estrogen receptor 2 (ER beta) (ESR2) - coding DNA reference sequence

(used for variant description)

(last modified August 8, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_001040275.1 in the ESR2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011535.1, covering ESR2 transcript NM_001040275.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.49188
             ctcggtctttaaaaggaagaaggggcttatcgttaagtcgcttgtgat       c.-421

 .         .         .         .         .         .                g.49248
 cttttcagtttctccagctgctggctttttggacacccactcccccgccaggaggcagtt       c.-361

 .         .         .         .         .         .                g.49308
 gcaagcgcggaggctgcgagaaataactgcctcttgaaacttgcagggcgaagagcaggc       c.-301

 .         .         .         .         .         .                g.49368
 ggcgagcgctgggccggggagggaccacccgagctgcgacgggctctggggctgcggggc       c.-241

 .         .         .         .         .         .                g.49428
 agggctggcgcccggagcctgagctgcaggaggtgcgctcgctttcctcaacaggtggcg       c.-181

 .         .         .         .         .         .                g.49488
 gcggggcgcgcgccgggagaccccccctaatgcgggaaaagcacgtgtccgcattttaga       c.-121

 .         .         .          | 02        .         .             g.60505
 gaaggcaaggccggtgtgtttatctgcaag | ccattatacttgcccacgaatctttgagaa    c.-61

 .         .         .         .         .         .                g.60565
 cattataatgacctttgtgcctcttcttgcaaggtgttttctcagctgttatctcaagac       c.-1

          .         .         .         .         .         .       g.60625
 ATGGATATAAAAAACTCACCATCTAGCCTTAATTCTCCTTCCTCCTACAACTGCAGTCAA       c.60
 M  D  I  K  N  S  P  S  S  L  N  S  P  S  S  Y  N  C  S  Q         p.20

          .         .         .         .         .         .       g.60685
 TCCATCTTACCCCTGGAGCACGGCTCCATATACATACCTTCCTCCTATGTAGACAGCCAC       c.120
 S  I  L  P  L  E  H  G  S  I  Y  I  P  S  S  Y  V  D  S  H         p.40

          .         .         .         .         .         .       g.60745
 CATGAATATCCAGCCATGACATTCTATAGCCCTGCTGTGATGAATTACAGCATTCCCAGC       c.180
 H  E  Y  P  A  M  T  F  Y  S  P  A  V  M  N  Y  S  I  P  S         p.60

          .         .         .         .         .         .       g.60805
 AATGTCACTAACTTGGAAGGTGGGCCTGGTCGGCAGACCACAAGCCCAAATGTGTTGTGG       c.240
 N  V  T  N  L  E  G  G  P  G  R  Q  T  T  S  P  N  V  L  W         p.80

          .         .         .         .         .         .       g.60865
 CCAACACCTGGGCACCTTTCTCCTTTAGTGGTCCATCGCCAGTTATCACATCTGTATGCG       c.300
 P  T  P  G  H  L  S  P  L  V  V  H  R  Q  L  S  H  L  Y  A         p.100

          .         .         .         .         .         .       g.60925
 GAACCTCAAAAGAGTCCCTGGTGTGAAGCAAGATCGCTAGAACACACCTTACCTGTAAAC       c.360
 E  P  Q  K  S  P  W  C  E  A  R  S  L  E  H  T  L  P  V  N         p.120

    | 03     .         .         .         .         .         .    g.63455
 AG | AGAGACACTGAAAAGGAAGGTTAGTGGGAACCGTTGCGCCAGCCCTGTTACTGGTCCA    c.420
 R  |  E  T  L  K  R  K  V  S  G  N  R  C  A  S  P  V  T  G  P      p.140

          .         .         .         .         .         .       g.63515
 GGTTCAAAGAGGGATGCTCACTTCTGCGCTGTCTGCAGCGATTACGCATCGGGATATCAC       c.480
 G  S  K  R  D  A  H  F  C  A  V  C  S  D  Y  A  S  G  Y  H         p.160

          .         .         .         .         .      | 04  .    g.74644
 TATGGAGTCTGGTCGTGTGAAGGATGTAAGGCCTTTTTTAAAAGAAGCATTCAAG | GACAT    c.540
 Y  G  V  W  S  C  E  G  C  K  A  F  F  K  R  S  I  Q  G |   H      p.180

          .         .         .         .         .         .       g.74704
 AATGATTATATTTGTCCAGCTACAAATCAGTGTACAATCGATAAAAACCGGCGCAAGAGC       c.600
 N  D  Y  I  C  P  A  T  N  Q  C  T  I  D  K  N  R  R  K  S         p.200

          .         .         .         .         .   | 05     .    g.82810
 TGCCAGGCCTGCCGACTTCGGAAGTGTTACGAAGTGGGAATGGTGAAGTGTG | GCTCCCGG    c.660
 C  Q  A  C  R  L  R  K  C  Y  E  V  G  M  V  K  C  G |   S  R      p.220

          .         .         .         .         .         .       g.82870
 AGAGAGAGATGTGGGTACCGCCTTGTGCGGAGACAGAGAAGTGCCGACGAGCAGCTGCAC       c.720
 R  E  R  C  G  Y  R  L  V  R  R  Q  R  S  A  D  E  Q  L  H         p.240

