exocyst complex component 4 (EXOC4) - coding DNA reference sequence

(used for variant description)

(last modified December 23, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_021807.3 in the EXOC4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000007.13, covering EXOC4 transcript NM_021807.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5035
                          ttccttggagcctagcggctctccccgcgtccaag       c.-1

          .         .         .         .         .         .       g.5095
 ATGGCGGCAGAAGCAGCTGGTGGGAAATACAGAAGCACAGTCAGCAAAAGCAAAGACCCC       c.60
 M  A  A  E  A  A  G  G  K  Y  R  S  T  V  S  K  S  K  D  P         p.20

          .         .       | 02 .         .         .         .    g.26948
 TCGGGGCTGCTCATCTCTGTGATCAG | GACTCTGTCTACTAGTGACGATGTCGAAGACAGG    c.120
 S  G  L  L  I  S  V  I  R  |  T  L  S  T  S  D  D  V  E  D  R      p.40

          .         .         .         .         .         .       g.27008
 GAAAATGAAAAGGGTCGCCTTGAAGAAGCCTACGAGAAATGTGACCGTGACCTGGATGAA       c.180
 E  N  E  K  G  R  L  E  E  A  Y  E  K  C  D  R  D  L  D  E         p.60

          .         .         .         .         .         .       g.27068
 TTGATTGTACAGCACTACACAGAATTGACGACAGCCATTCGCACATACCAGAGCATCACA       c.240
 L  I  V  Q  H  Y  T  E  L  T  T  A  I  R  T  Y  Q  S  I  T         p.80

          .         .         .       | 03 .         .         .    g.40877
 GAGCGCATCACTAACTCCCGAAATAAAATAAAGCAG | GTAAAAGAGAACCTGCTTTCATGC    c.300
 E  R  I  T  N  S  R  N  K  I  K  Q   | V  K  E  N  L  L  S  C      p.100

          .         .         .         .         .         .       g.40937
 AAGATGCTGCTGCACTGCAAACGGGATGAGCTTCGGAAACTGTGGATTGAAGGAATTGAG       c.360
 K  M  L  L  H  C  K  R  D  E  L  R  K  L  W  I  E  G  I  E         p.120

          .         .         .         .         .         .       g.40997
 CATAAGCATGTCCTGAACTTGTTGGATGAAATTGAGAATATCAAGCAAGTGCCTCAAAAG       c.420
 H  K  H  V  L  N  L  L  D  E  I  E  N  I  K  Q  V  P  Q  K         p.140

          .         .         .         .         .  | 04      .    g.57817
 CTGGAACAGTGCATGGCCAGCAAGCACTATCTCAGTGCCACTGACATGTTG | GTGTCAGCA    c.480
 L  E  Q  C  M  A  S  K  H  Y  L  S  A  T  D  M  L   | V  S  A      p.160

          .         .         .         .         .         .       g.57877
 GTTGAGTCTTTGGAGGGCCCCCTGCTCCAGGTGGAAGGACTGAGTGACCTTCGACTAGAG       c.540
 V  E  S  L  E  G  P  L  L  Q  V  E  G  L  S  D  L  R  L  E         p.180

          .         .         .         .         .         .       g.57937
 CTTCACAGCAAGAAGATGAACCTTCACTTGGTTCTCATAGATGAACTACACCGGCACCTG       c.600
 L  H  S  K  K  M  N  L  H  L  V  L  I  D  E  L  H  R  H  L         p.200

          .         .         .         .         .       | 05 .    g.69219
 TACATCAAATCGACTAGCCGAGTTGTGCAGCGTAACAAGGAAAAAGGGAAAATCAG | CTCC    c.660
 Y  I  K  S  T  S  R  V  V  Q  R  N  K  E  K  G  K  I  S  |  S      p.220

          .         .         .         .         .         .       g.69279
 CTCGTGAAAGATGCTTCTGTTCCTCTGATTGATGTTACAAACCTCCCTACTCCTCGAAAA       c.720
 L  V  K  D  A  S  V  P  L  I  D  V  T  N  L  P  T  P  R  K         p.240

          .         .         .         .    | 06    .         .    g.108278
 TTCCTTGATACCTCTCACTATTCTACTGCTGGAAGCTCAAGTG | TGAGGGAGATAAATCTG    c.780
 F  L  D  T  S  H  Y  S  T  A  G  S  S  S  V |   R  E  I  N  L      p.260

          .         .         .         .         .         .       g.108338
 CAGGACATCAAGGAAGATTTAGAATTGGATCCAGAGGAAAACAGCACCCTGTTTATGGGT       c.840
 Q  D  I  K  E  D  L  E  L  D  P  E  E  N  S  T  L  F  M  G         p.280

