coagulation factor II (thrombin) (F2) - coding DNA reference sequence

(used for variant description)

(last modified July 28, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_000506.3 in the F2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008953.1, covering F2 transcript NM_000506.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5043
                  gtcaggacagacaattcctcagtgacccaggagctgacacact       c.-1

          .         .         .         .         .         .       g.5103
 ATGGCGCACGTCCGAGGCTTGCAGCTGCCTGGCTGCCTGGCCCTGGCTGCCCTGTGTAGC       c.60
 M  A  H  V  R  G  L  Q  L  P  G  C  L  A  L  A  A  L  C  S         p.20

          .          | 02        .         .         .         .    g.5550
 CTTGTGCACAGCCAGCATG | TGTTCCTGGCTCCTCAGCAAGCACGGTCGCTGCTCCAGCGG    c.120
 L  V  H  S  Q  H  V |   F  L  A  P  Q  Q  A  R  S  L  L  Q  R      p.40

          .         .         .         .         .         .       g.5610
 GTCCGGCGAGCCAACACCTTCTTGGAGGAGGTGCGCAAGGGCAACCTGGAGCGAGAGTGC       c.180
 V  R  R  A  N  T  F  L  E  E  V  R  K  G  N  L  E  R  E  C         p.60

          .         .         .         .         .         .       g.5670
 GTGGAGGAGACGTGCAGCTACGAGGAGGCCTTCGAGGCTCTGGAGTCCTCCACGGCTACG       c.240
 V  E  E  T  C  S  Y  E  E  A  F  E  A  L  E  S  S  T  A  T         p.80

  | 03       .         .      | 04  .         .         .         . g.6632
  | GATGTGTTCTGGGCCAAGTACACAG | CTTGTGAGACAGCGAGGACGCCTCGAGATAAGCTT c.300
  | D  V  F  W  A  K  Y  T  A |   C  E  T  A  R  T  P  R  D  K  L   p.100

          .       | 05 .         .         .         .         .    g.9031
 GCTGCATGTCTGGAAG | GTAACTGTGCTGAGGGTCTGGGTACGAACTACCGAGGGCATGTG    c.360
 A  A  C  L  E  G |   N  C  A  E  G  L  G  T  N  Y  R  G  H  V      p.120

          .         .         .         .         .         .       g.9091
 AACATCACCCGGTCAGGCATTGAGTGCCAGCTATGGAGGAGTCGCTACCCACATAAGCCT       c.420
 N  I  T  R  S  G  I  E  C  Q  L  W  R  S  R  Y  P  H  K  P         p.140

    | 06     .         .         .         .         .         .    g.9247
 GA | AATCAACTCCACTACCCATCCTGGGGCCGACCTACAGGAGAATTTCTGCCGCAACCCC    c.480
 E  |  I  N  S  T  T  H  P  G  A  D  L  Q  E  N  F  C  R  N  P      p.160

          .         .         .         .         .         .       g.9307
 GACAGCAGCACCACGGGACCCTGGTGCTACACTACAGACCCCACCGTGAGGAGGCAGGAA       c.540
 D  S  S  T  T  G  P  W  C  Y  T  T  D  P  T  V  R  R  Q  E         p.180

          .          | 07        .         .         .         .    g.11707
 TGCAGCATCCCTGTCTGTG | GCCAGGATCAAGTCACTGTAGCGATGACTCCACGCTCCGAA    c.600
 C  S  I  P  V  C  G |   Q  D  Q  V  T  V  A  M  T  P  R  S  E      p.200

          .         .         .         .         .         .       g.11767
 GGCTCCAGTGTGAATCTGTCACCTCCATTGGAGCAGTGTGTCCCTGATCGGGGGCAGCAG       c.660
 G  S  S  V  N  L  S  P  P  L  E  Q  C  V  P  D  R  G  Q  Q         p.220

          .         .         .         .         .         .       g.11827
 TACCAGGGGCGCCTGGCGGTGACCACACATGGGCTCCCCTGCCTGGCCTGGGCCAGCGCA       c.720
 Y  Q  G  R  L  A  V  T  T  H  G  L  P  C  L  A  W  A  S  A         p.240

          .         .         .         .         .         .       g.11887
 CAGGCCAAGGCCCTGAGCAAGCACCAGGACTTCAACTCAGCTGTGCAGCTGGTGGAGAAC       c.780
 Q  A  K  A  L  S  K  H  Q  D  F  N  S  A  V  Q  L  V  E  N         p.260

          .         .         .         .         .         .       g.11947
 TTCTGCCGCAACCCAGACGGGGATGAGGAGGGCGTGTGGTGCTATGTGGCCGGGAAGCCT       c.840
 F  C  R  N  P  D  G  D  E  E  G  V  W  C  Y  V  A  G  K  P         p.280

          .         .         .     | 08   .         .         .    g.12331
 GGCGACTTTGGGTACTGCGACCTCAACTATTGTG | AGGAGGCCGTGGAGGAGGAGACAGGA    c.900
 G  D  F  G  Y  C  D  L  N  Y  C  E |   E  A  V  E  E  E  T  G      p.300

          .         .         .         .         .         .       g.12391
 GATGGGCTGGATGAGGACTCAGACAGGGCCATCGAAGGGCGTACCGCCACCAGTGAGTAC       c.960
 D  G  L  D  E  D  S  D  R  A  I  E  G  R  T  A  T  S  E  Y         p.320

