eyes absent homolog 4 (Drosophila) (EYA4) - coding DNA reference sequence

(used for variant description)

(last modified February 18, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_004100.4 in the EYA4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011596.1, covering EYA4 transcript NM_004100.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5038
                       gcaaaacttccatcctgtccacgtgaagttgtcgctgc       c.-421

 .         .         .         .         .         .                g.5098
 cttagagagggggaaagagctgcgggaaaagccggggagtgacgactgcggcggctgggc       c.-361

 .         .         .         .         .         .                g.5158
 gcgctctctcattttcttttcttctcctttcccccctgtcgcagtccggagttttggctc       c.-301

 .         .         .         .         .         .                g.5218
 ctctcctttcctcctccccctcggagccggcttctccctccgccccgcttctcccccgct       c.-241

 .         .         .         .         .         .                g.5278
 tgtgtacgctatttgttgtggggtggccgaaggggatgtcctgttttcaccagaggcaca       c.-181

 .         .         .         .         .         .                g.5338
 gcgcgaaggggaaacttcgacactggaaggaacgagaataaatacttaattacggacgca       c.-121

 .         .         .         .         .         .     | 02       g.38364
 ctgaaccgcggctgggacagacacttcgggaacccgaggcggaccgggcgacgag | atagt    c.-61

 .         .         .         .         .         .                g.38424
 catttttacttgaaggaagctgcttctacttgggagtggcaggagaagtgagaaaaccac       c.-1

          .         .         .    | 03    .         .         .    g.146062
 ATGGAAGACTCCCAGGATTTAAATGAACAATCA | GTAAAGAAAACGTGCACAGAATCAGAT    c.60
 M  E  D  S  Q  D  L  N  E  Q  S   | V  K  K  T  C  T  E  S  D      p.20

          .         .    | 04    .         .         .         .    g.210310
 GTTTCACAATCTCAGAATTCCAG | GTCTATGGAAATGCAGGACCTAGCAAGTCCTCATACT    c.120
 V  S  Q  S  Q  N  S  R  |  S  M  E  M  Q  D  L  A  S  P  H  T      p.40

          .         .         .         .         .         .       g.210370
 CTTGTTGGAGGTGGTGATACTCCAGGTAGCTCCAAACTGGAAAAATCTAATCTCAGCAGC       c.180
 L  V  G  G  G  D  T  P  G  S  S  K  L  E  K  S  N  L  S  S         p.60

          .         .         | 05         .         .         .    g.211786
 ACATCAGTTACTACAAATGGGACAGGAG | GGGAAAACATGACTGTTTTAAACACAGCAGAC    c.240
 T  S  V  T  T  N  G  T  G  G |   E  N  M  T  V  L  N  T  A  D      p.80

          .         .         .        | 06.         .         .    g.220222
 TGGTTGCTGAGTTGCAACACCCCCTCTTCTGCAACAA | TGTCTCTTCTTGCAGTCAAAACA    c.300
 W  L  L  S  C  N  T  P  S  S  A  T  M |   S  L  L  A  V  K  T      p.100

          .         .         .         .         .         .       g.220282
 GAGCCCTTGAACAGCAGTGAAACCACAGCCACGACTGGAGATGGAGCGCTTGACACTTTT       c.360
 E  P  L  N  S  S  E  T  T  A  T  T  G  D  G  A  L  D  T  F         p.120

          . | 07       .         .         .         .         .    g.224807
 ACTGGGTCAG | TAATTACAAGTAGTGGCTACAGCCCCAGATCAGCACATCAGTATTCCCCA    c.420
 T  G  S  V |   I  T  S  S  G  Y  S  P  R  S  A  H  Q  Y  S  P      p.140

          .        | 08.         .         .         .         .    g.226021
 CAGCTGTATCCTTCCAA | GCCCTATCCACACATTCTTTCTACACCAGCAGCTCAAACAATG    c.480
 Q  L  Y  P  S  K  |  P  Y  P  H  I  L  S  T  P  A  A  Q  T  M      p.160