          .         .         .         .         .         .       g.108398
 ATCCTCATTAAGGGCTTGGCGAAACTGAAGAAGATCCCAGAAACAGTTAAGGCAATCATA       c.900
 I  L  I  K  G  L  A  K  L  K  K  I  P  E  T  V  K  A  I  I         p.300

          .         .         .         .         .         .       g.108458
 GAGCGCTTGGAGCAGGAGTTGAAGCAAATTGTGAAGAGGTCTACAACCCAGGTGGCAGAC       c.960
 E  R  L  E  Q  E  L  K  Q  I  V  K  R  S  T  T  Q  V  A  D         p.320

          .         .         .         .        | 07.         .    g.126772
 AGTGGCTATCAGCGGGGGGAGAACGTTACTGTGGAGAACCAACCAAG | GTTGCTTCTAGAA    c.1020
 S  G  Y  Q  R  G  E  N  V  T  V  E  N  Q  P  R  |  L  L  L  E      p.340

          .         .         .         .         .         .       g.126832
 CTGCTGGAGTTACTGTTTGACAAGTTTAATGCTGTAGCCGCTGCACACTCTGTGGTCCTG       c.1080
 L  L  E  L  L  F  D  K  F  N  A  V  A  A  A  H  S  V  V  L         p.360

          .         .         .         .         .         .       g.126892
 GGATACCTGCAGGACACTGTAGTGACTCCACTGACTCAGCAGGAAGATATCAAACTGTAT       c.1140
 G  Y  L  Q  D  T  V  V  T  P  L  T  Q  Q  E  D  I  K  L  Y         p.380

          .         .         .         .   | 08     .         .    g.227277
 GATATGGCAGATGTATGGGTGAAGATCCAAGATGTTCTACAG | ATGCTATTAACTGAGTAC    c.1200
 D  M  A  D  V  W  V  K  I  Q  D  V  L  Q   | M  L  L  T  E  Y      p.400

          .         .         .         .         .         .       g.227337
 TTGGATATGAAAAATACTCGTACGGCCTCTGAACCATCAGCTCAACTAAGCTATGCCAGC       c.1260
 L  D  M  K  N  T  R  T  A  S  E  P  S  A  Q  L  S  Y  A  S         p.420

          .         .         .         .         .         .       g.227397
 ACTGGACGAGAGTTTGCAGCCTTTTTTGCCAAGAAGAAACCTCAAAGGCCAAAAAATTCT       c.1320
 T  G  R  E  F  A  A  F  F  A  K  K  K  P  Q  R  P  K  N  S         p.440

          | 09         .         .         .         .         .    g.232033
 CTTTTCAA | GTTCGAATCGTCCTCCCATGCCATCAGTATGAGCGCCTATCTGCGAGAACAG    c.1380
 L  F  K  |  F  E  S  S  S  H  A  I  S  M  S  A  Y  L  R  E  Q      p.460

          .         .         .        | 10.         .         .    g.381998
 AGAAGGGAGCTCTATAGTCGGAGTGGAGAACTGCAAG | GGGGTCCTGATGACAACTTAATT    c.1440
 R  R  E  L  Y  S  R  S  G  E  L  Q  G |   G  P  D  D  N  L  I      p.480

          .         .         .         .         .         .       g.382058
 GAAGGTGGAGGAACAAAATTTGTCTGCAAACCTGGAGCCAGAAACATTACCGTCATATTC       c.1500
 E  G  G  G  T  K  F  V  C  K  P  G  A  R  N  I  T  V  I  F         p.500

          .     | 11   .         .         .         .         .    g.569301
 CACCCATTACTAAG | ATTTATTCAGGAGATTGAGCATGCTCTGGGTCTTGGCCCAGCCAAA    c.1560
 H  P  L  L  R  |  F  I  Q  E  I  E  H  A  L  G  L  G  P  A  K      p.520

          .         .         .         .         .         .       g.569361
 CAGTGTCCTCTTCGAGAGTTTCTCACCGTGTACATCAAAAACATCTTTCTCAATCAAGTC       c.1620
 Q  C  P  L  R  E  F  L  T  V  Y  I  K  N  I  F  L  N  Q  V         p.540

          .         .         .         .         .         .       g.569421
 TTGGCTGAGATCAACAAGGAGATTGAAGGAGTCACTAAAACATCTGACCCTTTGAAGATT       c.1680
 L  A  E  I  N  K  E  I  E  G  V  T  K  T  S  D  P  L  K  I         p.560

          .         .         .         .         .     | 12   .    g.647535
 CTGGCCAACGCAGACACCATGAAGGTGCTGGGAGTGCAGCGGCCTCTCCTACAG | AGCACA    c.1740
 L  A  N  A  D  T  M  K  V  L  G  V  Q  R  P  L  L  Q   | S  T      p.580

