Fanconi anemia, complementation group G (FANCG) - coding DNA reference sequence

(used for variant description)

(last modified October 5, 2014)


This file was created to facilitate the description of sequence variants in the FANCG gene based on a coding DNA reference sequence following the HGVS recommendations. The sequence was taken from NG_007312.1 (identical to LRG_499), covering FANCG transcript NM_004629.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5012
                                                 aggaggacctgg       c.-481

 .         .         .         .         .         .                g.5072
 gggtgtggcagcgaggaagggccgagccacggactgtggggccgaaactcgctcccgccc       c.-421

 .         .         .         .         .         .                g.5132
 accctttctcgaggctgtggcctccgcgagagccgagcgggccgcaccgccggccgtgcg       c.-361

 .         .         .         .         .         .                g.5192
 actgccccagtcagacacgaccccggcttctagcccgcctaagcctgtttggggttgctg       c.-301

 .         .         .         .         .         .                g.5252
 actcgtttcctccccgagtttcccgcgggaactaactcttcaagaggaccaaccgcagcc       c.-241

 .         .         .         .         .         .                g.5312
 cagagcttcgcagacccggccaaccagaggcgaggttgagagcccggcgggccgcgggga       c.-181

 .         .         .         .         .         .                g.5372
 gagagcgtcccatctgtcctggaaagcctgggcgggtggattgggaccccgagagaagca       c.-121

 .         .         .         .         .         .                g.5432
 ggggagctcggcggggtgcagaagtgcccaggcccctccccgctggggttgggagcttgg       c.-61

 .         .         .         .         .         .                g.5492
 gcaggccagcttcacccttcctaagtccgcttctggtctccgggcccagcctcggccacc       c.-1

          .         .         .         .         .         .       g.5552
 ATGTCCCGCCAGACCACCTCTGTGGGCTCCAGCTGCCTGGACCTGTGGAGGGAAAAGAAT       c.60
 M  S  R  Q  T  T  S  V  G  S  S  C  L  D  L  W  R  E  K  N         p.20

          .         .     | 02   .         .         .         .    g.5811
 GACCGGCTCGTTCGACAGGCCAAG | GTGGCTCAGAACTCCGGTCTGACTCTGAGGCGACAG    c.120
 D  R  L  V  R  Q  A  K   | V  A  Q  N  S  G  L  T  L  R  R  Q      p.40

          .         .         .         .         .      | 03  .    g.6285
 CAGTTGGCTCAGGATGCACTGGAAGGGCTCAGAGGGCTCCTCCATAGTCTGCAAG | GGCTC    c.180
 Q  L  A  Q  D  A  L  E  G  L  R  G  L  L  H  S  L  Q  G |   L      p.60

          .         .         .         .         .         .       g.6345
 CCTGCAGCTGTTCCTGTTCTTCCCTTGGAGCTGACTGTCACCTGCAACTTCATTATCCTG       c.240
 P  A  A  V  P  V  L  P  L  E  L  T  V  T  C  N  F  I  I  L         p.80

          .         .         .         .         .         .       g.6405
 AGGGCAAGCTTGGCCCAGGGTTTCACAGAGGATCAGGCCCAGGATATCCAGCGGAGCCTA       c.300
 R  A  S  L  A  Q  G  F  T  E  D  Q  A  Q  D  I  Q  R  S  L         p.100

         | 04.         .         .         .         .         .    g.6726
 GAGAGAG | TGCTGGAGACACAGGAGCAGCAGGGGCCCAGGTTGGAACAGGGGCTCAGGGAG    c.360
 E  R  V |   L  E  T  Q  E  Q  Q  G  P  R  L  E  Q  G  L  R  E      p.120

          .         .         .         .         .         .       g.6786
 CTGTGGGACTCTGTCCTTCGTGCTTCCTGCCTTCTGCCGGAGCTGCTGTCTGCCCTGCAC       c.420
 L  W  D  S  V  L  R  A  S  C  L  L  P  E  L  L  S  A  L  H         p.140

          .         .         .         .         .         .       g.6846
 CGCCTGGTTGGCCTGCAGGCTGCCCTCTGGTTGAGTGCTGACCGTCTTGGGGACCTGGCC       c.480
 R  L  V  G  L  Q  A  A  L  W  L  S  A  D  R  L  G  D  L  A         p.160