          .         .         .         .         .         .       g.226081
 TCTGCCTATGCAGGCCAGACTCAGTATTCGGGGATGCAGCAGCCAGCCGTCTACACAGCC       c.540
 S  A  Y  A  G  Q  T  Q  Y  S  G  M  Q  Q  P  A  V  Y  T  A         p.180

          .         .         .         . | 09       .         .    g.226284
 TACTCACAGACAGGACAGCCCTACAGCTTGCCCACTTACG | ATTTGGGTGTGATGTTGCCA    c.600
 Y  S  Q  T  G  Q  P  Y  S  L  P  T  Y  D |   L  G  V  M  L  P      p.200

          .         .         .         .         .         .       g.226344
 GCCATCAAGACAGAGAGTGGACTTTCCCAAACTCAGTCCCCATTACAGAGTGGCTGCCTC       c.660
 A  I  K  T  E  S  G  L  S  Q  T  Q  S  P  L  Q  S  G  C  L         p.220

          .         .         .         .         .         .       g.226404
 AGTTACAGCCCAGGGTTCTCTACCCCACAGCCAGGCCAGACACCTTATTCTTACCAAATG       c.720
 S  Y  S  P  G  F  S  T  P  Q  P  G  Q  T  P  Y  S  Y  Q  M         p.240

      | 10   .         .         .         .         .         .    g.228478
 CCAG | GTTCTAGTTTTGCACCATCATCTACTATTTATGCAAATAATTCAGTTTCCAATTCA    c.780
 P  G |   S  S  F  A  P  S  S  T  I  Y  A  N  N  S  V  S  N  S      p.260

          .         .     | 11   .         .         .         .    g.232245
 ACGAATTTCAGTGGTTCACAACAG | GATTATCCATCCTATACAGCCTTTGGCCAAAACCAG    c.840
 T  N  F  S  G  S  Q  Q   | D  Y  P  S  Y  T  A  F  G  Q  N  Q      p.280

          .         .         .         .         .         .       g.232305
 TATGCACAGTATTATTCAGCATCAACGTATGGAGCGTATATGACATCGAATAACACAGCC       c.900
 Y  A  Q  Y  Y  S  A  S  T  Y  G  A  Y  M  T  S  N  N  T  A         p.300

          .         .         .         .         .         .       g.232365
 GATGGCACACCCTCTTCAACCTCTACTTATCAGTTGCAGGAATCTCTCCCAGGACTGACT       c.960
 D  G  T  P  S  S  T  S  T  Y  Q  L  Q  E  S  L  P  G  L  T         p.320

          . | 12       .         .         .         .         .    g.245156
 AACCAACCAG | GAGAGTTCGATACCATGCAGAGTCCCTCCACACCCATCAAAGATCTTGAT    c.1020
 N  Q  P  G |   E  F  D  T  M  Q  S  P  S  T  P  I  K  D  L  D      p.340

          .         .         .         .         .         .       g.245216
 GAGAGAACCTGTAGGAGTTCTGGGTCAAAGTCCAGAGGAAGAGGCCGGAAAAATAATCCC       c.1080
 E  R  T  C  R  S  S  G  S  K  S  R  G  R  G  R  K  N  N  P         p.360

          .         .        | 13.         .         .         .    g.246708
 TCCCCGCCTCCTGATAGTGACCTGGAG | CGTGTGTTTGTCTGGGATTTGGATGAAACCATC    c.1140
 S  P  P  P  D  S  D  L  E   | R  V  F  V  W  D  L  D  E  T  I      p.380

          .         .         .         .         .  | 14      .    g.269758
 ATTGTTTTTCACTCACTGCTCACCGGGTCTTATGCACAGAAGTATGGCAAG | GATCCCCCC    c.1200
 I  V  F  H  S  L  L  T  G  S  Y  A  Q  K  Y  G  K   | D  P  P      p.400

          .         .         .         .         .         .       g.269818
 ATGGCTGTAACCCTTGGACTCCGCATGGAAGAAATGATTTTTAATCTTGCTGATACTCAT       c.1260
 M  A  V  T  L  G  L  R  M  E  E  M  I  F  N  L  A  D  T  H         p.420

