Fanconi anemia, complementation group C (FANCC) - coding DNA reference sequence

(used for variant description)

(last modified October 6, 2014)


This file was created to facilitate the description of sequence variants in the FANCE gene based on a coding DNA reference sequence following the HGVS recommendations. The sequence was taken from NG_011707.1 (identical to LRG_497), covering FANCE transcript NM_000136.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5022
                                       agaatgcactgctgacacgtgt       c.-241

 .         .         .         .         .         .                g.5082
 gcgcgcgcgcggctccactgccgggcgaccgcgggaaaattccaaaaaaactcaaaaagc       c.-181

 .         .         .         .         .         .                g.5142
 caatacgaggcaaagccaaattttcaagccacagatcccgggcggtggcttcctttccgc       c.-121

 .         .         .         .         .  | 02      .             g.73358
 cactgcccaaactgctgaagcagctcccgcgaggaccacccg | atttaatgtgtgccgacc    c.-61

 .         .         .         .         .         .                g.73418
 atttccttcagtgctggacaggctgctgtgaagggacatcaccttttcgctttttccaag       c.-1

          .         .         .         .         .         .       g.73478
 ATGGCTCAAGATTCAGTAGATCTTTCTTGTGATTATCAGTTTTGGATGCAGAAGCTTTCT       c.60
 M  A  Q  D  S  V  D  L  S  C  D  Y  Q  F  W  M  Q  K  L  S         p.20

          .         .         .         .         .         .       g.73538
 GTATGGGATCAGGCTTCCACTTTGGAAACCCAGCAAGACACCTGTCTTCACGTGGCTCAG       c.120
 V  W  D  Q  A  S  T  L  E  T  Q  Q  D  T  C  L  H  V  A  Q         p.40

          .         .         .         .      | 03  .         .    g.75208
 TTCCAGGAGTTCCTAAGGAAGATGTATGAAGCCTTGAAAGAGATG | GATTCTAATACAGTC    c.180
 F  Q  E  F  L  R  K  M  Y  E  A  L  K  E  M   | D  S  N  T  V      p.60

          .         .         .         .         .         .       g.75268
 ATTGAAAGATTCCCCACAATTGGTCAACTGTTGGCAAAAGCTTGTTGGAATCCTTTTATT       c.240
 I  E  R  F  P  T  I  G  Q  L  L  A  K  A  C  W  N  P  F  I         p.80

          . | 04       .         .         .         .         .    g.82016
 TTAGCATATG | ATGAAAGCCAAAAAATTCTAATATGGTGCTTATGTTGTCTAATTAACAAA    c.300
 L  A  Y  D |   E  S  Q  K  I  L  I  W  C  L  C  C  L  I  N  K      p.100

          .         .         .         .      | 05  .         .    g.150577
 GAACCACAGAATTCTGGACAATCAAAACTTAACTCCTGGATACAG | GGTGTATTATCTCAT    c.360
 E  P  Q  N  S  G  Q  S  K  L  N  S  W  I  Q   | G  V  L  S  H      p.120

          .         .         .         .         .         .       g.150637
 ATACTTTCAGCACTCAGATTTGATAAAGAAGTTGCTCTTTTCACTCAAGGTCTTGGGTAT       c.420
 I  L  S  A  L  R  F  D  K  E  V  A  L  F  T  Q  G  L  G  Y         p.140

          .         .         .       | 06 .         .         .    g.151590
 GCACCTATAGATTACTATCCTGGTTTGCTTAAAAAT | ATGGTTTTATCATTAGCGTCTGAA    c.480
 A  P  I  D  Y  Y  P  G  L  L  K  N   | M  V  L  S  L  A  S  E      p.160

          .         .         .         .  | 07      .         .    g.172641
 CTCAGAGAGAATCATCTTAATGGATTTAACACTCAAAGGCG | AATGGCTCCCGAGCGAGTG    c.540
 L  R  E  N  H  L  N  G  F  N  T  Q  R  R  |  M  A  P  E  R  V      p.180

          .         .         .         .         .         .       g.172701
 GCGTCCCTGTCACGAGTTTGTGTCCCACTTATTACCCTGACAGATGTTGACCCCCTGGTG       c.600
 A  S  L  S  R  V  C  V  P  L  I  T  L  T  D  V  D  P  L  V         p.200

