exocyst complex component 6B (EXOC6B) - coding DNA reference sequence

(used for variant description)

(last modified October 30, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_015189.1 in the EXOC6B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.11, covering EXOC6B transcript NM_015189.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5018
                                           gagcctgagggaggggtc       c.-121

 .         .         .         .         .         .                g.5078
 ggcctgcgggtagccagaggctggggcggctgtggagcctgtggtgggagcggcattgtg       c.-61

 .         .         .         .         .         .                g.5138
 gggcagggaaaaggtgagccgagccgacggaggggacgcgctgcggggcgcccccagtct       c.-1

          .         .         .         .         .         .       g.5198
 ATGGAGCGGGGTAAGATGGCGGAGGCGGAGAGCCTGGAGACAGCGGCAGAGCACGAGCGG       c.60
 M  E  R  G  K  M  A  E  A  E  S  L  E  T  A  A  E  H  E  R         p.20

          .         .         .         .         .    | 02    .    g.89586
 ATCCTGCGAGAGATCGAGAGCACTGACACGGCCTGCATCGGGCCCACGCTCAG | GTCTGTT    c.120
 I  L  R  E  I  E  S  T  D  T  A  C  I  G  P  T  L  R  |  S  V      p.40

          .         .         .         .         .         .       g.89646
 TATGATGGTGAAGAACATGGACGTTTCATGGAGAAGCTTGAAACTCGTATCCGTAATCAC       c.180
 Y  D  G  E  E  H  G  R  F  M  E  K  L  E  T  R  I  R  N  H         p.60

          .         .         .         .         .         .       g.89706
 GACCGAGAAATTGAGAAAATGTGCAACTTTCATTACCAGGGCTTTGTGGACTCTATAACT       c.240
 D  R  E  I  E  K  M  C  N  F  H  Y  Q  G  F  V  D  S  I  T         p.80

          .         .         .          | 03        .         .    g.97951
 GAACTGCTGAAAGTGAGAGGAGAAGCCCAGAAACTCAAA | AATCAAGTGACGGATACTAAT    c.300
 E  L  L  K  V  R  G  E  A  Q  K  L  K   | N  Q  V  T  D  T  N      p.100

          .         .        | 04.         .         .         .    g.99836
 AGAAAACTACAACATGAGGGAAAGGAA | CTGGTAATAGCAATGGAAGAGCTGAAGCAGTGT    c.360
 R  K  L  Q  H  E  G  K  E   | L  V  I  A  M  E  E  L  K  Q  C      p.120

          .         .         .         .         .         | 05    g.99998
 CGACTACAACAGAGAAATATTTCTGCCACTGTTGATAAATTAATGCTGTGTCTTCCAG | TC    c.420
 R  L  Q  Q  R  N  I  S  A  T  V  D  K  L  M  L  C  L  P  V |       p.140

          .         .         .         .     | 06   .         .    g.112757
 CTAGAGATGTACAGCAAACTGAGGGACCAGATGAAAACTAAAAG | GCATTATCCTGCACTG    c.480
 L  E  M  Y  S  K  L  R  D  Q  M  K  T  K  R  |  H  Y  P  A  L      p.160

          .         .         .         .         .         .       g.112817
 AAAACTCTGGAACATCTAGAGCATACCTACCTGCCTCAAGTAAGCCACTATCGATTCTGC       c.540
 K  T  L  E  H  L  E  H  T  Y  L  P  Q  V  S  H  Y  R  F  C         p.180

          .         .         .         .         .         .       g.112877
 AAGGTGATGGTGGACAACATCCCCAAGCTTCGAGAAGAAATAAAAGATGTTTCTATGTCC       c.600
 K  V  M  V  D  N  I  P  K  L  R  E  E  I  K  D  V  S  M  S         p.200

          .         .         .         .         .         .       g.112937
 GATCTCAAAGACTTTCTGGAGAGCATCCGCAAACATTCAGACAAAATTGGAGAGACTGCC       c.660
 D  L  K  D  F  L  E  S  I  R  K  H  S  D  K  I  G  E  T  A         p.220

           | 07        .         .         .         .         .    g.255431
 ATGAAGCAA | GCCCAGCAGCAAAGAAACCTGGATAACATCGTCTTGCAACAACCCAGAATA    c.720
 M  K  Q   | A  Q  Q  Q  R  N  L  D  N  I  V  L  Q  Q  P  R  I      p.240

          .         .         .         .         .         .       g.255491
 GGTAGCAAGAGGAAATCTAAGAAAGATGCATATATAATCTTTGATACAGAGATAGAAAGT       c.780
 G  S  K  R  K  S  K  K  D  A  Y  I  I  F  D  T  E  I  E  S         p.260

