coagulation factor VIII, procoagulant component (F8) - coding DNA reference sequence

(used for variant description)

(last modified July 28, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_000132.3 in the F8 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011403.1, covering F8 transcript NM_000132.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5051
          gcttagtgctgagcacatccagtgggtaaagttccttaaaatgctctgcaa       c.-121

 .         .         .         .         .         .                g.5111
 agaaattgggacttttcattaaatcagaaattttacttttttcccctcctgggagctaaa       c.-61

 .         .         .         .         .         .                g.5171
 gatattttagagaagaattaaccttttgcttctccagttgaacatttgtagcaataagtc       c.-1

          .         .         .         .         .         .       g.5231
 ATGCAAATAGAGCTCTCCACCTGCTTCTTTCTGTGCCTTTTGCGATTCTGCTTTAGTGCC       c.60
 M  Q  I  E  L  S  T  C  F  F  L  C  L  L  R  F  C  F  S  A         p.20

          .         .         .         .         .         .       g.5291
 ACCAGAAGATACTACCTGGGTGCAGTGGAACTGTCATGGGACTATATGCAAAGTGATCTC       c.120
 T  R  R  Y  Y  L  G  A  V  E  L  S  W  D  Y  M  Q  S  D  L         p.40

          .         .    | 02    .         .         .         .    g.28160
 GGTGAGCTGCCTGTGGACGCAAG | ATTTCCTCCTAGAGTGCCAAAATCTTTTCCATTCAAC    c.180
 G  E  L  P  V  D  A  R  |  F  P  P  R  V  P  K  S  F  P  F  N      p.60

          .         .         .         .         .         .       g.28220
 ACCTCAGTCGTGTACAAAAAGACTCTGTTTGTAGAATTCACGGATCACCTTTTCAACATC       c.240
 T  S  V  V  Y  K  K  T  L  F  V  E  F  T  D  H  L  F  N  I         p.80

          .         .      | 03  .         .         .         .    g.30663
 GCTAAGCCAAGGCCACCCTGGATGG | GTCTGCTAGGTCCTACCATCCAGGCTGAGGTTTAT    c.300
 A  K  P  R  P  P  W  M  G |   L  L  G  P  T  I  Q  A  E  V  Y      p.100

          .         .         .         .         .         .       g.30723
 GATACAGTGGTCATTACACTTAAGAACATGGCTTCCCATCCTGTCAGTCTTCATGCTGTT       c.360
 D  T  V  V  I  T  L  K  N  M  A  S  H  P  V  S  L  H  A  V         p.120

          .         .         | 04         .         .         .    g.34607
 GGTGTATCCTACTGGAAAGCTTCTGAGG | GAGCTGAATATGATGATCAGACCAGTCAAAGG    c.420
 G  V  S  Y  W  K  A  S  E  G |   A  E  Y  D  D  Q  T  S  Q  R      p.140

          .         .         .         .         .         .       g.34667
 GAGAAAGAAGATGATAAAGTCTTCCCTGGTGGAAGCCATACATATGTCTGGCAGGTCCTG       c.480
 E  K  E  D  D  K  V  F  P  G  G  S  H  T  Y  V  W  Q  V  L         p.160

          .         .         .         .         .         .       g.34727
 AAAGAGAATGGTCCAATGGCCTCTGACCCACTGTGCCTTACCTACTCATATCTTTCTCAT       c.540
 K  E  N  G  P  M  A  S  D  P  L  C  L  T  Y  S  Y  L  S  H         p.180

          .         .         .         .         .         .       g.34787
 GTGGACCTGGTAAAAGACTTGAATTCAGGCCTCATTGGAGCCCTACTAGTATGTAGAGAA       c.600
 V  D  L  V  K  D  L  N  S  G  L  I  G  A  L  L  V  C  R  E         p.200

   | 05      .         .         .         .         .         .    g.40477
 G | GGAGTCTGGCCAAGGAAAAGACACAGACCTTGCACAAATTTATACTACTTTTTGCTGTA    c.660
 G |   S  L  A  K  E  K  T  Q  T  L  H  K  F  I  L  L  F  A  V      p.220

          . | 06       .         .         .         .         .    g.42970
 TTTGATGAAG | GGAAAAGTTGGCACTCAGAAACAAAGAACTCCTTGATGCAGGATAGGGAT    c.720
 F  D  E  G |   K  S  W  H  S  E  T  K  N  S  L  M  Q  D  R  D      p.240

          .         .         .         .         .         .       g.43030
 GCTGCATCTGCTCGGGCCTGGCCTAAAATGCACACAGTCAATGGTTATGTAAACAGGTCT       c.780
 A  A  S  A  R  A  W  P  K  M  H  T  V  N  G  Y  V  N  R  S         p.260

         | 07.         .         .         .         .         .    g.58224
 CTGCCAG | GTCTGATTGGATGCCACAGGAAATCAGTCTATTGGCATGTGATTGGAATGGGC    c.840
 L  P  G |   L  I  G  C  H  R  K  S  V  Y  W  H  V  I  G  M  G      p.280

          .         .         .         .         .         .       g.58284
 ACCACTCCTGAAGTGCACTCAATATTCCTCGAAGGTCACACATTTCTTGTGAGGAACCAT       c.900
 T  T  P  E  V  H  S  I  F  L  E  G  H  T  F  L  V  R  N  H         p.300

