fatty acid 2-hydroxylase (FA2H) - coding DNA reference sequence

(used for variant description)

(last modified December 1, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_024306.4 in the FA2H gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_017070.1, covering FA2H transcript NM_024306.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5016
                                             cccgggatgttagagg       c.-61

 .         .         .         .         .         .                g.5076
 cgctcagggtggcagcagagcagacgccgggctgcgcgctgggagctgcggtctccggcc       c.-1

          .         .         .         .         .         .       g.5136
 ATGGCCCCCGCTCCGCCCCCCGCCGCCTCCTTCTCGCCCTCCGAGGTCCAGCGGCGCCTG       c.60
 M  A  P  A  P  P  P  A  A  S  F  S  P  S  E  V  Q  R  R  L         p.20

          .         .         .         .         .         .       g.5196
 GCGGCCGGCGCGTGCTGGGTCCGCCGCGGGGCCCGCCTCTACGACCTCTCCAGCTTCGTG       c.120
 A  A  G  A  C  W  V  R  R  G  A  R  L  Y  D  L  S  S  F  V         p.40

          .         .         .         .         .         .       g.5256
 CGGCACCACCCGGGGGGCGAGCAGCTGCTGCGGGCCAGGGCGGGCCAGGACATCAGCGCC       c.180
 R  H  H  P  G  G  E  Q  L  L  R  A  R  A  G  Q  D  I  S  A         p.60

          .         .         .         .         .         .       g.5316
 GACCTGGACGGGCCGCCGCACAGGCACTCGGCCAACGCGCGCCGCTGGCTGGAGCAGTAC       c.240
 D  L  D  G  P  P  H  R  H  S  A  N  A  R  R  W  L  E  Q  Y         p.80

          .         .         . | 02       .         .         .    g.39746
 TACGTGGGAGAGCTCCGCGGGGAGCAGCAG | GGCTCCATGGAGAACGAGCCTGTAGCCCTT    c.300
 Y  V  G  E  L  R  G  E  Q  Q   | G  S  M  E  N  E  P  V  A  L      p.100

          .         .         .         .         .         .       g.39806
 GAGGAAACTCAGAAGACAGATCCTGCTATGGAACCACGGTTCAAAGTGGTGGATTGGGAC       c.360
 E  E  T  Q  K  T  D  P  A  M  E  P  R  F  K  V  V  D  W  D         p.120

     | 03    .         .         .         .         .         .    g.52502
 AAG | GACCTGGTGGACTGGCGAAAGCCTCTCCTGTGGCAGGTGGGCCACTTGGGAGAGAAG    c.420
 K   | D  L  V  D  W  R  K  P  L  L  W  Q  V  G  H  L  G  E  K      p.140

          .         .         .         .         .         .       g.52562
 TACGATGAGTGGGTTCACCAGCCGGTGACCAGGCCCATCCGCCTCTTCCACTCAGACCTC       c.480
 Y  D  E  W  V  H  Q  P  V  T  R  P  I  R  L  F  H  S  D  L         p.160

          .         .       | 04 .         .         .         .    g.53534
 ATTGAGGGCCTCTCTAAGACTGTCTG | GTACAGTGTCCCCATCATCTGGGTGCCCCTGGTG    c.540
 I  E  G  L  S  K  T  V  W  |  Y  S  V  P  I  I  W  V  P  L  V      p.180

          .         .         .         .         .         .       g.53594
 CTGTATCTCAGCTGGTCCTACTACCGAACCTTTGCCCAGGGCAACGTCCGACTCTTCACG       c.600
 L  Y  L  S  W  S  Y  Y  R  T  F  A  Q  G  N  V  R  L  F  T         p.200

          .    | 05    .         .         .         .         .    g.60718
 TCATTTACAACAG | AGTACACGGTGGCAGTGCCCAAGTCCATGTTCCCCGGGCTCTTCATG    c.660
 S  F  T  T  E |   Y  T  V  A  V  P  K  S  M  F  P  G  L  F  M      p.220

          .         .         .         .         .         .       g.60778
 CTGGGGACATTCCTCTGGAGCCTCATCGAGTACCTCATCCACCGCTTCCTGTTCCACATG       c.720
 L  G  T  F  L  W  S  L  I  E  Y  L  I  H  R  F  L  F  H  M         p.240

          .         .         .         .         .         .       g.60838
 AAGCCCCCCAGCGACAGCTATTACCTCATCATGCTGCACTTCGTCATGCACGGCCAGCAC       c.780
 K  P  P  S  D  S  Y  Y  L  I  M  L  H  F  V  M  H  G  Q  H         p.260

        | 06 .         .         .         .         .         .    g.63286
 CACAAG | GCACCCTTCGACGGCTCCCGCCTGGTCTTCCCCCCTGTGCCAGCCTCCCTGGTG    c.840
 H  K   | A  P  F  D  G  S  R  L  V  F  P  P  V  P  A  S  L  V      p.280