          .         .         .         .         .         .       g.172761
 GAGGCTCTCCTCATCTGTCATGGACGTGAACCTCAGGAAATCCTCCAGCCAGAGTTCTTT       c.660
 E  A  L  L  I  C  H  G  R  E  P  Q  E  I  L  Q  P  E  F  F         p.220

          .         .       | 08 .         .         .         .    g.187241
 GAGGCTGTAAACGAGGCCATTTTGCT | GAAGAAGATTTCTCTCCCCATGTCAGCTGTAGTC    c.720
 E  A  V  N  E  A  I  L  L  |  K  K  I  S  L  P  M  S  A  V  V      p.240

          .         .         .         .         .         .       g.187301
 TGCCTCTGGCTTCGGCACCTTCCCAGCCTTGAAAAAGCAATGCTGCATCTTTTTGAAAAG       c.780
 C  L  W  L  R  H  L  P  S  L  E  K  A  M  L  H  L  F  E  K         p.260

          .         .         .         .         .         .       g.187361
 CTAATCTCCAGTGAGAGAAATTGTCTGAGAAGGATCGAATGCTTTATAAAAGATTCATCG       c.840
 L  I  S  S  E  R  N  C  L  R  R  I  E  C  F  I  K  D  S  S         p.280

     | 09    .         .         .         .         .       | 10 . g.197528
 CTG | CCTCAAGCAGCCTGCCACCCTGCCATATTCCGGGTTGTTGATGAGATGTTCAG | GTGT c.900
 L   | P  Q  A  A  C  H  P  A  I  F  R  V  V  D  E  M  F  R  |  C   p.300

          .         .         .         .         .         .       g.197588
 GCACTCCTGGAAACCGATGGGGCCCTGGAAATCATAGCCACTATTCAGGTGTTTACGCAG       c.960
 A  L  L  E  T  D  G  A  L  E  I  I  A  T  I  Q  V  F  T  Q         p.320

          .         .         .       | 11 .         .         .    g.205343
 TGCTTTGTAGAAGCTCTGGAGAAAGCAAGCAAGCAG | CTGCGGTTTGCACTCAAGACCTAC    c.1020
 C  F  V  E  A  L  E  K  A  S  K  Q   | L  R  F  A  L  K  T  Y      p.340

          .         .         .         .         .   | 12     .    g.208007
 TTTCCTTACACTTCTCCATCTCTTGCCATGGTGCTGCTGCAAGACCCTCAAG | ATATCCCT    c.1080
 F  P  Y  T  S  P  S  L  A  M  V  L  L  Q  D  P  Q  D |   I  P      p.360

          .         .         .         .         .         .       g.208067
 CGGGGACACTGGCTCCAGACACTGAAGCATATTTCTGAACTGCTCAGAGAAGCAGTTGAA       c.1140
 R  G  H  W  L  Q  T  L  K  H  I  S  E  L  L  R  E  A  V  E         p.380

          .     | 13   .         .         .         .         .    g.211118
 GACCAGACTCATGG | GTCCTGCGGAGGTCCCTTTGAGAGCTGGTTCCTGTTCATTCACTTC    c.1200
 D  Q  T  H  G  |  S  C  G  G  P  F  E  S  W  F  L  F  I  H  F      p.400

          .         .         .         .         .         .       g.211178
 GGAGGATGGGCTGAGATGGTGGCAGAGCAATTACTGATGTCGGCAGCCGAACCCCCCACG       c.1260
 G  G  W  A  E  M  V  A  E  Q  L  L  M  S  A  A  E  P  P  T         p.420

          .         .         .         .         .         .       g.211238
 GCCCTGCTGTGGCTCTTGGCCTTCTACTACGGCCCCCGTGATGGGAGGCAGCAGAGAGCA       c.1320
 A  L  L  W  L  L  A  F  Y  Y  G  P  R  D  G  R  Q  Q  R  A         p.440

           | 14        .         .         .         .         .    g.215491
 CAGACTATG | GTCCAGGTGAAGGCCGTGCTGGGCCACCTCCTGGCAATGTCCAGAAGCAGC    c.1380
 Q  T  M   | V  Q  V  K  A  V  L  G  H  L  L  A  M  S  R  S  S      p.460

