establishment of cohesion 1 homolog 2 (S. cerevisiae) (ESCO2) - coding DNA reference sequence

(used for variant description)

(last modified August 4, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_001017420.2 in the ESCO2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008117.1, covering ESCO2 transcript NM_001017420.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5023
                                      attatttgaagacgctcacggag       c.-61

 .         .         .         .         .    | 02    .             g.5974
 cggctggctaggctgaggagagctcgccgggctctgaggcgcag | gaattcaataaagaaa    c.-1

          .         .         .         .         .    | 03    .    g.6828
 ATGGCAGCTCTTACTCCAAGGAAGAGGAAGCAGGATTCTTTGAAGTGTGACAG | CCTTTTA    c.60
 M  A  A  L  T  P  R  K  R  K  Q  D  S  L  K  C  D  S  |  L  L      p.20

          .         .         .         .         .         .       g.6888
 CACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTATCAAAACAGT       c.120
 H  F  T  E  N  L  F  P  S  P  N  K  K  H  C  F  Y  Q  N  S         p.40

          .         .         .         .         .         .       g.6948
 GATAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTC       c.180
 D  K  N  E  E  N  L  H  C  S  Q  Q  E  H  F  V  L  S  A  L         p.60

          .         .         .         .         .         .       g.7008
 AAAACAACTGAAATAAATAGACTGCCATCAGCAAATCAAGGCTCACCATTTAAATCTGCG       c.240
 K  T  T  E  I  N  R  L  P  S  A  N  Q  G  S  P  F  K  S  A         p.80

          .         .         .         .         .         .       g.7068
 CTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACTGGAGAGAAAG       c.300
 L  S  T  V  S  F  Y  N  Q  N  K  W  Y  L  N  P  L  E  R  K         p.100

          .         .         .         .         .         .       g.7128
 CTGATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCC       c.360
 L  I  K  E  S  R  S  T  C  L  K  T  N  D  E  D  K  S  F  P         p.120

          .         .         .         .         .         .       g.7188
 ATTGTGACAGAAAAAATGCAAGGAAAACCAGTCTGCTCCAAGAAGAACAACAAAAAACCA       c.420
 I  V  T  E  K  M  Q  G  K  P  V  C  S  K  K  N  N  K  K  P         p.140

          .         .         .         .         .         .       g.7248
 CAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCCTGTATCAAGG       c.480
 Q  K  S  L  T  A  K  Y  Q  P  K  Y  R  H  I  K  P  V  S  R         p.160

          .         .         .         .         .         .       g.7308
 AATTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAAT       c.540
 N  S  R  N  S  K  Q  N  R  V  I  Y  K  P  I  V  E  K  E  N         p.180

          .         .         .         .         .         .       g.7368
 AATTGTCATTCAGCTGAAAATAATTCCAATGCTCCTCGGGTTCTGAGCCAAAAAATAAAA       c.600
 N  C  H  S  A  E  N  N  S  N  A  P  R  V  L  S  Q  K  I  K         p.200

          .         .         .         .         .         .       g.7428
 CCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATCTTCTCTTAGA       c.660
 P  Q  V  T  L  Q  G  G  A  A  F  F  V  R  K  K  S  S  L  R         p.220

          .         .         .         .         .         .       g.7488
 AAATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTC       c.720
 K  S  S  L  E  N  E  P  S  L  G  R  T  Q  K  S  K  S  E  V         p.240

          .         .         .         .         .         .       g.7548
 ATTGAAGATTCTGATGTAGAGACTGTCAGTGAAAAAAAAACTTTTGCGACAAGGCAAGTG       c.780
 I  E  D  S  D  V  E  T  V  S  E  K  K  T  F  A  T  R  Q  V         p.260

          .         .         .         .         .         .       g.7608
 CCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGCAAGCAGTAAA       c.840
 P  K  C  L  V  L  E  E  K  L  K  I  G  L  L  S  A  S  S  K         p.280

          .         .  | 04      .         .         .         .    g.10672
 AATAAAGAGAAATTAATAAAG | GATTCATCAGATGACAGAGTTTCTTCAAAGGAACATAAA    c.900
 N  K  E  K  L  I  K   | D  S  S  D  D  R  V  S  S  K  E  H  K      p.300

