ezrin (EZR) - coding DNA reference sequence

(used for variant description)

(last modified October 31, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_003379.4 in the EZR gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering EZR transcript NM_003379.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.6151
                          agtgctgggcggggcgctgactcacccgggcccgg       c.-181

 .         .         .         .         .         .                g.6211
 gctggccggttcttaagcggcagcgcgctgcgggcgccgagtgtcgggcgcggcaggagg       c.-121

 .         .         .         .         .         .                g.6271
 acgaggcagggcgggcgggcgctctaagggttctgctctgactccaggttgggacagcgt       c.-61

 .         .         .         .         .         .                g.6331
 cttcgctgctgctggatagtcgtgttttcggggatcgaggatactcaccagaaaccgaaa       c.-1

          .   | 02     .         .         .         .         .    g.35101
 ATGCCGAAACCA | ATCAATGTCCGAGTTACCACCATGGATGCAGAGCTGGAGTTTGCAATC    c.60
 M  P  K  P   | I  N  V  R  V  T  T  M  D  A  E  L  E  F  A  I      p.20

          .         .         .       | 03 .         .         .    g.37245
 CAGCCAAATACAACTGGAAAACAGCTTTTTGATCAG | GTGGTAAAGACTATCGGCCTCCGG    c.120
 Q  P  N  T  T  G  K  Q  L  F  D  Q   | V  V  K  T  I  G  L  R      p.40

          .         .         .         .         .         .       g.37305
 GAAGTGTGGTACTTTGGCCTCCACTATGTGGATAATAAAGGATTTCCTACCTGGCTGAAG       c.180
 E  V  W  Y  F  G  L  H  Y  V  D  N  K  G  F  P  T  W  L  K         p.60

          .   | 04     .         .         .         .         .    g.38889
 CTGGATAAGAAG | GTGTCTGCCCAGGAGGTCAGGAAGGAGAATCCCCTCCAGTTCAAGTTC    c.240
 L  D  K  K   | V  S  A  Q  E  V  R  K  E  N  P  L  Q  F  K  F      p.80

          .         .         .         .         .         .       g.38949
 CGGGCCAAGTTCTACCCTGAAGATGTGGCTGAGGAGCTCATCCAGGACATCACCCAGAAA       c.300
 R  A  K  F  Y  P  E  D  V  A  E  E  L  I  Q  D  I  T  Q  K         p.100

          .         .         .         .         .         .       g.39009
 CTTTTCTTCCTCCAAGTGAAGGAAGGAATCCTTAGCGATGAGATCTACTGCCCCCCTGAG       c.360
 L  F  F  L  Q  V  K  E  G  I  L  S  D  E  I  Y  C  P  P  E         p.120

          .         .         .         .         .         .       g.39069
 ACTGCCGTGCTCTTGGGGTCCTACGCTGTGCAGGCCAAGTTTGGGGACTACAACAAAGAA       c.420
 T  A  V  L  L  G  S  Y  A  V  Q  A  K  F  G  D  Y  N  K  E         p.140

          .         .         .         .        | 05.         .    g.39710
 GTGCACAAGTCTGGGTACCTCAGCTCTGAGCGGCTGATCCCTCAAAG | AGTGATGGACCAG    c.480
 V  H  K  S  G  Y  L  S  S  E  R  L  I  P  Q  R  |  V  M  D  Q      p.160

          .         .         .         .         .         .       g.39770
 CACAAACTTACCAGGGACCAGTGGGAGGACCGGATCCAGGTGTGGCATGCGGAACACCGT       c.540
 H  K  L  T  R  D  Q  W  E  D  R  I  Q  V  W  H  A  E  H  R         p.180

          .  | 06      .         .         .         .         .    g.40807
 GGGATGCTCAA | AGATAATGCTATGTTGGAATACCTGAAGATTGCTCAGGACCTGGAAATG    c.600
 G  M  L  K  |  D  N  A  M  L  E  Y  L  K  I  A  Q  D  L  E  M      p.200

          .         .         .         .         .         .       g.40867
 TATGGAATCAACTATTTCGAGATAAAAAACAAGAAAGGAACAGACCTTTGGCTTGGAGTT       c.660
 Y  G  I  N  Y  F  E  I  K  N  K  K  G  T  D  L  W  L  G  V         p.220

          .         .         .         | 07         .         .    g.47942
 GATGCCCTTGGACTGAATATTTATGAGAAAGATGATAA | GTTAACCCCAAAGATTGGCTTT    c.720
 D  A  L  G  L  N  I  Y  E  K  D  D  K  |  L  T  P  K  I  G  F      p.240