          .         .         .         .         .         .       g.58344
 CGCCAGGCGTCCTTGGAAATCTCGCCAATAACTTTCCTTACTGCTCAAACACTCTTGATG       c.960
 R  Q  A  S  L  E  I  S  P  I  T  F  L  T  A  Q  T  L  L  M         p.320

          .         .         .         .          | 08        .    g.61047
 GACCTTGGACAGTTTCTACTGTTTTGTCATATCTCTTCCCACCAACATG | ATGGCATGGAA    c.1020
 D  L  G  Q  F  L  L  F  C  H  I  S  S  H  Q  H  D |   G  M  E      p.340

          .         .         .         .         .         .       g.61107
 GCTTATGTCAAAGTAGACAGCTGTCCAGAGGAACCCCAACTACGAATGAAAAATAATGAA       c.1080
 A  Y  V  K  V  D  S  C  P  E  E  P  Q  L  R  M  K  N  N  E         p.360

          .         .         .         .         .         .       g.61167
 GAAGCGGAAGACTATGATGATGATCTTACTGATTCTGAAATGGATGTGGTCAGGTTTGAT       c.1140
 E  A  E  D  Y  D  D  D  L  T  D  S  E  M  D  V  V  R  F  D         p.380

          .         .         .         .         .         .       g.61227
 GATGACAACTCTCCTTCCTTTATCCAAATTCGCTCAGTTGCCAAGAAGCATCCTAAAACT       c.1200
 D  D  N  S  P  S  F  I  Q  I  R  S  V  A  K  K  H  P  K  T         p.400

          .         .         .         .         .         .       g.61287
 TGGGTACATTACATTGCTGCTGAAGAGGAGGACTGGGACTATGCTCCCTTAGTCCTCGCC       c.1260
 W  V  H  Y  I  A  A  E  E  E  D  W  D  Y  A  P  L  V  L  A         p.420

          .  | 09      .         .         .         .         .    g.61631
 CCCGATGACAG | AAGTTATAAAAGTCAATATTTGAACAATGGCCCTCAGCGGATTGGTAGG    c.1320
 P  D  D  R  |  S  Y  K  S  Q  Y  L  N  N  G  P  Q  R  I  G  R      p.440

          .         .         .         .         .         .       g.61691
 AAGTACAAAAAAGTCCGATTTATGGCATACACAGATGAAACCTTTAAGACTCGTGAAGCT       c.1380
 K  Y  K  K  V  R  F  M  A  Y  T  D  E  T  F  K  T  R  E  A         p.460

          .         .         .         .         .         .       g.61751
 ATTCAGCATGAATCAGGAATCTTGGGACCTTTACTTTATGGGGAAGTTGGAGACACACTG       c.1440
 I  Q  H  E  S  G  I  L  G  P  L  L  Y  G  E  V  G  D  T  L         p.480

     | 10    .         .         .         .         .         .    g.66612
 TTG | ATTATATTTAAGAATCAAGCAAGCAGACCATATAACATCTACCCTCACGGAATCACT    c.1500
 L   | I  I  F  K  N  Q  A  S  R  P  Y  N  I  Y  P  H  G  I  T      p.500

          .         .         .        | 11.         .         .    g.70575
 GATGTCCGTCCTTTGTATTCAAGGAGATTACCAAAAG | GTGTAAAACATTTGAAGGATTTT    c.1560
 D  V  R  P  L  Y  S  R  R  L  P  K  G |   V  K  H  L  K  D  F      p.520

          .         .         .         .         .         .       g.70635
 CCAATTCTGCCAGGAGAAATATTCAAATATAAATGGACAGTGACTGTAGAAGATGGGCCA       c.1620
 P  I  L  P  G  E  I  F  K  Y  K  W  T  V  T  V  E  D  G  P         p.540

          .         .         .         .         .         .       g.70695
 ACTAAATCAGATCCTCGGTGCCTGACCCGCTATTACTCTAGTTTCGTTAATATGGAGAGA       c.1680
 T  K  S  D  P  R  C  L  T  R  Y  Y  S  S  F  V  N  M  E  R         p.560

          .         .         .         .         .         .       g.70755
 GATCTAGCTTCAGGACTCATTGGCCCTCTCCTCATCTGCTACAAAGAATCTGTAGATCAA       c.1740
 D  L  A  S  G  L  I  G  P  L  L  I  C  Y  K  E  S  V  D  Q         p.580

          .   | 12     .         .         .         .         .    g.73729
 AGAGGAAACCAG | ATAATGTCAGACAAGAGGAATGTCATCCTGTTTTCTGTATTTGATGAG    c.1800
 R  G  N  Q   | I  M  S  D  K  R  N  V  I  L  F  S  V  F  D  E      p.600

          .         .         .         .         .         .       g.73789
 AACCGAAGCTGGTACCTCACAGAGAATATACAACGCTTTCTCCCCAATCCAGCTGGAGTG       c.1860
 N  R  S  W  Y  L  T  E  N  I  Q  R  F  L  P  N  P  A  G  V         p.620

          .         .         .         .    | 13    .         .    g.79833
 CAGCTTGAGGATCCAGAGTTCCAAGCCTCCAACATCATGCACA | GCATCAATGGCTATGTT    c.1920
 Q  L  E  D  P  E  F  Q  A  S  N  I  M  H  S |   I  N  G  Y  V      p.640

