fibulin 5 (FBLN5) - coding DNA reference sequence

(used for variant description)

(last modified October 14, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_006329.3 in the FBLN5 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008254.1, covering FBLN5 transcript NM_006329.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5053
        cgcccctcgccttctgcccgggcgctcgcagccgagcgcggccggggaagggc       c.-421

 .         .         .         .         .         .                g.5113
 tctcctcccagcgccgagcactgggccctggcagacgccccaagattgttgtgaggagtc       c.-361

 .         .         .         .         .         .                g.5173
 tagccagttggtgagcgctgtaatctgaaccagctgtgtccagactgaggccccatttgc       c.-301

 .         .         .         .         .         .                g.5233
 attgtttaacatacttagaaaatgaagtgttcatttttaacattcctcctccaattggtt       c.-241

 .         .         .         .         .         .                g.5293
 taatgctgaattactgaagagggctaagcaaaaccaggtgcttgcgctgagggctctgca       c.-181

 .         .         .         .         .         .                g.5353
 gtggctgggaggaccccggcgctctccccgtgtcctctccacgactcgctcggcccctct       c.-121

 .         .         .         .         .         .                g.5413
 ggaataaaacacccgcgagccccgagggcccagaggaggccgacgtgcccgagctcctcc       c.-61

 .         .         .         .         .         .                g.5473
 gggggtcccgcccgcgagctttcttctcgccttcgcatctcctcctcgcgcgtcttggac       c.-1

          .        | 02.         .         .         .         .    g.9784
 ATGCCAGGAATAAAAAG | GATACTCACTGTTACCATTCTGGCTCTCTGTCTTCCAAGCCCT    c.60
 M  P  G  I  K  R  |  I  L  T  V  T  I  L  A  L  C  L  P  S  P      p.20

          .   | 03     .         .         .         .         .    g.12134
 GGGAATGCACAG | GCACAGTGCACGAATGGCTTTGACCTGGATCGCCAGTCAGGACAGTGT    c.120
 G  N  A  Q   | A  Q  C  T  N  G  F  D  L  D  R  Q  S  G  Q  C      p.40

      | 04   .         .         .         .         .         .    g.15557
 TTAG | ATATTGATGAATGCCGAACCATCCCCGAGGCCTGCCGAGGAGACATGATGTGTGTT    c.180
 L  D |   I  D  E  C  R  T  I  P  E  A  C  R  G  D  M  M  C  V      p.60

          .         .         .         .         .         .       g.15617
 AACCAAAATGGCGGGTATTTATGCATTCCCCGGACAAACCCTGTGTATCGAGGGCCCTAC       c.240
 N  Q  N  G  G  Y  L  C  I  P  R  T  N  P  V  Y  R  G  P  Y         p.80

          .         .         .         .         .         .       g.15677
 TCGAACCCCTACTCGACCCCCTACTCAGGTCCGTACCCAGCAGCTGCCCCACCACTCTCA       c.300
 S  N  P  Y  S  T  P  Y  S  G  P  Y  P  A  A  A  P  P  L  S         p.100

          .         .         .         .         .         .       g.15737
 GCTCCAAACTATCCCACGATCTCCAGGCCTCTTATATGCCGCTTTGGATACCAGATGGAT       c.360
 A  P  N  Y  P  T  I  S  R  P  L  I  C  R  F  G  Y  Q  M  D         p.120

          .          | 05        .         .         .         .    g.57671
 GAAAGCAACCAATGTGTGG | ATGTGGACGAGTGTGCAACAGATTCCCACCAGTGCAACCCC    c.420
 E  S  N  Q  C  V  D |   V  D  E  C  A  T  D  S  H  Q  C  N  P      p.140

          .         .         .         .         .         .       g.57731
 ACCCAGATCTGCATCAATACTGAAGGCGGGTACACCTGCTCCTGCACCGACGGATATTGG       c.480
 T  Q  I  C  I  N  T  E  G  G  Y  T  C  S  C  T  D  G  Y  W         p.160

          .         .   | 06     .         .         .         .    g.61403
 CTTCTGGAAGGCCAGTGCTTAG | ACATTGATGAATGTCGCTATGGTTACTGCCAGCAGCTC    c.540
 L  L  E  G  Q  C  L  D |   I  D  E  C  R  Y  G  Y  C  Q  Q  L      p.180

          .         .         .         .         .         .       g.61463
 TGTGCGAATGTTCCTGGATCCTATTCTTGTACATGCAACCCTGGTTTTACCCTCAATGAG       c.600
 C  A  N  V  P  G  S  Y  S  C  T  C  N  P  G  F  T  L  N  E         p.200

          .          | 07        .         .         .         .    g.65431
 GATGGAAGGTCTTGCCAAG | ATGTGAACGAGTGTGCCACCGAGAACCCCTGCGTGCAAACC    c.660
 D  G  R  S  C  Q  D |   V  N  E  C  A  T  E  N  P  C  V  Q  T      p.220

          .         .         .         .         .         .       g.65491
 TGCGTCAACACCTACGGCTCTTTCATCTGCCGCTGTGACCCAGGATATGAACTTGAGGAA       c.720
 C  V  N  T  Y  G  S  F  I  C  R  C  D  P  G  Y  E  L  E  E         p.240