          .         .  | 15      .         .         .         .    g.276403
 TTGTTTTTTAATGATTTAGAG | GAGTGTGATCAAGTTCATATAGATGATGTTTCCTCTGAT    c.1320
 L  F  F  N  D  L  E   | E  C  D  Q  V  H  I  D  D  V  S  S  D      p.440

          .         . | 16       .         .         .         .    g.276561
 GATAATGGGCAGGACTTAAG | TACCTACAGTTTTGCAACTGATGGCTTCCATGCAGCTGCA    c.1380
 D  N  G  Q  D  L  S  |  T  Y  S  F  A  T  D  G  F  H  A  A  A      p.460

          .         .         .         .         .         .       g.276621
 AGTAGTGCAAACCTTTGTTTGCCAACAGGTGTAAGAGGAGGGGTTGACTGGATGAGGAAG       c.1440
 S  S  A  N  L  C  L  P  T  G  V  R  G  G  V  D  W  M  R  K         p.480

          .         .         .         .         .         .       g.276681
 TTGGCTTTTCGTTACAGAAGAGTAAAAGAATTATATAACACCTACAAGAACAACGTTGGA       c.1500
 L  A  F  R  Y  R  R  V  K  E  L  Y  N  T  Y  K  N  N  V  G         p.500

   | 17      .         .         .         .         .         .    g.279023
 G | GACTCCTTGGCCCTGCCAAGAGGGATGCCTGGCTACAGTTAAGGGCAGAGATTGAAGGT    c.1560
 G |   L  L  G  P  A  K  R  D  A  W  L  Q  L  R  A  E  I  E  G      p.520

          .         .         .         .         .       | 18 .    g.286703
 CTGACAGATTCCTGGCTAACAAATGCACTTAAGTCTTTATCAATTATTAGCACTAG | GAGT    c.1620
 L  T  D  S  W  L  T  N  A  L  K  S  L  S  I  I  S  T  R  |  S      p.540

          .         .         .         .         .         .       g.286763
 AACTGCATAAATGTCTTGGTAACGACAACTCAACTGATCCCAGCACTTGCGAAGGTTCTA       c.1680
 N  C  I  N  V  L  V  T  T  T  Q  L  I  P  A  L  A  K  V  L         p.560

          .         .         .         .         .         | 19    g.288799
 CTCTATAGTTTAGGAGGTGCTTTCCCCATTGAGAATATTTACAGTGCAACTAAAATAG | GA    c.1740
 L  Y  S  L  G  G  A  F  P  I  E  N  I  Y  S  A  T  K  I  G |       p.580

          .         .         .         .         .         .       g.288859
 AAAGAAAGTTGCTTTGAACGAATAATGCAAAGGTTTGGCAGAAAAGTAGTGTATGTTGTA       c.1800
 K  E  S  C  F  E  R  I  M  Q  R  F  G  R  K  V  V  Y  V  V         p.600

          .         .         .          | 20        .         .    g.292389
 ATTGGGGATGGTGTAGAAGAAGAACAGGCAGCAAAAAAG | CACAACATGCCCTTCTGGAGG    c.1860
 I  G  D  G  V  E  E  E  Q  A  A  K  K   | H  N  M  P  F  W  R      p.620

          .         .         .         .         .         .       g.292449
 ATATCCAGTCACTCAGACCTCCTGGCTCTCCACCAAGCACTGGAATTAGAGTATTTGTAA       c.1920
 I  S  S  H  S  D  L  L  A  L  H  Q  A  L  E  L  E  Y  L  X         p.639

          .         .         .         .         .         .       g.292509
 ctgtgttctttagccggagatccattttttatatttcaagtacactgaatttttatgtgt       c.*60

          .         .         .         .         .         .       g.292569
 gattcaatgcctctggctctacacatataaattgtcttaatggatgaaatcatatttgga       c.*120

          .         .         .         .         .         .       g.292629
 ataaaaattccagaatgaagaattcagattgctgaatggagttaaactttagtgctacag       c.*180

          .         .         .         .         .         .       g.292689
 aaaagaaactctatggtcttatatttacaacactttaatgggttttttaaaaatctgtgg       c.*240