          .         .         .         .         .         .       g.647595
 ATCATTGTGGAGAAGACAGTTCAAGACCTCCTGAACCTGATGCATGACTTGAGTGCATAT       c.1800
 I  I  V  E  K  T  V  Q  D  L  L  N  L  M  H  D  L  S  A  Y         p.600

          .         .         .         .         .         .       g.647655
 TCAGATCAATTCCTCAACATGGTGTGCGTGAAGCTCCAGGAGTACAAGGACACCTGCACT       c.1860
 S  D  Q  F  L  N  M  V  C  V  K  L  Q  E  Y  K  D  T  C  T         p.620

          .  | 13      .         .         .         .         .    g.669562
 GCAGCTTACAG | GGGTATTGTCCAGTCAGAAGAAAAACTTGTCATCAGTGCATCCTGGGCA    c.1920
 A  A  Y  R  |  G  I  V  Q  S  E  E  K  L  V  I  S  A  S  W  A      p.640

          .         .         .         .         .         .       g.669622
 AAAGATGATGATATCAGCAGACTCTTGAAATCTCTACCAAACTGGATGAATATGGCTCAA       c.1980
 K  D  D  D  I  S  R  L  L  K  S  L  P  N  W  M  N  M  A  Q         p.660

          .         .         .         .        | 14.         .    g.689834
 CCCAAACAGCTGAGGCCAAAAAGAGAGGAGGAAGAAGATTTCATAAG | GGCAGCTTTTGGC    c.2040
 P  K  Q  L  R  P  K  R  E  E  E  E  D  F  I  R  |  A  A  F  G      p.680

          .         .         .         .         .         .       g.689894
 AAGGAGTCTGAAGTTCTTATTGGGAACCTGGGTGATAAATTAATCCCTCCACAAGACATC       c.2100
 K  E  S  E  V  L  I  G  N  L  G  D  K  L  I  P  P  Q  D  I         p.700

          .         .         .         .         .         .       g.689954
 CTTCGTGACGTCAGTGACCTCAAAGCCTTGGCCAACATGCATGAAAGCCTGGAATGGTTG       c.2160
 L  R  D  V  S  D  L  K  A  L  A  N  M  H  E  S  L  E  W  L         p.720

          .         .         .         .       | 15 .         .    g.749436
 GCAAGTCGAACAAAGTCAGCTTTCTCCAATCTTTCTACATCCCAGA | TGCTTTCTCCTGCT    c.2220
 A  S  R  T  K  S  A  F  S  N  L  S  T  S  Q  M |   L  S  P  A      p.740

          .         .         .         .         .         .       g.749496
 CAAGACAGCCACACGAACACGGATCTCCCCCCAGTGTCAGAGCAGATCATGCAGACTCTC       c.2280
 Q  D  S  H  T  N  T  D  L  P  P  V  S  E  Q  I  M  Q  T  L         p.760

          .         .         .         .         .         .       g.749556
 AGTGAACTTGCCAAATCGTTCCAGGATATGGCTGACCGCTGCTTGCTTGTCTTACATCTG       c.2340
 S  E  L  A  K  S  F  Q  D  M  A  D  R  C  L  L  V  L  H  L         p.780

          | 16         .         .         .         .         .    g.756894
 GAAGTGAG | GGTTCACTGTTTCCACTATCTTATCCCTCTTGCAAAGGAGGGGAACTATGCC    c.2400
 E  V  R  |  V  H  C  F  H  Y  L  I  P  L  A  K  E  G  N  Y  A      p.800

          .         .         .         .         .         .       g.756954
 ATTGTGGCTAATGTGGAAAGTATGGATTATGACCCCCTGGTGGTCAAGCTCAACAAAGAT       c.2460
 I  V  A  N  V  E  S  M  D  Y  D  P  L  V  V  K  L  N  K  D         p.820

          .         .         .         .         .         .       g.757014
 ATCAGCGCCATTGAAGAGGCCATGAGCGCCAGCCTTCAGCAGCACAAGTTCCAGTATATC       c.2520
 I  S  A  I  E  E  A  M  S  A  S  L  Q  Q  H  K  F  Q  Y  I         p.840

         | 17.         .         .         .         .         .    g.759659
 TTCGAAG | GCCTGGGCCACCTGATCTCCTGCATCCTCATTAATGGTGCCCAGTACTTCAGG    c.2580
 F  E  G |   L  G  H  L  I  S  C  I  L  I  N  G  A  Q  Y  F  R      p.860

          .         .         .         .         .         .       g.759719
 CGCATCAGTGAGTCTGGCATCAAGAAAATGTGTAGGAACATTTTTGTTCTTCAGCAGAAT       c.2640
 R  I  S  E  S  G  I  K  K  M  C  R  N  I  F  V  L  Q  Q  N         p.880