          .         .         .         .         .         .       g.79893
 TTTGATAGTTTGCAGTTGTCAGTTTGTTTGCATGAGGTGGCATACTGGTACATTCTAAGC       c.1980
 F  D  S  L  Q  L  S  V  C  L  H  E  V  A  Y  W  Y  I  L  S         p.660

          .         .         .         .         .         .       g.79953
 ATTGGAGCACAGACTGACTTCCTTTCTGTCTTCTTCTCTGGATATACCTTCAAACACAAA       c.2040
 I  G  A  Q  T  D  F  L  S  V  F  F  S  G  Y  T  F  K  H  K         p.680

          .         .         .         .         .         .       g.80013
 ATGGTCTATGAAGACACACTCACCCTATTCCCATTCTCAGGAGAAACTGTCTTCATGTCG       c.2100
 M  V  Y  E  D  T  L  T  L  F  P  F  S  G  E  T  V  F  M  S         p.700

          .    | 14    .         .         .         .         .    g.96094
 ATGGAAAACCCAG | GTCTATGGATTCTGGGGTGCCACAACTCAGACTTTCGGAACAGAGGC    c.2160
 M  E  N  P  G |   L  W  I  L  G  C  H  N  S  D  F  R  N  R  G      p.720

          .         .         .         .         .         .       g.96154
 ATGACCGCCTTACTGAAGGTTTCTAGTTGTGACAAGAACACTGGTGATTATTACGAGGAC       c.2220
 M  T  A  L  L  K  V  S  S  C  D  K  N  T  G  D  Y  Y  E  D         p.740

          .         .         .         .         .         .       g.96214
 AGTTATGAAGATATTTCAGCATACTTGCTGAGTAAAAACAATGCCATTGAACCAAGAAGC       c.2280
 S  Y  E  D  I  S  A  Y  L  L  S  K  N  N  A  I  E  P  R  S         p.760

          .         .         .         .         .         .       g.96274
 TTCTCCCAGAATTCAAGACACCCTAGCACTAGGCAAAAGCAATTTAATGCCACCACAATT       c.2340
 F  S  Q  N  S  R  H  P  S  T  R  Q  K  Q  F  N  A  T  T  I         p.780

          .         .         .         .         .         .       g.96334
 CCAGAAAATGACATAGAGAAGACTGACCCTTGGTTTGCACACAGAACACCTATGCCTAAA       c.2400
 P  E  N  D  I  E  K  T  D  P  W  F  A  H  R  T  P  M  P  K         p.800

          .         .         .         .         .         .       g.96394
 ATACAAAATGTCTCCTCTAGTGATTTGTTGATGCTCTTGCGACAGAGTCCTACTCCACAT       c.2460
 I  Q  N  V  S  S  S  D  L  L  M  L  L  R  Q  S  P  T  P  H         p.820

          .         .         .         .         .         .       g.96454
 GGGCTATCCTTATCTGATCTCCAAGAAGCCAAATATGAGACTTTTTCTGATGATCCATCA       c.2520
 G  L  S  L  S  D  L  Q  E  A  K  Y  E  T  F  S  D  D  P  S         p.840

          .         .         .         .         .         .       g.96514
 CCTGGAGCAATAGACAGTAATAACAGCCTGTCTGAAATGACACACTTCAGGCCACAGCTC       c.2580
 P  G  A  I  D  S  N  N  S  L  S  E  M  T  H  F  R  P  Q  L         p.860

          .         .         .         .         .         .       g.96574
 CATCACAGTGGGGACATGGTATTTACCCCTGAGTCAGGCCTCCAATTAAGATTAAATGAG       c.2640
 H  H  S  G  D  M  V  F  T  P  E  S  G  L  Q  L  R  L  N  E         p.880

          .         .         .         .         .         .       g.96634
 AAACTGGGGACAACTGCAGCAACAGAGTTGAAGAAACTTGATTTCAAAGTTTCTAGTACA       c.2700
 K  L  G  T  T  A  A  T  E  L  K  K  L  D  F  K  V  S  S  T         p.900

          .         .         .         .         .         .       g.96694
 TCAAATAATCTGATTTCAACAATTCCATCAGACAATTTGGCAGCAGGTACTGATAATACA       c.2760
 S  N  N  L  I  S  T  I  P  S  D  N  L  A  A  G  T  D  N  T         p.920

          .         .         .         .         .         .       g.96754
 AGTTCCTTAGGACCCCCAAGTATGCCAGTTCATTATGATAGTCAATTAGATACCACTCTA       c.2820
 S  S  L  G  P  P  S  M  P  V  H  Y  D  S  Q  L  D  T  T  L         p.940

          .         .         .         .         .         .       g.96814
 TTTGGCAAAAAGTCATCTCCCCTTACTGAGTCTGGTGGACCTCTGAGCTTGAGTGAAGAA       c.2880
 F  G  K  K  S  S  P  L  T  E  S  G  G  P  L  S  L  S  E  E         p.960

          .         .         .         .         .         .       g.96874
 AATAATGATTCAAAGTTGTTAGAATCAGGTTTAATGAATAGCCAAGAAAGTTCATGGGGA       c.2940
 N  N  D  S  K  L  L  E  S  G  L  M  N  S  Q  E  S  S  W  G         p.980