          .         .         .         .         .         .       g.292749
 aggttgctggtacacaccaaatgagtccaaactggaatgagcagctttagcaaagaactc       c.*300

          .         .         .         .         .         .       g.292809
 ttaccctggcaaagcagcaacacacatgctccgtctgacaaggtggtcaacaacattcct       c.*360

          .         .         .         .         .         .       g.292869
 caaaatgggagatcttctcagccctgaggtttgaatctgactttagcctacctaacccag       c.*420

          .         .         .         .         .         .       g.292929
 aaaatctgaattggaatgcactcagactgtataaggacagtcctatttagacatgtaatt       c.*480

          .         .         .         .         .         .       g.292989
 tgtgtaaattattgatgaaaataatttactgtgactttattagcagctgactttcaaagt       c.*540

          .         .         .         .         .         .       g.293049
 ggatgcaatttttctttcttttgttggggaggggaatgggaggggaaatgggaatataat       c.*600

          .         .         .         .         .         .       g.293109
 attgtctcttttttaagtttggcaaacagaatgttcatactgatgtgttgtgccttaaag       c.*660

          .         .         .         .         .         .       g.293169
 acaagacagcatttgtgtgttacaatgtaactttggttaaaatctctgtagataatgaaa       c.*720

          .         .         .         .         .         .       g.293229
 aaaaacaaaaaaaaaaacctttgtgatgattcttaacatgaccaaatttaaaagtcaagc       c.*780

          .         .         .         .         .         .       g.293289
 tctcagagcttaattaccgcatcagcaagaaactgagtattttttgcaataagaaaacaa       c.*840

          .         .         .         .         .         .       g.293349
 caataataaaggaaagcttgtgtttcatttgggttcttaataattccaataattgtatga       c.*900

          .         .         .         .         .         .       g.293409
 ggcaactatttgcgcatccaaccatgagtggaaggtttgggaaagactgtgggaccttta       c.*960

          .         .         .         .         .         .       g.293469
 cttagaaagtgaaatgtatgtagaagtctcaagtaccccttctacagttttactggagaa       c.*1020

          .         .         .         .         .         .       g.293529
 aactaagagccatattcatgacaacttgcacagttttgaggttgagacttttgatatgtg       c.*1080

          .         .         .         .         .         .       g.293589
 taagttgcatagaggaggatattatcatgcaaatcatgagcaattatcacataaactttt       c.*1140

          .         .         .         .         .         .       g.293649
 ttagaatgtgccatgaacatggcataaaattcacattgagtgcacagggcttaaaataaa       c.*1200

          .         .         .         .         .         .       g.293709
 gctaagtatgtttattcccaatgccatggcaaaaatgataatatcatcagaaatggaagg       c.*1260

          .         .         .         .         .         .       g.293769
 cagttctcccagatggtgtctaatgaaagcaatgagtctatgaaaattttacctagaata       c.*1320

          .         .         .         .         .         .       g.293829
 tcatcataaattaaattagcaagtgcgctggatcttggcagcgctgctgaaatgacaaca       c.*1380

          .         .         .         .         .         .       g.293889
 gtaaaataatacctggttctccatctgaatacatcaatgcaggttctcctcgtaacagac       c.*1440

          .         .         .         .         .         .       g.293949
 ttgcatatgtttgttagtttctgcctgtattgtcactgcgcaacggatggcattcattac       c.*1500

          .         .         .         .         .         .       g.294009
 aagaagagcccatcatcgttgtgtttgcatggtttttttccttgtgtgtagcccatgttg       c.*1560

          .         .         .         .         .         .       g.294069
 ggaacacgatacaggttctcctcttatttcctatgacacgatttcccttgtggaaattta       c.*1620

          .         .         .         .         .         .       g.294129
 agactttaagaactagagtatttttatggtgtctgcacctgcagttctgtgtttaaaatg       c.*1680

          .         .         .         .         .         .       g.294189
 tcataatgtggatcctggagtcaggctactagtcagtgcccctagccagaggctggttca       c.*1740

          .         .         .         .         .         .       g.294249
 tgagttcatcaactgaggcctctgtggcttcaataaagtctacattttgctcacagatca       c.*1800

