estrogen-related receptor beta (ESRRB) - coding DNA reference sequence

(used for variant description)

(last modified August 8, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_004452.3 in the ESRRB gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012278.1, covering ESRRB transcript NM_004452.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5011
                                                  ccgcagagagg       c.-361

 .         .         .         .         .         .                g.5071
 tgtggtcagggacatttcccctggccgggagcccatggagcactgtcctcagagatgcgc       c.-301

 .         .         .         .         .         .                g.5131
 aggttaggctcactgtctaggccaggcccaccttagtcactgtggactggcaatggaagc       c.-241

 .         .         .         .         .         .                g.5191
 tcttcctggacacacctgccctagccctcaccctggggtggaagagaaatgagcttggct       c.-181

 .         .         .         .         .         | 02             g.38060
 tgcaactcagaccattccacggaggcatcctccccttcctgggctggtg | aataaaagttt    c.-121

 .         .         .         .         .         .   | 03         g.41203
 cctgaggtcaaggacttccttttccctgccaaaatggtgtccagaactttgag | gccagag    c.-61

 .         .         .         .         .       | 04 .             g.73007
 gtgatccagtgatttgggagctgcaggtcacacaggctgctcagagg | gctgctgaacagg    c.-1

          .         .         .         .         .         .       g.73067
 ATGTCCTCGGACGACAGGCACCTGGGCTCCAGCTGCGGCTCCTTCATCAAGACTGAGCCG       c.60
 M  S  S  D  D  R  H  L  G  S  S  C  G  S  F  I  K  T  E  P         p.20

          .         .         .         .         .         .       g.73127
 TCCAGCCCGTCCTCGGGCATCGATGCCCTCAGCCACCACAGCCCCAGTGGCTCGTCCGAC       c.120
 S  S  P  S  S  G  I  D  A  L  S  H  H  S  P  S  G  S  S  D         p.40

          .         .         .         .         .         .       g.73187
 GCCAGCGGCGGCTTTGGCCTGGCCCTGGGCACCCACGCCAACGGTCTGGACTCGCCACCC       c.180
 A  S  G  G  F  G  L  A  L  G  T  H  A  N  G  L  D  S  P  P         p.60

          .         .         .         .         .         .       g.73247
 ATGTTTGCAGGCGCCGGGCTGGGAGGCACCCCATGCCGCAAGAGCTACGAGGACTGTGCC       c.240
 M  F  A  G  A  G  L  G  G  T  P  C  R  K  S  Y  E  D  C  A         p.80

          .         .         .         .         .         .       g.73307
 AGCGGCATCATGGAGGACTCGGCCATCAAGTGCGAGTACATGCTCAACGCCATCCCCAAG       c.300
 S  G  I  M  E  D  S  A  I  K  C  E  Y  M  L  N  A  I  P  K         p.100

          .         .         .         .         .         .       g.73367
 CGCCTGTGCCTCGTGTGCGGGGACATTGCCTCTGGCTACCACTACGGCGTGGCCTCCTGC       c.360
 R  L  C  L  V  C  G  D  I  A  S  G  Y  H  Y  G  V  A  S  C         p.120

          .         .         .        | 05.         .         .    g.96221
 GAGGCTTGCAAGGCCTTCTTCAAGAGGACTATCCAAG | GGAACATTGAGTACAGCTGCCCG    c.420
 E  A  C  K  A  F  F  K  R  T  I  Q  G |   N  I  E  Y  S  C  P      p.140

          .         .         .         .         .         .       g.96281
 GCCACCAACGAGTGCGAGATCACCAAACGGAGGCGCAAGTCCTGCCAGGCCTGCCGCTTC       c.480
 A  T  N  E  C  E  I  T  K  R  R  R  K  S  C  Q  A  C  R  F         p.160

          .         .         .     | 06   .         .         .    g.115695
 ATGAAATGCCTCAAAGTGGGGATGCTGAAGGAAG | GTGTGCGCCTTGATCGAGTGCGTGGA    c.540
 M  K  C  L  K  V  G  M  L  K  E  G |   V  R  L  D  R  V  R  G      p.180

