family with sequence similarity 20, member C (FAM20C) - coding DNA reference sequence

(used for variant description)

(last modified September 11, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_020223.3 in the FAM20C gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_033970.1, covering FAM20C transcript NM_020223.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5051
          gcggccgctccggagaggccgagcggggacgggcccgagatggcgcgggga       c.-181

 .         .         .         .         .         .                g.5111
 cccagcgctccggcggcgggcgccctgcacgcggcccgggcccggggacagccccggagc       c.-121

 .         .         .         .         .         .                g.5171
 tggtagccgcccggcaccgatggaccttgacccgcgaggcggcgccgcgctcgtgcccag       c.-61

 .         .         .         .         .         .                g.5231
 ctgcagctagaggggcgcgcgggcagaacgcgctccaggcccgggccggcccgcgcggcc       c.-1

          .         .         .         .         .         .       g.5291
 ATGAAGATGATGCTGGTGCGCCGGTTCCGCGTGCTCATCCTGATGGTGTTCCTGGTGGCC       c.60
 M  K  M  M  L  V  R  R  F  R  V  L  I  L  M  V  F  L  V  A         p.20

          .         .         .         .         .         .       g.5351
 TGCGCGCTGCACATCGCCCTGGACCTGCTGCCCAGGCTGGAGCGACGCGGCGCGCGGCCC       c.120
 C  A  L  H  I  A  L  D  L  L  P  R  L  E  R  R  G  A  R  P         p.40

          .         .         .         .         .         .       g.5411
 TCGGGGGAGCCCGGCTGTTCGTGCGCGCAGCCCGCCGCCGAGGTGGCCGCGCCCGGCTGG       c.180
 S  G  E  P  G  C  S  C  A  Q  P  A  A  E  V  A  A  P  G  W         p.60

          .         .         .         .         .         .       g.5471
 GCCCAGGTTCGGGGCCGCCCCGGGGAGCCCCCGGCCGCCTCCTCCGCCGCCGGCGACGCG       c.240
 A  Q  V  R  G  R  P  G  E  P  P  A  A  S  S  A  A  G  D  A         p.80

          .         .         .         .         .         .       g.5531
 GGCTGGCCCAACAAGCACACGCTCCGCATCCTGCAGGACTTCAGCTCCGACCCCTCCTCC       c.300
 G  W  P  N  K  H  T  L  R  I  L  Q  D  F  S  S  D  P  S  S         p.100

          .         .         .         .         .         .       g.5591
 AACCTCTCGTCCCACTCGCTGGAGAAACTGCCGCCCGCGGCCGAGCCGGCCGAGCGCGCC       c.360
 N  L  S  S  H  S  L  E  K  L  P  P  A  A  E  P  A  E  R  A         p.120

          .         .         .         .         .         .       g.5651
 TTGCGGGGGCGGGATCCCGGCGCCCTAAGACCCCACGACCCCGCGCACCGGCCGCTGCTG       c.420
 L  R  G  R  D  P  G  A  L  R  P  H  D  P  A  H  R  P  L  L         p.140

          .         .         .         .         .         .       g.5711
 CGAGACCCCGGCCCGCGTCGGTCCGAGTCGCCCCCCGGCCCCGGCGGAGACGCCTCCCTC       c.480
 R  D  P  G  P  R  R  S  E  S  P  P  G  P  G  G  D  A  S  L         p.160

          .         .         .         .         .         .       g.5771
 CTGGCCAGGCTGTTCGAGCACCCGCTTTACCGGGTGGCGGTTCCGCCGCTCACGGAGGAG       c.540
 L  A  R  L  F  E  H  P  L  Y  R  V  A  V  P  P  L  T  E  E         p.180

          .         .         .         .         .         .       g.5831
 GACGTCCTGTTCAATGTGAACAGCGACACCAGGCTCAGCCCCAAAGCGGCGGAGAACCCG       c.600
 D  V  L  F  N  V  N  S  D  T  R  L  S  P  K  A  A  E  N  P         p.200

       | 02  .         .         .         .         .         .    g.7640
 GACTG | GCCGCATGCGGGTGCTGAAGGTGCAGAATTCCTCTCCCCCGGGGAGGCGGCCGTG    c.660
 D  W  |  P  H  A  G  A  E  G  A  E  F  L  S  P  G  E  A  A  V      p.220