          .         .         . | 05       .         .         .    g.7647
 TTGTTACTAGAGACCCTGAATGGCAGCCAG | AGTGGAGCCTCTAAGGATCTGCTGTTACTT    c.540
 L  L  L  E  T  L  N  G  S  Q   | S  G  A  S  K  D  L  L  L  L      p.180

          .         .         .         .         .         .       g.7707
 CTGAAAACTTGGAGTCCCCCAGCTGAGGAATTAGATGCTCCATTGACCCTGCAGGATGCC       c.600
 L  K  T  W  S  P  P  A  E  E  L  D  A  P  L  T  L  Q  D  A         p.200

          .         .         .         .       | 06 .         .    g.7929
 CAGGGATTGAAGGATGTCCTCCTGACAGCATTTGCCTACCGCCAAG | GTCTCCAGGAGCTG    c.660
 Q  G  L  K  D  V  L  L  T  A  F  A  Y  R  Q  G |   L  Q  E  L      p.220

          .         .         .         .         .         .       g.7989
 ATCACAGGGAACCCAGACAAGGCACTAAGCAGCCTTCATGAAGCGGCCTCAGGCCTGTGT       c.720
 I  T  G  N  P  D  K  A  L  S  S  L  H  E  A  A  S  G  L  C         p.240

          .         .         .         .         .        | 07.    g.8149
 CCACGGCCTGTGTTGGTCCAGGTGTACACAGCACTGGGGTCCTGTCACCGTAAGATG | GGA    c.780
 P  R  P  V  L  V  Q  V  Y  T  A  L  G  S  C  H  R  K  M   | G      p.260

          .         .         .         .         .         .       g.8209
 AATCCACAGAGAGCACTGTTGTACTTGGTTGCAGCCCTGAAAGAGGGATCAGCCTGGGGT       c.840
 N  P  Q  R  A  L  L  Y  L  V  A  A  L  K  E  G  S  A  W  G         p.280

          .         .         .         .         .         .       g.8269
 CCTCCACTTCTGGAGGCCTCTAGGCTCTATCAGCAACTGGGGGACACAACAGCAGAGCTG       c.900
 P  P  L  L  E  A  S  R  L  Y  Q  Q  L  G  D  T  T  A  E  L         p.300

          .         .     | 08   .         .         .         .    g.8469
 GAGAGTCTGGAGCTGCTAGTTGAG | GCCTTGAATGTCCCATGCAGTTCCAAAGCCCCGCAG    c.960
 E  S  L  E  L  L  V  E   | A  L  N  V  P  C  S  S  K  A  P  Q      p.320

          .         .         .         .         .         .       g.8529
 TTTCTCATTGAGGTAGAATTACTACTGCCACCACCTGACCTAGCCTCACCCCTTCATTGT       c.1020
 F  L  I  E  V  E  L  L  L  P  P  P  D  L  A  S  P  L  H  C         p.340

          .         .         .         .         .       | 09 .    g.8992
 GGCACTCAGAGCCAGACCAAGCACATACTAGCAAGCAGGTGCCTACAGACGGGGAG | GGCA    c.1080
 G  T  Q  S  Q  T  K  H  I  L  A  S  R  C  L  Q  T  G  R  |  A      p.360

          .         .         .         .         .         .       g.9052
 GGAGACGCTGCAGAGCATTACTTGGACCTGCTGGCCCTGTTGCTGGATAGCTCGGAGCCA       c.1140
 G  D  A  A  E  H  Y  L  D  L  L  A  L  L  L  D  S  S  E  P         p.380

     | 10    .         .         .         .         .         .    g.9319
 AGG | TTCTCCCCACCCCCCTCCCCTCCAGGGCCCTGTATGCCTGAGGTGTTTTTGGAGGCA    c.1200
 R   | F  S  P  P  P  S  P  P  G  P  C  M  P  E  V  F  L  E  A      p.400

          .         .         .         .         .         .       g.9379
 GCGGTAGCACTGATCCAGGCAGGCAGAGCCCAAGATGCCTTGACTCTATGTGAGGAGTTG       c.1260
 A  V  A  L  I  Q  A  G  R  A  Q  D  A  L  T  L  C  E  E  L         p.420