          .         .         .         .         .         .       g.215551
 AGCCTCTCAGCCCAGGACCTGCAGACGGTAGCAGGACAGGGCACAGACACAGACCTCAGA       c.1440
 S  L  S  A  Q  D  L  Q  T  V  A  G  Q  G  T  D  T  D  L  R         p.480

          .         .         .         .         .         .       g.215611
 GCTCCTGCACAACAGCTGATCAGGCACCTTCTCCTCAACTTCCTGCTCTGGGCTCCTGGA       c.1500
 A  P  A  Q  Q  L  I  R  H  L  L  L  N  F  L  L  W  A  P  G         p.500

          .         .         .    | 15    .         .         .    g.220886
 GGCCACACGATCGCCTGGGATGTCATCACCCTG | ATGGCTCACACTGCTGAGATAACTCAC    c.1560
 G  H  T  I  A  W  D  V  I  T  L   | M  A  H  T  A  E  I  T  H      p.520

          .         .         .         .         .         .       g.220946
 GAGATCATTGGCTTTCTTGACCAGACCTTGTACAGATGGAATCGTCTTGGCATTGAAAGC       c.1620
 E  I  I  G  F  L  D  Q  T  L  Y  R  W  N  R  L  G  I  E  S         p.540

          .         .         .         .         .                 g.221003
 CCTAGATCAGAAAAACTGGCCCGAGAGCTCCTTAAAGAGCTGCGAACTCAAGTCTAG          c.1677
 P  R  S  E  K  L  A  R  E  L  L  K  E  L  R  T  Q  V  X            p.558

          .         .         .         .         .         .       g.221063
 aaggcacgcaggccgtgtgggtgcccggcgtgagggatcaggctcgccagggccacagga       c.*60

          .         .         .         .         .         .       g.221123
 caggtgatgacctgtggccacgcatttgtggagtaagtgccctcgctgggctgtgagaat       c.*120

          .         .         .         .         .         .       g.221183
 gagctgtacacatcttgggacaatctgctagtatctattttacaaaatgcagagccaggt       c.*180

          .         .         .         .         .         .       g.221243
 ccctcagcccagactcagtcagacatgttcactaatgactcaagtgagccttcggtactc       c.*240

          .         .         .         .         .         .       g.221303
 ctggtgcccgcccggccagaccgtcagcttgataattactaaagcaaaggcctgggtggg       c.*300

          .         .         .         .         .         .       g.221363
 agaacaggtttctagtttttacccaagtcaagctgcacatctattatttaaaaattcaaa       c.*360

          .         .         .         .         .         .       g.221423
 gtcttagaaccaagaatttggtcatgaaccattaaagaatttagagagaacttagctctt       c.*420

          .         .         .         .         .         .       g.221483
 tttagactctttttaggagtcagggatctgggataaagccacactgtcttgctgtatgga       c.*480

          .         .         .         .         .         .       g.221543
 gaaattcttcaaggggagtcagggtccctcaggcttcccttgtgtctccctggacctgcc       c.*540

          .         .         .         .         .         .       g.221603
 tgacaggccacaggagcagacagcacacccaagcccgggcctccggcacactctttccac       c.*600

          .         .         .         .         .         .       g.221663
 tctgtatttgctaaatgatgctaactgctaccaaaaggcccttgggacatcagaggagcc       c.*660

          .         .         .         .         .         .       g.221723
 ggcaggcgaaggtagaggatgtgttccagaaacattagaaggcaggattaattcagttag       c.*720

          .         .         .         .         .         .       g.221783
 ttagttctcttgttaaatggaaatgggaattggaaattcctgataaagaattggcctggc       c.*780

          .         .         .         .         .         .       g.221843
 tgggtgcagtggctcacacctgtgatcccagcactttgggaggccaaggcagggggatta       c.*840

          .         .         .         .         .         .       g.221903
 cttcagcccaggagttccagactgcctggctaacatggcaataccctatctctactaaaa       c.*900

          .         .         .         .         .         .       g.221963
 atacaaaaattatcggggtgcaatggcatgcatctgtaatcccagctattcaagaggctg       c.*960

          .         .         .         .         .         .       g.222023
 aggcatgaggatctcttgaacccgggaggtgggagttgtagtgagccgagatcatgacac       c.*1020

          .         .         .         .         .         .       g.222083
 tgcactccagcctgggcaacagagcgagaccatctcttaaaaaaaggcattgttagtgta       c.*1080