          .         .         .         .         .         .       g.7700
 GACTCCTATCCCAACTGGCTCAAGTTCCACATTGGTATCAACCGGTACGAGCTGTACTCC       c.720
 D  S  Y  P  N  W  L  K  F  H  I  G  I  N  R  Y  E  L  Y  S         p.240

          .         .         .         .         .         .       g.7760
 AGACACAACCCGGCCATCGAGGCCCTGCTGCACGACCTCAGCTCCCAGAGGATCACCAGC       c.780
 R  H  N  P  A  I  E  A  L  L  H  D  L  S  S  Q  R  I  T  S         p.260

      | 03   .         .         .         .         .         .    g.20985
 GTGG | CCATGAAGTCGGGGGGCACGCAGCTGAAGCTCATCATGACCTTCCAGAATTACGGG    c.840
 V  A |   M  K  S  G  G  T  Q  L  K  L  I  M  T  F  Q  N  Y  G      p.280

          .         .    | 04    .         .         .         .    g.56087
 CAAGCGCTGTTCAAACCCATGAA | ACAAACGAGGGAGCAGGAGACACCCCCTGACTTTTTT    c.900
 Q  A  L  F  K  P  M  K  |  Q  T  R  E  Q  E  T  P  P  D  F  F      p.300

          .         .         .         .         .       | 05 .    g.57954
 TATTTCTCTGACTACGAGAGGCACAATGCGGAGATTGCTGCCTTCCACCTGGACAG | GATC    c.960
 Y  F  S  D  Y  E  R  H  N  A  E  I  A  A  F  H  L  D  R  |  I      p.320

          .         .         .         .         .         .       g.58014
 CTGGACTTCCGCCGGGTCCCTCCCGTGGCCGGCAGGATGGTCAACATGACCAAGGAGATC       c.1020
 L  D  F  R  R  V  P  P  V  A  G  R  M  V  N  M  T  K  E  I         p.340

          .         .         .         .         .   | 06     .    g.65492
 CGGGACGTCACACGGGACAAGAAGCTCTGGAGGACCTTCTTCATCTCTCCAG | CCAACAAC    c.1080
 R  D  V  T  R  D  K  K  L  W  R  T  F  F  I  S  P  A |   N  N      p.360

          .         .         .         .         .         .       g.65552
 ATCTGCTTCTACGGCGAGTGTTCCTACTACTGCTCCACGGAGCACGCCCTGTGCGGGAAG       c.1140
 I  C  F  Y  G  E  C  S  Y  Y  C  S  T  E  H  A  L  C  G  K         p.380

          .         .         .         .         .         .       g.65612
 CCAGACCAGATCGAGGGCTCGCTGGCGGCCTTCCTGCCCGACCTGTCCCTGGCCAAGAGG       c.1200
 P  D  Q  I  E  G  S  L  A  A  F  L  P  D  L  S  L  A  K  R         p.400

          .         .         .         .         .    | 07    .    g.66296
 AAGACCTGGCGGAACCCTTGGCGGCGTTCCTACCACAAGCGCAAGAAGGCCGA | GTGGGAG    c.1260
 K  T  W  R  N  P  W  R  R  S  Y  H  K  R  K  K  A  E  |  W  E      p.420

          .         .         .         .         .         .       g.66356
 GTGGACCCTGACTACTGCGAGGAGGTGAAGCAGACACCGCCCTACGACAGCAGCCACCGC       c.1320
 V  D  P  D  Y  C  E  E  V  K  Q  T  P  P  Y  D  S  S  H  R         p.440

          .         .         .         .    | 08    .         .    g.66657
 ATCCTGGACGTCATGGACATGACGATCTTCGACTTCCTCATGG | GAAACATGGACCGTCAC    c.1380
 I  L  D  V  M  D  M  T  I  F  D  F  L  M  G |   N  M  D  R  H      p.460