          .         .         .         .         .         .       g.96934
 AAAAATGTATCGTCAACAGAGAGTGGTAGGTTATTTAAAGGGAAAAGAGCTCATGGACCT       c.3000
 K  N  V  S  S  T  E  S  G  R  L  F  K  G  K  R  A  H  G  P         p.1000

          .         .         .         .         .         .       g.96994
 GCTTTGTTGACTAAAGATAATGCCTTATTCAAAGTTAGCATCTCTTTGTTAAAGACAAAC       c.3060
 A  L  L  T  K  D  N  A  L  F  K  V  S  I  S  L  L  K  T  N         p.1020

          .         .         .         .         .         .       g.97054
 AAAACTTCCAATAATTCAGCAACTAATAGAAAGACTCACATTGATGGCCCATCATTATTA       c.3120
 K  T  S  N  N  S  A  T  N  R  K  T  H  I  D  G  P  S  L  L         p.1040

          .         .         .         .         .         .       g.97114
 ATTGAGAATAGTCCATCAGTCTGGCAAAATATATTAGAAAGTGACACTGAGTTTAAAAAA       c.3180
 I  E  N  S  P  S  V  W  Q  N  I  L  E  S  D  T  E  F  K  K         p.1060

          .         .         .         .         .         .       g.97174
 GTGACACCTTTGATTCATGACAGAATGCTTATGGACAAAAATGCTACAGCTTTGAGGCTA       c.3240
 V  T  P  L  I  H  D  R  M  L  M  D  K  N  A  T  A  L  R  L         p.1080

          .         .         .         .         .         .       g.97234
 AATCATATGTCAAATAAAACTACTTCATCAAAAAACATGGAAATGGTCCAACAGAAAAAA       c.3300
 N  H  M  S  N  K  T  T  S  S  K  N  M  E  M  V  Q  Q  K  K         p.1100

          .         .         .         .         .         .       g.97294
 GAGGGCCCCATTCCACCAGATGCACAAAATCCAGATATGTCGTTCTTTAAGATGCTATTC       c.3360
 E  G  P  I  P  P  D  A  Q  N  P  D  M  S  F  F  K  M  L  F         p.1120

          .         .         .         .         .         .       g.97354
 TTGCCAGAATCAGCAAGGTGGATACAAAGGACTCATGGAAAGAACTCTCTGAACTCTGGG       c.3420
 L  P  E  S  A  R  W  I  Q  R  T  H  G  K  N  S  L  N  S  G         p.1140

          .         .         .         .         .         .       g.97414
 CAAGGCCCCAGTCCAAAGCAATTAGTATCCTTAGGACCAGAAAAATCTGTGGAAGGTCAG       c.3480
 Q  G  P  S  P  K  Q  L  V  S  L  G  P  E  K  S  V  E  G  Q         p.1160

          .         .         .         .         .         .       g.97474
 AATTTCTTGTCTGAGAAAAACAAAGTGGTAGTAGGAAAGGGTGAATTTACAAAGGACGTA       c.3540
 N  F  L  S  E  K  N  K  V  V  V  G  K  G  E  F  T  K  D  V         p.1180

          .         .         .         .         .         .       g.97534
 GGACTCAAAGAGATGGTTTTTCCAAGCAGCAGAAACCTATTTCTTACTAACTTGGATAAT       c.3600
 G  L  K  E  M  V  F  P  S  S  R  N  L  F  L  T  N  L  D  N         p.1200

          .         .         .         .         .         .       g.97594
 TTACATGAAAATAATACACACAATCAAGAAAAAAAAATTCAGGAAGAAATAGAAAAGAAG       c.3660
 L  H  E  N  N  T  H  N  Q  E  K  K  I  Q  E  E  I  E  K  K         p.1220

          .         .         .         .         .         .       g.97654
 GAAACATTAATCCAAGAGAATGTAGTTTTGCCTCAGATACATACAGTGACTGGCACTAAG       c.3720
 E  T  L  I  Q  E  N  V  V  L  P  Q  I  H  T  V  T  G  T  K         p.1240

          .         .         .         .         .         .       g.97714
 AATTTCATGAAGAACCTTTTCTTACTGAGCACTAGGCAAAATGTAGAAGGTTCATATGAC       c.3780
 N  F  M  K  N  L  F  L  L  S  T  R  Q  N  V  E  G  S  Y  D         p.1260

          .         .         .         .         .         .       g.97774
 GGGGCATATGCTCCAGTACTTCAAGATTTTAGGTCATTAAATGATTCAACAAATAGAACA       c.3840
 G  A  Y  A  P  V  L  Q  D  F  R  S  L  N  D  S  T  N  R  T         p.1280

          .         .         .         .         .         .       g.97834
 AAGAAACACACAGCTCATTTCTCAAAAAAAGGGGAGGAAGAAAACTTGGAAGGCTTGGGA       c.3900
 K  K  H  T  A  H  F  S  K  K  G  E  E  E  N  L  E  G  L  G         p.1300

          .         .         .         .         .         .       g.97894
 AATCAAACCAAGCAAATTGTAGAGAAATATGCATGCACCACAAGGATATCTCCTAATACA       c.3960
 N  Q  T  K  Q  I  V  E  K  Y  A  C  T  T  R  I  S  P  N  T         p.1320

