family with sequence similarity 111, member B (FAM111B) - coding DNA reference sequence

(used for variant description)

(last modified January 23, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_198947.3 in the FAM111B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000011.9, covering FAM111B transcript NM_198947.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5003
                                                          gcg       c.-241

 .         .         .         .         .         .                g.5063
 ggaaaagttcagctgagagatataaaagagcagtctttccagcacctgcaaatccagagc       c.-181

 .         .         .         .         .         | 02             g.6494
 ggcgggcactgacgggcacttgcaccgtgtggacagactctccggttct | ggggaaatcca    c.-121

 .         .         .         .    | 03    .         .             g.7381
 gtccctgttactccattttggccagaaattcaag | acatttcaggtggcagaataaattca    c.-61

 .         .         .         .         .         .                g.7441
 atccttgtttctccatcttatcgagtagtagaagttagttacattctctttgaactcatc       c.-1

          .         .         .         .         .         .       g.7501
 ATGAATTCCATGAAGACTGAAGAAAACAAGTCATTTAGCGCTATGGAAGATGACCAGAGG       c.60
 M  N  S  M  K  T  E  E  N  K  S  F  S  A  M  E  D  D  Q  R         p.20

          .         .  | 04      .         .         .         .    g.22033
 ACTAGACCTGAAGTTTCAAAG | GATACTGTCATGAAGCAGACACATGCTGACACACCTGTT    c.120
 T  R  P  E  V  S  K   | D  T  V  M  K  Q  T  H  A  D  T  P  V      p.40

          .         .         .         .         .         .       g.22093
 GATCATTGTCTATCTGGCATAAGAAAGTGTAGCAGCACCTTTAAGCTTAAAAGTGAAGTC       c.180
 D  H  C  L  S  G  I  R  K  C  S  S  T  F  K  L  K  S  E  V         p.60

          .         .         .         .         .         .       g.22153
 AACAAGCATGAAACAGCCCTTGAAATGCAGAATCCAAATTTGAACAATAAAGAATGTTGT       c.240
 N  K  H  E  T  A  L  E  M  Q  N  P  N  L  N  N  K  E  C  C         p.80

          .         .         .         .         .         .       g.22213
 TTCACCTTTACGTTGAATGGAAACTCCAGAAAATTAGACCGTAGTGTGTTTACAGCATAT       c.300
 F  T  F  T  L  N  G  N  S  R  K  L  D  R  S  V  F  T  A  Y         p.100

          .         .         .         .         .         .       g.22273
 GGTAAACCCAGCGAGAGTATCTACTCAGCCCTGAGTGCTAATGACTATTTCAGTGAAAGG       c.360
 G  K  P  S  E  S  I  Y  S  A  L  S  A  N  D  Y  F  S  E  R         p.120

          .         .         .         .         .         .       g.22333
 ATAAAGAATCAGTTTAATAAGAACATTATTGTTTATGAAGAAAAGACAATAGATGGACAT       c.420
 I  K  N  Q  F  N  K  N  I  I  V  Y  E  E  K  T  I  D  G  H         p.140

          .         .         .         .         .         .       g.22393
 ATAAATTTAGGAATGCCTCTCAAGTGCCTGCCTAGTGATTCTCATTTTAAAATTACATTT       c.480
 I  N  L  G  M  P  L  K  C  L  P  S  D  S  H  F  K  I  T  F         p.160

          .         .         .         .         .         .       g.22453
 GGTCAAAGAAAGAGTAGCAAAGAAGATGGACACATATTACGCCAATGTGAAAATCCAAAC       c.540
 G  Q  R  K  S  S  K  E  D  G  H  I  L  R  Q  C  E  N  P  N         p.180

          .         .         .         .         .         .       g.22513
 ATGGAATGCATTCTTTTTCATGTTGTTGCTATAGGAAGGACAAGAAAGAAGATTGTTAAG       c.600
 M  E  C  I  L  F  H  V  V  A  I  G  R  T  R  K  K  I  V  K         p.200

          .         .         .         .         .         .       g.22573
 ATCAACGAACTTCATGAAAAAGGAAGTAAACTTTGTATTTATGCCTTGAAGGGTGAGACT       c.660
 I  N  E  L  H  E  K  G  S  K  L  C  I  Y  A  L  K  G  E  T         p.220

          .         .         .         .         .         .       g.22633
 ATTGAAGGAGCCTTATGCAAGGATGGCCGTTTTCGGTCTGACATAGGTGAATTTGAATGG       c.720
 I  E  G  A  L  C  K  D  G  R  F  R  S  D  I  G  E  F  E  W         p.240

          .         .         .         .         .         .       g.22693
 AAACTAAAGGAAGGTCATAAGAAAATTTATGGAAAACAGTCCATGGTGGATGAAGTATCT       c.780
 K  L  K  E  G  H  K  K  I  Y  G  K  Q  S  M  V  D  E  V  S         p.260

          .         .         .         .         .         .       g.22753
 GGAAAAGTCTTAGAAATGGACATTTCAAAAAAAAAAGCATTACAACAGAAAGATATCCAT       c.840
 G  K  V  L  E  M  D  I  S  K  K  K  A  L  Q  Q  K  D  I  H         p.280