          .         .         .         .         .         .       g.63346
 ATCGGCGTCTTCTACTTGTGCATGCAGCTCATCCTGCCCGAGGCAGTAGGGGGCACTGTG       c.900
 I  G  V  F  Y  L  C  M  Q  L  I  L  P  E  A  V  G  G  T  V         p.300

          .         .         .         .         .         .       g.63406
 TTTGCGGGGGGCCTCCTGGGCTACGTCCTCTATGACATGACCCATTACTACCTGCACTTT       c.960
 F  A  G  G  L  L  G  Y  V  L  Y  D  M  T  H  Y  Y  L  H  F         p.320

          .         .         .         .         .         .       g.63466
 GGCTCGCCGCACAAGGGCTCCTACCTGTACAGCCTGAAGGCCCACCACGTCAAGCACCAC       c.1020
 G  S  P  H  K  G  S  Y  L  Y  S  L  K  A  H  H  V  K  H  H         p.340

          .          | 07        .         .         .         .    g.65603
 TTTGCACATCAGAAGTCAG | GATTTGGTATCAGCACTAAATTGTGGGATTACTGTTTCCAC    c.1080
 F  A  H  Q  K  S  G |   F  G  I  S  T  K  L  W  D  Y  C  F  H      p.360

          .         .         .                                     g.65642
 ACCCTCACTCCAGAGAAACCCCACCTGAAGACGCAGTGA                            c.1119
 T  L  T  P  E  K  P  H  L  K  T  Q  X                              p.372

          .         .         .         .         .         .       g.65702
 caactcccaccccctccgtcctgccctcagcccggccctggccccttcccgacccccacc       c.*60

          .         .         .         .         .         .       g.65762
 cgccattcagaccccattaagaaggttggcttggccaggcaggatgggctgtgtccggcc       c.*120

          .         .         .         .         .         .       g.65822
 ctgcagcctagtggaaggtgctgagggggccctgaggcaggaccgccctcctgacccctg       c.*180

          .         .         .         .         .         .       g.65882
 gtaggagggtcacatccacttggtggccaggtggcccttggtgacccacttcttcctgga       c.*240

          .         .         .         .         .         .       g.65942
 gcgtccctgcctagagctcagcccacaggactgcttcaggccgtggccacaggtagcagc       c.*300

          .         .         .         .         .         .       g.66002
 cgcaaggggaaatgaagaaaactgagccctcgtggccacctgtgtcacccttgtgcctta       c.*360

          .         .         .         .         .         .       g.66062
 gcctcatgggctgcctaggagctgcctgcacggcacagctcgctttcacagtcagaagtg       c.*420

          .         .         .         .         .         .       g.66122
 ggtctgtgggatctgtggtccctgtcctccctgctgtcccttctggggaggctttggtgg       c.*480

          .         .         .         .         .         .       g.66182
 ctctgaggtggacaaagagctctcgcaagaagagacagcgtgatgcctcccacagtccac       c.*540

          .         .         .         .         .         .       g.66242
 cccagaccctggggcagcccctctggccctgccagctgcctgcgtcgttgggcccagggt       c.*600

          .         .         .         .         .         .       g.66302
 ggctggcaggagtcccagctgcttgctttaggacctggcagcttttcttgccgtccctcc       c.*660

          .         .         .         .         .         .       g.66362
 cctgcctccagaatcacagcccttctccccaagggaggctgaggaggcttctccaccagt       c.*720

          .         .         .         .         .         .       g.66422
 ggcagccccaccccgtccctggccattcttggcctccaccccgctcaggcccctactcgg       c.*780

          .         .         .         .         .         .       g.66482
 gcgctcccagaaggagccacctctcagtgcctcacctccccctgcctcccagcctccgca       c.*840

          .         .         .         .         .         .       g.66542
 gatgaggttcctgccccttcctcctcgtaaccaaaaccctcactgctcccaggacggtct       c.*900

          .         .         .         .         .         .       g.66602
 tatttataaaccagatacatgttcttagtctggtcccagaccaaggagctggtcagacgg       c.*960

          .         .         .         .         .         .       g.66662
 ccctttctaatcctacatgttgagcttatgtaaaaaatgttgtttcctcctgtttttggt       c.*1020

          .         .         .         .         .         .       g.66722
 tcctttcttacccacaaaccattactacttgaaacttaaaaaactcgccaagtgtaaagg       c.*1080

          .         .         .         .         .         .       g.66782
 ctaaagagaagcagtttgacggaccttgtgatttgtactgtttgctgcggagctatttaa       c.*1140

          .         .         .         .         .         .       g.66842
 agattttggaataaatatacaaaactacggttgtgaaataaaaacttaaattgtatattt       c.*1200

          .         .         .                                     g.66877
 tgaaaaataaaacactgaaaagaaaccaacaaaaa                                c.*1235

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Fatty acid 2-hydroxylase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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