          .         .         .         .    | 09    .         .    g.12535
 CAGACTTTCTTCAATCCGAGGACCTTTGGCTCGGGAGAGGCAG | ACTGTGGGCTGCGACCT    c.1020
 Q  T  F  F  N  P  R  T  F  G  S  G  E  A  D |   C  G  L  R  P      p.340

          .         .         .         .         .         .       g.12595
 CTGTTCGAGAAGAAGTCGCTGGAGGACAAAACCGAAAGAGAGCTCCTGGAATCCTACATC       c.1080
 L  F  E  K  K  S  L  E  D  K  T  E  R  E  L  L  E  S  Y  I         p.360

          .         .         .         .         . | 10       .    g.13813
 GACGGGCGCATTGTGGAGGGCTCGGATGCAGAGATCGGCATGTCACCTTG | GCAGGTGATG    c.1140
 D  G  R  I  V  E  G  S  D  A  E  I  G  M  S  P  W  |  Q  V  M      p.380

          .         .         .         .         .         .       g.13873
 CTTTTCCGGAAGAGTCCCCAGGAGCTGCTGTGTGGGGCCAGCCTCATCAGTGACCGCTGG       c.1200
 L  F  R  K  S  P  Q  E  L  L  C  G  A  S  L  I  S  D  R  W         p.400

          .         .         .         .         .         .       g.13933
 GTCCTCACCGCCGCCCACTGCCTCCTGTACCCGCCCTGGGACAAGAACTTCACCGAGAAT       c.1260
 V  L  T  A  A  H  C  L  L  Y  P  P  W  D  K  N  F  T  E  N         p.420

          .         .         .         | 11         .         .    g.14493
 GACCTTCTGGTGCGCATTGGCAAGCACTCCCGCACCAG | GTACGAGCGAAACATTGAAAAG    c.1320
 D  L  L  V  R  I  G  K  H  S  R  T  R  |  Y  E  R  N  I  E  K      p.440

          .         .         .         .         .         .       g.14553
 ATATCCATGTTGGAAAAGATCTACATCCACCCCAGGTACAACTGGCGGGAGAACCTGGAC       c.1380
 I  S  M  L  E  K  I  Y  I  H  P  R  Y  N  W  R  E  N  L  D         p.460

          .         .         .         .         .         .       g.14613
 CGGGACATTGCCCTGATGAAGCTGAAGAAGCCTGTTGCCTTCAGTGACTACATTCACCCT       c.1440
 R  D  I  A  L  M  K  L  K  K  P  V  A  F  S  D  Y  I  H  P         p.480

          .         .         .   | 12     .         .         .    g.15215
 GTGTGTCTGCCCGACAGGGAGACGGCAGCCAG | CTTGCTCCAGGCTGGATACAAGGGGCGG    c.1500
 V  C  L  P  D  R  E  T  A  A  S  |  L  L  Q  A  G  Y  K  G  R      p.500

          .         .         .         .         .         .       g.15275
 GTGACAGGCTGGGGCAACCTGAAGGAGACGTGGACAGCCAACGTTGGTAAGGGGCAGCCC       c.1560
 V  T  G  W  G  N  L  K  E  T  W  T  A  N  V  G  K  G  Q  P         p.520

          .         .         .         .         .         .       g.15335
 AGTGTCCTGCAGGTGGTGAACCTGCCCATTGTGGAGCGGCCGGTCTGCAAGGACTCCACC       c.1620
 S  V  L  Q  V  V  N  L  P  I  V  E  R  P  V  C  K  D  S  T         p.540

          .         .         .     | 13   .         .         .    g.24881
 CGGATCCGCATCACTGACAACATGTTCTGTGCTG | GTTACAAGCCTGATGAAGGGAAACGA    c.1680
 R  I  R  I  T  D  N  M  F  C  A  G |   Y  K  P  D  E  G  K  R      p.560

          .         .         .         .      | 14  .         .    g.25087
 GGGGATGCCTGTGAAGGTGACAGTGGGGGACCCTTTGTCATGAAG | AGCCCCTTTAACAAC    c.1740
 G  D  A  C  E  G  D  S  G  G  P  F  V  M  K   | S  P  F  N  N      p.580

          .         .         .         .         .         .       g.25147
 CGCTGGTATCAAATGGGCATCGTCTCATGGGGTGAAGGCTGTGACCGGGATGGGAAATAT       c.1800
 R  W  Y  Q  M  G  I  V  S  W  G  E  G  C  D  R  D  G  K  Y         p.600

          .         .         .         .         .         .       g.25207
 GGCTTCTACACACATGTGTTCCGCCTGAAGAAGTGGATACAGAAGGTCATTGATCAGTTT       c.1860
 G  F  Y  T  H  V  F  R  L  K  K  W  I  Q  K  V  I  D  Q  F         p.620

                                                                    g.25216
 GGAGAGTAG                                                          c.1869
 G  E  X                                                            p.622

          .         .         .         .         .         .       g.25276
 ggggccactcatattctgggctcctggaaccaatcccgtgaaagaattatttttgtgttt       c.*60

          .         .         .                                     g.25314
 ctaaaactatggttcccaataaaagtgactctcagcga                             c.*98

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Coagulation factor II (thrombin) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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