          .         .         .         .         .         .       g.82930
 TGTGCCGGCAAGGCCAAGAGAAGTGGCGGCCACGCGCCCCGAGTGCGGGAGCTGCTGCTG       c.780
 C  A  G  K  A  K  R  S  G  G  H  A  P  R  V  R  E  L  L  L         p.260

          .         .         .         .         .         .       g.82990
 GACGCCCTGAGCCCCGAGCAGCTAGTGCTCACCCTCCTGGAGGCTGAGCCGCCCCATGTG       c.840
 D  A  L  S  P  E  Q  L  V  L  T  L  L  E  A  E  P  P  H  V         p.280

          .         .         .         .         .         .       g.83050
 CTGATCAGCCGCCCCAGTGCGCCCTTCACCGAGGCCTCCATGATGATGTCCCTGACCAAG       c.900
 L  I  S  R  P  S  A  P  F  T  E  A  S  M  M  M  S  L  T  K         p.300

          .         .         .         .         .   | 06     .    g.86194
 TTGGCCGACAAGGAGTTGGTACACATGATCAGCTGGGCCAAGAAGATTCCCG | GCTTTGTG    c.960
 L  A  D  K  E  L  V  H  M  I  S  W  A  K  K  I  P  G |   F  V      p.320

          .         .         .         .         .         .       g.86254
 GAGCTCAGCCTGTTCGACCAAGTGCGGCTCTTGGAGAGCTGTTGGATGGAGGTGTTAATG       c.1020
 E  L  S  L  F  D  Q  V  R  L  L  E  S  C  W  M  E  V  L  M         p.340

          .         .         .         .         .         .       g.86314
 ATGGGGCTGATGTGGCGCTCAATTGACCACCCCGGCAAGCTCATCTTTGCTCCAGATCTT       c.1080
 M  G  L  M  W  R  S  I  D  H  P  G  K  L  I  F  A  P  D  L         p.360

          .  | 07      .         .         .         .         .    g.93920
 GTTCTGGACAG | GGATGAGGGGAAATGCGTAGAAGGAATTCTGGAAATCTTTGACATGCTC    c.1140
 V  L  D  R  |  D  E  G  K  C  V  E  G  I  L  E  I  F  D  M  L      p.380

          .         .         .         .         .         .       g.93980
 CTGGCAACTACTTCAAGGTTTCGAGAGTTAAAACTCCAACACAAAGAATATCTCTGTGTC       c.1200
 L  A  T  T  S  R  F  R  E  L  K  L  Q  H  K  E  Y  L  C  V         p.400

          .         .      | 08  .         .         .         .    g.108435
 AAGGCCATGATCCTGCTCAATTCCA | GTATGTACCCTCTGGTCACAGCGACCCAGGATGCT    c.1260
 K  A  M  I  L  L  N  S  S |   M  Y  P  L  V  T  A  T  Q  D  A      p.420

          .         .         .         .         .         .       g.108495
 GACAGCAGCCGGAAGCTGGCTCACTTGCTGAACGCCGTGACCGATGCTTTGGTTTGGGTG       c.1320
 D  S  S  R  K  L  A  H  L  L  N  A  V  T  D  A  L  V  W  V         p.440

          .         .         .         .         .         .       g.108555
 ATTGCCAAGAGCGGCATCTCCTCCCAGCAGCAATCCATGCGCCTGGCTAACCTCCTGATG       c.1380
 I  A  K  S  G  I  S  S  Q  Q  Q  S  M  R  L  A  N  L  L  M         p.460

          .         .       | 09 .         .         .         .    g.115970
 CTCCTGTCCCACGTCAGGCATGCGAG | GGCAGAAAAGGCCTCTCAAACACTCACCTCATTT    c.1440
 L  L  S  H  V  R  H  A  R  |  A  E  K  A  S  Q  T  L  T  S  F      p.480

          .         .         .         .                           g.116018
 GGAATGAAGATGGAGACTCTTTTGCCTGAAGCAACGATGGAGCAGTGA                   c.1488
 G  M  K  M  E  T  L  L  P  E  A  T  M  E  Q  X                     p.495

          .         .         .         .         .         .       g.116078
 ccctctaatcaactcggtggcctaaagaaaaatcttgggtaacattttcacttcagtttc       c.*60

          .         .         .         .         .         .       g.116138
 cctctgggatcattgtaatccatgaaaaaaataattttaaagaaagagttaaaatacttt       c.*120

          .         .         .         .         .         .       g.116198
 gaagttagttatgtggttaaaaaccaccttcctttctattatcaatccaacaatttgata       c.*180

          .         .         .         .         .         .       g.116258
 actgtaaacgctaaagtgaagacggattctcttcagatggtctccttaactgcccagggc       c.*240

          .         .         .         .         .         .       g.116318
 ttgcagatgtctcacccatgaggggcaccaatgtagaaagctgaggcttcatctactgat       c.*300

          .         .         .         .         .         .       g.116378
 gagcttcactggtttcccctgaggtttgtgctttggcagagaaggggaggaggggactgg       c.*360

          .         .         .         .         .         .       g.116438
 gattgtgtggtcagctgtgcctgccaacagatgcaggttaggaactgtgttcagtatctt       c.*420

          .         .         .         .         .         .       g.116498
 ccaataagaaaggggaaatgccgatgcctatcctctttgtttaggtagaaagtaaaatgc       c.*480

          .         .                                               g.116518
 tactggacttaaatgggcaa                                               c.*500

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Estrogen receptor 2 (ER beta) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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