          .         .         .         .        | 18.         .    g.816234
 TTGACCAACATCACCATGTCGCGGGAGGCAGACCTGGACTTTGCAAG | GCAGTACTACGAG    c.2700
 L  T  N  I  T  M  S  R  E  A  D  L  D  F  A  R  |  Q  Y  Y  E      p.900

          .         .         .         .         .         .       g.816294
 ATGCTTTACAACACAGCTGACGAGCTCCTGAACCTGGTGGTGGACCAGGGTGTGAAGTAC       c.2760
 M  L  Y  N  T  A  D  E  L  L  N  L  V  V  D  Q  G  V  K  Y         p.920

          .         .         .         .         .         .       g.816354
 ACGGAGCTGGAGTACATCCACGCTCTGACCCTGCTGCACCGCAGCCAGACTGGGGTGGGG       c.2820
 T  E  L  E  Y  I  H  A  L  T  L  L  H  R  S  Q  T  G  V  G         p.940

          .         .         .         .         .         .       g.816414
 GAACTGACCACCCAGAACACGAGGCTGCAGAGGCTCAAAGAGATCATCTGCGAGCAGGCT       c.2880
 E  L  T  T  Q  N  T  R  L  Q  R  L  K  E  I  I  C  E  Q  A         p.960

          .         .         .         .                           g.816459
 GCCATCAAGCAAGCCACCAAGGACAAGAAGATAACTACCGTTTAG                      c.2925
 A  I  K  Q  A  T  K  D  K  K  I  T  T  V  X                        p.974

          .         .         .         .         .         .       g.816519
 cagggcgtactgcggttggtgacgggggtcccctcagtcacactcacttttttccttggt       c.*60

          .         .         .         .         .         .       g.816579
 atgttattgagtatattctgagcttagttttctctacagtgatactttagtggagaggag       c.*120

          .         .         .         .         .         .       g.816639
 gtgtaaggattctttctctctggttttggcttttcatataaatgctaaaggaaggcgaca       c.*180

          .         .         .         .         .         .       g.816699
 gtacagagtgttttggttgaacaactactttaatgcagtcaaatctaacgggactagggt       c.*240

          .         .         .         .         .         .       g.816759
 gggatagggaggaaggtggtatcaaattgttggactctgaaaaacaagtggatggattac       c.*300

          .         .         .         .         .         .       g.816819
 taatatttgatttattactcaatatatatataattccagccttggaaagtaggaaagtag       c.*360

          .         .         .         .         .         .       g.816879
 gctgctacctaacttttagtcccttccaaaaccatttagtagggttctattacataaaca       c.*420

          .         .         .         .         .         .       g.816939
 gtagggtttttcctctcctgaccttatccgtttacagttcaatgaaataagtgtatgtgc       c.*480

          .         .         .         .         .         .       g.816999
 attgctgtctgtctctattgccaaaatcaaataaatggcttctcagctgctgtttacaac       c.*540

          .         .         .         .         .         .       g.817059
 aaacttccctaaccaaaacagaacctctaatttagggctaggaatagaagtcttttgatc       c.*600

          .         .         .         .         .         .       g.817119
 ccagtccctgggacagttttgtatgctgtatcttgtacacaggttgtaggttggtttatt       c.*660

          .         .         .         .         .         .       g.817179
 gccattttgttttatttctgctgtataaaaaccaagagccagacaattagacaactatgg       c.*720

          .         .         .         .         .         .       g.817239
 aggaatgaaaggcaattcaaacatctgcttgattcccgccccgccacccctaatttctga       c.*780

          .         .         .         .         .         .       g.817299
 gagaataatggttagagaacattgcatctcacttgaaacatcctttgggggtaaatgatt       c.*840

          .         .         .         .         .         .       g.817359
 cttaggtgctcacttggtctgagctcagctgaatgcagggaagatgggacagagtgacat       c.*900

          .         .         .         .         .         .       g.817419
 ttctcctctgtgcggcctccagctgagcctgtctctgaattgttccctcccccgcaatgt       c.*960

          .         .         .         .         .         .       g.817479
 gggcacttaccatgttcctggcacactggacctcaccatgtcccccggtcaccagtcctc       c.*1020

          .         .         .         .         .         .       g.817539
 ttgctgcccatggttcataggtcatagaaggcagcaatgcactgactgggccacatcttg       c.*1080

          .         .         .         .         .         .       g.817599
 aaaactcgtggaaagggaaaggggaggagatgggactttgaccacacacagtgatgcctc       c.*1140

          .         .         .         .         .         .       g.817659
 acaccctgaaggtgggggattttgtacctgtttgtacaactttggtcttgatgggaaaaa       c.*1200

          .         .         .                                     g.817692
 tggagaattaaaaagtgttttgagaagcttaaa                                  c.*1233

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Exocyst complex component 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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