          .         .         .         .         .         .       g.48002
 CCTTGGAGTGAAATCAGGAACATCTCTTTCAATGACAAAAAGTTTGTCATTAAACCCATC       c.780
 P  W  S  E  I  R  N  I  S  F  N  D  K  K  F  V  I  K  P  I         p.260

          .      | 08  .         .         .         .         .    g.53062
 GACAAGAAGGCACCT | GACTTTGTGTTTTATGCCCCACGTCTGAGAATCAACAAGCGGATC    c.840
 D  K  K  A  P   | D  F  V  F  Y  A  P  R  L  R  I  N  K  R  I      p.280

          .         .         .         .         .         .       g.53122
 CTGCAGCTCTGCATGGGCAACCATGAGTTGTATATGCGCCGCAGGAAGCCTGACACCATC       c.900
 L  Q  L  C  M  G  N  H  E  L  Y  M  R  R  R  K  P  D  T  I         p.300

          .         .         .         .         .          | 09    g.53531
 GAGGTGCAGCAGATGAAGGCCCAGGCCCGGGAGGAGAAGCATCAGAAGCAGCTGGAGCG | G    c.960
 E  V  Q  Q  M  K  A  Q  A  R  E  E  K  H  Q  K  Q  L  E  R  |      p.320

          .         .         .         .         .         .       g.53591
 CAACAGCTGGAAACAGAGAAGAAAAGGAGAGAAACCGTGGAGAGAGAGAAAGAGCAGATG       c.1020
 Q  Q  L  E  T  E  K  K  R  R  E  T  V  E  R  E  K  E  Q  M         p.340

          .         .         .         .         .         .       g.53651
 ATGCGCGAGAAGGAGGAGTTGATGCTGCGGCTGCAGGACTATGAGGAGAAGACAAAGAAG       c.1080
 M  R  E  K  E  E  L  M  L  R  L  Q  D  Y  E  E  K  T  K  K         p.360

          . | 10       .         .         .         .         .    g.54530
 GCAGAGAGAG | AGCTCTCGGAGCAGATTCAGAGGGCCCTGCAGCTGGAGGAGGAGAGGAAG    c.1140
 A  E  R  E |   L  S  E  Q  I  Q  R  A  L  Q  L  E  E  E  R  K      p.380

          .         .         .         .         .         .       g.54590
 CGGGCACAGGAGGAGGCCGAGCGCCTAGAGGCTGACCGTATGGCTGCACTGCGGGCTAAG       c.1200
 R  A  Q  E  E  A  E  R  L  E  A  D  R  M  A  A  L  R  A  K         p.400

          .         .         .         .         .  | 11      .    g.55015
 GAGGAGCTGGAGAGACAGGCGGTGGATCAGATAAAGAGCCAGGAGCAGCTG | GCTGCGGAG    c.1260
 E  E  L  E  R  Q  A  V  D  Q  I  K  S  Q  E  Q  L   | A  A  E      p.420

          .         .         .         .         .         .       g.55075
 CTTGCAGAATACACTGCCAAGATTGCCCTCCTGGAAGAGGCGCGGAGGCGCAAGGAGGAT       c.1320
 L  A  E  Y  T  A  K  I  A  L  L  E  E  A  R  R  R  K  E  D         p.440

          .         .     | 12   .         .         .         .    g.56948
 GAAGTTGAAGAGTGGCAGCACAGG | GCCAAAGAAGCCCAGGATGACCTGGTGAAGACCAAG    c.1380
 E  V  E  E  W  Q  H  R   | A  K  E  A  Q  D  D  L  V  K  T  K      p.460

          .         .         .         .         .         .       g.57008
 GAGGAGCTGCACCTGGTGATGACAGCACCCCCGCCCCCACCACCCCCCGTGTACGAGCCG       c.1440
 E  E  L  H  L  V  M  T  A  P  P  P  P  P  P  P  V  Y  E  P         p.480

          .         .         .         .         .         .       g.57068
 GTGAGCTACCATGTCCAGGAGAGCTTGCAGGATGAGGGCGCAGAGCCCACGGGCTACAGC       c.1500
 V  S  Y  H  V  Q  E  S  L  Q  D  E  G  A  E  P  T  G  Y  S         p.500

