACTCCATGAGCGTCAACCTCACCCGCCGGACCCTTGACCGGTGCCAG       c.780
 N  V  C  I  D  S  M  S  V  N  L  T  R  R  T  L  D  R  C  Q         p.260

          .         .         .      | 10  .         .         .    g.11493
 GGCAACCTGGAGACCCTGCAGAAGACGGTGCTCAG | GATCAAAGAGACAGACGAGCAGCGC    c.840
 G  N  L  E  T  L  Q  K  T  V  L  R  |  I  K  E  T  D  E  Q  R      p.280

          .         .         .         .         .         .       g.11553
 CTGCGGGACGAGTACCGGCGTCTGGTGGAGGGGCTGCGGGAGGCCAGCGCCGCCCGGGAG       c.900
 L  R  D  E  Y  R  R  L  V  E  G  L  R  E  A  S  A  A  R  E         p.300

          .         .         .         .          | 11        .    g.11687
 ACGGACGCCCACCTGGCCAACCCCGTGCTGCCCGACGAAGTGCTGCAGG | AGGCAGTGCCT    c.960
 T  D  A  H  L  A  N  P  V  L  P  D  E  V  L  Q  E |   A  V  P      p.320

          .         .         .         .         .         .       g.11747
 GGCTCCATCCGCACGGCCGAGCATTTCCTGGGCTTCCTGAGGCGGCTGCTGGAGTACGTG       c.1020
 G  S  I  R  T  A  E  H  F  L  G  F  L  R  R  L  L  E  Y  V         p.340

          .         .         .         .         .         .       g.11807
 AAGTGGCGGCTGCGTGTGCAGCATGTGGTGCAGGAGAGCCCGCCCGCCTTCCTGAGCGGC       c.1080
 K  W  R  L  R  V  Q  H  V  V  Q  E  S  P  P  A  F  L  S  G         p.360

          .         .         .         | 12         .         .    g.13967
 CTGGCCCAGCGCGTGTGCATCCAGCGCAAGCCCCTCAG | ATTCTGTGCTGAACGCCTCCGG    c.1140
 L  A  Q  R  V  C  I  Q  R  K  P  L  R  |  F  C  A  E  R  L  R      p.380

          .         .         .         .         .         .       g.14027
 TCCCTGCTGCATACTCTGGAGATCACCGACCTTGCTGACTTCTCCCCGCTCACCCTCCTT       c.1200
 S  L  L  H  T  L  E  I  T  D  L  A  D  F  S  P  L  T  L  L         p.400

          .         .         .        | 13.         .         .    g.17911
 GCTAACTTTGCCACCCTTGTCAGCACCTACGCCAAAG | GCTTCACCATCATCATCGAGCCC    c.1260
 A  N  F  A  T  L  V  S  T  Y  A  K  G |   F  T  I  I  I  E  P      p.420

          .         .         .         .        | 14.         .    g.18057
 TTTGACGACAGAACCCCGACCATTGCCAACCCCATCCTGCACTTCAG | CTGCATGGACGCC    c.1320
 F  D  D  R  T  P  T  I  A  N  P  I  L  H  F  S  |  C  M  D  A      p.440

          .         .         .         .         .        | 15.    g.18219
 TCGCTGGCCATCAAACCCGTATTTGAGCGTTTCCAGTCTGTCATCATCACATCTGGG | ACA    c.1380
 S  L  A  I  K  P  V  F  E  R  F  Q  S  V  I  I  T  S  G   | T      p.460

          .         .         .         .         .         .       g.18279
 CTGTCCCCGCTGGACATCTACCCCAAGATCCTGGACTTCCACCCCGTCACCATGGCAACC       c.1440
 L  S  P  L  D  I  Y  P  K  I  L  D  F  H  P  V  T  M  A  T         p.480

          .         .         .          | 16        .         .    g.19880
 TTCACCATGACGCTGGCACGGGTCTGCCTCTGCCCTATG | ATCATCGGCCGTGGCAATGAC    c.1500
 F  T  M  T  L  A  R  V  C  L  C  P  M   | I  I  G  R  G  N  D      p.500

          .         .         .         .    | 17    .         .    g.20753
 CAGGTGGCCATCAGCTCCAAATTTGAGACCCGGGAGGATATTG | CTGTGATCCGGAACTAT    c.1560
 Q  V  A  I  S  S  K  F  E  T  R  E  D  I  A |   V  I  R  N  Y      p.520

          .         .         .         .         .         .       g.20813
 GGGAACCTCCTGCTGGAGATGTCCGCTGTGGTCCCTGATGGCATCGTGGCCTTCTTCACC       c.1620
 G  N  L  L  L  E  M  S  A  V  V  P  D  G  I  V  A  F  F  T         p.540

