coagulation factor IX (F9) - coding DNA reference sequence

(used for variant description)

(last modified July 28, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_000133.3 in the F9 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007994.1, covering F9 transcript NM_000133.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5029
                                accactttcacaatctgctagcaaaggtt       c.-1

          .         .         .         .         .         .       g.5089
 ATGCAGCGCGTGAACATGATCATGGCAGAATCACCAGGCCTCATCACCATCTGCCTTTTA       c.60
 M  Q  R  V  N  M  I  M  A  E  S  P  G  L  I  T  I  C  L  L         p.20

          .         .         | 02         .         .         .    g.11306
 GGATATCTACTCAGTGCTGAATGTACAG | TTTTTCTTGATCATGAAAACGCCAACAAAATT    c.120
 G  Y  L  L  S  A  E  C  T  V |   F  L  D  H  E  N  A  N  K  I      p.40

          .         .         .         .         .         .       g.11366
 CTGAATCGGCCAAAGAGGTATAATTCAGGTAAATTGGAAGAGTTTGTTCAAGGGAACCTT       c.180
 L  N  R  P  K  R  Y  N  S  G  K  L  E  E  F  V  Q  G  N  L         p.60

          .         .         .         .         .         .       g.11426
 GAGAGAGAATGTATGGAAGAAAAGTGTAGTTTTGAAGAAGCACGAGAAGTTTTTGAAAAC       c.240
 E  R  E  C  M  E  E  K  C  S  F  E  E  A  R  E  V  F  E  N         p.80

          .   | 03     .         .        | 04.         .         . g.15363
 ACTGAAAGAACA | ACTGAATTTTGGAAGCAGTATGTTG | ATGGAGATCAGTGTGAGTCCAAT c.300
 T  E  R  T   | T  E  F  W  K  Q  Y  V  D |   G  D  Q  C  E  S  N   p.100

          .         .         .         .         .         .       g.15423
 CCATGTTTAAATGGCGGCAGTTGCAAGGATGACATTAATTCCTATGAATGTTGGTGTCCC       c.360
 P  C  L  N  G  G  S  C  K  D  D  I  N  S  Y  E  C  W  C  P         p.120

          .         .         .  | 05      .         .         .    g.22656
 TTTGGATTTGAAGGAAAGAACTGTGAATTAG | ATGTAACATGTAACATTAAGAATGGCAGA    c.420
 F  G  F  E  G  K  N  C  E  L  D |   V  T  C  N  I  K  N  G  R      p.140

          .         .         .         .         .         .       g.22716
 TGCGAGCAGTTTTGTAAAAATAGTGCTGATAACAAGGTGGTTTGCTCCTGTACTGAGGGA       c.480
 C  E  Q  F  C  K  N  S  A  D  N  K  V  V  C  S  C  T  E  G         p.160

          .         .         .         . | 06       .         .    g.25346
 TATCGACTTGCAGAAAACCAGAAGTCCTGTGAACCAGCAG | TGCCATTTCCATGTGGAAGA    c.540
 Y  R  L  A  E  N  Q  K  S  C  E  P  A  V |   P  F  P  C  G  R      p.180

          .         .         .         .         .         .       g.25406
 GTTTCTGTTTCACAAACTTCTAAGCTCACCCGTGCTGAGACTGTTTTTCCTGATGTGGAC       c.600
 V  S  V  S  Q  T  S  K  L  T  R  A  E  T  V  F  P  D  V  D         p.200

          .         .         .         .         .         .       g.25466
 TATGTAAATTCTACTGAAGCTGAAACCATTTTGGATAACATCACTCAAAGCACCCAATCA       c.660
 Y  V  N  S  T  E  A  E  T  I  L  D  N  I  T  Q  S  T  Q  S         p.220

          .         .         .         .         .         .       g.25526
 TTTAATGACTTCACTCGGGTTGTTGGTGGAGAAGATGCCAAACCAGGTCAATTCCCTTGG       c.720
 F  N  D  F  T  R  V  V  G  G  E  D  A  K  P  G  Q  F  P  W         p.240

     | 07    .         .         .         .         .         .    g.35062
 CAG | GTTGTTTTGAATGGTAAAGTTGATGCATTCTGTGGAGGCTCTATCGTTAATGAAAAA    c.780
 Q   | V  V  L  N  G  K  V  D  A  F  C  G  G  S  I  V  N  E  K      p.260

          .         .         .         .         .         | 08    g.35790
 TGGATTGTAACTGCTGCCCACTGTGTTGAAACTGGTGTTAAAATTACAGTTGTCGCAG | GT    c.840
 W  I  V  T  A  A  H  C  V  E  T  G  V  K  I  T  V  V  A  G |       p.280

          .         .         .         .         .         .       g.35850
 GAACATAATATTGAGGAGACAGAACATACAGAGCAAAAGCGAAATGTGATTCGAATTATT       c.900
 E  H  N  I  E  E  T  E  H  T  E  Q  K  R  N  V  I  R  I  I         p.300

          .         .         .         .         .         .       g.35910
 CCTCACCACAACTACAATGCAGCTATTAATAAGTACAACCATGACATTGCCCTTCTGGAA       c.960
 P  H  H  N  Y  N  A  A  I  N  K  Y  N  H  D  I  A  L  L  E         p.320

          .         .         .         .         .         .       g.35970
 CTGGACGAACCCTTAGTGCTAAACAGCTACGTTACACCTATTTGCATTGCTGACAAGGAA       c.1020
 L  D  E  P  L  V  L  N  S  Y  V  T  P  I  C  I  A  D  K  E         p.340