          .         .         .         .         .      | 05  .    g.14464
 GTTGATAAAAATGAGGCTTTTTCTTCAGAGGATTCTCTTGGTGAGAATAAGACAA | TTTCT    c.960
 V  D  K  N  E  A  F  S  S  E  D  S  L  G  E  N  K  T  I |   S      p.320

          .         .         .         .         .    | 06    .    g.18351
 CCTAAGTCCACTGTCTATCCAATCTTCAGTGCATCTTCAGTCAATTCAAAAAG | ATCTTTA    c.1020
 P  K  S  T  V  Y  P  I  F  S  A  S  S  V  N  S  K  R  |  S  L      p.340

          .         .         .         .         .         .       g.18411
 GGTGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATATCCAGAAA       c.1080
 G  E  E  Q  F  S  V  G  S  V  N  F  M  K  Q  T  N  I  Q  K         p.360

          .         .         .         .         .  | 07      .    g.19315
 AATACTAATACCAGAGATACAAGTAAAAAAACAAAAGACCAGCTCATCATC | GACGCTGGT    c.1140
 N  T  N  T  R  D  T  S  K  K  T  K  D  Q  L  I  I   | D  A  G      p.380

          .         .         .         .         .         .       g.19375
 CAGAAACATTTTGGGGCTACTGTGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAAC       c.1200
 Q  K  H  F  G  A  T  V  C  K  S  C  G  M  I  Y  T  A  S  N         p.400

          .         .         .         .         .         .       g.19435
 CCTGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAATCAAATAT       c.1260
 P  E  D  E  M  Q  H  V  Q  H  H  H  R  F  L  E  G  I  K  Y         p.420

     | 08    .         .         .         .         .         .    g.22479
 GTG | GGTTGGAAGAAAGAACGTGTAGTAGCAGAGTTTTGGGATGGGAAAATCGTGTTGGTT    c.1320
 V   | G  W  K  K  E  R  V  V  A  E  F  W  D  G  K  I  V  L  V      p.440

          .         .         .    | 09    .         .         .    g.23154
 CTGCCACATGATCCAAGCTTTGCTATCAAAAAG | GTAGAAGATGTCCAAGAACTTGTTGAT    c.1380
 L  P  H  D  P  S  F  A  I  K  K   | V  E  D  V  Q  E  L  V  D      p.460

          .         .         .         .         .         .       g.23214
 AATGAATTGGGCTTCCAGCAAGTTGTTCCTAAATGTCCAAACAAAATAAAAACTTTTCTT       c.1440
 N  E  L  G  F  Q  Q  V  V  P  K  C  P  N  K  I  K  T  F  L         p.480

          .         .         .         .         .        | 10.    g.30003
 TTTATATCTGATGAAAAGAGAGTAGTTGGGTGTTTAATTGCAGAACCCATCAAACAG | GCA    c.1500
 F  I  S  D  E  K  R  V  V  G  C  L  I  A  E  P  I  K  Q   | A      p.500

          .         .         .         .         .         .       g.30063
 TTTCGTGTCCTGTCTGAACCAATTGGTCCAGAATCCCCAAGCTCTACGGAATGTCCTAGG       c.1560
 F  R  V  L  S  E  P  I  G  P  E  S  P  S  S  T  E  C  P  R         p.520

          .         .         .         .         .         .       g.30123
 GCTTGGCAATGTTCAGATGTACCAGAACCTGCAGTCTGTGGGATAAGTAGAATCTGGGTT       c.1620
 A  W  Q  C  S  D  V  P  E  P  A  V  C  G  I  S  R  I  W  V         p.540

          .         .         .         .         .    | 11    .    g.33772
 TTCAGACTGAAGAGAAGAAAGCGCATTGCAAGACGACTGGTTGATACCCTCAG | GAATTGC    c.1680
 F  R  L  K  R  R  K  R  I  A  R  R  L  V  D  T  L  R  |  N  C      p.560

          .         .         .         .         .         .       g.33832
 TTCATGTTTGGCTGTTTTCTCAGCACTGATGAAATAGCATTTTCTGACCCAACACCAGAT       c.1740
 F  M  F  G  C  F  L  S  T  D  E  I  A  F  S  D  P  T  P  D         p.580