          .         .         .         .         .         .       g.57128
 GCGGAGCTGTCTAGTGAGGGCATCCGGGATGACCGCAATGAGGAGAAGCGCATCACTGAG       c.1560
 A  E  L  S  S  E  G  I  R  D  D  R  N  E  E  K  R  I  T  E         p.520

          .         .         .       | 13 .         .         .    g.57370
 GCAGAGAAGAACGAGCGTGTGCAGCGGCAGCTGCTG | ACGCTGAGCAGCGAGCTGTCCCAG    c.1620
 A  E  K  N  E  R  V  Q  R  Q  L  L   | T  L  S  S  E  L  S  Q      p.540

          .         .         .         .         .         .       g.57430
 GCCCGAGATGAGAATAAGAGGACCCACAATGACATCATCCACAACGAGAACATGAGGCAA       c.1680
 A  R  D  E  N  K  R  T  H  N  D  I  I  H  N  E  N  M  R  Q         p.560

          .         .         .         .         .         .       g.57490
 GGCCGGGACAAGTACAAGACGCTGCGGCAGATCCGGCAGGGCAACACCAAGCAGCGCATC       c.1740
 G  R  D  K  Y  K  T  L  R  Q  I  R  Q  G  N  T  K  Q  R  I         p.580

          .         .                                               g.57511
 GACGAGTTCGAGGCCCTGTAA                                              c.1761
 D  E  F  E  A  L  X                                                p.586

          .         .         .         .         .         .       g.57571
 cagccaggccaggaccaagggcagaggggtgctcatagcgggcgctgccagccccgccac       c.*60

          .         .         .         .         .         .       g.57631
 gcttgtgtctttagtgctccaagtctaggaactccctcagatcccagttcctttagaaag       c.*120

          .         .         .         .         .         .       g.57691
 cagttacccaacagaaacattctgggctgggaaccagggaggcgccctggtttgttttcc       c.*180

          .         .         .         .         .         .       g.57751
 ccagttgtaatagtgccaagcaggcctgattctcgcgattattctcgaatcacctcctgt       c.*240

          .         .         .         .         .         .       g.57811
 gttgtgctgggagcaggactgattgaattacggaaaatgcctgtaaagtctgagtaagaa       c.*300

          .         .         .         .         .         .       g.57871
 acttcatgctggcctgtgtgatacaagagtcagcatcattaaaggaaacgtggcaggact       c.*360

          .         .         .         .         .         .       g.57931
 tccatctgtgccatacttgttctgtattcgaaatgagctcaaattgattttttaatttct       c.*420

          .         .         .         .         .         .       g.57991
 atgaaggatccatctttgtatatttacatgcttagaggggtgaaaattattttggaaatt       c.*480

          .         .         .         .         .         .       g.58051
 gagtctgaagcactctcgcacacacagtgattccctcctcccgtcactccacgcagctgg       c.*540

          .         .         .         .         .         .       g.58111
 cagagagcacagtgatcaccagcgtgagtggtggaggaggacacttggattttttttttt       c.*600

          .         .         .         .         .         .       g.58171
 gttttttttttttttgcttaacagttttagaatacattgtacttatacaccttattaatg       c.*660

          .         .         .         .         .         .       g.58231
 atcagctatatactatttatatacaagtgataatacagatttgtaacattagttttaaaa       c.*720

          .         .         .         .         .         .       g.58291
 agggaaagttttgttctgtatattttgttaccttttacagaataaaagaattacatatga       c.*780

          .         .         .         .         .         .       g.58351
 aaaaccctctaaaccatggcacttgatgtgatgtggcaggagggcagtggtggagctgga       c.*840

          .         .         .         .         .         .       g.58411
 cctgcctgctgcagtcacgtgtaaacaggattattattagtgttttatgcatgtaatgga       c.*900

          .         .         .         .         .         .       g.58471
 ctatgcacacttttaattttgtcagattcacacatgccactatgagctttcagactccag       c.*960

          .         .         .         .         .         .       g.58531
 ctgtgaagagactctgtttgcttgtgtttgtttgtttgcagtctctctctgccatggcct       c.*1020

          .         .         .         .         .         .       g.58591
 tggcaggctgctggaaggcagcttgtggaggccgttggttccgcccactcattccttctc       c.*1080

          .         .         .         .         .         .       g.58651
 gtgcactgctttctccttcacagctaagatgccatgtgcaggtggattccatgccgcaga       c.*1140

          .         .         .                                     g.58684
 catgaaataaaagctttgcaaaggcacgaagca                                  c.*1173

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Ezrin protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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