          .         .         .         .         .         .       g.36030
 TACACGAACATCTTCCTCAAATTTGGATCTGGCTATGTAAGTGGCTGGGGAAGAGTCTTC       c.1080
 Y  T  N  I  F  L  K  F  G  S  G  Y  V  S  G  W  G  R  V  F         p.360

          .         .         .         .         .         .       g.36090
 CACAAAGGGAGATCAGCTTTAGTTCTTCAGTACCTTAGAGTTCCACTTGTTGACCGAGCC       c.1140
 H  K  G  R  S  A  L  V  L  Q  Y  L  R  V  P  L  V  D  R  A         p.380

          .         .         .         .         .         .       g.36150
 ACATGTCTTCGATCTACAAAGTTCACCATCTATAACAACATGTTCTGTGCTGGCTTCCAT       c.1200
 T  C  L  R  S  T  K  F  T  I  Y  N  N  M  F  C  A  G  F  H         p.400

          .         .         .         .         .         .       g.36210
 GAAGGAGGTAGAGATTCATGTCAAGGAGATAGTGGGGGACCCCATGTTACTGAAGTGGAA       c.1260
 E  G  G  R  D  S  C  Q  G  D  S  G  G  P  H  V  T  E  V  E         p.420

          .         .         .         .         .         .       g.36270
 GGGACCAGTTTCTTAACTGGAATTATTAGCTGGGGTGAAGAGTGTGCAATGAAAGGCAAA       c.1320
 G  T  S  F  L  T  G  I  I  S  W  G  E  E  C  A  M  K  G  K         p.440

          .         .         .         .         .         .       g.36330
 TATGGAATATATACCAAGGTATCCCGGTATGTCAACTGGATTAAGGAAAAAACAAAGCTC       c.1380
 Y  G  I  Y  T  K  V  S  R  Y  V  N  W  I  K  E  K  T  K  L         p.460

                                                                    g.36336
 ACTTAA                                                             c.1386
 T  X                                                               p.461

          .         .         .         .         .         .       g.36396
 tgaaagatggatttccaaggttaattcattggaattgaaaattaacagggcctctcacta       c.*60

          .         .         .         .         .         .       g.36456
 actaatcactttcccatcttttgttagatttgaatatatacattctatgatcattgcttt       c.*120

          .         .         .         .         .         .       g.36516
 ttctctttacaggggagaatttcatattttacctgagcaaattgattagaaaatggaacc       c.*180

          .         .         .         .         .         .       g.36576
 actagaggaatataatgtgttaggaaattacagtcatttctaagggcccagcccttgaca       c.*240

          .         .         .         .         .         .       g.36636
 aaattgtgaagttaaattctccactctgtccatcagatactatggttctccactatggca       c.*300

          .         .         .         .         .         .       g.36696
 actaactcactcaattttccctccttagcagcattccatcttcccgatcttctttgcttc       c.*360

          .         .         .         .         .         .       g.36756
 tccaaccaaaacatcaatgtttattagttctgtatacagtacaggatctttggtctactc       c.*420

          .         .         .         .         .         .       g.36816
 tatcacaaggccagtaccacactcatgaagaaagaacacaggagtagctgagaggctaaa       c.*480

          .         .         .         .         .         .       g.36876
 actcatcaaaaacactactccttttcctctaccctattcctcaatcttttaccttttcca       c.*540

          .         .         .         .         .         .       g.36936
 aatcccaatccccaaatcagtttttctctttcttactccctctctcccttttaccctcca       c.*600

          .         .         .         .         .         .       g.36996
 tggtcgttaaaggagagatggggagcatcattctgttatacttctgtacacagttataca       c.*660

          .         .         .         .         .         .       g.37056
 tgtctatcaaacccagacttgcttccgtagtggagacttgcttttcagaacatagggatg       c.*720

          .         .         .         .         .         .       g.37116
 aagtaaggtgcctgaaaagtttgggggaaaagtttctttcagagagttaagttattttat       c.*780

          .         .         .         .         .         .       g.37176
 atatataatatatatataaaatatataatatacaatataaatatatagtgtgtgtgtatg       c.*840

          .         .         .         .         .         .       g.37236
 cgtgtgtgtagacacacacgcatacacacatataatggaagcaataagccattctaagag       c.*900

          .         .         .         .         .         .       g.37296
 cttgtatggttatggaggtctgactaggcatgatttcacgaaggcaagattggcatatca       c.*960

          .         .         .         .         .         .       g.37356
 ttgtaactaaaaaagctgacattgacccagacatattgtactctttctaaaaataataat       c.*1020

          .         .         .         .         .         .       g.37416
 aataatgctaacagaaagaagagaaccgttcgtttgcaatctacagctagtagagacttt       c.*1080

          .         .         .         .         .         .       g.37476
 gaggaagaattcaacagtgtgtcttcagcagtgttcagagccaagcaagaagttgaagtt       c.*1140

          .         .         .         .         .         .       g.37536
 gcctagaccagaggacataagtatcatgtctcctttaactagcataccccgaagtggaga       c.*1200

          .         .         .         .         .         .       g.37596
 agggtgcagcaggctcaaaggcataagtcattccaatcagccaactaagttgtccttttc       c.*1260

          .         .         .         .         .         .       g.37656
 tggtttcgtgttcaccatggaacattttgattatagttaatccttctatcttgaatcttc       c.*1320

          .         .         .         .         .         .       g.37716
 tagagagttgctgaccaactgacgtatgtttccctttgtgaattaataaactggtgttct       c.*1380

                                                                    g.37723
 ggttcat                                                            c.*1387

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Coagulation factor IX protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 10c
©2004-2014 Leiden University Medical Center