          .          | 08        .         .         .         .    g.69667
 GATGGCGTTCATTGCAGTG | ATATGGACGAGTGCAGCTTCTCTGAGTTCCTCTGCCAACAT    c.780
 D  G  V  H  C  S  D |   M  D  E  C  S  F  S  E  F  L  C  Q  H      p.260

          .         .         .         .         .         .       g.69727
 GAGTGTGTGAACCAGCCCGGCACATACTTCTGCTCCTGCCCTCCAGGCTACATCCTGCTG       c.840
 E  C  V  N  Q  P  G  T  Y  F  C  S  C  P  P  G  Y  I  L  L         p.280

          .         .   | 09     .         .         .         .    g.71322
 GATGACAACCGAAGCTGCCAAG | ACATCAACGAATGTGAGCACAGGAACCACACGTGCAAC    c.900
 D  D  N  R  S  C  Q  D |   I  N  E  C  E  H  R  N  H  T  C  N      p.300

          .         .         .         .         .         .       g.71382
 CTGCAGCAGACGTGCTACAATTTACAAGGGGGCTTCAAATGCATTGACCCCATCCGCTGT       c.960
 L  Q  Q  T  C  Y  N  L  Q  G  G  F  K  C  I  D  P  I  R  C         p.320

          .         .          | 10        .         .         .    g.75051
 GAGGAGCCTTATCTGAGGATCAGTGATAA | CCGCTGTATGTGTCCTGCTGAGAACCCTGGC    c.1020
 E  E  P  Y  L  R  I  S  D  N  |  R  C  M  C  P  A  E  N  P  G      p.340

          .         .         .         .         .         .       g.75111
 TGCAGAGACCAGCCCTTTACCATCTTGTACCGGGACATGGACGTGGTGTCAGGACGCTCC       c.1080
 C  R  D  Q  P  F  T  I  L  Y  R  D  M  D  V  V  S  G  R  S         p.360

          .         .         .         .         .         .       g.75171
 GTTCCCGCTGACATCTTCCAAATGCAAGCCACGACCCGCTACCCTGGGGCCTATTACATT       c.1140
 V  P  A  D  I  F  Q  M  Q  A  T  T  R  Y  P  G  A  Y  Y  I         p.380

          .         .         .         .      | 11  .         .    g.82332
 TTCCAGATCAAATCTGGGAATGAGGGCAGAGAATTTTACATGCGG | CAAACGGGCCCCATC    c.1200
 F  Q  I  K  S  G  N  E  G  R  E  F  Y  M  R   | Q  T  G  P  I      p.400

          .         .         .         .         .         .       g.82392
 AGTGCCACCCTGGTGATGACACGCCCCATCAAAGGGCCCCGGGAAATCCAGCTGGACTTG       c.1260
 S  A  T  L  V  M  T  R  P  I  K  G  P  R  E  I  Q  L  D  L         p.420

          .         .         .         .         .         .       g.82452
 GAAATGATCACTGTCAACACTGTCATCAACTTCAGAGGCAGCTCCGTGATCCGACTGCGG       c.1320
 E  M  I  T  V  N  T  V  I  N  F  R  G  S  S  V  I  R  L  R         p.440

          .         .                                               g.82479
 ATATATGTGTCGCAGTACCCATTCTGA                                        c.1347
 I  Y  V  S  Q  Y  P  F  X                                          p.448

          .         .         .         .         .         .       g.82539
 gcctcgggctggagcctccgacgctgcctctcattggcaccaagggacaggagaagagag       c.*60

          .         .         .         .         .         .       g.82599
 gaaataacagagagaatgagagcgacacagacgttaggcatttcctgctgaacgtttccc       c.*120

          .         .         .         .         .         .       g.82659
 cgaagagtcagccccgacttcctgactctcacctgtactattgcagacctgtcaccctgc       c.*180

          .         .         .         .         .         .       g.82719
 aggacttgccacccccagttcctatgacacagttatcaaaaagtattatcattgctcccc       c.*240

          .         .         .         .         .         .       g.82779
 tgatagaagattgttggtgaattttcaaggccttcagtttatttccactattttcaaaga       c.*300

          .         .         .         .         .         .       g.82839
 aaatagattaggtttgcgggggtctgagtctatgttcaaagactgtgaacagcttgctgt       c.*360

          .         .         .         .         .         .       g.82899
 cacttcttcacctcttccactccttctctcactgtgttactgctttgcaaagacccggga       c.*420

          .         .         .         .         .         .       g.82959
 gctggcggggaaccctgggagtagctagtttgctttttgcgtacacagagaaggctatgt       c.*480

          .         .         .         .         .         .       g.83019
 aaacaaaccacagcaggatcgaagggtttttagagaatgtgtttcaaaaccatgcctggt       c.*540

          .         .         .         .         .         .       g.83079
 attttcaaccataaaagaagtttcagttgtccttaaatttgtataacggtttaattctgt       c.*600

          .         .         .         .         .         .       g.83139
 cttgttcattttgagtatttttaaaaaatatgtcgtagaattccttcgaaaggccttcag       c.*660

          .         .         .         .         .         .       g.83199
 acacatgctatgttctgtcttcccaaacccagtctcctctccattttagcccagtgtttt       c.*720

          .         .         .         .         .         .       g.83259
 ctttgaggaccccttaatcttgctttctttagaatttttacccaattggattggaatgca       c.*780

          .         .         .                                     g.83292
 gaggtctccaaactgattaaatatttgaagaga                                  c.*813

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Fibulin 5 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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