          .         .         .         .         .         .       g.115755
 GGCCGTCAGAAATACAAGCGACGGCTGGACTCAGAGAGCAGCCCATACCTGAGCTTACAA       c.600
 G  R  Q  K  Y  K  R  R  L  D  S  E  S  S  P  Y  L  S  L  Q         p.200

          .         .      | 07  .         .         .         .    g.116286
 ATTTCTCCACCTGCTAAAAAGCCAT | TGACCAAGATTGTCTCATACCTACTGGTGGCTGAG    c.660
 I  S  P  P  A  K  K  P  L |   T  K  I  V  S  Y  L  L  V  A  E      p.220

          .         .         .         .         .         .       g.116346
 CCGGACAAGCTCTATGCCATGCCTCCCCCTGGTATGCCTGAGGGGGACATCAAGGCCCTG       c.720
 P  D  K  L  Y  A  M  P  P  P  G  M  P  E  G  D  I  K  A  L         p.240

          .         .         .         .         .         .       g.116406
 ACCACTCTCTGTGACCTGGCAGACCGAGAGCTTGTGGTCATCATTGGCTGGGCCAAGCAC       c.780
 T  T  L  C  D  L  A  D  R  E  L  V  V  I  I  G  W  A  K  H         p.260

         | 08.         .         .         .         .         .    g.125153
 ATCCCAG | GCTTCTCAAGCCTCTCCCTGGGGGACCAGATGAGCCTGCTGCAGAGTGCCTGG    c.840
 I  P  G |   F  S  S  L  S  L  G  D  Q  M  S  L  L  Q  S  A  W      p.280

          .         .         .         .         .         .       g.125213
 ATGGAAATCCTCATCCTGGGCATCGTGTACCGCTCGCTGCCCTATGACGACAAGCTGGTG       c.900
 M  E  I  L  I  L  G  I  V  Y  R  S  L  P  Y  D  D  K  L  V         p.300

          .         .         .         .         .         .       g.125273
 TACGCTGAGGACTACATCATGGATGAGGAGCACTCCCGCCTCGCGGGGCTGCTGGAGCTC       c.960
 Y  A  E  D  Y  I  M  D  E  E  H  S  R  L  A  G  L  L  E  L         p.320

          .         .         .         .         .         .       g.125333
 TACCGGGCCATCCTGCAGCTGGTACGCAGGTACAAGAAGCTCAAGGTGGAGAAGGAGGAG       c.1020
 Y  R  A  I  L  Q  L  V  R  R  Y  K  K  L  K  V  E  K  E  E         p.340

          .         .         .        | 09.         .         .    g.131890
 TTTGTGACGCTCAAGGCCCTGGCCCTCGCCAACTCCG | ATTCCATGTACATCGAGGATCTA    c.1080
 F  V  T  L  K  A  L  A  L  A  N  S  D |   S  M  Y  I  E  D  L      p.360

          .         .         .         .         .         .       g.131950
 GAGGCTGTCCAGAAGCTGCAGGACCTGCTGCACGAGGCACTGCAGGACTACGAGCTGAGC       c.1140
 E  A  V  Q  K  L  Q  D  L  L  H  E  A  L  Q  D  Y  E  L  S         p.380

          .         .         .         .         .         .       g.132010
 CAGCGCCATGAGGAGCCCTGGAGGACGGGCAAGCTGCTGCTGACACTGCCGCTGCTGCGG       c.1200
 Q  R  H  E  E  P  W  R  T  G  K  L  L  L  T  L  P  L  L  R         p.400

          .         .         .         .         .         .       g.132070
 CAGACGGCCGCCAAGGCCGTGCAGCACTTCTATAGCGTCAAACTGCAGGGCAAAGTGCCC       c.1260
 Q  T  A  A  K  A  V  Q  H  F  Y  S  V  K  L  Q  G  K  V  P         p.420

          .         .         .       | 10 .         .         .    g.133540
 ATGCACAAACTCTTCCTGGAGATGCTGGAGGCCAAG | GTTGGCCAAGAGCAGCTTAGAGGA    c.1320
 M  H  K  L  F  L  E  M  L  E  A  K   | V  G  Q  E  Q  L  R  G      p.440