          .         .         .         .         .         .       g.97954
 AGCCAGCAGAATTTTGTCACGCAACGTAGTAAGAGAGCTTTGAAACAATTCAGACTCCCA       c.4020
 S  Q  Q  N  F  V  T  Q  R  S  K  R  A  L  K  Q  F  R  L  P         p.1340

          .         .         .         .         .         .       g.98014
 CTAGAAGAAACAGAACTTGAAAAAAGGATAATTGTGGATGACACCTCAACCCAGTGGTCC       c.4080
 L  E  E  T  E  L  E  K  R  I  I  V  D  D  T  S  T  Q  W  S         p.1360

          .         .         .         .         .         .       g.98074
 AAAAACATGAAACATTTGACCCCGAGCACCCTCACACAGATAGACTACAATGAGAAGGAG       c.4140
 K  N  M  K  H  L  T  P  S  T  L  T  Q  I  D  Y  N  E  K  E         p.1380

          .         .         .         .         .         .       g.98134
 AAAGGGGCCATTACTCAGTCTCCCTTATCAGATTGCCTTACGAGGAGTCATAGCATCCCT       c.4200
 K  G  A  I  T  Q  S  P  L  S  D  C  L  T  R  S  H  S  I  P         p.1400

          .         .         .         .         .         .       g.98194
 CAAGCAAATAGATCTCCATTACCCATTGCAAAGGTATCATCATTTCCATCTATTAGACCT       c.4260
 Q  A  N  R  S  P  L  P  I  A  K  V  S  S  F  P  S  I  R  P         p.1420

          .         .         .         .         .         .       g.98254
 ATATATCTGACCAGGGTCCTATTCCAAGACAACTCTTCTCATCTTCCAGCAGCATCTTAT       c.4320
 I  Y  L  T  R  V  L  F  Q  D  N  S  S  H  L  P  A  A  S  Y         p.1440

          .         .         .         .         .         .       g.98314
 AGAAAGAAAGATTCTGGGGTCCAAGAAAGCAGTCATTTCTTACAAGGAGCCAAAAAAAAT       c.4380
 R  K  K  D  S  G  V  Q  E  S  S  H  F  L  Q  G  A  K  K  N         p.1460

          .         .         .         .         .         .       g.98374
 AACCTTTCTTTAGCCATTCTAACCTTGGAGATGACTGGTGATCAAAGAGAGGTTGGCTCC       c.4440
 N  L  S  L  A  I  L  T  L  E  M  T  G  D  Q  R  E  V  G  S         p.1480

          .         .         .         .         .         .       g.98434
 CTGGGGACAAGTGCCACAAATTCAGTCACATACAAGAAAGTTGAGAACACTGTTCTCCCG       c.4500
 L  G  T  S  A  T  N  S  V  T  Y  K  K  V  E  N  T  V  L  P         p.1500

          .         .         .         .         .         .       g.98494
 AAACCAGACTTGCCCAAAACATCTGGCAAAGTTGAATTGCTTCCAAAAGTTCACATTTAT       c.4560
 K  P  D  L  P  K  T  S  G  K  V  E  L  L  P  K  V  H  I  Y         p.1520

          .         .         .         .         .         .       g.98554
 CAGAAGGACCTATTCCCTACGGAAACTAGCAATGGGTCTCCTGGCCATCTGGATCTCGTG       c.4620
 Q  K  D  L  F  P  T  E  T  S  N  G  S  P  G  H  L  D  L  V         p.1540

          .         .         .         .         .         .       g.98614
 GAAGGGAGCCTTCTTCAGGGAACAGAGGGAGCGATTAAGTGGAATGAAGCAAACAGACCT       c.4680
 E  G  S  L  L  Q  G  T  E  G  A  I  K  W  N  E  A  N  R  P         p.1560

          .         .         .         .         .         .       g.98674
 GGAAAAGTTCCCTTTCTGAGAGTAGCAACAGAAAGCTCTGCAAAGACTCCCTCCAAGCTA       c.4740
 G  K  V  P  F  L  R  V  A  T  E  S  S  A  K  T  P  S  K  L         p.1580

          .         .         .         .         .         .       g.98734
 TTGGATCCTCTTGCTTGGGATAACCACTATGGTACTCAGATACCAAAAGAAGAGTGGAAA       c.4800
 L  D  P  L  A  W  D  N  H  Y  G  T  Q  I  P  K  E  E  W  K         p.1600

          .         .         .         .         .         .       g.98794
 TCCCAAGAGAAGTCACCAGAAAAAACAGCTTTTAAGAAAAAGGATACCATTTTGTCCCTG       c.4860
 S  Q  E  K  S  P  E  K  T  A  F  K  K  K  D  T  I  L  S  L         p.1620

          .         .         .         .         .         .       g.98854
 AACGCTTGTGAAAGCAATCATGCAATAGCAGCAATAAATGAGGGACAAAATAAGCCCGAA       c.4920
 N  A  C  E  S  N  H  A  I  A  A  I  N  E  G  Q  N  K  P  E         p.1640

          .         .         .         .         .         .       g.98914
 ATAGAAGTCACCTGGGCAAAGCAAGGTAGGACTGAAAGGCTGTGCTCTCAAAACCCACCA       c.4980
 I  E  V  T  W  A  K  Q  G  R  T  E  R  L  C  S  Q  N  P  P         p.1660