          .         .         .         .         .         .       g.294309
 caacattcactgtggaaatatgatttcatttctttaggctacaaacctgtatttctttac       c.*1860

          .         .         .         .         .         .       g.294369
 tgaatgctaaggccatgtttatattgggtagaaagatattgagatcccaattttgtacaa       c.*1920

          .         .         .         .         .         .       g.294429
 gattgtgatttcattatctaaaccttaaacttaatcctttaaattttgtagcttttggct       c.*1980

          .         .         .         .         .         .       g.294489
 gcatctgccccaagtactattccaggcaaattaaagttggaatacctttaataatataaa       c.*2040

          .         .         .         .         .         .       g.294549
 aataatgatagtaaatcttatacttctgttggcccttagcttgaaaatagcagttaaaaa       c.*2100

          .         .         .         .         .         .       g.294609
 aatttaaatgttgccttgattatcagtacttaattatgttgtgcactaaaaccttaaata       c.*2160

          .         .         .         .         .         .       g.294669
 tttattactgtgaataaaaacaaattatctttactgtatagctggtttctttaaatgttg       c.*2220

          .         .         .         .         .         .       g.294729
 atagaattgtggcattacatctaaatttgtaagtcttttcatatcaaacaagcaaggctt       c.*2280

          .         .         .         .         .         .       g.294789
 tttatgctgctaagtctgtgggtgcagaaagaaacaccccttggaagggcaaagagaagc       c.*2340

          .         .         .         .         .         .       g.294849
 cggctggttgcatcaccccgtgcagtttctcacacacatctctttttctgattctgtgtt       c.*2400

          .         .         .         .         .         .       g.294909
 cagaagaggctgccggcataaaacctaaatgcaaggttgacggagaacagcttgtctggc       c.*2460

          .         .         .         .         .         .       g.294969
 acaacaatggtgcaggcccacgagccagcatcacagcttggccatgggacgttgagtatg       c.*2520

          .         .         .         .         .         .       g.295029
 cacaaactagaactcttcccttcccaccttaggaatagaaaatcctcttcctttctaatc       c.*2580

          .         .         .         .         .         .       g.295089
 tgaaaaacgaaaactgaacaaacacaaaaccaaccccttggcagttcccacctcctattg       c.*2640

          .         .         .         .         .         .       g.295149
 acatatggaatattgtgccttattgtaaaccagtttgaaaaatgttctgtaactaaagtg       c.*2700

          .         .         .         .         .         .       g.295209
 ggttttcggctattatgtatacagcttggtatattactacgaaagataaccaccttgtgt       c.*2760

          .         .         .         .         .         .       g.295269
 tgcaccttaaaaatatcaagaccatgtaatttccataacaaaataggtggcctggctatg       c.*2820

          .         .         .         .         .         .       g.295329
 gtattatagcatacaattaggacactatgcccctgcaaaattttgtaaatcaaattcaga       c.*2880

          .         .         .         .         .         .       g.295389
 ggcaaaaacatattttagaatcatacagtttgcacacgacaagtaggtaataactgtctc       c.*2940

          .         .         .         .         .         .       g.295449
 taaaaatgttttctccttagtccgcaatgagctaagattcagaatagtgtcaacagcatg       c.*3000

          .         .         .         .         .         .       g.295509
 ctcctatatgaagttgttttttttaaagcacatttgtttatgacaagcctacattctcag       c.*3060

          .         .         .         .         .         .       g.295569
 tgaatatggcatttagtatttcttttgaaaacaaacttaagcatcatgagccaaagttgc       c.*3120

          .         .         .         .         .         .       g.295629
 actttgactcccaactacggtagcattatggacatctcacaatgtcaagggtttctgtta       c.*3180

          .         .         .         .         .         .       g.295689
 tgtattagtaaagtatagattattggggcctacataatttaaaagaaatgtaaattaata       c.*3240

          .         .         .         .         .         .       g.295749
 ttaaaagcttgtaaaaatatgtatatctttactatttctcaataaatacctttgcaattg       c.*3300

          .                                                         g.295764
 ttttcatttccttca                                                    c.*3315

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Eyes absent homolog 4 (Drosophila) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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