          .         .         .         .         .         .       g.33892
 GGCAAGTTATTTGCAACCAAGTACTGCAACACCCCTAATTTCCTCGTATATAATTTTAAT       c.1800
 G  K  L  F  A  T  K  Y  C  N  T  P  N  F  L  V  Y  N  F  N         p.600

                                                                    g.33898
 AGTTAA                                                             c.1806
 S  X                                                               p.601

          .         .         .         .         .         .       g.33958
 agctgatttcagttataaaggagttactatctggataagttcaaagagctccttattata       c.*60

          .         .         .         .         .         .       g.34018
 aaatacaaactatttaatatcaaaataaaaaataccgagactcacactcatacacacaca       c.*120

          .         .         .         .         .         .       g.34078
 cacacacacgcacacacacatatcacagttttgttccttatgagttgaaaagtcaggaat       c.*180

          .         .         .         .         .         .       g.34138
 aaatttgttgaaaattatctggggattcaaaggaaaaatctttgggtgattccctgatta       c.*240

          .         .         .         .         .         .       g.34198
 gcactctgaatgtttaattatgaaactttgtagctataactggaaaattacctgactctt       c.*300

          .         .         .         .         .         .       g.34258
 tgtaagagtattaaatacaaagtgatttttctctagaaatgtgacctggtcttttataaa       c.*360

          .         .         .         .         .         .       g.34318
 gcccactcttagaccaggattatctaatgccacatcagaagcaaacaggcaaatttaaac       c.*420

          .         .         .         .         .         .       g.34378
 ttgggcaagtaatttctgtgcccaatttgtaaagggaattcctgaatttttttttttttt       c.*480

          .         .         .         .         .         .       g.34438
 taatagaggcatgggtctcactgtgttgcccaggctggtctgaaacttttgggctcaagc       c.*540

          .         .         .         .         .         .       g.34498
 gatcctcccaaaacgctgggattacagtcatgagccaccgtgcccagcctaattcctgac       c.*600

          .         .         .         .         .         .       g.34558
 ttctctatacagagtcttcacttgataggcactcgtctgtagtaactcagtttgaatatc       c.*660

          .         .         .         .         .         .       g.34618
 tttagaaaatgtttagaatttatttgtaacaagatggtaaggaataagattatcccatat       c.*720

          .         .         .         .         .         .       g.34678
 gcatttctgtagagcagaatttgatagcttagtgttcaatctttttgaaaataaatgttt       c.*780

          .         .         .         .         .         .       g.34738
 acctgtcatcagatttaattaaaattatacttagtaattgcactattacttagttaattt       c.*840

          .         .         .         .         .         .       g.34798
 ttgttgtatggaaatattggtagtactactttgggaacctgttactgacaattgatgtca       c.*900

          .         .         .         .         .         .       g.34858
 ttaacaaaatgcctagttggattagatgttttcattttctaattttttgcttgtttaaaa       c.*960

          .         .         .         .         .         .       g.34918
 tgcaccttacttgttctgagatacctggcaaaagtctttacaaaatgtatggtaatagaa       c.*1020

          .         .         .         .         .         .       g.34978
 ccaaggttagtaaatatacataggctggtggatgagagaccatggaactgtgtaaataca       c.*1080

          .         .         .         .         .         .       g.35038
 cttaaatgttcacacatttttctagtgtaattcttggatactttaaaaagcaaaacattg       c.*1140

          .         .         .         .         .         .       g.35098
 ttcaaattgttttgattctgaaaaatcattcaactgctaactggcaataagactctaggc       c.*1200

          .         .         .         .         .         .       g.35158
 aagtcgttttccagattgtaattatatgtagaaactattcatctgcattcattttatttg       c.*1260

          .         .         .         .         .         .       g.35218
 cctgtaagttaacatgtttccaaaatttaaaagcctgggtccccaaaagaatgtggaagt       c.*1320

          .         .         .         .         .         .       g.35278
 attaaaatgtatgtaattatgcaaacattttaatgctattttctgcacttatttctttta       c.*1380

          .         .         .         .         .         .       g.35338
 aatattttatttaaaatttttaattaacattttgtttgcttaatgcttttgttatgaatc       c.*1440

          .         .         .                                     g.35368
 aattaaaattctttattttatacaactaaa                                     c.*1470

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Establishment of cohesion 1 homolog 2 (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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