          .         .         .         .         .         .       g.98974
 GTCTTGAAACGCCATCAACGGGAAATAACTCGTACTACTCTTCAGTCAGATCAAGAGGAA       c.5040
 V  L  K  R  H  Q  R  E  I  T  R  T  T  L  Q  S  D  Q  E  E         p.1680

          .         .         .         .         .         .       g.99034
 ATTGACTATGATGATACCATATCAGTTGAAATGAAGAAGGAAGATTTTGACATTTATGAT       c.5100
 I  D  Y  D  D  T  I  S  V  E  M  K  K  E  D  F  D  I  Y  D         p.1700

          .         .         .         .         .         .       g.99094
 GAGGATGAAAATCAGAGCCCCCGCAGCTTTCAAAAGAAAACACGACACTATTTTATTGCT       c.5160
 E  D  E  N  Q  S  P  R  S  F  Q  K  K  T  R  H  Y  F  I  A         p.1720

          .         .         .         .         .          | 15    g.121151
 GCAGTGGAGAGGCTCTGGGATTATGGGATGAGTAGCTCCCCACATGTTCTAAGAAACAG | G    c.5220
 A  V  E  R  L  W  D  Y  G  M  S  S  S  P  H  V  L  R  N  R  |      p.1740

          .         .         .         .         .         .       g.121211
 GCTCAGAGTGGCAGTGTCCCTCAGTTCAAGAAAGTTGTTTTCCAGGAATTTACTGATGGC       c.5280
 A  Q  S  G  S  V  P  Q  F  K  K  V  V  F  Q  E  F  T  D  G         p.1760

          .         .         .         .         .         .       g.121271
 TCCTTTACTCAGCCCTTATACCGTGGAGAACTAAATGAACATTTGGGACTCCTGGGGCCA       c.5340
 S  F  T  Q  P  L  Y  R  G  E  L  N  E  H  L  G  L  L  G  P         p.1780

          .         .         .    | 16    .         .         .    g.122727
 TATATAAGAGCAGAAGTTGAAGATAATATCATG | GTAACTTTCAGAAATCAGGCCTCTCGT    c.5400
 Y  I  R  A  E  V  E  D  N  I  M   | V  T  F  R  N  Q  A  S  R      p.1800

          .         .         .         .         .         .       g.122787
 CCCTATTCCTTCTATTCTAGCCTTATTTCTTATGAGGAAGATCAGAGGCAAGGAGCAGAA       c.5460
 P  Y  S  F  Y  S  S  L  I  S  Y  E  E  D  Q  R  Q  G  A  E         p.1820

          .         .         .         .         .         .       g.122847
 CCTAGAAAAAACTTTGTCAAGCCTAATGAAACCAAAACTTACTTTTGGAAAGTGCAACAT       c.5520
 P  R  K  N  F  V  K  P  N  E  T  K  T  Y  F  W  K  V  Q  H         p.1840

          .         .         .         .         .         .       g.122907
 CATATGGCACCCACTAAAGATGAGTTTGACTGCAAAGCCTGGGCTTATTTCTCTGATGTT       c.5580
 H  M  A  P  T  K  D  E  F  D  C  K  A  W  A  Y  F  S  D  V         p.1860

        | 17 .         .         .         .         .         .    g.123253
 GACCTG | GAAAAAGATGTGCACTCAGGCCTGATTGGACCCCTTCTGGTCTGCCACACTAAC    c.5640
 D  L   | E  K  D  V  H  S  G  L  I  G  P  L  L  V  C  H  T  N      p.1880

          .         .         .         .         .         .       g.123313
 ACACTGAACCCTGCTCATGGGAGACAAGTGACAGTACAGGAATTTGCTCTGTTTTTCACC       c.5700
 T  L  N  P  A  H  G  R  Q  V  T  V  Q  E  F  A  L  F  F  T         p.1900

          .         .         .         .         .         .       g.123373
 ATCTTTGATGAGACCAAAAGCTGGTACTTCACTGAAAATATGGAAAGAAACTGCAGGGCT       c.5760
 I  F  D  E  T  K  S  W  Y  F  T  E  N  M  E  R  N  C  R  A         p.1920

          .         .         .         .         .      | 18  .    g.123640
 CCCTGCAATATCCAGATGGAAGATCCCACTTTTAAAGAGAATTATCGCTTCCATG | CAATC    c.5820
 P  C  N  I  Q  M  E  D  P  T  F  K  E  N  Y  R  F  H  A |   I      p.1940

          .         .         .         .         .         .       g.123700
 AATGGCTACATAATGGATACACTACCTGGCTTAGTAATGGCTCAGGATCAAAGGATTCGA       c.5880
 N  G  Y  I  M  D  T  L  P  G  L  V  M  A  Q  D  Q  R  I  R         p.1960

          .         .         .         .         .         .       g.123760
 TGGTATCTGCTCAGCATGGGCAGCAATGAAAACATCCATTCTATTCATTTCAGTGGACAT       c.5940
 W  Y  L  L  S  M  G  S  N  E  N  I  H  S  I  H  F  S  G  H         p.1980

          .         .         .         .         .         | 19    g.125558
 GTGTTCACTGTACGAAAAAAAGAGGAGTATAAAATGGCACTGTACAATCTCTATCCAG | GT    c.6000
 V  F  T  V  R  K  K  E  E  Y  K  M  A  L  Y  N  L  Y  P  G |       p.2000

