Fanconi anemia, complementation group L (FANCL) - coding DNA reference sequence

(used for variant description)

(last modified October 5, 2014)


This file was created to facilitate the description of sequence variants in the FANCL gene based on a coding DNA reference sequence following the HGVS recommendations. The sequence was taken from NG_007418.1, covering FANCL transcript NM_018062.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5006
                                                      agcggac       c.-61

 .         .         .         .         .         .                g.5066
 tgcgcatgtgcaggacccagcaggtctagagcttttctgtgtttctccggacttcgagcc       c.-1

          .         .         .         .         .         .       g.5126
 ATGGCGGTGACGGAAGCGAGCCTGTTGCGCCAGTGCCCCCTGCTTCTGCCCCAGAACCGG       c.60
 M  A  V  T  E  A  S  L  L  R  Q  C  P  L  L  L  P  Q  N  R         p.20

          .         .         .       | 02 .         .         .    g.14291
 TCGAAAACCGTGTATGAGGGATTCATCTCGGCTCAG | GGAAGAGACTTCCACCTTAGGATA    c.120
 S  K  T  V  Y  E  G  F  I  S  A  Q   | G  R  D  F  H  L  R  I      p.40

          .         .         .      | 03  .         .         .    g.16530
 GTGTTGCCTGAAGATTTACAACTGAAGAATGCAAG | ATTATTATGTAGTTGGCAGCTGAGA    c.180
 V  L  P  E  D  L  Q  L  K  N  A  R  |  L  L  C  S  W  Q  L  R      p.60

          .         .         .       | 04 .         .         .    g.19619
 ACAATACTTAGTGGATACCATCGAATAGTACAACAG | AGAATGCAGCACTCTCCTGATCTA    c.240
 T  I  L  S  G  Y  H  R  I  V  Q  Q   | R  M  Q  H  S  P  D  L      p.80

          .         .         .    | 05    .         .         .    g.24364
 ATGAGCTTTATGATGGAGTTGAAGATGCTTTTG | GAAGTTGCCTTAAAGAATAGACAAGAG    c.300
 M  S  F  M  M  E  L  K  M  L  L   | E  V  A  L  K  N  R  Q  E      p.100

          .         .         .         .         .         .       g.24424
 CTGTATGCACTACCTCCTCCTCCCCAGTTCTACTCAAGCCTTATTGAAGAGATAGGAACT       c.360
 L  Y  A  L  P  P  P  P  Q  F  Y  S  S  L  I  E  E  I  G  T         p.120

          .     | 06   .         .         .         .         .    g.42199
 CTTGGTTGGGATAA | ACTTGTGTATGCGGATACCTGCTTCAGTACCATCAAGTTAAAAGCA    c.420
 L  G  W  D  K  |  L  V  Y  A  D  T  C  F  S  T  I  K  L  K  A      p.140

          .         .         .         .         .  | 07      .    g.47726
 GAAGATGCTTCTGGTAGAGAGCATTTAATCACTCTCAAGTTGAAGGCAAAG | TATCCTGCA    c.480
 E  D  A  S  G  R  E  H  L  I  T  L  K  L  K  A  K   | Y  P  A      p.160

          .         .         .         .         .         .       g.47786
 GAATCACCAGATTATTTTGTGGATTTTCCTGTTCCATTTTGTGCCTCCTGGACACCTCAG       c.540
 E  S  P  D  Y  F  V  D  F  P  V  P  F  C  A  S  W  T  P  Q         p.180

  | 08       .         .         .         .         .         .    g.80565
  | AGCTCCTTAATAAGCATTTATAGTCAGTTTTTGGCAGCAATAGAATCACTAAAGGCATTC    c.600
  | S  S  L  I  S  I  Y  S  Q  F  L  A  A  I  E  S  L  K  A  F      p.200

          .         .         .         .         .         .       g.80625
 TGGGATGTTATGGATGAAATCGATGAGAAGACCTGGGTACTTGAGCCAGAAAAACCTCCA       c.660
 W  D  V  M  D  E  I  D  E  K  T  W  V  L  E  P  E  K  P  P         p.220