          .         .         .         .         .         .       g.66717
 CACTACGAGACTTTTGAGAAGTTTGGGAATGAAACGTTCATCATCCACTTAGACAATGGA       c.1440
 H  Y  E  T  F  E  K  F  G  N  E  T  F  I  I  H  L  D  N  G         p.480

       | 09  .         .         .         .         .         .    g.68336
 AGAGG | GTTTGGGAAGTATTCGCACGACGAGCTCTCCATCCTGGTGCCGCTACAGCAGTGC    c.1500
 R  G  |  F  G  K  Y  S  H  D  E  L  S  I  L  V  P  L  Q  Q  C      p.500

       | 10  .         .         .         .         .         .    g.69421
 TGCAG | GATCCGGAAGTCCACCTACCTGCGTCTGCAGCTCCTGGCCAAGGAGGAGTACAAG    c.1560
 C  R  |  I  R  K  S  T  Y  L  R  L  Q  L  L  A  K  E  E  Y  K      p.520

          .         .         .         .         .         .       g.69481
 CTGAGCCTGCTGATGGCCGAGTCTCTGCGGGGGGACCAGGTGGCACCCGTGCTGTACCAG       c.1620
 L  S  L  L  M  A  E  S  L  R  G  D  Q  V  A  P  V  L  Y  Q         p.540

          .         .         .         .         .         .       g.69541
 CCGCACCTGGAGGCCCTGGACCGGCGGCTCCGCGTCGTGCTAAAGGCCGTCCGGGACTGC       c.1680
 P  H  L  E  A  L  D  R  R  L  R  V  V  L  K  A  V  R  D  C         p.560

          .         .         .         .         .         .       g.69601
 GTGGAGAGGAACGGGCTCCACAGCGTGGTGGATGACGACCTGGACACTGAGCACAGAGCC       c.1740
 V  E  R  N  G  L  H  S  V  V  D  D  D  L  D  T  E  H  R  A         p.580

          .                                                         g.69616
 GCCTCGGCGAGGTAG                                                    c.1755
 A  S  A  R  X                                                      p.584

          .         .         .         .         .         .       g.69676
 tgtccgccggccgctgcgctgcccgggacggagacagaggcgccggacctcccagcaagc       c.*60

          .         .         .         .         .         .       g.69736
 gcatgcgcccgtcgtgaattcagtgaattcagaggcaggacgggatcatccggagtcggg       c.*120

          .         .         .         .         .         .       g.69796
 agctgctgccacaggaggcgaggctccccaggtctcataggacacattttgtcagtgttt       c.*180

          .         .         .         .         .         .       g.69856
 gaccagaaaagcttgggaaggaagcgctgtctgtgctcacggacagaggcggccggcgcc       c.*240

          .         .         .         .         .         .       g.69916
 ggaggcattccatcctttctgtagggaaaggagcctttatttactattttgtatttatat       c.*300

          .         .         .         .         .         .       g.69976
 ttgatgaataagtatataaacagagacgtgtacacagatgccaatcacctaccaaaccaa       c.*360

          .         .         .         .         .         .       g.70036
 acacgaggaccgccctccctggttctgggggcccctcaaggccaagctcacccctcaagt       c.*420

          .         .         .         .         .         .       g.70096
 gctctcacactcgggacctaattcaagtaaaaaccctttctccttcctggggcctcggct       c.*480

          .         .         .         .         .         .       g.70156
 cctggagggctggagggtctcgtctgaggacgggaggaggctctcgctggacgtctggcc       c.*540

          .         .         .         .         .         .       g.70216
 tgtgcgctggtggacggatgcctacgtggttttggaggacccgatgaccaggcgtcctgc       c.*600

          .         .         .         .         .         .       g.70276
 gagtccgcccgctggcctgcagcacccacctcggacttggctgtggacggttggtgcaag       c.*660

          .         .         .         .         .         .       g.70336
 tgcatcctgcagggctggctgtgcgcagctgtgggctgacctttgcagagttttgtggaa       c.*720

          .         .         .         .         .         .       g.70396
 tagtttgcaatgtcataaaagtgcaataaaggtacagcagatgtgtgtcggcctcacggg       c.*780

          .                                                         g.70410
 gcgggtccctcaca                                                     c.*794

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Family with sequence similarity 20, member C protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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