          .         .         .         .         .         .       g.125618
 GTTTTTGAGACAGTGGAAATGTTACCATCCAAAGCTGGAATTTGGCGGGTGGAATGCCTT       c.6060
 V  F  E  T  V  E  M  L  P  S  K  A  G  I  W  R  V  E  C  L         p.2020

          .         .         .         .         .      | 20  .    g.126286
 ATTGGCGAGCATCTACATGCTGGGATGAGCACACTTTTTCTGGTGTACAGCAATA | AGTGT    c.6120
 I  G  E  H  L  H  A  G  M  S  T  L  F  L  V  Y  S  N  K |   C      p.2040

          .         .         .         .         .         .       g.126346
 CAGACTCCCCTGGGAATGGCTTCTGGACACATTAGAGATTTTCAGATTACAGCTTCAGGA       c.6180
 Q  T  P  L  G  M  A  S  G  H  I  R  D  F  Q  I  T  A  S  G         p.2060

         | 21.         .         .         .         .         .    g.127825
 CAATATG | GACAGTGGGCCCCAAAGCTGGCCAGACTTCATTATTCCGGATCAATCAATGCC    c.6240
 Q  Y  G |   Q  W  A  P  K  L  A  R  L  H  Y  S  G  S  I  N  A      p.2080

          .         .         .    | 22    .         .         .    g.131518
 TGGAGCACCAAGGAGCCCTTTTCTTGGATCAAG | GTGGATCTGTTGGCACCAATGATTATT    c.6300
 W  S  T  K  E  P  F  S  W  I  K   | V  D  L  L  A  P  M  I  I      p.2100

          .         .         .         .         .         .       g.131578
 CACGGCATCAAGACCCAGGGTGCCCGTCAGAAGTTCTCCAGCCTCTACATCTCTCAGTTT       c.6360
 H  G  I  K  T  Q  G  A  R  Q  K  F  S  S  L  Y  I  S  Q  F         p.2120

          .         .         .         .         .         .       g.131638
 ATCATCATGTATAGTCTTGATGGGAAGAAGTGGCAGACTTATCGAGGAAATTCCACTGGA       c.6420
 I  I  M  Y  S  L  D  G  K  K  W  Q  T  Y  R  G  N  S  T  G         p.2140

           | 23        .         .         .         .         .    g.164547
 ACCTTAATG | GTCTTCTTTGGCAATGTGGATTCATCTGGGATAAAACACAATATTTTTAAC    c.6480
 T  L  M   | V  F  F  G  N  V  D  S  S  G  I  K  H  N  I  F  N      p.2160

          .         .         .         .         .         .       g.164607
 CCTCCAATTATTGCTCGATACATCCGTTTGCACCCAACTCATTATAGCATTCGCAGCACT       c.6540
 P  P  I  I  A  R  Y  I  R  L  H  P  T  H  Y  S  I  R  S  T         p.2180

          .         .         .     | 24   .         .         .    g.165883
 CTTCGCATGGAGTTGATGGGCTGTGATTTAAATA | GTTGCAGCATGCCATTGGGAATGGAG    c.6600
 L  R  M  E  L  M  G  C  D  L  N  S |   C  S  M  P  L  G  M  E      p.2200

          .         .         .         .         .         .       g.165943
 AGTAAAGCAATATCAGATGCACAGATTACTGCTTCATCCTACTTTACCAATATGTTTGCC       c.6660
 S  K  A  I  S  D  A  Q  I  T  A  S  S  Y  F  T  N  M  F  A         p.2220

          .         .         .         .         .         .       g.166003
 ACCTGGTCTCCTTCAAAAGCTCGACTTCACCTCCAAGGGAGGAGTAATGCCTGGAGACCT       c.6720
 T  W  S  P  S  K  A  R  L  H  L  Q  G  R  S  N  A  W  R  P         p.2240

     | 25    .         .         .         .         .         .    g.167172
 CAG | GTGAATAATCCAAAAGAGTGGCTGCAAGTGGACTTCCAGAAGACAATGAAAGTCACA    c.6780
 Q   | V  N  N  P  K  E  W  L  Q  V  D  F  Q  K  T  M  K  V  T      p.2260

          .         .         .         .         .         .       g.167232
 GGAGTAACTACTCAGGGAGTAAAATCTCTGCTTACCAGCATGTATGTGAAGGAGTTCCTC       c.6840
 G  V  T  T  Q  G  V  K  S  L  L  T  S  M  Y  V  K  E  F  L         p.2280

          .         .         .         .         .         .       g.167292
 ATCTCCAGCAGTCAAGATGGCCATCAGTGGACTCTCTTTTTTCAGAATGGCAAAGTAAAG       c.6900
 I  S  S  S  Q  D  G  H  Q  W  T  L  F  F  Q  N  G  K  V  K         p.2300

  | 26       .         .         .         .         .         .    g.190031
  | GTTTTTCAGGGAAATCAAGACTCCTTCACACCTGTGGTGAACTCTCTAGACCCACCGTTA    c.6960
  | V  F  Q  G  N  Q  D  S  F  T  P  V  V  N  S  L  D  P  P  L      p.2320