          .         .         .  | 09      .         .         .    g.82891
 CGGAGTGCAACAGCACGCAGAATTGCATTAG | GTAATAATGTTTCCATAAATATAGAGGTA    c.720
 R  S  A  T  A  R  R  I  A  L  G |   N  N  V  S  I  N  I  E  V      p.240

          .         .         .         .         .      | 10  .    g.83310
 GACCCCAGGCATCCTACTATGCTTCCTGAGTGCTTCTTTCTTGGAGCTGACCATG | TGGTA    c.780
 D  P  R  H  P  T  M  L  P  E  C  F  F  L  G  A  D  H  V |   V      p.260

          .         .         .         .  | 11      .         .    g.83451
 AAACCCCTGGGAATTAAGCTGAGCAGGAACATACATTTGTG | GGATCCAGAAAATAGTGTG    c.840
 K  P  L  G  I  K  L  S  R  N  I  H  L  W  |  D  P  E  N  S  V      p.280

          .         .         .         .         .         .       g.83511
 TTACAAAATTTGAAAGATGTTTTAGAAATTGATTTTCCAGCTCGTGCTATCCTGGAAAAA       c.900
 L  Q  N  L  K  D  V  L  E  I  D  F  P  A  R  A  I  L  E  K         p.300

     | 12    .         .         .         .         .         .    g.84798
 TCT | GATTTTACTATGGATTGTGGAATTTGTTATGCTTATCAACTTGACGGTACCATTCCT    c.960
 S   | D  F  T  M  D  C  G  I  C  Y  A  Y  Q  L  D  G  T  I  P      p.320

          .         .         .         .         .         .       g.84858
 GATCAAGTGTGTGATAATTCTCAGTGTGGACAACCTTTCCATCAAATATGCTTATATGAG       c.1020
 D  Q  V  C  D  N  S  Q  C  G  Q  P  F  H  Q  I  C  L  Y  E         p.340

  | 13       .         .         .         .         .         .    g.86260
  | TGGCTGAGAGGACTACTAACTAGTAGACAGAGTTTTAACATCATATTTGGTGAATGTCCA    c.1080
  | W  L  R  G  L  L  T  S  R  Q  S  F  N  I  I  F  G  E  C  P      p.360

          .   | 14     .         .         .                        g.86627
 TATTGTAGTAAG | CCAATTACCTTAAAAATGTCTGGAAGGAAACACTGA                c.1128
 Y  C  S  K   | P  I  T  L  K  M  S  G  R  K  H  X                  p.375

          .         .         .         .         .         .       g.86687
 aataagaatacaacatttcggtgaagagctggaaacttaaaaaattatcaaaaggaattt       c.*60

          .         .         .         .         .         .       g.86747
 tggtatcatcttcagagaaaaaataaagcaagaaatactaacatcaaaaggacaggtatg       c.*120

          .         .         .         .         .         .       g.86807
 atgatgcgataataataaacatctgcgtttgtctcttcactaagagtaaactgggaaatt       c.*180

          .         .         .         .         .         .       g.86867
 gtaggccaaagtccagttgaactttctaagtctgtgatccccgtgctgactgtggaagtg       c.*240

          .         .         .         .         .         .       g.86927
 tatttataccaagatggagatcttgacttcttgaatatatctggactggtaaaatcttga       c.*300

          .         .         .         .         .         .       g.86987
 tgaggctcataaaatgagtttgggaattgtgtatagctgattttttgtgggaaactgttt       c.*360

          .         .         .         .         .         .       g.87047
 acttcattcaaaggttcttgagactcttgatatttctgtcttctccttgtgctttcctat       c.*420

          .         .         .         .         .         .       g.87107
 ggaaaaaatacatatatagtttagtttgttagacgtgagttatccaagtatttattttgt       c.*480

          .         .         .         .                           g.87149
 gtagtgtgtaagaatgctaaataaaatgttatacaagatcaa                         c.*522

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Fanconi anemia, complementation group L protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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