          .         .         .         .      | 18  .         .    g.22268
 AGCTACCAGTACATGGAGAGCACCGTGGCCTCCTGGTATGAGCAG | GGGATCCTTGAGAAC    c.1680
 S  Y  Q  Y  M  E  S  T  V  A  S  W  Y  E  Q   | G  I  L  E  N      p.560

          .         .         .         .         .         .       g.22328
 ATCCAGAGGAACAAGCTGCTCTTTATTGAGACCCAGGATGGTGCCGAAACCAGTGTCGCC       c.1740
 I  Q  R  N  K  L  L  F  I  E  T  Q  D  G  A  E  T  S  V  A         p.580

          .         | 19         .         .         .         .    g.22474
 CTGGAGAAGTACCAGGAG | GCCTGCGAGAATGGCCGCGGGGCCATCCTGCTGTCAGTGGCC    c.1800
 L  E  K  Y  Q  E   | A  C  E  N  G  R  G  A  I  L  L  S  V  A      p.600

          .         .         .  | 20      .         .         .    g.22800
 CGGGGCAAAGTGTCCGAGGGAATCGACTTTG | TGCACCACTACGGGCGGGCCGTCATCATG    c.1860
 R  G  K  V  S  E  G  I  D  F  V |   H  H  Y  G  R  A  V  I  M      p.620

          .         .         .         .   | 21     .         .    g.22956
 TTTGGCGTCCCCTACGTCTACACACAGAGCCGCATTCTCAAG | GCGCGGCTGGAATACCTG    c.1920
 F  G  V  P  Y  V  Y  T  Q  S  R  I  L  K   | A  R  L  E  Y  L      p.640

          .         .         .         .         .         .       g.23016
 CGGGACCAGTTCCAGATTCGTGAGAATGACTTTCTTACCTTCGATGCCATGCGCCACGCG       c.1980
 R  D  Q  F  Q  I  R  E  N  D  F  L  T  F  D  A  M  R  H  A         p.660

          .         .         .         .         .         .       g.23076
 GCCCAGTGTGTGGGTCGGGCCATCAGGGGCAAGACGGACTACGGCCTCATGGTCTTTGCC       c.2040
 A  Q  C  V  G  R  A  I  R  G  K  T  D  Y  G  L  M  V  F  A         p.680

        | 22 .         .         .         .         .         .    g.23289
 GACAAG | CGGTTTGCCCGTGGGGACAAGCGGGGGAAGCTGCCCCGCTGGATCCAGGAGCAC    c.2100
 D  K   | R  F  A  R  G  D  K  R  G  K  L  P  R  W  I  Q  E  H      p.700

          .         .         .         .         .         .       g.23349
 CTCACAGATGCCAACCTCAACCTGACCGTGGACGAGGGTGTCCAGGTGGCCAAGTACTTC       c.2160
 L  T  D  A  N  L  N  L  T  V  D  E  G  V  Q  V  A  K  Y  F         p.720

          .         .         . | 23       .         .         .    g.23896
 CTGCGGCAGATGGCACAGCCCTTCCACCGG | GAGGATCAGCTGGGCCTGTCCCTGCTCAGC    c.2220
 L  R  Q  M  A  Q  P  F  H  R   | E  D  Q  L  G  L  S  L  L  S      p.740

          .         .         .         .         .         .       g.23956
 CTGGAGCAGCTAGAATCAGAGGAGACGCTGAAGAGGATAGAGCAGATTGCTCAGCAGCTC       c.2280
 L  E  Q  L  E  S  E  E  T  L  K  R  I  E  Q  I  A  Q  Q  L         p.760

                                                                    g.23959
 TGA                                                                c.2283
 X                                                                  p.760

          .         .         .         .         .         .       g.24019
 gtggggcgggtggggccataaacggttcctggtgactcctgagtcttgcctggccctggt       c.*60

          .         .         .         .         .         .       g.24079
 tcccagcggcggtggtgctagaaggtcttatgaagtcaggtgacatttctcactgtcacg       c.*120

          .         .         .         .         .         .       g.24139
 tccacagcctttaatcgcaggagaaggcagctatccaccaggtacccagaggcaaggggg       c.*180

          .         .         .         .         .                 g.24197
 ggccaggagatgatagaccccctctcaccccaccagcccatccctcctgcactgttcc         c.*238

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Excision repair cross-complementing rodent repair deficiency, complementation group 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 18
©2004-2017 Leiden University Medical Center