          .         .         .         .         .         .       g.222143
 atctcaaggttaacatttatttcatgtcagtacagggtgctttttcctttcagggacatt       c.*1140

          .         .         .         .         .         .       g.222203
 ctggaattgtattggttgtacattcttttgtgtctattctgtttgtcaagtgagtcaaga       c.*1200

          .         .         .         .         .         .       g.222263
 cttgcttttgtccattttgatttgtgtgtattagtctgagtcttggctccgttttgaggt       c.*1260

          .         .         .         .         .         .       g.222323
 atgagcaaagttttgctggattagaagttaacctttagggaaattccttattttggtatg       c.*1320

          .         .         .         .         .         .       g.222383
 tggcaatgctaatagatccactgaagatctggaaaattccaggaacttttcacctgagcc       c.*1380

          .         .         .         .         .         .       g.222443
 tttcttctgagaaatgctgcagtcagaagggtgtgctggtaaagtattttggtggcagct       c.*1440

          .         .         .         .         .         .       g.222503
 gccatcatggtcattgccttcatataacatgcttcgtgctcatggtcattgccttcatat       c.*1500

          .         .         .         .         .         .       g.222563
 aacatgcttcgtgccatcatgatccttgccttcatataacaaacatgcttcgtcagaggt       c.*1560

          .         .         .         .         .         .       g.222623
 gttggggttgaaaaaggagctgcatgcttcactggagttgagggcctctctcctgttctg       c.*1620

          .         .         .         .         .         .       g.222683
 actttaagccagaacttgtggctgggccatggaagctgtgactcctctgtggacatggtg       c.*1680

          .         .         .         .         .         .       g.222743
 gcagcagggaacccctagagagaggggccactgggaccaggcctcctgttgtggagggac       c.*1740

          .         .         .         .         .         .       g.222803
 tcctgggacagtcctccaccctgtcctgtggtcctgtgtacagggttggcctcttcctcc       c.*1800

          .         .         .         .         .         .       g.222863
 tcccctgccaggcctctgcccatgccccttccttccttctcctgggactggtgaagctag       c.*1860

          .         .         .         .         .         .       g.222923
 gcatctggaagacttcttcctagcctggaagccctgacctcggcccatctgcagaatctc       c.*1920

          .         .         .         .         .         .       g.222983
 ccagttccttcacagctgccgagtcctctcacgggtgcggtggaggcggccttgccggtg       c.*1980

          .         .         .         .         .         .       g.223043
 gtgctttctgggcagccaggggttcctgggtgggaggactgtccctctggggacgtggca       c.*2040

          .         .         .         .         .         .       g.223103
 ctgaagtgcctgctggcttcatgtggccctttgccctttcccagcctgagagatgctcaa       c.*2100

          .         .         .         .         .         .       g.223163
 aggtggggagctgggggagccacccctcggccattccctccacctccaagacaggtggcg       c.*2160

          .         .         .         .         .         .       g.223223
 gccgggcaggcactcttaagcccacctccccctcttgttgccttcgatttcggcaaagcc       c.*2220

          .         .         .         .         .         .       g.223283
 tgggcaggtgccaccgggaaggaatggcatccgagatgctgggcggggacgcggcgtggc       c.*2280

          .         .         .         .         .         .       g.223343
 cgagggggccttgacggcgttggcggggcctgggcacaggggcagccgcagggaggcagg       c.*2340

          .         .         .         .         .         .       g.223403
 gatggcaaggcgtgaagccaccctggaaggaactggaccaaggtcttcagaggtgcgaca       c.*2400

          .         .         .         .         .         .       g.223463
 gggtctggaatctgaccttactctagcaggagtttttgtagactctccctgatagtttag       c.*2460

          .         .         .         .         .         .       g.223523
 tttttgataaagcatgctggtaaaaccactaccctcagagagagccaaaaatacagaaga       c.*2520

          .         .         .         .         .         .       g.223583
 ggcggagagcgcccctccaaccaggctgttattcccctggactccgtgacatctgtggaa       c.*2580

          .         .         .         .         .         .       g.223643
 ttttttagctctttaaaatctgtaatttgttgtctattttttcattctaaataaaacttc       c.*2640

          .                                                         g.223656
 agtttgcacctaa                                                      c.*2653

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Fanconi anemia, complementation group C protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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