          .         .         .         .         .         .       g.9439
 CTCAGCCGCACATCATCTCTGCTACCCAAGATGTCCCGGCTGTGGGAAGATGCCAGAAAA       c.1320
 L  S  R  T  S  S  L  L  P  K  M  S  R  L  W  E  D  A  R  K         p.440

          .         .         .         .         .         .       g.9499
 GGAACCAAGGAACTGCCATACTGCCCACTCTGGGTCTCTGCCACCCACCTGCTTCAGGGC       c.1380
 G  T  K  E  L  P  Y  C  P  L  W  V  S  A  T  H  L  L  Q  G         p.460

          .         .         .         .         .    | 11    .    g.9698
 CAGGCCTGGGTTCAACTGGGTGCCCAAAAAGTGGCAATTAGTGAATTTAGCAG | GTGCCTC    c.1440
 Q  A  W  V  Q  L  G  A  Q  K  V  A  I  S  E  F  S  R  |  C  L      p.480

          .         .         .         . | 12       .         .    g.9954
 GAGCTGCTCTTCCGGGCCACACCTGAGGAAAAAGAACAAG | GGGCAGCTTTCAACTGTGAG    c.1500
 E  L  L  F  R  A  T  P  E  E  K  E  Q  G |   A  A  F  N  C  E      p.500

          .         .         .         .         .         .       g.10014
 CAGGGATGTAAGTCAGATGCGGCACTGCAGCAGCTTCGGGCAGCCGCCCTAATTAGTCGT       c.1560
 Q  G  C  K  S  D  A  A  L  Q  Q  L  R  A  A  A  L  I  S  R         p.520

          .         .         .         .         .         .       g.10074
 GGACTGGAATGGGTAGCCAGCGGCCAGGATACCAAAGCCTTACAGGACTTCCTCCTCAGT       c.1620
 G  L  E  W  V  A  S  G  Q  D  T  K  A  L  Q  D  F  L  L  S         p.540

          .       | 13 .         .         .         .         .    g.10566
 GTGCAGATGTGCCCAG | GTAATCGAGACACTTACTTTCACCTGCTTCAGACTCTGAAGAGG    c.1680
 V  Q  M  C  P  G |   N  R  D  T  Y  F  H  L  L  Q  T  L  K  R      p.560

          .         .         .         .         .         .       g.10626
 CTAGATCGGAGGGATGAGGCCACTGCACTCTGGTGGAGGCTGGAGGCCCAAACTAAGGGG       c.1740
 L  D  R  R  D  E  A  T  A  L  W  W  R  L  E  A  Q  T  K  G         p.580

          .         . | 14       .         .         .         .    g.10840
 TCACATGAAGATGCTCTGTG | GTCTCTCCCCCTGTACCTAGAAAGCTATTTGAGCTGGATC    c.1800
 S  H  E  D  A  L  W  |  S  L  P  L  Y  L  E  S  Y  L  S  W  I      p.600

          .         .         .         .         .         .       g.10900
 CGTCCCTCTGATCGTGACGCCTTCCTTGAAGAATTTCGGACATCTCTGCCAAAGTCTTGT       c.1860
 R  P  S  D  R  D  A  F  L  E  E  F  R  T  S  L  P  K  S  C         p.620

                                                                    g.10909
 GACCTGTAG                                                          c.1869
 D  L  X                                                            p.622

          .         .         .         .         .         .       g.10969
 ctgccacgttttgaagagcttgagctgggtccccagtgggctgtctctctgtggggaggg       c.*60

          .         .         .         .         .         .       g.11029
 ctttctgcttcaccatcattaggaatgtgaccattcctatataattcctggactggtgag       c.*120

          .         .         .         .         .         .       g.11089
 attggtggtaggcctgtgaaatttgccctagttactaccattctcgttttggaggaaaca       c.*180

          .         .         .         .         .         .       g.11149
 atctctgccaccaccaagtcattgactttgctcgaggcaccttttttcctgtttctcctt       c.*240

          .         .         .                                     g.11179
 ttctgttgtcgagtaaaatttcatatttat                                     c.*270

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Fanconi anemia, complementation group G protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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