          .         .         .         .         .         .       g.255551
 ACTAGTCCGAAGTCTGAACAGGATTCAGGAATTCTGGATGTTGAAGACGAGGAAGATGAT       c.840
 T  S  P  K  S  E  Q  D  S  G  I  L  D  V  E  D  E  E  D  D         p.280

        | 08 .         .         .         .         .         .    g.271581
 GAAGAG | GTACCTGGGGCCCAAGATTTGGTGGATTTCTCTCCAGTTTATCGATGTCTACAT    c.900
 E  E   | V  P  G  A  Q  D  L  V  D  F  S  P  V  Y  R  C  L  H      p.300

          .      | 09  .         .         .         .         .    g.315967
 ATATATTCTGTCCTG | GGTGCCCGGGAAACATTTGAGAATTACTACCGAAAACAGAGGCGA    c.960
 I  Y  S  V  L   | G  A  R  E  T  F  E  N  Y  Y  R  K  Q  R  R      p.320

          .         .         .          | 10        .         .    g.316389
 AAACAGGCTCGTTTGGTACTTCAACCTCCATCTAACATG | CATGAAACTTTAGATGGCTAC    c.1020
 K  Q  A  R  L  V  L  Q  P  P  S  N  M   | H  E  T  L  D  G  Y      p.340

          .         .       | 11 .         .         .         .    g.317830
 AGGAAGTATTTTAATCAAATTGTAGG | CTTTTTTGTGGTTGAAGATCACATTTTACATACA    c.1080
 R  K  Y  F  N  Q  I  V  G  |  F  F  V  V  E  D  H  I  L  H  T      p.360

          .         .         .         .         .         .       g.317890
 ACCCAGGGCTTAGTAAATAGAGCCTACATTGATGAACTGTGGGAAATGGCACTTTCAAAA       c.1140
 T  Q  G  L  V  N  R  A  Y  I  D  E  L  W  E  M  A  L  S  K         p.380

          .         .        | 12.         .         .         .    g.331109
 ACCATCGCAGCACTCCGTACCCACTCG | TCTTACTGTTCTGATCCAAACCTTGTGTTAGAT    c.1200
 T  I  A  A  L  R  T  H  S   | S  Y  C  S  D  P  N  L  V  L  D      p.400

          .         .         .          | 13        .         .    g.332518
 TTGAAGAACCTCATTGTGCTTTTTGCTGACACACTTCAG | GTGTATGGTTTCCCTGTAAAT    c.1260
 L  K  N  L  I  V  L  F  A  D  T  L  Q   | V  Y  G  F  P  V  N      p.420

          .         .         .         .         .         .       g.332578
 CAGCTTTTTGACATGCTGTTAGAAATCAGAGACCAATATAGTGAAACTCTGCTAAAGAAG       c.1320
 Q  L  F  D  M  L  L  E  I  R  D  Q  Y  S  E  T  L  L  K  K         p.440

          .        | 14.         .         .         .         .    g.334532
 TGGGCAGGTATTTTCAG | AAACATACTTGATTCTGACAACTACAGTCCTATACCAGTAACA    c.1380
 W  A  G  I  F  R  |  N  I  L  D  S  D  N  Y  S  P  I  P  V  T      p.460

          .         .         .         .         .         .       g.334592
 AGTGAAGAGATGTACAAAAAGGTGGTAGGACAATTCCCATTTCAAGATATAGAACTGGAA       c.1440
 S  E  E  M  Y  K  K  V  V  G  Q  F  P  F  Q  D  I  E  L  E         p.480

     | 15    .         .         .         .         .         .    g.335566
 AAG | CAACCATTTCCAAAAAAGTTTCCTTTCTCTGAATTTGTGCCAAAAGTTTACAACCAA    c.1500
 K   | Q  P  F  P  K  K  F  P  F  S  E  F  V  P  K  V  Y  N  Q      p.500

          .         .         .         .         .    | 16    .    g.338626
 ATTAAAGAATTTATCTACGCTTGTCTGAAGTTTTCAGAAGATCTTCATCTAAG | CTCAACT    c.1560
 I  K  E  F  I  Y  A  C  L  K  F  S  E  D  L  H  L  S  |  S  T      p.520

          .         .         .         .         .         .       g.338686
 GAAGTTGATGACATGATTCGGAAATCAACAAACCTGTTGCTAACCAGGACTCTGAGCAAC       c.1620
 E  V  D  D  M  I  R  K  S  T  N  L  L  L  T  R  T  L  S  N         p.540