          .         .         .         .         .         .       g.133600
 TCTCCCAAGGATGAAAGAATGTCAAGCCATGATGGAAAATGCCCCTTCCAATCAGCTGCC       c.1380
 S  P  K  D  E  R  M  S  S  H  D  G  K  C  P  F  Q  S  A  A         p.460

          .         .         .         .         .         .       g.133660
 TTCACAAGCAGGGATCAGAGCAACTCCCCGGGGATCCCCAATCCACGCCCTTCTAGTCCA       c.1440
 F  T  S  R  D  Q  S  N  S  P  G  I  P  N  P  R  P  S  S  P         p.480

          .         .         .         .         .         .       g.133720
 ACCCCCCTCAATGAGAGAGGCAGGCAGATCTCACCCAGCACTAGGACACCAGGAGGCCAG       c.1500
 T  P  L  N  E  R  G  R  Q  I  S  P  S  T  R  T  P  G  G  Q         p.500

  | 11       .         .                                            g.134408
  | GGAAAGCATCTCTGGCTCACCATGTAA                                     c.1527
  | G  K  H  L  W  L  T  M  X                                       p.508

          .         .         .         .         .         .       g.134468
 catctggcttggagcaagtgggtgttctgcacaccaggcagctgcacctcactggatcta       c.*60

          .         .         .         .         .         .       g.134528
 gtgttgctgcgagtgacctcacttcagagcccctctagcagagtggggcggaagtcctga       c.*120

          .         .         .         .         .         .       g.134588
 tggttggtgtccatgaggtggaagctgcttttatacttaaaactcagatcacaacaggaa       c.*180

          .         .         .         .         .         .       g.134648
 atgtgtcagtaacaatggaactccatccaatgggaaagttcctggtactgaaggggtcca       c.*240

          .         .         .         .         .         .       g.134708
 ttggacactcagaaaagaagttcaggggccaacttcttagctggaatcctggccagatga       c.*300

          .         .         .         .         .         .       g.134768
 ggaccctctccggggaagggagaggactgacttagtggaaggtggtgaagtgaggagagt       c.*360

          .         .         .         .         .         .       g.134828
 ttaggggaaccttcccccagtggaacagatctcaagtttaccctaaacctgccatttctg       c.*420

          .         .         .         .         .         .       g.134888
 gaaaatctgtaaagaggaaacagcctgtctcagctgtactctcatgatacaggtcatttg       c.*480

          .         .         .         .         .         .       g.134948
 aaatgaaccaagaaataaaacatgaaaatccaaccatggagaaggtggtatggctgggtt       c.*540

          .         .         .         .         .         .       g.135008
 ttgtttggtccccttgtccttatacgttctaaagtttccagactggctttgtcactttgt       c.*600

          .         .         .         .         .         .       g.135068
 gaactcgtcatgtgtgaaaaccaatctttgcatatagggaacttcctcgggccacacttt       c.*660

          .         .         .         .         .         .       g.135128
 aagaaccaagtaagaggctctcaagactccagcagagtcgggaggccatggcagcgcctt       c.*720

          .         .         .         .         .         .       g.135188
 agaggagctggaacctgcacccacctgtgtcggtggggggggcctcctttccccatagac       c.*780

          .         .         .         .         .         .       g.135248
 tctgccctccctctgtgcagatggaagtggcaggggagggtgaccagcttgtgacaagaa       c.*840

          .         .         .         .         .         .       g.135308
 gactgaagggtccagagtccatgctcacggaacagcaccaaagaaaagcactatgtggaa       c.*900

          .         .         .         .         .         .       g.135368
 agattgttttattttctaataatgataatatggctggaatggcttcttaagatgtatata       c.*960

          .         .         .         .         .         .       g.135428
 ttttttaaaatggcagttccccattgcagcatcacctacttgtatgtctttctgcctctg       c.*1020

          .         .         .         .         .         .       g.135488
 tatatgttctcccagaaacccccatgtaaatcaaatgccctaggatgcttccatcctggt       c.*1080

          .         .         .                                     g.135524
 cccatgtatctggaatctaataaataaggaaaggaa                               c.*1116

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Estrogen-related receptor beta protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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