          .         .         .         .         .         .       g.22813
 AAAAAAATTAAACAGAATGAAAGTGCCACTGATGAAATTAATCACCAGAGTCTGATACAG       c.900
 K  K  I  K  Q  N  E  S  A  T  D  E  I  N  H  Q  S  L  I  Q         p.300

          .         .         .         .         .         .       g.22873
 TCTAAGAAAAAAGTCCACAAACCAAAGAAAGATGGAGAGACCAAAGATGTAGAACACAGC       c.960
 S  K  K  K  V  H  K  P  K  K  D  G  E  T  K  D  V  E  H  S         p.320

          .         .         .         .         .         .       g.22933
 AGAGAGCAAATTCTCCCACCTCAGGATCTAAGCCATTATATTAAAGATAAAACTCGCCAG       c.1020
 R  E  Q  I  L  P  P  Q  D  L  S  H  Y  I  K  D  K  T  R  Q         p.340

          .         .         .         .         .         .       g.22993
 ACAATTCCCAGGATTAGAAATTATTACTTTTGTAGTTTGCCCCGAAAATATAGGCAAATA       c.1080
 T  I  P  R  I  R  N  Y  Y  F  C  S  L  P  R  K  Y  R  Q  I         p.360

          .         .         .         .         .         .       g.23053
 AACTCACAAGTTAGACGGAGGCCGCATCTGGGTAGGCGGTATGCTATTAATCTGGATGTC       c.1140
 N  S  Q  V  R  R  R  P  H  L  G  R  R  Y  A  I  N  L  D  V         p.380

          .         .         .         .         .         .       g.23113
 CAAAAGGAGGCAATTAATCTCTTAAAGAATTATCAAACGTTGAATGAAGCCATAATGCAT       c.1200
 Q  K  E  A  I  N  L  L  K  N  Y  Q  T  L  N  E  A  I  M  H         p.400

          .         .         .         .         .         .       g.23173
 CAGTATCCGAATTTTAAAGAGGAGGCACAGTGGGTAAGAAAATATTTTCGGGAAGAACAA       c.1260
 Q  Y  P  N  F  K  E  E  A  Q  W  V  R  K  Y  F  R  E  E  Q         p.420

          .         .         .         .         .         .       g.23233
 AAGAGAATGAATCTTTCACCAGCTAAGCAATTCAACATATATAAAAAGGACTTCGGAAAA       c.1320
 K  R  M  N  L  S  P  A  K  Q  F  N  I  Y  K  K  D  F  G  K         p.440

          .         .         .         .         .         .       g.23293
 ATGACTGCAAATTCTGTTTCAGTTGCAACCTGCGAACAGCTTACATATTATAGCAAGTCA       c.1380
 M  T  A  N  S  V  S  V  A  T  C  E  Q  L  T  Y  Y  S  K  S         p.460

          .         .         .         .         .         .       g.23353
 GTTGGGTTCATGCAATGGGACAATAATGGAAACACAGGTAATGCTACTTGCTTTGTCTTC       c.1440
 V  G  F  M  Q  W  D  N  N  G  N  T  G  N  A  T  C  F  V  F         p.480

          .         .         .         .         .         .       g.23413
 AATGGTGGTTATATTTTCACCTGTCGACATGTTGTACATCTTATGGTGGGTAAAAACACA       c.1500
 N  G  G  Y  I  F  T  C  R  H  V  V  H  L  M  V  G  K  N  T         p.500

          .         .         .         .         .         .       g.23473
 CATCCAAGTTTGTGGCCAGATATAATTAGCAAATGTGCGAAGGTAACCTTCACTTATACA       c.1560
 H  P  S  L  W  P  D  I  I  S  K  C  A  K  V  T  F  T  Y  T         p.520

          .         .         .         .         .         .       g.23533
 GAGTTCTGCCCTACTCCTGACAATTGGTTTTCCATTGAGCCATGGCTTAAAGTGTCCAAT       c.1620
 E  F  C  P  T  P  D  N  W  F  S  I  E  P  W  L  K  V  S  N         p.540

          .         .         .         .         .         .       g.23593
 GAAAATCTAGATTATGCCATTTTAAAACTAAAAGAAAATGGAAATGCGTTTCCTCCAGGA       c.1680
 E  N  L  D  Y  A  I  L  K  L  K  E  N  G  N  A  F  P  P  G         p.560

          .         .         .         .         .         .       g.23653
 CTATGGCGACAGATTTCTCCTCAACCATCTACTGGTTTGATTTATTTAATTGGTCATCCT       c.1740
 L  W  R  Q  I  S  P  Q  P  S  T  G  L  I  Y  L  I  G  H  P         p.580

          .         .         .         .         .         .       g.23713
 GAAGGCCAGATCAAGAAAATAGATGGTTGTACTGTGATTCCTCTAAACGAACGATTGAAA       c.1800
 E  G  Q  I  K  K  I  D  G  C  T  V  I  P  L  N  E  R  L  K         p.600