          .         .         .         .      | 17  .         .    g.350313
 TCTCTGCAGAATGTAATTAAAAGGAAGAATATTGGGCTTACTGAG | CTTGTTCAGATTATT    c.1680
 S  L  Q  N  V  I  K  R  K  N  I  G  L  T  E   | L  V  Q  I  I      p.560

          .         .         .         .         .         .       g.350373
 ATCAATACAACACATTTGGAGAAATCCTGTAAGTACTTGGAAGAATTTATCACCAACATC       c.1740
 I  N  T  T  H  L  E  K  S  C  K  Y  L  E  E  F  I  T  N  I         p.580

          .         .         .         .         .         .       g.350433
 ACTAATGTGCTTCCAGAGACAGTTCACACTACCAAGCTCTATGGCACCACAACTTTTAAG       c.1800
 T  N  V  L  P  E  T  V  H  T  T  K  L  Y  G  T  T  T  F  K         p.600

  | 18       .         .         .         .         .         .    g.365769
  | GATGCTAGACATGCAGCTGAAGAAGAGATTTATACCAACTTAAACCAGAAGATTGACCAG    c.1860
  | D  A  R  H  A  A  E  E  E  I  Y  T  N  L  N  Q  K  I  D  Q      p.620

          .         .         .         .         .         .       g.365829
 TTCCTACAGCTGGCAGACTATGACTGGATGACCGGAGATTTGGGCAACAAAGCTAGTGAT       c.1920
 F  L  Q  L  A  D  Y  D  W  M  T  G  D  L  G  N  K  A  S  D         p.640

          .         .         .         .         .         .       g.365889
 TACCTGGTAGACCTCATTGCCTTTCTTCGTAGCACCTTTGCTGTATTCACACACCTTCCT       c.1980
 Y  L  V  D  L  I  A  F  L  R  S  T  F  A  V  F  T  H  L  P         p.660

  | 19       .         .         .         .         .         .    g.451238
  | GGAAAGGTGGCCCAGACAGCGTGTATGTCAGCTTGCAAGCATTTAGCCACATCCTTGATG    c.2040
  | G  K  V  A  Q  T  A  C  M  S  A  C  K  H  L  A  T  S  L  M      p.680

          .         .         .         .         .         .       g.451298
 CAACTTTTGTTGGAAGCTGAAGTGCGGCAGCTCACCTTGGGAGCATTACAGCAGTTCAAC       c.2100
 Q  L  L  L  E  A  E  V  R  Q  L  T  L  G  A  L  Q  Q  F  N         p.700

          .         .   | 20     .         .         .         .    g.496066
 TTGGACGTCAGAGAATGTGAAC | AGTTTGCCAGATCCGGCCCGGTGCCTGGGTTCCAGGAG    c.2160
 L  D  V  R  E  C  E  Q |   F  A  R  S  G  P  V  P  G  F  Q  E      p.720

          .         .         .       | 21 .         .         .    g.646885
 GACACGCTGCAGTTGGCCTTCATCGACTTGAGACAA | CTTTTGGATCTTTTCATCCAGTGG    c.2220
 D  T  L  Q  L  A  F  I  D  L  R  Q   | L  L  D  L  F  I  Q  W      p.740

          .         .         .         .         .         .       g.646945
 GATTGGTCAACCTACCTTGCTGACTATGGTCAGCCCAACTGCAAGTACCTCCGGGTAAAC       c.2280
 D  W  S  T  Y  L  A  D  Y  G  Q  P  N  C  K  Y  L  R  V  N         p.760

          .         .          | 22        .         .         .    g.651618
 CCAGTGACTGCTCTGACCCTGCTTGAGAA | GATGAAGGATACTAGCCGCAAGAACAACATG    c.2340
 P  V  T  A  L  T  L  L  E  K  |  M  K  D  T  S  R  K  N  N  M      p.780

          .         .         .         .         .         .       g.651678
 TTTGCACAGTTTCGGAAAAATGAGCGAGACAAGCAGAAACTCATTGACACCGTGGCCAAG       c.2400
 F  A  Q  F  R  K  N  E  R  D  K  Q  K  L  I  D  T  V  A  K         p.800

          .         .         .                                     g.651714
 CAGCTCCGAGGACTCATCAGCAGCCACCACTCATGA                               c.2436
 Q  L  R  G  L  I  S  S  H  H  S  X                                 p.811

          .         .                                               g.651734
 agggtgaccccggacccaca                                               c.*20

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Exocyst complex component 6B protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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