          .         .         .         .         .         .       g.190091
 CTGACTCGCTACCTTCGAATTCACCCCCAGAGTTGGGTGCACCAGATTGCCCTGAGGATG       c.7020
 L  T  R  Y  L  R  I  H  P  Q  S  W  V  H  Q  I  A  L  R  M         p.2340

          .         .         .                                     g.190127
 GAGGTTCTGGGCTGCGAGGCACAGGACCTCTACTGA                               c.7056
 E  V  L  G  C  E  A  Q  D  L  Y  X                                 p.2351

          .         .         .         .         .         .       g.190187
 gggtggccactgcagcacctgccactgccgtcacctctccctcctcagctccagggcagt       c.*60

          .         .         .         .         .         .       g.190247
 gtccctccctggcttgccttctacctttgtgctaaatcctagcagacactgccttgaagc       c.*120

          .         .         .         .         .         .       g.190307
 ctcctgaattaactatcatcagtcctgcatttctttggtggggggccaggagggtgcatc       c.*180

          .         .         .         .         .         .       g.190367
 caatttaacttaactcttacctattttctgcagctgctcccagattactccttccttcca       c.*240

          .         .         .         .         .         .       g.190427
 atataactaggcaaaaagaagtgaggagaaacctgcatgaaagcattcttccctgaaaag       c.*300

          .         .         .         .         .         .       g.190487
 ttaggcctctcagagtcaccacttcctctgttgtagaaaaactatgtgatgaaactttga       c.*360

          .         .         .         .         .         .       g.190547
 aaaagatatttatgatgttaacatttcaggttaagcctcatacgtttaaaataaaactct       c.*420

          .         .         .         .         .         .       g.190607
 cagttgtttattatcctgatcaagcatggaacaaagcatgtttcaggatcagatcaatac       c.*480

          .         .         .         .         .         .       g.190667
 aatcttggagtcaaaaggcaaatcatttggacaatctgcaaaatggagagaatacaataa       c.*540

          .         .         .         .         .         .       g.190727
 ctactacagtaaagtctgtttctgcttccttacacatagatataattatgttatttagtc       c.*600

          .         .         .         .         .         .       g.190787
 attatgaggggcacattcttatctccaaaactagcattcttaaactgagaattatagatg       c.*660

          .         .         .         .         .         .       g.190847
 gggttcaagaatccctaagtcccctgaaattatataaggcattctgtataaatgcaaatg       c.*720

          .         .         .         .         .         .       g.190907
 tgcatttttctgacgagtgtccatagatataaagccatttggtcttaattctgaccaata       c.*780

          .         .         .         .         .         .       g.190967
 aaaaaataagtcaggaggatgcaattgttgaaagctttgaaataaaataacaatgtcttc       c.*840

          .         .         .         .         .         .       g.191027
 ttgaaatttgtgatggccaagaaagaaaatgatgatgacattaggcttctaaaggacata       c.*900

          .         .         .         .         .         .       g.191087
 catttaatatttctgtggaaatatgaggaaaatccatggttatctgagataggagataca       c.*960

          .         .         .         .         .         .       g.191147
 aactttgtaattctaataatgcactcagtttactctctccctctactaatttcctgctga       c.*1020

          .         .         .         .         .         .       g.191207
 aaataacacaacaaaaatgtaacaggggaaattatataccgtgactgaaaactagagtcc       c.*1080

          .         .         .         .         .         .       g.191267
 tacttacatagttgaaatatcaaggaggtcagaagaaaattggactggtgaaaacagaaa       c.*1140

          .         .         .         .         .         .       g.191327
 aaacactccagtctgccatatcaccacacaataggatcccccttcttgccctccaccccc       c.*1200

          .         .         .         .         .         .       g.191387
 ataagattgtgaagggtttactgctccttccatctgcctgaccccttcactatgactaca       c.*1260

          .         .         .         .         .         .       g.191447
 cagaatctcctgatagtaaagggggctggaggcaaggataagttatagagcagttggagg       c.*1320

          .         .         .         .         .         .       g.191507
 aagcatccaaagattgcaacccagggcaaatggaaaacaggagatcctaatatgaaagaa       c.*1380

          .         .         .         .         .         .       g.191567
 aaatggatcccaatctgagaaaaggcaaaagaatggctacttttttctatgctggagtat       c.*1440

          .         .         .         .         .         .       g.191627
 tttctaataatcctgcttgacccttatctgacctctttggaaactataacatagctgtca       c.*1500

          .         .         .         .         .         .       g.191687
 cagtatagtcacaatccacaaatgatgcaggtgcaaatggtttatagccctgtgaagttc       c.*1560

          .         .         .         .         .         .       g.191747
 ttaaagtttagaggctaacttacagaaatgaataagttgttttgttttatagcccggtag       c.*1620

          .         .         .         .         .         .       g.191807
 aggagttaaccccaaaggtgatatggttttatttcctgttatgtttaacttgataatctt       c.*1680

          .         .         .         .         .         .       g.191867
 attttggcattcttttcccattgactatatacatctctatttctcaaatgttcatggaac       c.*1740

          .         .         .         .         .         .       g.191927
 tagctcttttattttcctgctggtttcttcagtaatgagttaaataaaacattgacacat       c.*1800

                                                                    g.191936
 acaaacaaa                                                          c.*1809

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Coagulation factor VIII, procoagulant component protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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