          .         .         .         .         .         .       g.23773
 AAATATCCAAACGATTGTCAAGATGGGTTGGTAGATCTCTATGATACCACCAGTAATGTA       c.1860
 K  Y  P  N  D  C  Q  D  G  L  V  D  L  Y  D  T  T  S  N  V         p.620

          .         .         .         .         .         .       g.23833
 TACTGTATGTTTACCCAAAGAAGTTTCCTATCAGAGGTTTGGAACACACACACGCTTAGT       c.1920
 Y  C  M  F  T  Q  R  S  F  L  S  E  V  W  N  T  H  T  L  S         p.640

          .         .         .         .         .         .       g.23893
 TATGATACTTGTTTCTCTGATGGGTCCTCAGGCTCCCCAGTGTTTAATGCATCTGGCAAA       c.1980
 Y  D  T  C  F  S  D  G  S  S  G  S  P  V  F  N  A  S  G  K         p.660

          .         .         .         .         .         .       g.23953
 TTGGTTGCTTTGCATACCTTTGGGCTTTTTTATCAACGAGGATTTAATGTGCATGCCCTT       c.2040
 L  V  A  L  H  T  F  G  L  F  Y  Q  R  G  F  N  V  H  A  L         p.680

          .         .         .         .         .         .       g.24013
 ATTGAATTTGGTTATTCTATGGATTCTATTCTTTGTGATATTAAAAAGACAAATGAGAGC       c.2100
 I  E  F  G  Y  S  M  D  S  I  L  C  D  I  K  K  T  N  E  S         p.700

          .         .         .         .         .         .       g.24073
 TTGTATAAATCATTAAATGATGAGAAACTTGAGACCTACGATGAAGAGAAAGGTAAACAA       c.2160
 L  Y  K  S  L  N  D  E  K  L  E  T  Y  D  E  E  K  G  K  Q         p.720

          .         .         .         .                           g.24118
 GAGTCATCACTTCAAGATCATCAGATTGAACCCATGGAATGTTAG                      c.2205
 E  S  S  L  Q  D  H  Q  I  E  P  M  E  C  X                        p.734

          .         .         .         .         .         .       g.24178
 aaaagagatgctgtcttcaagaaaatatgccaataattcctggcaaagatttcatgacaa       c.*60

          .         .         .         .         .         .       g.24238
 agacacttaaagcaattgcaacaaaagtgaaaattggcaaatgagacctaattaaatctt       c.*120

          .         .         .         .         .         .       g.24298
 ctgcacagcaaaagaaactatcaacagggtaaacacacaacctacggaatgggagaaaat       c.*180

          .         .         .         .         .         .       g.24358
 atttgcaaactatgcatacagcaaagatctaatattcagaatccattaggaacttaaaca       c.*240

          .         .         .         .         .         .       g.24418
 gattaacaagcaaaaaaaacaagcaaccccattaaaaagtgggcaaaggacatgaacaaa       c.*300

          .         .         .         .         .         .       g.24478
 cacttttcaaaagaagatatacacatggccaacaaggatatgaaaaaatacctgatatca       c.*360

          .         .         .         .         .         .       g.24538
 ctaatcattagagaaatgcaaatcaaaaaaatgccatcacactaatcagaatggctgtta       c.*420

          .         .         .         .         .         .       g.24598
 ttaaaatgccaaaaaattacagatgctggcgaggttgcagagaaaggggaatgcttatac       c.*480

          .         .         .         .         .         .       g.24658
 actgctagtgggaaaataaattagttcagccattgtggaaagcagttgggtgatttctaa       c.*540

          .         .         .         .         .         .       g.24718
 aagaacttaaaacagctaccattcaagccagcaatctcatgactgggtatatgtccaaag       c.*600

          .         .         .         .         .         .       g.24778
 gaatataaattgttctaccataaagacatgcacatatatgttcactgcagcactattcac       c.*660

          .         .         .         .         .         .       g.24838
 aatagcaaaacatgaaatcaacctaaatgcccatcaatggtagactggataaagaaaatg       c.*720

          .         .         .         .         .         .       g.24898
 tgacacatatacaccatagcatactacacagccataaaaaagtacaagatcatgtgcttt       c.*780

          .         .         .         .         .         .       g.24958
 gcagcaacatggatggaactgaaggtcattatcctaagcgaactaatgcaggaacagaaa       c.*840

          .         .         .         .         .         .       g.25018
 gccaagtaccacatgttctctcataagtggaagctaaatattgagtacacatggacacaa       c.*900

          .         .         .         .         .         .       g.25078
 agaagaaaacaacagatatggggcctacttgagggtggagggtgggaggagggtgaagac       c.*960

          .         .         .         .         .         .       g.25138
 tgaaaaactgcctatggggtactatgcttattacctgggtgatgaaataatctgaacaca       c.*1020

          .         .         .         .         .         .       g.25198
 aaaccctggtgacatgcagtttacctatataacaaaactgcacatggactcttaaaccta       c.*1080

          .         .         .                                     g.25231
 aataaaagtttaaaatatatataatgccaataa                                  c.*1113

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Family with sequence similarity 111, member B protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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